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The map label for this gene is fhs [H]

Identifier: 158422521

GI number: 158422521

Start: 1005514

End: 1007250

Strand: Direct

Name: fhs [H]

Synonym: AZC_0897

Alternate gene names: 158422521

Gene position: 1005514-1007250 (Clockwise)

Preceding gene: 158422520

Following gene: 158422523

Centisome position: 18.73

GC content: 69.6

Gene sequence:

>1737_bases
ATGACCGAGCCCTCTGTCCGTTTCCGCCATCGAGGACCCCGCATGCACACGACGGCCCGCCATATCGATCCCATGAGCGA
TGCCGCCATCGCAGCGACCGTGACGCCCGAGCCCATCGAGGCGGTGGGCGCGCGGCTCGGCATCCCGGCGGACGCGCTCT
ATCGCTACGGGCCGCACAAGGCGAAGCTGTCGCTCGATTTCATCCGCGAGATCGAGGACCGCCCCACGGGCAAGCTCATC
CTCGTCACGGCCATCAGCCCCACGCCGGCGGGCGAGGGCAAGACCACCACCACCATCGGCCTCGGTGACGCGCTCAACCG
CATCGGCGCCAAGACCGCCGTGTGCCTGCGCGAGCCCTCGCTCGGCCCCTGCTTCGGTGCCAAGGGCGGCGCCACCGGCG
GCGGACGGGCGCAGATCGTGCCCATGCAGGACATCAACCTGCACTTCACCGGCGACCTGCACGCCATCGGCGCGGCGCAC
AACCTGCTCTCCGCGCTCATCGACAACCACATCTACTGGGGCAACGCCCTCGACATCGACACCCGCCGCATCGCCTGGAA
GCGGGTGGTGGACCTCAACGACCGTGCGCTCCGCTCCATCGTGGTGGGCCTTGGCGGCCCCGCGAACGGCTTCCCGCGCG
AGGACGGGTTCGACATCACGGTGGCGAGCGAGGTGATGGCCATCTTCTGCCTCGCCAAGTCGCTGGAGGAGCTGGAGGAC
CGGCTCTCGCAGATGGTGGTGGCGCAGACCCGCGCCAAGGGCATTGTCCGGGCCGAGGCGCTGAAGGGCATCGGCTCCAT
GGTGGCGCTGCTGCGCGATGCCTTCCAGCCGAACCTCGTGCAGACCATGGAGCACACGCCGGCCTTCGTGCACGGCGGCC
CCTTCGCCAACATCGCCCACGGCTGCAATTCGGTGATCGCCACCCGCAGCGCGCTGCGCCTGGCGGACTATGTGGTGACG
GAAGCCGGCTTCGGTGCCGATCTGGGCGCCGAGAAGTTCCTCGACATCAAGTGCCGGCAGGCCGGTCTTGCCCCGGCGGC
GTCCGTGGTGGTCGCGACCGTCCGGGCACTCAAGATGCATGGCGGCGTCGGCCTCAAGGATCTGGTGAAGGAGGATGCCG
GTGCGGTGGTCCTCGGTGCCGCGAACCTGCGCCGGCATGTGGAGAACATGCAGAAGTTCGGCATCCCCGTCGTGGTGGCG
CTGAACCGCTTCCTCTCCGACACGCCGGCCGAGGTGGATGCCGTACGCGGCGTGCTCGCGGACCTCGGCGTGAACGTGCA
TGTTTGCAGCCACTGGGCCGAGGGCGGAGCGGGGGCCGAGGCGCTGGCCGAAGAGGTGAAGATGCTGGCGGCGCGGCCGA
GCCAGTTCCGCACCCTCTATCCCGATGCGATGCCGCTGGCCGGAAAGATCGAGACCATCGCCCGCGAGATTTACCGTGCC
GGCGACGTGGCCCTGAGCCCGGACGCCGCCCGCCGCCTCACGGAACTGGAGGCCGCCGGCTTCGGCGATCTGCCAGTGTG
CATGGCCAAGACCCAGTACAGCTTCTCCGCCGACCCCAAGCTGCGCAACGCGCCGACCGGTCACACGATCCCGGTCCGCG
AAGTGCGCCTCTCGGCCGGAGCCGGCTTCGTGGTGGCGCTCACCGGCGATGTCATGACCATGCCGGGCCTGCCCTCCGTG
CCTGCCGCCGAGCATATCTTCGTGGACGCGGACGGGGTGATCGGCGGCCTCTCCTGA

Upstream 100 bases:

>100_bases
AAGAGGAGCTTGACCGCTTGCGGCGTCTGGGCGCGGCGCGCTAGAGGCTGAAGGCGCACTTCAACCGGTCCAGCGTCCCG
CCTCCGGGCGGCGCGCGCCC

Downstream 100 bases:

>100_bases
GGGGCTGCGCCCGTTTGCCCACTCCCACGACCTATTCCCTTTCCGCCTGTCGGGCGCCTCCCTTTAGGCGGGGAACCCTC
CCCCCTTGTGGGGGAGGGCA

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MTEPSVRFRHRGPRMHTTARHIDPMSDAAIAATVTPEPIEAVGARLGIPADALYRYGPHKAKLSLDFIREIEDRPTGKLI
LVTAISPTPAGEGKTTTTIGLGDALNRIGAKTAVCLREPSLGPCFGAKGGATGGGRAQIVPMQDINLHFTGDLHAIGAAH
NLLSALIDNHIYWGNALDIDTRRIAWKRVVDLNDRALRSIVVGLGGPANGFPREDGFDITVASEVMAIFCLAKSLEELED
RLSQMVVAQTRAKGIVRAEALKGIGSMVALLRDAFQPNLVQTMEHTPAFVHGGPFANIAHGCNSVIATRSALRLADYVVT
EAGFGADLGAEKFLDIKCRQAGLAPAASVVVATVRALKMHGGVGLKDLVKEDAGAVVLGAANLRRHVENMQKFGIPVVVA
LNRFLSDTPAEVDAVRGVLADLGVNVHVCSHWAEGGAGAEALAEEVKMLAARPSQFRTLYPDAMPLAGKIETIAREIYRA
GDVALSPDAARRLTELEAAGFGDLPVCMAKTQYSFSADPKLRNAPTGHTIPVREVRLSAGAGFVVALTGDVMTMPGLPSV
PAAEHIFVDADGVIGGLS

Sequences:

>Translated_578_residues
MTEPSVRFRHRGPRMHTTARHIDPMSDAAIAATVTPEPIEAVGARLGIPADALYRYGPHKAKLSLDFIREIEDRPTGKLI
LVTAISPTPAGEGKTTTTIGLGDALNRIGAKTAVCLREPSLGPCFGAKGGATGGGRAQIVPMQDINLHFTGDLHAIGAAH
NLLSALIDNHIYWGNALDIDTRRIAWKRVVDLNDRALRSIVVGLGGPANGFPREDGFDITVASEVMAIFCLAKSLEELED
RLSQMVVAQTRAKGIVRAEALKGIGSMVALLRDAFQPNLVQTMEHTPAFVHGGPFANIAHGCNSVIATRSALRLADYVVT
EAGFGADLGAEKFLDIKCRQAGLAPAASVVVATVRALKMHGGVGLKDLVKEDAGAVVLGAANLRRHVENMQKFGIPVVVA
LNRFLSDTPAEVDAVRGVLADLGVNVHVCSHWAEGGAGAEALAEEVKMLAARPSQFRTLYPDAMPLAGKIETIAREIYRA
GDVALSPDAARRLTELEAAGFGDLPVCMAKTQYSFSADPKLRNAPTGHTIPVREVRLSAGAGFVVALTGDVMTMPGLPSV
PAAEHIFVDADGVIGGLS
>Mature_577_residues
TEPSVRFRHRGPRMHTTARHIDPMSDAAIAATVTPEPIEAVGARLGIPADALYRYGPHKAKLSLDFIREIEDRPTGKLIL
VTAISPTPAGEGKTTTTIGLGDALNRIGAKTAVCLREPSLGPCFGAKGGATGGGRAQIVPMQDINLHFTGDLHAIGAAHN
LLSALIDNHIYWGNALDIDTRRIAWKRVVDLNDRALRSIVVGLGGPANGFPREDGFDITVASEVMAIFCLAKSLEELEDR
LSQMVVAQTRAKGIVRAEALKGIGSMVALLRDAFQPNLVQTMEHTPAFVHGGPFANIAHGCNSVIATRSALRLADYVVTE
AGFGADLGAEKFLDIKCRQAGLAPAASVVVATVRALKMHGGVGLKDLVKEDAGAVVLGAANLRRHVENMQKFGIPVVVAL
NRFLSDTPAEVDAVRGVLADLGVNVHVCSHWAEGGAGAEALAEEVKMLAARPSQFRTLYPDAMPLAGKIETIAREIYRAG
DVALSPDAARRLTELEAAGFGDLPVCMAKTQYSFSADPKLRNAPTGHTIPVREVRLSAGAGFVVALTGDVMTMPGLPSVP
AAEHIFVDADGVIGGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=610, Percent_Identity=43.9344262295082, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI36796743, Length=629, Percent_Identity=42.7662957074722, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=41.8604651162791, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=621, Percent_Identity=43.8003220611916, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17568739, Length=621, Percent_Identity=43.8003220611916, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=41.4944356120827, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321643, Length=624, Percent_Identity=40.224358974359, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=43.7601296596434, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=43.7601296596434, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=43.7601296596434, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=43.7601296596434, Blast_Score=460, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60970; Mature: 60839

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPSVRFRHRGPRMHTTARHIDPMSDAAIAATVTPEPIEAVGARLGIPADALYRYGPHK
CCCCCCCHHCCCCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHCCCCH
AKLSLDFIREIEDRPTGKLILVTAISPTPAGEGKTTTTIGLGDALNRIGAKTAVCLREPS
HEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEECHHHHHHHCCCEEEEEECCC
LGPCFGAKGGATGGGRAQIVPMQDINLHFTGDLHAIGAAHNLLSALIDNHIYWGNALDID
CCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHCCEEECCEECCC
TRRIAWKRVVDLNDRALRSIVVGLGGPANGFPREDGFDITVASEVMAIFCLAKSLEELED
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RLSQMVVAQTRAKGIVRAEALKGIGSMVALLRDAFQPNLVQTMEHTPAFVHGGPFANIAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCHHHHHH
GCNSVIATRSALRLADYVVTEAGFGADLGAEKFLDIKCRQAGLAPAASVVVATVRALKMH
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHHC
GGVGLKDLVKEDAGAVVLGAANLRRHVENMQKFGIPVVVALNRFLSDTPAEVDAVRGVLA
CCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHH
DLGVNVHVCSHWAEGGAGAEALAEEVKMLAARPSQFRTLYPDAMPLAGKIETIAREIYRA
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHHHHHHC
GDVALSPDAARRLTELEAAGFGDLPVCMAKTQYSFSADPKLRNAPTGHTIPVREVRLSAG
CCCEECCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCC
AGFVVALTGDVMTMPGLPSVPAAEHIFVDADGVIGGLS
CCEEEEEECCEEECCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
TEPSVRFRHRGPRMHTTARHIDPMSDAAIAATVTPEPIEAVGARLGIPADALYRYGPHK
CCCCCCHHCCCCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHCCCCH
AKLSLDFIREIEDRPTGKLILVTAISPTPAGEGKTTTTIGLGDALNRIGAKTAVCLREPS
HEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEECHHHHHHHCCCEEEEEECCC
LGPCFGAKGGATGGGRAQIVPMQDINLHFTGDLHAIGAAHNLLSALIDNHIYWGNALDID
CCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHCCEEECCEECCC
TRRIAWKRVVDLNDRALRSIVVGLGGPANGFPREDGFDITVASEVMAIFCLAKSLEELED
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RLSQMVVAQTRAKGIVRAEALKGIGSMVALLRDAFQPNLVQTMEHTPAFVHGGPFANIAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCHHHHHH
GCNSVIATRSALRLADYVVTEAGFGADLGAEKFLDIKCRQAGLAPAASVVVATVRALKMH
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHHC
GGVGLKDLVKEDAGAVVLGAANLRRHVENMQKFGIPVVVALNRFLSDTPAEVDAVRGVLA
CCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHH
DLGVNVHVCSHWAEGGAGAEALAEEVKMLAARPSQFRTLYPDAMPLAGKIETIAREIYRA
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHHHHHHC
GDVALSPDAARRLTELEAAGFGDLPVCMAKTQYSFSADPKLRNAPTGHTIPVREVRLSAG
CCCEECCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCC
AGFVVALTGDVMTMPGLPSVPAAEHIFVDADGVIGGLS
CCEEEEEECCEEECCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA