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The map label for this gene is qacE [H]

Identifier: 158421950

GI number: 158421950

Start: 375949

End: 376278

Strand: Reverse

Name: qacE [H]

Synonym: AZC_0326

Alternate gene names: 158421950

Gene position: 376278-375949 (Counterclockwise)

Preceding gene: 158421951

Following gene: 158421947

Centisome position: 7.01

GC content: 65.45

Gene sequence:

>330_bases
ATGACCTATGCGCTGCTGTTCGTGGCCATCGTCGCCGAAGTCATCGCCACCTCGGCGCTCAAGGCAGCCGAGGGCTTCAC
CCGGCTGGTGCCGAGCCTGATCGTCATCGTCGGATATGGCGTGGCGTTCGTCTGCCTGTCGCTGACGCTGAAGACGATTC
CGGTGGGCATCGCCTATGCCACATGGTCGGGCGTCGGCATCGTGCTGGTGGCCGGCGTGGGCTGGGCGCTCTACGGCCAG
AGCCTCGATCTTGCCGGCGCGGTGGGCCTCGGGCTCATCATCGCCGGCGTCCTAATCGTCAATCTGGTATCGAAGACGGC
GGTGCACTGA

Upstream 100 bases:

>100_bases
CGGATACGTCCTTTCCGAGCCGTATGCGGGAAACTGCGGATTTTACCTCCACGCCGCGCGCGATAGTGTTTCGACGCACT
TCCCGTGCCGGACCTGATCC

Downstream 100 bases:

>100_bases
CCGCCGGGCGACTCAGGCCCCGGTGGGGCTCAGCACCAGGCTCAGCATGCGCTGGCCGGCGGTCCACTGGGCCTGGAACA
GCGCGCCGGCCATGCCCTGC

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MTYALLFVAIVAEVIATSALKAAEGFTRLVPSLIVIVGYGVAFVCLSLTLKTIPVGIAYATWSGVGIVLVAGVGWALYGQ
SLDLAGAVGLGLIIAGVLIVNLVSKTAVH

Sequences:

>Translated_109_residues
MTYALLFVAIVAEVIATSALKAAEGFTRLVPSLIVIVGYGVAFVCLSLTLKTIPVGIAYATWSGVGIVLVAGVGWALYGQ
SLDLAGAVGLGLIIAGVLIVNLVSKTAVH
>Mature_108_residues
TYALLFVAIVAEVIATSALKAAEGFTRLVPSLIVIVGYGVAFVCLSLTLKTIPVGIAYATWSGVGIVLVAGVGWALYGQS
LDLAGAVGLGLIIAGVLIVNLVSKTAVH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=101, Percent_Identity=54.4554455445545, Blast_Score=107, Evalue=2e-25,
Organism=Escherichia coli, GI1787883, Length=99, Percent_Identity=40.4040404040404, Blast_Score=65, Evalue=7e-13,
Organism=Escherichia coli, GI87082378, Length=98, Percent_Identity=36.734693877551, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11042; Mature: 10911

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYALLFVAIVAEVIATSALKAAEGFTRLVPSLIVIVGYGVAFVCLSLTLKTIPVGIAYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWSGVGIVLVAGVGWALYGQSLDLAGAVGLGLIIAGVLIVNLVSKTAVH
HHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYALLFVAIVAEVIATSALKAAEGFTRLVPSLIVIVGYGVAFVCLSLTLKTIPVGIAYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWSGVGIVLVAGVGWALYGQSLDLAGAVGLGLIIAGVLIVNLVSKTAVH
HHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]