Click here to switch to the map view.

The map label for this gene is lysR [H]

Identifier: 158421828

GI number: 158421828

Start: 246528

End: 247478

Strand: Direct

Name: lysR [H]

Synonym: AZC_0204

Alternate gene names: 158421828

Gene position: 246528-247478 (Clockwise)

Preceding gene: 158421827

Following gene: 158421830

Centisome position: 4.59

GC content: 66.67

Gene sequence:

>951_bases
ATGCGCTACACGTTGCGGCAGCTCGAATATTTCATCGCGGCGGGTGAGACGGGATCGATCACCCTCGCCTCCGAGCGCAT
CAGCATTTCCCAGCCGTCCATCTCCACGGCCATCAGCCATCTGGAGCAGGAACTGGGCGTGCAGCTCTTCGTGCGCCATC
ACGCGCAGGGCCTCTCGCTGACCCCCGTGGGCCGCAAGCTTCTCGCCGAGGCCAAGCACCTCATCGAGCAGGCGGAAGGG
CTCTATGCCGTCGCCTCGGAAGCGACCGACCAGGTGCGCGGACAATTGTCCGTGGGCTGCATGGTGACGCTGGCGCCCAT
GATCCTGCCCGAACTCTCCCACGGCTTCACCACCGCCTATCCCGGCGCGCAGATCCGCCATGTGGAGGCCAATCAGGAAC
GCCTTCTGGACGGCCTGCGCCGCGCCGAGATCGACATTGCCGTCACCTACGATCTCCAGATCCCCGACGGCGTCACCTTC
ACGCCGCTGGCCAGCCTGCCGCCCCATGTGGTGGTGAGCGAGGCCCACCCTTTCGCCCGCCTGTCCGCGGTGAGCCTGAA
GGATCTGGCGGACGAGCCGCTGATCCTCCTCGATCTGCCCATCAGCTCCGAATATTTCCTCGCGCTGTTCCTGCAGGAAG
GGATCCAGCCGCGCATCCATTCCCGCTCCGCCTATCAGGAGGTGGTGCGGACCATGGTGGCGAACGGCTATGGCTACACG
CTGGCCAACGTCCGGCCGCGCTCCGACATCGCGCTGGACGGGAGGCGGGTGGTGCGGGTGCGCATCGCCGGCGAGCACCG
GCCCATGGTGGTCGGGACCGCCACCGTCTCGCAGTTCAAGAAATCCCGCCTGCTGCAGAGCTTCGAGGCCCACTGCCGGT
CCTTCATCTCGGACGCCTACATTCCCGGCATGGTCGCCCCGGCCATTGACCGCCGGACGCGCAGAACCTGA

Upstream 100 bases:

>100_bases
GCGACGCCTGAGGCCGACGTGCCGCTCCGCGTGCGACGGACCCTCCGACATTCTCCGGCGGCGCTCTCGCAAGGCGCCGC
CGGACGGGGTATGGATCGGC

Downstream 100 bases:

>100_bases
ACCCGCGGTTTGCCTGAGACGCCTCAGGTCGCCCGGCTCGTCCTCGCGCCCCAGCTGGCGCGCTCCGCATAGACCCGCGT
TACGTCTTCCATATTCTCCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cys regulon transcriptional activator [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MRYTLRQLEYFIAAGETGSITLASERISISQPSISTAISHLEQELGVQLFVRHHAQGLSLTPVGRKLLAEAKHLIEQAEG
LYAVASEATDQVRGQLSVGCMVTLAPMILPELSHGFTTAYPGAQIRHVEANQERLLDGLRRAEIDIAVTYDLQIPDGVTF
TPLASLPPHVVVSEAHPFARLSAVSLKDLADEPLILLDLPISSEYFLALFLQEGIQPRIHSRSAYQEVVRTMVANGYGYT
LANVRPRSDIALDGRRVVRVRIAGEHRPMVVGTATVSQFKKSRLLQSFEAHCRSFISDAYIPGMVAPAIDRRTRRT

Sequences:

>Translated_316_residues
MRYTLRQLEYFIAAGETGSITLASERISISQPSISTAISHLEQELGVQLFVRHHAQGLSLTPVGRKLLAEAKHLIEQAEG
LYAVASEATDQVRGQLSVGCMVTLAPMILPELSHGFTTAYPGAQIRHVEANQERLLDGLRRAEIDIAVTYDLQIPDGVTF
TPLASLPPHVVVSEAHPFARLSAVSLKDLADEPLILLDLPISSEYFLALFLQEGIQPRIHSRSAYQEVVRTMVANGYGYT
LANVRPRSDIALDGRRVVRVRIAGEHRPMVVGTATVSQFKKSRLLQSFEAHCRSFISDAYIPGMVAPAIDRRTRRT
>Mature_316_residues
MRYTLRQLEYFIAAGETGSITLASERISISQPSISTAISHLEQELGVQLFVRHHAQGLSLTPVGRKLLAEAKHLIEQAEG
LYAVASEATDQVRGQLSVGCMVTLAPMILPELSHGFTTAYPGAQIRHVEANQERLLDGLRRAEIDIAVTYDLQIPDGVTF
TPLASLPPHVVVSEAHPFARLSAVSLKDLADEPLILLDLPISSEYFLALFLQEGIQPRIHSRSAYQEVVRTMVANGYGYT
LANVRPRSDIALDGRRVVRVRIAGEHRPMVVGTATVSQFKKSRLLQSFEAHCRSFISDAYIPGMVAPAIDRRTRRT

Specific function: This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for cysB is N-acetylserine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=239, Percent_Identity=28.8702928870293, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787530, Length=237, Percent_Identity=26.5822784810127, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693105, Length=195, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=28.2608695652174, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789204, Length=292, Percent_Identity=27.0547945205479, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=24.7967479674797, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788887, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=26.2931034482759, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=27.5720164609054, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787601, Length=189, Percent_Identity=26.4550264550265, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790262, Length=218, Percent_Identity=26.1467889908257, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788748, Length=252, Percent_Identity=24.6031746031746, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=25.0847457627119, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI87081904, Length=231, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788481, Length=196, Percent_Identity=30.1020408163265, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34844; Mature: 34844

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTLRQLEYFIAAGETGSITLASERISISQPSISTAISHLEQELGVQLFVRHHAQGLSL
CCCHHHHHHHHHEECCCCCEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TPVGRKLLAEAKHLIEQAEGLYAVASEATDQVRGQLSVGCMVTLAPMILPELSHGFTTAY
CHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEECC
PGAQIRHVEANQERLLDGLRRAEIDIAVTYDLQIPDGVTFTPLASLPPHVVVSEAHPFAR
CCCEEEEECCCHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHH
LSAVSLKDLADEPLILLDLPISSEYFLALFLQEGIQPRIHSRSAYQEVVRTMVANGYGYT
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEE
LANVRPRSDIALDGRRVVRVRIAGEHRPMVVGTATVSQFKKSRLLQSFEAHCRSFISDAY
ECCCCCCCCEEECCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPGMVAPAIDRRTRRT
CCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRYTLRQLEYFIAAGETGSITLASERISISQPSISTAISHLEQELGVQLFVRHHAQGLSL
CCCHHHHHHHHHEECCCCCEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TPVGRKLLAEAKHLIEQAEGLYAVASEATDQVRGQLSVGCMVTLAPMILPELSHGFTTAY
CHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEECC
PGAQIRHVEANQERLLDGLRRAEIDIAVTYDLQIPDGVTFTPLASLPPHVVVSEAHPFAR
CCCEEEEECCCHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHH
LSAVSLKDLADEPLILLDLPISSEYFLALFLQEGIQPRIHSRSAYQEVVRTMVANGYGYT
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEE
LANVRPRSDIALDGRRVVRVRIAGEHRPMVVGTATVSQFKKSRLLQSFEAHCRSFISDAY
ECCCCCCCCEEECCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPGMVAPAIDRRTRRT
CCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]