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The map label for this gene is argE [H]

Identifier: 158421825

GI number: 158421825

Start: 244109

End: 245257

Strand: Direct

Name: argE [H]

Synonym: AZC_0201

Alternate gene names: 158421825

Gene position: 244109-245257 (Clockwise)

Preceding gene: 158421824

Following gene: 158421826

Centisome position: 4.55

GC content: 68.84

Gene sequence:

>1149_bases
ATGAGCACGCTCGATCTCCTCGATCGGCTGATCGCCTTTCCGACGGTGAGCCGCGATCCCAACCGCGAGCTGATCGCCTT
CGTGCAGGCCTTCCTCGGCCAGCACGGCATCGCCAGCGAGATCATTGCAACGCCGGACGGAAGGAAGGCGAATCTCTTCG
CCACCATCGGCCCCACCGACCGGCCCGGCATCATGCTCTCCGGCCATACGGACGTGGTGCCCGTGGAGGGGCAGGCCTGG
ACGGCTGATCCGTTCCGCCTGCGCGTCGCGGACGGACGCGCCTATGGGCGCGGGGCGGCGGACATGAAGGGCTTCCTCGC
CGCAGCGCTCGCCCTCGCGGCACGGGCAGCGGCACGGCCGCTCGAAACGCCGCTGCACCTCGCCCTCAGTCATGACGAGG
AGGTGGGCTGCGTCGGTGTGCGCTCGCTCATCGAACGCCTGTCCACGGCTTCCGTGCGCCCGCGCCTGTGCATTATCGGC
GAGCCGACCTCGCTGCGTGTCGCCACCGGCCACAAGGGCAAGCTCGCGGCGCGCGCCACCTGCTGCGGCGTGGAAGGCCA
TTCCGCTCTGGCGCCGAAGGCGCTCAACGCCATCCATCTGGCGTGCGATTTCGTGGGCCTCCTGCGCACCCATCAGGACC
GCATCGCCGAGAGCGGCGCACGGGACGCGGATTACGACATCCCCTACACGACGCTGCACGCTGGCGTTATCGCCGGTGGC
ACGGCGCTCAACATCGTGCCGAACCGCTGCACGGTGGATTTCGAGATCCGCAACATCGCGCAGGACGACGCCTCGGAGGT
GCTCACCCGCCTGCTGGACGACGCCGCGCGACTGGTCGCCGAACGCCGCGCGGCCTTTCCCGCCGCCGACATCGCGGTGG
AGGTGGTGAACGACTATCCCGGACTTGCCACGCCCAAGGAGGCGGAGGTGGTGGCCTTCGTGCAGGCGCTGGTGGACGAC
GCCTCCACCTTCAAGGTGGCGTTCGGCACGGAAGGTGGACTGTTCGATGCCCGCCTGTCCATTCCCACCGTCATCTGCGG
CCCCGGCTCCATGGACCAGGGCCATAAGCCGGACGAATTCATCGCCCTCGACCAGTTGGAGGCCTGCGACCGGATGATGG
ACCGGCTTCTCCATCGGCTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CCATCGCGCACCGGGGCATCATGCTGGTGAAGGGACGTGTCGTCGCCTCCGGGGACGCGGCAACGCTCCTCTCCAACGAC
GCCGTGCGCCACCTCTACCT

Downstream 100 bases:

>100_bases
GGCCGGAGCAGACCCGCTTTCCGCATCGCCGCCGGGCGGCTCCGGCCGGCACCTTTATCGATCGAAGACGTGAGGCACGC
CCATGATTCACCGCCGCATC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSTLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTDRPGIMLSGHTDVVPVEGQAW
TADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARPLETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIG
EPTSLRVATGHKGKLAARATCCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGG
TALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYPGLATPKEAEVVAFVQALVDD
ASTFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEFIALDQLEACDRMMDRLLHRLAA

Sequences:

>Translated_382_residues
MSTLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTDRPGIMLSGHTDVVPVEGQAW
TADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARPLETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIG
EPTSLRVATGHKGKLAARATCCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGG
TALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYPGLATPKEAEVVAFVQALVDD
ASTFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEFIALDQLEACDRMMDRLLHRLAA
>Mature_381_residues
STLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTDRPGIMLSGHTDVVPVEGQAWT
ADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARPLETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIGE
PTSLRVATGHKGKLAARATCCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGGT
ALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYPGLATPKEAEVVAFVQALVDDA
STFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEFIALDQLEACDRMMDRLLHRLAA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=268, Percent_Identity=24.6268656716418, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1790395, Length=384, Percent_Identity=33.0729166666667, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788816, Length=396, Percent_Identity=29.040404040404, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17551016, Length=361, Percent_Identity=28.2548476454294, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 40621; Mature: 40490

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTD
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHEECCCCCCEEEEEEECCCC
RPGIMLSGHTDVVPVEGQAWTADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARP
CCCEEEECCCCEEECCCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIGEPTSLRVATGHKGKLAARAT
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCEEEEEE
CCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
TALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYP
CEEEEECCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEHHCCC
GLATPKEAEVVAFVQALVDDASTFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEF
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCHH
IALDQLEACDRMMDRLLHRLAA
EEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTD
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHEECCCCCCEEEEEEECCCC
RPGIMLSGHTDVVPVEGQAWTADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARP
CCCEEEECCCCEEECCCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIGEPTSLRVATGHKGKLAARAT
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCEEEEEE
CCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
TALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYP
CEEEEECCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEHHCCC
GLATPKEAEVVAFVQALVDDASTFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEF
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCHH
IALDQLEACDRMMDRLLHRLAA
EEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]