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The map label for this gene is adiC [H]

Identifier: 158422606

GI number: 158422606

Start: 1093743

End: 1095269

Strand: Reverse

Name: adiC [H]

Synonym: AZC_0982

Alternate gene names: 158422606

Gene position: 1095269-1093743 (Counterclockwise)

Preceding gene: 158422607

Following gene: 158422605

Centisome position: 20.4

GC content: 66.4

Gene sequence:

>1527_bases
ATGTCCTCCACCGACACCGCCCCTGCCGCTTCCACCGACGCCGAGGCCGCAAAGATCGGCCTCGTGCCGGCGACCCTGAT
GGTCGCCGGCAACATGATGGGATCGGGCGTCTTCATGCTGCCCGCCAATCTCGCCGCCATCGGCTCCATCGCCGTCATTG
GCTGGCTGATCACCATCGCCGGCGCCGTGGCGCTGGCGCTGACCTTCGCCCGCCTCGCGGCCATCGATCCGGCGGCCGGT
GGTCCGTATGCCTATGCCCGCAAGGCCTTCGGCGACTATATGGGCTACCAGACCAACCTCATCTACTGGCTGGCCAATGT
GGTGGGCAACGTGGGCCTCGCGGTGGCCGGGCTCGGCTATCTCACCGCCTTCTTCCCGGCACTGAAGGACCCGCTCACCT
CCGCCCTGGCGCAGGTGGCGCTCATCTGGTTCTTCACCTATGCCAACATCCTCGGCCCGAACGTGGTCGGCCGGCTGCAG
TCCTTCACGACGGTCTTCGCCCTCATCCCCATCCTCGGCATGGCGGTGTTCGGCTGGTTCTGGTTCTCTCCGGCAACCTA
TGCGGAGGGCTGGAACGTCTCCGGCAAGGAGAGCGGGGCGGCCATCATGGCGACGCTCAACTTCACCCTCTGGGCCTTCA
TCGGCGTGGAGAGCGCCTCCGTATCGGCGGGCGTGGTACGCAATCCGCAGCGCAACGTGCCCATCGCCACTGTGGGCGGC
GTGGTGCTGGCAGCTGTCGCCTACATCCTCTCCTCCACCGTCATCATGGGCATGATCCCGAACAAGGCGCTCATCGCCTC
CTCGGCACCCTTTGCGGATGCCGCGCGGCTGGCACTGGGCGATATCGCGGGCTCGGCGGTGGCCATCTGCGCGGCGCTGG
GCTGCCTTGGCTCGCTCGCCGGCTGGACGCTGCTCGTCGGCCAGACTGCGAAGGCGGCAGCGGATGATGGGCTCTTCGGA
GCCGTGTTCGCCAAGGTGAACGCGAAGGGCGTGCCCTCGGCGGGCCTTGCCATCGTCGCCGCGATCATGACCGTGCAGGT
GTTCGCGACCATGTCGCCGACCGCCAGCCAGCAGTTCGGCAAGATTGCGTCCATCGCGGTCATCATGACGCTGTTGCCCT
ACATCTATTCCGCCATTTCCATCAAGGTTCTGGGCTACAGGAAGATGCCCACGCACCAGTACAACATCTATGTTCTGGTG
GGCCTCGGGGCTGCCGCCTACAGCCTCGTCGCCCTCGTGGGCTCGGACGGCGAGCAGACCCGCTGGTCGCTGATCTTCGT
CATCGCCACCATCGTCTTCTATTCGGCGGCCATCACCCGCAAGCGGGAGATCGAGGAGAAGCATCTGGTGCCCGGAGGCG
CGGCGCCCACCTGGATCCGCTATGTGACGGTGACAGCCACCATCCTCGCACTCGCCGGCCTGTTCTGGATGTCCATCGGA
CGTTACGAGACTCAGAACCTGCGGACCCGCTCGCCCGTCCCGCCCGCACAGACGACGATGCCCGCGCCCGTCGGGACGAC
GAAATAG

Upstream 100 bases:

>100_bases
TGACCTGCGCTTCCCCGGCTTTGCCCACGACACGCACGGCGTGGAGGTGGAGGACGGGCGCTATCTCATCCACCGCATCG
TGCGCTGAGGGGCTGCGAGC

Downstream 100 bases:

>100_bases
CCTGTCGGCCCATGCCGGCCGCCCCAGCACCGGCTTGGGTCTCCGTTCCTGACCTTATGATTAGTATGGCCAACTGCACT
CTGACGTTACGGCGGGTGGC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSSTDTAPAASTDAEAAKIGLVPATLMVAGNMMGSGVFMLPANLAAIGSIAVIGWLITIAGAVALALTFARLAAIDPAAG
GPYAYARKAFGDYMGYQTNLIYWLANVVGNVGLAVAGLGYLTAFFPALKDPLTSALAQVALIWFFTYANILGPNVVGRLQ
SFTTVFALIPILGMAVFGWFWFSPATYAEGWNVSGKESGAAIMATLNFTLWAFIGVESASVSAGVVRNPQRNVPIATVGG
VVLAAVAYILSSTVIMGMIPNKALIASSAPFADAARLALGDIAGSAVAICAALGCLGSLAGWTLLVGQTAKAAADDGLFG
AVFAKVNAKGVPSAGLAIVAAIMTVQVFATMSPTASQQFGKIASIAVIMTLLPYIYSAISIKVLGYRKMPTHQYNIYVLV
GLGAAAYSLVALVGSDGEQTRWSLIFVIATIVFYSAAITRKREIEEKHLVPGGAAPTWIRYVTVTATILALAGLFWMSIG
RYETQNLRTRSPVPPAQTTMPAPVGTTK

Sequences:

>Translated_508_residues
MSSTDTAPAASTDAEAAKIGLVPATLMVAGNMMGSGVFMLPANLAAIGSIAVIGWLITIAGAVALALTFARLAAIDPAAG
GPYAYARKAFGDYMGYQTNLIYWLANVVGNVGLAVAGLGYLTAFFPALKDPLTSALAQVALIWFFTYANILGPNVVGRLQ
SFTTVFALIPILGMAVFGWFWFSPATYAEGWNVSGKESGAAIMATLNFTLWAFIGVESASVSAGVVRNPQRNVPIATVGG
VVLAAVAYILSSTVIMGMIPNKALIASSAPFADAARLALGDIAGSAVAICAALGCLGSLAGWTLLVGQTAKAAADDGLFG
AVFAKVNAKGVPSAGLAIVAAIMTVQVFATMSPTASQQFGKIASIAVIMTLLPYIYSAISIKVLGYRKMPTHQYNIYVLV
GLGAAAYSLVALVGSDGEQTRWSLIFVIATIVFYSAAITRKREIEEKHLVPGGAAPTWIRYVTVTATILALAGLFWMSIG
RYETQNLRTRSPVPPAQTTMPAPVGTTK
>Mature_507_residues
SSTDTAPAASTDAEAAKIGLVPATLMVAGNMMGSGVFMLPANLAAIGSIAVIGWLITIAGAVALALTFARLAAIDPAAGG
PYAYARKAFGDYMGYQTNLIYWLANVVGNVGLAVAGLGYLTAFFPALKDPLTSALAQVALIWFFTYANILGPNVVGRLQS
FTTVFALIPILGMAVFGWFWFSPATYAEGWNVSGKESGAAIMATLNFTLWAFIGVESASVSAGVVRNPQRNVPIATVGGV
VLAAVAYILSSTVIMGMIPNKALIASSAPFADAARLALGDIAGSAVAICAALGCLGSLAGWTLLVGQTAKAAADDGLFGA
VFAKVNAKGVPSAGLAIVAAIMTVQVFATMSPTASQQFGKIASIAVIMTLLPYIYSAISIKVLGYRKMPTHQYNIYVLVG
LGAAAYSLVALVGSDGEQTRWSLIFVIATIVFYSAAITRKREIEEKHLVPGGAAPTWIRYVTVTATILALAGLFWMSIGR
YETQNLRTRSPVPPAQTTMPAPVGTTK

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=353, Percent_Identity=25.7790368271955, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=433, Percent_Identity=54.2725173210162, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1790575, Length=440, Percent_Identity=40.2272727272727, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1786908, Length=438, Percent_Identity=34.0182648401827, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1787890, Length=419, Percent_Identity=29.5942720763723, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87082250, Length=326, Percent_Identity=26.6871165644172, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790653, Length=416, Percent_Identity=22.1153846153846, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786302, Length=403, Percent_Identity=22.5806451612903, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=410, Percent_Identity=26.0975609756098, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982612, Length=410, Percent_Identity=23.4146341463415, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982608, Length=410, Percent_Identity=23.4146341463415, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=343, Percent_Identity=23.9067055393586, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24667468, Length=434, Percent_Identity=24.6543778801843, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52660; Mature: 52529

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTDTAPAASTDAEAAKIGLVPATLMVAGNMMGSGVFMLPANLAAIGSIAVIGWLITIA
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHHHHHHH
GAVALALTFARLAAIDPAAGGPYAYARKAFGDYMGYQTNLIYWLANVVGNVGLAVAGLGY
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
LTAFFPALKDPLTSALAQVALIWFFTYANILGPNVVGRLQSFTTVFALIPILGMAVFGWF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WFSPATYAEGWNVSGKESGAAIMATLNFTLWAFIGVESASVSAGVVRNPQRNVPIATVGG
HCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHH
VVLAAVAYILSSTVIMGMIPNKALIASSAPFADAARLALGDIAGSAVAICAALGCLGSLA
HHHHHHHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GWTLLVGQTAKAAADDGLFGAVFAKVNAKGVPSAGLAIVAAIMTVQVFATMSPTASQQFG
HHHEEECCCHHHHCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
KIASIAVIMTLLPYIYSAISIKVLGYRKMPTHQYNIYVLVGLGAAAYSLVALVGSDGEQT
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCH
RWSLIFVIATIVFYSAAITRKREIEEKHLVPGGAAPTWIRYVTVTATILALAGLFWMSIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RYETQNLRTRSPVPPAQTTMPAPVGTTK
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSTDTAPAASTDAEAAKIGLVPATLMVAGNMMGSGVFMLPANLAAIGSIAVIGWLITIA
CCCCCCCCCCCCCHHHHCCCHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHHHHHHH
GAVALALTFARLAAIDPAAGGPYAYARKAFGDYMGYQTNLIYWLANVVGNVGLAVAGLGY
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
LTAFFPALKDPLTSALAQVALIWFFTYANILGPNVVGRLQSFTTVFALIPILGMAVFGWF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WFSPATYAEGWNVSGKESGAAIMATLNFTLWAFIGVESASVSAGVVRNPQRNVPIATVGG
HCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHH
VVLAAVAYILSSTVIMGMIPNKALIASSAPFADAARLALGDIAGSAVAICAALGCLGSLA
HHHHHHHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GWTLLVGQTAKAAADDGLFGAVFAKVNAKGVPSAGLAIVAAIMTVQVFATMSPTASQQFG
HHHEEECCCHHHHCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
KIASIAVIMTLLPYIYSAISIKVLGYRKMPTHQYNIYVLVGLGAAAYSLVALVGSDGEQT
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCH
RWSLIFVIATIVFYSAAITRKREIEEKHLVPGGAAPTWIRYVTVTATILALAGLFWMSIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RYETQNLRTRSPVPPAQTTMPAPVGTTK
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]