Click here to switch to the map view.

The map label for this gene is ydgK [H]

Identifier: 158422367

GI number: 158422367

Start: 837494

End: 838792

Strand: Direct

Name: ydgK [H]

Synonym: AZC_0743

Alternate gene names: 158422367

Gene position: 837494-838792 (Clockwise)

Preceding gene: 158422366

Following gene: 158422371

Centisome position: 15.6

GC content: 69.28

Gene sequence:

>1299_bases
ATGAAGCCAGTGATGAGTGAAAGCCGCACGGCGGTCATCGGTGCGATGATCGTCGTGCTGGGGCCGATCAGCATGTCGCT
CTACACACCGGCCATGCCGGCGCTGGTGGAGGCCTTTCACACCACGCCGGCCCTGTTGAAGCTCACGCTCTCCGTCTATT
TCTTCGGCTTCGCCTTTTCCCAGCTCGCCTGCGGGCCGCTCTCCGATGCCTTCGGGCGGCGGCCCACGGCGCTCGGCTTC
TTCGCCATCTATCTGGCGGGCAGCGTGGTGGCGGCCTTCGCGCCGGACATCACCGCGCTGATCATCGGCCGCGGCCTTCA
GGGGATCGGCGTGGCTGCGGGCCCCGCCGTCTCCCGTGCCATCGTGCGCGACCAGTTCACCGGCCAGCCGTCCGCCCGCA
TCATGAACCTGATCGCCACCATGCTGGCGATCGGGCCCGCCATCGCCCCGACGCTCGGCGGCCTCATCCTCTCGACCGTG
GGCTGGTCGGCCATCTTTCTCGTGATGGTGATCTATGGCCTCGTGCTCGTGCTGCTGCTGGCGGTCCTTGTACCGGAGAC
CAATGCGGCCCCGCTGCGGGCCAACGCCCATCCGGCCACGGTTGCCCGCAATTATGGGACGCTGCTGTCGGACCGGCGCT
TTCTCCAGCCGAGCCTGGTGATCGGTTTCACGCTCGGCGGCATCTATACGCTCGCTGCCATCCTGCCCTTCGTGCTCATC
GAGCGGGTGGGCCTCTCGCCCATCGGCTTCGGCATCGCCATGATCTGCCAAACCGGCTCGTTCATGACGGGCTCGCTGGT
CACCGGCCGGCTGCTCAGGCGCTTCAAGGCGGAGGCACTGGTGCCCTTCGGCCTCGCTATCGTGCTGGCGGCGGCGGTCG
GCATGGCCTTCGCGACCCGCCTGTGGCCCCTCTCGGCGGTGGCCACCATGCTGCCGGTGGCGGTCTGGGCCTTCGGCATC
GCCGTGCTGCTGCCCGGCGGCACCACGGGCGCGCTCGCCAATTTCCCGAGGATGGCCGGTGCGGCTTCCGCCATGATGGG
CTTCATGCAGATCGGCGGCGGACTGCTGGGCACCATGCTGGCGAGTGCCTTCGCGGTGCCCGGCGACGCGCTGGTGATCG
TGGTGCCGGGTCTCGCGGCGGCTGCGCTCGTCGCCTTTGTCTTGCTGCGACCGGCGGAGCCGTCCCGCGTGGCGGCCCGC
ATCAGCGAGCCGGATCTCGAGATCTCCACGGACCCCGCCGGCATCGTCGGCGCTGCAGGCGACGAGATCGAGGCCGAGGT
CTTCCGCAAGCGCGCCTGA

Upstream 100 bases:

>100_bases
AAATCCTCAACGGCCTCTCGGAAGACCAGATCGCCAATTTCAGGACCGCCCTCGACCGGATGCGCGTGAACCTGGTGGCG
GGGAGAGATGCGGACGACGC

Downstream 100 bases:

>100_bases
CGCGCCCGCTGCCGGGTTCTCGGGGAGCGGCGCCTGCCTCGGACCTGTGCGGGCGCTACTTCAGTTCGATCTTGTACATC
TGCGTGAGGCAGTTGCCCGG

Product: drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKPVMSESRTAVIGAMIVVLGPISMSLYTPAMPALVEAFHTTPALLKLTLSVYFFGFAFSQLACGPLSDAFGRRPTALGF
FAIYLAGSVVAAFAPDITALIIGRGLQGIGVAAGPAVSRAIVRDQFTGQPSARIMNLIATMLAIGPAIAPTLGGLILSTV
GWSAIFLVMVIYGLVLVLLLAVLVPETNAAPLRANAHPATVARNYGTLLSDRRFLQPSLVIGFTLGGIYTLAAILPFVLI
ERVGLSPIGFGIAMICQTGSFMTGSLVTGRLLRRFKAEALVPFGLAIVLAAAVGMAFATRLWPLSAVATMLPVAVWAFGI
AVLLPGGTTGALANFPRMAGAASAMMGFMQIGGGLLGTMLASAFAVPGDALVIVVPGLAAAALVAFVLLRPAEPSRVAAR
ISEPDLEISTDPAGIVGAAGDEIEAEVFRKRA

Sequences:

>Translated_432_residues
MKPVMSESRTAVIGAMIVVLGPISMSLYTPAMPALVEAFHTTPALLKLTLSVYFFGFAFSQLACGPLSDAFGRRPTALGF
FAIYLAGSVVAAFAPDITALIIGRGLQGIGVAAGPAVSRAIVRDQFTGQPSARIMNLIATMLAIGPAIAPTLGGLILSTV
GWSAIFLVMVIYGLVLVLLLAVLVPETNAAPLRANAHPATVARNYGTLLSDRRFLQPSLVIGFTLGGIYTLAAILPFVLI
ERVGLSPIGFGIAMICQTGSFMTGSLVTGRLLRRFKAEALVPFGLAIVLAAAVGMAFATRLWPLSAVATMLPVAVWAFGI
AVLLPGGTTGALANFPRMAGAASAMMGFMQIGGGLLGTMLASAFAVPGDALVIVVPGLAAAALVAFVLLRPAEPSRVAAR
ISEPDLEISTDPAGIVGAAGDEIEAEVFRKRA
>Mature_432_residues
MKPVMSESRTAVIGAMIVVLGPISMSLYTPAMPALVEAFHTTPALLKLTLSVYFFGFAFSQLACGPLSDAFGRRPTALGF
FAIYLAGSVVAAFAPDITALIIGRGLQGIGVAAGPAVSRAIVRDQFTGQPSARIMNLIATMLAIGPAIAPTLGGLILSTV
GWSAIFLVMVIYGLVLVLLLAVLVPETNAAPLRANAHPATVARNYGTLLSDRRFLQPSLVIGFTLGGIYTLAAILPFVLI
ERVGLSPIGFGIAMICQTGSFMTGSLVTGRLLRRFKAEALVPFGLAIVLAAAVGMAFATRLWPLSAVATMLPVAVWAFGI
AVLLPGGTTGALANFPRMAGAASAMMGFMQIGGGLLGTMLASAFAVPGDALVIVVPGLAAAALVAFVLLRPAEPSRVAAR
ISEPDLEISTDPAGIVGAAGDEIEAEVFRKRA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=349, Percent_Identity=29.2263610315186, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI48994889, Length=344, Percent_Identity=28.1976744186047, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790146, Length=403, Percent_Identity=27.7915632754342, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI87082312, Length=342, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787065, Length=335, Percent_Identity=25.3731343283582, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790794, Length=311, Percent_Identity=24.7588424437299, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081738, Length=175, Percent_Identity=31.4285714285714, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319517, Length=195, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324264, Length=163, Percent_Identity=28.8343558282209, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321838, Length=285, Percent_Identity=24.5614035087719, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322071, Length=163, Percent_Identity=28.2208588957055, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44447; Mature: 44447

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHCCC
>Mature Secondary Structure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CHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]