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The map label for this gene is galE [H]

Identifier: 158421677

GI number: 158421677

Start: 65771

End: 66748

Strand: Reverse

Name: galE [H]

Synonym: AZC_0053

Alternate gene names: 158421677

Gene position: 66748-65771 (Counterclockwise)

Preceding gene: 158421678

Following gene: 158421676

Centisome position: 1.24

GC content: 66.87

Gene sequence:

>978_bases
ATGCCGGGCAATCCCGTTCTGCTCCTGGTCGGCGGGACCGGCTTTGTCGGTGGTCATTTGGCACCCGCTCTCGTTGCCGC
GTTCCCGCGGCACCGCAGGGTCATGTTGAGCCGCGGTGAAGCAAGCGCGCGGCCCGACTGGGAGACGCTGGAGGGCGACC
TCTCCGATGCGGTTGCGATGGATCGGATCGTGGCCGAGCTGCGGCCGGAGGTGGTGATCCATCTCGCGGCGCAGGCGTCC
GTGGTCAGTGATCCCAACGCGACCTGGGTTGTGAACTGCGGCGGCACCTTCAATCTGGCCCGCGCCGTCGCACGCCACGT
CCCCCGAGGGCTCTTCTTCTTCTCGTCGTCCGGCGAGATTTATGGCGAGAGCTTCAACGACGGTCCGGCTCGCGAAGATA
CCGCGCCCAGGCCGATGAACGCCTATGCCGGTTCAAAGCTGGCGGCGGAAGCCGTCCTGCGCGCGCTGCTCCCGCAGGAA
TGGCGGCTCGTGATCGCACGGGCCTTCAACCATACGGGGCCGGGACAGGACGAGCGGTTCGTCCTGCCCTCGTTCGCCGC
CCAGATCGCACGGATCGAAGCCGGGCAGATCGCTCCGCGGATCCGTGTCGGCAACCTCGCCGCCGAGCGCGACTTCCTGC
ATGTGAAGGACGTCGTGGCCGCCTACATCGCGCTGCTGCACTATGAGGGGCCGGAACGGCGGATTCTGGTGAATGTCGCC
TCCGGCCACGTGTACGGCATCTCCGACCTGCTGGAGCGGCTGCGTGGGAGCGCACGGCGTCCGTTCGAGGTTGAGATCGA
CCCGGCCAGGATGCGTCCGTCGGACATTCCCTGTGCTGCCGGTGATCCCTCCCTGCTCAAGCAACTGGTGAACTGGACGC
CCCGGCATTCCATCCAGGAAACGCTGGATGAGTTGCTGGATTGGTGGCGGGCGGCGGTCCTCTCGGGCAGGGGCGAAGGC
GTCAGCACCAATCATTAG

Upstream 100 bases:

>100_bases
GGCGAAGGCCAAGCTCGGCTGGGAGCCCCAGATCACGCTCGACCAGATGATCCGCGAAATGGTGGATGCCGATCTCGCTC
GCCTGAAGCGGGCGTGATCC

Downstream 100 bases:

>100_bases
GTTGGATCGCTACGGCGATCTGGTGAACGACAGTATTTCCGAGGGCTGCGATACGACTGTTCCCGACCTTAAGGATCGGA
TCGTTGTGGAAACGGCCTCA

Product: GDP-6-deoxy-D-lyxo-4-hexulose reductase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MPGNPVLLLVGGTGFVGGHLAPALVAAFPRHRRVMLSRGEASARPDWETLEGDLSDAVAMDRIVAELRPEVVIHLAAQAS
VVSDPNATWVVNCGGTFNLARAVARHVPRGLFFFSSSGEIYGESFNDGPAREDTAPRPMNAYAGSKLAAEAVLRALLPQE
WRLVIARAFNHTGPGQDERFVLPSFAAQIARIEAGQIAPRIRVGNLAAERDFLHVKDVVAAYIALLHYEGPERRILVNVA
SGHVYGISDLLERLRGSARRPFEVEIDPARMRPSDIPCAAGDPSLLKQLVNWTPRHSIQETLDELLDWWRAAVLSGRGEG
VSTNH

Sequences:

>Translated_325_residues
MPGNPVLLLVGGTGFVGGHLAPALVAAFPRHRRVMLSRGEASARPDWETLEGDLSDAVAMDRIVAELRPEVVIHLAAQAS
VVSDPNATWVVNCGGTFNLARAVARHVPRGLFFFSSSGEIYGESFNDGPAREDTAPRPMNAYAGSKLAAEAVLRALLPQE
WRLVIARAFNHTGPGQDERFVLPSFAAQIARIEAGQIAPRIRVGNLAAERDFLHVKDVVAAYIALLHYEGPERRILVNVA
SGHVYGISDLLERLRGSARRPFEVEIDPARMRPSDIPCAAGDPSLLKQLVNWTPRHSIQETLDELLDWWRAAVLSGRGEG
VSTNH
>Mature_324_residues
PGNPVLLLVGGTGFVGGHLAPALVAAFPRHRRVMLSRGEASARPDWETLEGDLSDAVAMDRIVAELRPEVVIHLAAQASV
VSDPNATWVVNCGGTFNLARAVARHVPRGLFFFSSSGEIYGESFNDGPAREDTAPRPMNAYAGSKLAAEAVLRALLPQEW
RLVIARAFNHTGPGQDERFVLPSFAAQIARIEAGQIAPRIRVGNLAAERDFLHVKDVVAAYIALLHYEGPERRILVNVAS
GHVYGISDLLERLRGSARRPFEVEIDPARMRPSDIPCAAGDPSLLKQLVNWTPRHSIQETLDELLDWWRAAVLSGRGEGV
STNH

Specific function: Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=341, Percent_Identity=26.099706744868, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI7657641, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=24.7058823529412, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=24.7058823529412, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=24.7058823529412, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788366, Length=353, Percent_Identity=25.2124645892351, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786974, Length=331, Percent_Identity=23.5649546827795, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507723, Length=342, Percent_Identity=23.9766081871345, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI133901786, Length=280, Percent_Identity=23.5714285714286, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539424, Length=280, Percent_Identity=23.5714285714286, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133901790, Length=280, Percent_Identity=23.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901788, Length=280, Percent_Identity=23.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539422, Length=280, Percent_Identity=23.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=341, Percent_Identity=23.1671554252199, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=339, Percent_Identity=23.0088495575221, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24158427, Length=281, Percent_Identity=23.4875444839858, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35374; Mature: 35242

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGNPVLLLVGGTGFVGGHLAPALVAAFPRHRRVMLSRGEASARPDWETLEGDLSDAVAM
CCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCCCCCHHHHHCCHHHHHHH
DRIVAELRPEVVIHLAAQASVVSDPNATWVVNCGGTFNLARAVARHVPRGLFFFSSSGEI
HHHHHHHCCHHEEEEHHHHHEECCCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCE
YGESFNDGPAREDTAPRPMNAYAGSKLAAEAVLRALLPQEWRLVIARAFNHTGPGQDERF
ECCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEE
VLPSFAAQIARIEAGQIAPRIRVGNLAAERDFLHVKDVVAAYIALLHYEGPERRILVNVA
ECHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SGHVYGISDLLERLRGSARRPFEVEIDPARMRPSDIPCAAGDPSLLKQLVNWTPRHSIQE
CCCEECHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHH
TLDELLDWWRAAVLSGRGEGVSTNH
HHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PGNPVLLLVGGTGFVGGHLAPALVAAFPRHRRVMLSRGEASARPDWETLEGDLSDAVAM
CCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCCCCCHHHHHCCHHHHHHH
DRIVAELRPEVVIHLAAQASVVSDPNATWVVNCGGTFNLARAVARHVPRGLFFFSSSGEI
HHHHHHHCCHHEEEEHHHHHEECCCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCE
YGESFNDGPAREDTAPRPMNAYAGSKLAAEAVLRALLPQEWRLVIARAFNHTGPGQDERF
ECCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEE
VLPSFAAQIARIEAGQIAPRIRVGNLAAERDFLHVKDVVAAYIALLHYEGPERRILVNVA
ECHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SGHVYGISDLLERLRGSARRPFEVEIDPARMRPSDIPCAAGDPSLLKQLVNWTPRHSIQE
CCCEECHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHH
TLDELLDWWRAAVLSGRGEGVSTNH
HHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8355614 [H]