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The map label for this gene is algC [H]

Identifier: 158421909

GI number: 158421909

Start: 330853

End: 332352

Strand: Reverse

Name: algC [H]

Synonym: AZC_0285

Alternate gene names: 158421909

Gene position: 332352-330853 (Counterclockwise)

Preceding gene: 158421910

Following gene: 158421907

Centisome position: 6.19

GC content: 64.33

Gene sequence:

>1500_bases
ATGTTCCCGACGCCGAAGCCCGCACTGACGCCGAACACCTACGCCTATGAATCCGAGCCCATGGTGAAGCCCACCGGGTT
CCGCGAGTATGACGCCCGCTGGTTGTTCCAGAAGGAAATCAACCTCATGGGCGTGCAGGCGCTGGGCATGGGCCTCGGCA
CGCTGATGCACGAAATGGGCATCAAGCCGGAGATCGTCACCGGCCACGACTTCCGCGGTTATTCCTCCTCCATCAAGTAC
GCCATGGTCTCCGGCCTCATGGCCGCCGGCGTGAAGGTGCACGACATCGGCCTTGCCATGTCGCCCATGGCCTATTTCGC
CCAGTTCGCCCTCGACGTGCCGGCGGTGGCGATGGTCACGGCCTCGCACAATGACAATGGCTGGACCGGCGTGAAGATGG
GCGTGAACCGCCCCCTCACCTTCGGCCCGGATGAGATGACCCGCCTGAAGGAGATCGTGCTCTGTGCGAAGTTCGACCTG
AAGGGCGGCGGCGCCTATCAGTTCGTCGAGAACTTCCCCGAGATCTACATCAAGGATCTCACCGACCGGCCGAAGCTGAA
GCACCCCATCAAGGCGGTGGTGGCCTGCGGCAATGGCACGGCCGGCGCCTTCGCCCCGCGCATCCTTGAGGCGCTCGGCG
TGGAAGTGGTGCCGCTCGATACCGAGCTCGACCACTCCTTCCCGAAGTACAATCCGAACCCCGAAGACCTCGAGATGCTC
CACGCCATGCGCGATGCCGTGCTGGCCTCGGGCGCCGACGTGGCGCTGGGCTTCGACGGCGACGGCGACCGCTGCGGCGT
GGTGGACAATGAGGGCGAGGAAATCTTCGCCGACAAGATGGGCGTGATGCTCGCCCGCGACCTCGCCAAGCTCTATCCCA
ACTCCACCTTCGTGGTGGATGTGAAGTCCACGGGCCTGTTCGCCACTGATCCCGAGCTGATCAAGCTCGGCGTGAAGGCG
GATTACTGGAAGACCGGCCATTCCTACATGAAGCGCCGGGTGAACGAGAGCGGCGCCCTCGTCGGCTTCGAGAAGTCGGG
CCACTATTTCTTCAACAAGCCCATCGGCCGCGGCTATGACGACGGCCTCGTCTCGGCCATCGCCGTACTGGACATGCTCG
ATCGCAATCCGGGCAAGAAGCTCTCCGAACTGCGCCTCGCGCTGCCCAAGACCTGGTCGTCGCCCACCATGTCACCCCAC
TGCGCGGACGAGGCCAAGTACGGCATCGTGGAGCAGGTGGTGAAGCACTATCAGAAGCTTCAGGCCGAGGGCGCGAAGGT
GACGGGTCAGGCGATCCGCGACCTCGTGACGGTGAACGGCGTGCGCGTCACCACCGAAGACGGTTCCTGGGGCCTGGTGC
GCGCCTCCTCCAACAAGCCCGAACTGGTGGTGGTGGTGGAAAGCCCCGTCTCCGAGGCCCGCATGCGCGAGATGTTCGCC
GAGGTGGACAGCGTGCTGCGCACCCATCCGGAAGTCGGCGAGTACAACCAGAAGATCTGA

Upstream 100 bases:

>100_bases
GGCCAGCGCCATACAGCTGCGCTTCAGATTAGACAGGTCACAATTTCGTGCTATCGGGCGTTCCTGCCCGGAATGCACTC
CGCGCCGAGAGAGGCTTTTC

Downstream 100 bases:

>100_bases
CGCGCGGACAATCCGCCACATAAAGGAAAGCCCGCGCTCGGTGTCCCGTGCGCGGGCTTTCTGTTTTTGCGCTCCGTGCT
ATTCGGCGGCGGCGGGGGTG

Product: phosphoglucomutase/phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFPTPKPALTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGIKPEIVTGHDFRGYSSSIKY
AMVSGLMAAGVKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLCAKFDL
KGGGAYQFVENFPEIYIKDLTDRPKLKHPIKAVVACGNGTAGAFAPRILEALGVEVVPLDTELDHSFPKYNPNPEDLEML
HAMRDAVLASGADVALGFDGDGDRCGVVDNEGEEIFADKMGVMLARDLAKLYPNSTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNESGALVGFEKSGHYFFNKPIGRGYDDGLVSAIAVLDMLDRNPGKKLSELRLALPKTWSSPTMSPH
CADEAKYGIVEQVVKHYQKLQAEGAKVTGQAIRDLVTVNGVRVTTEDGSWGLVRASSNKPELVVVVESPVSEARMREMFA
EVDSVLRTHPEVGEYNQKI

Sequences:

>Translated_499_residues
MFPTPKPALTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGIKPEIVTGHDFRGYSSSIKY
AMVSGLMAAGVKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLCAKFDL
KGGGAYQFVENFPEIYIKDLTDRPKLKHPIKAVVACGNGTAGAFAPRILEALGVEVVPLDTELDHSFPKYNPNPEDLEML
HAMRDAVLASGADVALGFDGDGDRCGVVDNEGEEIFADKMGVMLARDLAKLYPNSTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNESGALVGFEKSGHYFFNKPIGRGYDDGLVSAIAVLDMLDRNPGKKLSELRLALPKTWSSPTMSPH
CADEAKYGIVEQVVKHYQKLQAEGAKVTGQAIRDLVTVNGVRVTTEDGSWGLVRASSNKPELVVVVESPVSEARMREMFA
EVDSVLRTHPEVGEYNQKI
>Mature_499_residues
MFPTPKPALTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGIKPEIVTGHDFRGYSSSIKY
AMVSGLMAAGVKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLCAKFDL
KGGGAYQFVENFPEIYIKDLTDRPKLKHPIKAVVACGNGTAGAFAPRILEALGVEVVPLDTELDHSFPKYNPNPEDLEML
HAMRDAVLASGADVALGFDGDGDRCGVVDNEGEEIFADKMGVMLARDLAKLYPNSTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNESGALVGFEKSGHYFFNKPIGRGYDDGLVSAIAVLDMLDRNPGKKLSELRLALPKTWSSPTMSPH
CADEAKYGIVEQVVKHYQKLQAEGAKVTGQAIRDLVTVNGVRVTTEDGSWGLVRASSNKPELVVVVESPVSEARMREMFA
EVDSVLRTHPEVGEYNQKI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=481, Percent_Identity=29.7297297297297, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789566, Length=188, Percent_Identity=31.3829787234043, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54649; Mature: 54649

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTPKPALTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMG
CCCCCCCCCCCCCEEECCCCCCCCCCCCHHCHHEEEEHHCCHHHHHHHHHHHHHHHHHHC
IKPEIVTGHDFRGYSSSIKYAMVSGLMAAGVKVHDIGLAMSPMAYFAQFALDVPAVAMVT
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEE
ASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLCAKFDLKGGGAYQFVENFPEIYIKDL
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCHHHHHCCCCEEEECC
TDRPKLKHPIKAVVACGNGTAGAFAPRILEALGVEVVPLDTELDHSFPKYNPNPEDLEML
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMRDAVLASGADVALGFDGDGDRCGVVDNEGEEIFADKMGVMLARDLAKLYPNSTFVVD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPELIKLGVKADYWKTGHSYMKRRVNESGALVGFEKSGHYFFNKPIGRGYD
EECCCCEECCHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCC
DGLVSAIAVLDMLDRNPGKKLSELRLALPKTWSSPTMSPHCADEAKYGIVEQVVKHYQKL
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QAEGAKVTGQAIRDLVTVNGVRVTTEDGSWGLVRASSNKPELVVVVESPVSEARMREMFA
HHCCCEECHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHH
EVDSVLRTHPEVGEYNQKI
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFPTPKPALTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMG
CCCCCCCCCCCCCEEECCCCCCCCCCCCHHCHHEEEEHHCCHHHHHHHHHHHHHHHHHHC
IKPEIVTGHDFRGYSSSIKYAMVSGLMAAGVKVHDIGLAMSPMAYFAQFALDVPAVAMVT
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEE
ASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLCAKFDLKGGGAYQFVENFPEIYIKDL
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCHHHHHCCCCEEEECC
TDRPKLKHPIKAVVACGNGTAGAFAPRILEALGVEVVPLDTELDHSFPKYNPNPEDLEML
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMRDAVLASGADVALGFDGDGDRCGVVDNEGEEIFADKMGVMLARDLAKLYPNSTFVVD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPELIKLGVKADYWKTGHSYMKRRVNESGALVGFEKSGHYFFNKPIGRGYD
EECCCCEECCHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCC
DGLVSAIAVLDMLDRNPGKKLSELRLALPKTWSSPTMSPHCADEAKYGIVEQVVKHYQKL
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QAEGAKVTGQAIRDLVTVNGVRVTTEDGSWGLVRASSNKPELVVVVESPVSEARMREMFA
HHCCCEECHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHH
EVDSVLRTHPEVGEYNQKI
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]