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The map label for this gene is moaA [H]

Identifier: 158422523

GI number: 158422523

Start: 1008040

End: 1009239

Strand: Direct

Name: moaA [H]

Synonym: AZC_0899

Alternate gene names: 158422523

Gene position: 1008040-1009239 (Clockwise)

Preceding gene: 158422521

Following gene: 158422524

Centisome position: 18.77

GC content: 67.17

Gene sequence:

>1200_bases
ATGAACTCCGTGCCGGCAGGTTGCCCGTTCGCCGGGTCATTGCAGCCGCCGGCCTACCAAACGGCACCTTGCATACGATA
TAAGGGAGATGCCCGAGCCGGCGCCAGACCGGCCGGCAGGGAGCTGTCAGGGTGTGAGGAGGCAGGCGTGGCGTTTGTGA
CCCGCGATCTTGGCGATCGCAGCGGCGGTTCCGCAACGGCCCTTGGTCCGCTGGTGGACACCTTCGGCCGTGCCGTGAGC
TATCTGCGTGTCTCGGTGACGGACCGGTGCGATTTCCGCTGTGTCTATTGCATGTCCGAGCACATGACCTTCCTGCCGAA
GCCCGACCTGCTGACGCTGGAGGAACTCGATCGCCTGTGCTCCGCATTTGTCGCCCGTGGCGTGCGCAAGCTGCGCCTCA
CCGGCGGCGAGCCCCTGGTGCGGCGCGACGTGATGACCCTGTTCCGCTCGCTCTCCCGCCATCTCGAGACCGGGCGGCTC
GAAGAACTCACCCTCACCACCAACGGCTCGCAGCTCGCCCGCTTCGCCGGCGATCTGGCTGCCTGCGGCGTGAAGCGCAT
CAACGTGTCCATCGATACGCTGGACCCGGACAAGTTCCGCGCCATCACCCGCTGGGGTGATCTCGCCAAGGTGCTGGAGG
GCGTGAAGGCGGCGCAGCGCGCGGGCATCCATGTGAAGCTCAATGCGGTGGCGCTGAAGGATGTGAACGAGCACGAAATC
CCGAGCCTCATGGAATGGGCGCACGGGGAGGGGCACGACCTGTCGCTCATCGAGGTGATGCCGCTCGGCGAGGTGGGTGC
GGAGCGGGTGGACCAATATCTACCGCTCTCCAAGGTGCGCGAGGATCTCGCGACCCGCTACACCCTCACCGACATCGACT
ATCGCACCGGCGGCCCCGCCCGCTATGTCTCGGTGAAGGAGACCGGCGGCCGGCTCGGCTTCATCACGCCGATGACCCAC
AATTTCTGCGAGGGCTGCAACCGCGTGCGCGTCACCTGCACGGGCACGCTCTACATGTGCCTCGGCCAGGACGATGCGGC
CGACCTGCGCGCGCCGCTCCGGGCCAGCGCCGATGACGGCGTGCTCCAGGCGGCGATCGATGCGGCCATCTTCCGCAAGC
CCAAGGGCCATGACTTCGTGATCGACCGCCAGACCCGCCAGCCGGCGGTCTCCCGCCACATGAGTACCACCGGCGGTTAG

Upstream 100 bases:

>100_bases
GTGAGGGCGCTCTTGTCGGGCGAAAGCCGGATTTCGCTGGGCCAGGTGGAGGCTTCTGCGGCGGTTCCAGCGGTTTCGGG
CGAAGGCGTATCGGTCATGC

Downstream 100 bases:

>100_bases
GAACCGTTCTGGATTGGGGCGAAGGGGAGGCGGGGCCATGCGGCGGGCGCCGGGCTTGTCTCGGAGCCCGGTGAAATGCG
CAACGGCGACCTCACGTCAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNSVPAGCPFAGSLQPPAYQTAPCIRYKGDARAGARPAGRELSGCEEAGVAFVTRDLGDRSGGSATALGPLVDTFGRAVS
YLRVSVTDRCDFRCVYCMSEHMTFLPKPDLLTLEELDRLCSAFVARGVRKLRLTGGEPLVRRDVMTLFRSLSRHLETGRL
EELTLTTNGSQLARFAGDLAACGVKRINVSIDTLDPDKFRAITRWGDLAKVLEGVKAAQRAGIHVKLNAVALKDVNEHEI
PSLMEWAHGEGHDLSLIEVMPLGEVGAERVDQYLPLSKVREDLATRYTLTDIDYRTGGPARYVSVKETGGRLGFITPMTH
NFCEGCNRVRVTCTGTLYMCLGQDDAADLRAPLRASADDGVLQAAIDAAIFRKPKGHDFVIDRQTRQPAVSRHMSTTGG

Sequences:

>Translated_399_residues
MNSVPAGCPFAGSLQPPAYQTAPCIRYKGDARAGARPAGRELSGCEEAGVAFVTRDLGDRSGGSATALGPLVDTFGRAVS
YLRVSVTDRCDFRCVYCMSEHMTFLPKPDLLTLEELDRLCSAFVARGVRKLRLTGGEPLVRRDVMTLFRSLSRHLETGRL
EELTLTTNGSQLARFAGDLAACGVKRINVSIDTLDPDKFRAITRWGDLAKVLEGVKAAQRAGIHVKLNAVALKDVNEHEI
PSLMEWAHGEGHDLSLIEVMPLGEVGAERVDQYLPLSKVREDLATRYTLTDIDYRTGGPARYVSVKETGGRLGFITPMTH
NFCEGCNRVRVTCTGTLYMCLGQDDAADLRAPLRASADDGVLQAAIDAAIFRKPKGHDFVIDRQTRQPAVSRHMSTTGG
>Mature_399_residues
MNSVPAGCPFAGSLQPPAYQTAPCIRYKGDARAGARPAGRELSGCEEAGVAFVTRDLGDRSGGSATALGPLVDTFGRAVS
YLRVSVTDRCDFRCVYCMSEHMTFLPKPDLLTLEELDRLCSAFVARGVRKLRLTGGEPLVRRDVMTLFRSLSRHLETGRL
EELTLTTNGSQLARFAGDLAACGVKRINVSIDTLDPDKFRAITRWGDLAKVLEGVKAAQRAGIHVKLNAVALKDVNEHEI
PSLMEWAHGEGHDLSLIEVMPLGEVGAERVDQYLPLSKVREDLATRYTLTDIDYRTGGPARYVSVKETGGRLGFITPMTH
NFCEGCNRVRVTCTGTLYMCLGQDDAADLRAPLRASADDGVLQAAIDAAIFRKPKGHDFVIDRQTRQPAVSRHMSTTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=37.6146788990826, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=37.6146788990826, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1786999, Length=332, Percent_Identity=33.433734939759, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=315, Percent_Identity=36.1904761904762, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=333, Percent_Identity=34.2342342342342, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566329, Length=312, Percent_Identity=34.9358974358974, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=38.2911392405063, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=38.4126984126984, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 43426; Mature: 43426

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVPAGCPFAGSLQPPAYQTAPCIRYKGDARAGARPAGRELSGCEEAGVAFVTRDLGDR
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCEEEEEECCCCC
SGGSATALGPLVDTFGRAVSYLRVSVTDRCDFRCVYCMSEHMTFLPKPDLLTLEELDRLC
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEHHCCEECCCCCEECHHHHHHHH
SAFVARGVRKLRLTGGEPLVRRDVMTLFRSLSRHLETGRLEELTLTTNGSQLARFAGDLA
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ACGVKRINVSIDTLDPDKFRAITRWGDLAKVLEGVKAAQRAGIHVKLNAVALKDVNEHEI
HCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCC
PSLMEWAHGEGHDLSLIEVMPLGEVGAERVDQYLPLSKVREDLATRYTLTDIDYRTGGPA
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCE
RYVSVKETGGRLGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQDDAADLRAPLRASADDG
EEEEEECCCCEEEEECCCHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHCCCCCCCCCH
VLQAAIDAAIFRKPKGHDFVIDRQTRQPAVSRHMSTTGG
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MNSVPAGCPFAGSLQPPAYQTAPCIRYKGDARAGARPAGRELSGCEEAGVAFVTRDLGDR
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCEEEEEECCCCC
SGGSATALGPLVDTFGRAVSYLRVSVTDRCDFRCVYCMSEHMTFLPKPDLLTLEELDRLC
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEHHCCEECCCCCEECHHHHHHHH
SAFVARGVRKLRLTGGEPLVRRDVMTLFRSLSRHLETGRLEELTLTTNGSQLARFAGDLA
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ACGVKRINVSIDTLDPDKFRAITRWGDLAKVLEGVKAAQRAGIHVKLNAVALKDVNEHEI
HCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCC
PSLMEWAHGEGHDLSLIEVMPLGEVGAERVDQYLPLSKVREDLATRYTLTDIDYRTGGPA
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCE
RYVSVKETGGRLGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQDDAADLRAPLRASADDG
EEEEEECCCCEEEEECCCHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHCCCCCCCCCH
VLQAAIDAAIFRKPKGHDFVIDRQTRQPAVSRHMSTTGG
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]