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The map label for this gene is cysM [C]

Identifier: 158421651

GI number: 158421651

Start: 28797

End: 29981

Strand: Reverse

Name: cysM [C]

Synonym: AZC_0027

Alternate gene names: 158421651

Gene position: 29981-28797 (Counterclockwise)

Preceding gene: 158421655

Following gene: 158421650

Centisome position: 0.56

GC content: 68.02

Gene sequence:

>1185_bases
TTGCGTTATCCGCAAATCGCCGCGGCCCCTGTGAATAATGGTCTGGTCATGAAGATCGAGCCCCTCTCCGCCGTTCCGTC
CCTCACGTCCCCCGCCGCCGGTGCGGCACCGAGCGAGCGGGACGCCCGCCGGATCTGGGCCGATCAGGCGCTCAGGATTC
TCGAGCGCGACGCCCGGCGGTCGGCAGATACCCACCTTCTGCCCTTCGAGGCGCACCGGCTCGGCGGCATCGACATCTAT
CTCAAGGATGAATCGAGCCACCCCACCGGCAGCCTGAAGCACAGGCTCGCCCGTTCACTCTTCCTGTTCGGCGTCTGCAA
CGGCCAGATCCGCGAAGGCATCACGCTGGTGGAAGCATCTTCCGGCTCAACAGCGGTTTCAGAAGCCTATTTCGCCCGCC
TGCTCGGCCTGCCCTTCTATGCGGTGATGACCCGCACCACCTCGCCGGAGAAGATCGCGGACATCGAGCGCGAGGGCGGG
CGCTGCCATTTCGTGGACGACAGCAGCGCGGTCTATGCGGAGGCCGCCGCCCTCGCGGAACGGCTCGGCGGGCTTTATGT
GGACCAGTTCACCAATGCCGAGCGCGTCACCGACTGGCGCGGCAACAACAACATCGCCGAATCCATCTTCCAGCAGATGC
AGGGCGAGCCGCGCAGCGTCCCCACCTGGATCGTGATGGGCGCGGGCACGGGGGGCACCTCGGCCACCATCGGCCGCTAC
CTGCGCTATCGCCACCATGCCACCCGCCTGTGCGTGGCTGACCCGGAAGGCTCCGTCTTCTACGACGCCTTCCGCACCGG
CGACCGCAGCCTCACCTCCTGCCCCGGATCGCGCATCGAGGGCATCGGCCGGCCGCGCGTGGAGCCCTCCTTCATCCCGG
AGGTGATCGACCACATGATCCGCGTGCCGGACGCCGCCTCCATCGCCGCCATGCGCGTGCTGGCGCGCCGGCTCGGCCGC
AAGGTCGGCCCCTCCACCGGCACCGCCTTCCATGCGCTGTGCATGCTCGCGGCCGAGATGATGGGGCGCGGCGAGACCGG
CTCGCTCGTCACCCTTATCTGTGACCGGGGCGAACGCTACCTGCGCAGCTATTATGACGATGCCTGGGTGGCGGCGCAGG
GCTTCGAGCTTGGCTCCCACGAGGCCCGCATGGAAACCTTCCTCGATCAGGGCGGCCCCTTCTGA

Upstream 100 bases:

>100_bases
GAATTTTTCGCGTATCCGGCGCAGAGCGAAATGAGATTGCGCAAAAGGGCTCCCGCAAGCATCGCAGGCGGTGATGATTT
CTGCGCGCGAGCGGTCATGA

Downstream 100 bases:

>100_bases
GCTCGCCCAGGGGAAGGGCGGCGGCGCGTCCATTTGCCCAACTTTTAGGCAGACATCGCCACCTCTGATCCGGCCGCTCT
GCCTCCGGCGGTGGCATGTG

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRYPQIAAAPVNNGLVMKIEPLSAVPSLTSPAAGAAPSERDARRIWADQALRILERDARRSADTHLLPFEAHRLGGIDIY
LKDESSHPTGSLKHRLARSLFLFGVCNGQIREGITLVEASSGSTAVSEAYFARLLGLPFYAVMTRTTSPEKIADIEREGG
RCHFVDDSSAVYAEAAALAERLGGLYVDQFTNAERVTDWRGNNNIAESIFQQMQGEPRSVPTWIVMGAGTGGTSATIGRY
LRYRHHATRLCVADPEGSVFYDAFRTGDRSLTSCPGSRIEGIGRPRVEPSFIPEVIDHMIRVPDAASIAAMRVLARRLGR
KVGPSTGTAFHALCMLAAEMMGRGETGSLVTLICDRGERYLRSYYDDAWVAAQGFELGSHEARMETFLDQGGPF

Sequences:

>Translated_394_residues
MRYPQIAAAPVNNGLVMKIEPLSAVPSLTSPAAGAAPSERDARRIWADQALRILERDARRSADTHLLPFEAHRLGGIDIY
LKDESSHPTGSLKHRLARSLFLFGVCNGQIREGITLVEASSGSTAVSEAYFARLLGLPFYAVMTRTTSPEKIADIEREGG
RCHFVDDSSAVYAEAAALAERLGGLYVDQFTNAERVTDWRGNNNIAESIFQQMQGEPRSVPTWIVMGAGTGGTSATIGRY
LRYRHHATRLCVADPEGSVFYDAFRTGDRSLTSCPGSRIEGIGRPRVEPSFIPEVIDHMIRVPDAASIAAMRVLARRLGR
KVGPSTGTAFHALCMLAAEMMGRGETGSLVTLICDRGERYLRSYYDDAWVAAQGFELGSHEARMETFLDQGGPF
>Mature_394_residues
MRYPQIAAAPVNNGLVMKIEPLSAVPSLTSPAAGAAPSERDARRIWADQALRILERDARRSADTHLLPFEAHRLGGIDIY
LKDESSHPTGSLKHRLARSLFLFGVCNGQIREGITLVEASSGSTAVSEAYFARLLGLPFYAVMTRTTSPEKIADIEREGG
RCHFVDDSSAVYAEAAALAERLGGLYVDQFTNAERVTDWRGNNNIAESIFQQMQGEPRSVPTWIVMGAGTGGTSATIGRY
LRYRHHATRLCVADPEGSVFYDAFRTGDRSLTSCPGSRIEGIGRPRVEPSFIPEVIDHMIRVPDAASIAAMRVLARRLGR
KVGPSTGTAFHALCMLAAEMMGRGETGSLVTLICDRGERYLRSYYDDAWVAAQGFELGSHEARMETFLDQGGPF

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=298, Percent_Identity=26.1744966442953, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI295821200, Length=298, Percent_Identity=26.1744966442953, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4557415, Length=298, Percent_Identity=26.1744966442953, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=360, Percent_Identity=32.2222222222222, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17539800, Length=389, Percent_Identity=29.0488431876607, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17539640, Length=383, Percent_Identity=28.4595300261097, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=26.578073089701, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=26.6891891891892, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=25.1572327044025, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321449, Length=321, Percent_Identity=28.6604361370716, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=25.08038585209, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=25.08038585209, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 43027; Mature: 43027

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYPQIAAAPVNNGLVMKIEPLSAVPSLTSPAAGAAPSERDARRIWADQALRILERDARR
CCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SADTHLLPFEAHRLGGIDIYLKDESSHPTGSLKHRLARSLFLFGVCNGQIREGITLVEAS
CCCCEECCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEEECC
SGSTAVSEAYFARLLGLPFYAVMTRTTSPEKIADIEREGGRCHFVDDSSAVYAEAAALAE
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RLGGLYVDQFTNAERVTDWRGNNNIAESIFQQMQGEPRSVPTWIVMGAGTGGTSATIGRY
HHCCEEHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
LRYRHHATRLCVADPEGSVFYDAFRTGDRSLTSCPGSRIEGIGRPRVEPSFIPEVIDHMI
HHHHHHHCEEEEECCCCCEEEHHHHCCCCCHHCCCCHHHCCCCCCCCCHHHHHHHHHHHH
RVPDAASIAAMRVLARRLGRKVGPSTGTAFHALCMLAAEMMGRGETGSLVTLICDRGERY
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHH
LRSYYDDAWVAAQGFELGSHEARMETFLDQGGPF
HHHHCCCHHEEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRYPQIAAAPVNNGLVMKIEPLSAVPSLTSPAAGAAPSERDARRIWADQALRILERDARR
CCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SADTHLLPFEAHRLGGIDIYLKDESSHPTGSLKHRLARSLFLFGVCNGQIREGITLVEAS
CCCCEECCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEEECC
SGSTAVSEAYFARLLGLPFYAVMTRTTSPEKIADIEREGGRCHFVDDSSAVYAEAAALAE
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RLGGLYVDQFTNAERVTDWRGNNNIAESIFQQMQGEPRSVPTWIVMGAGTGGTSATIGRY
HHCCEEHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
LRYRHHATRLCVADPEGSVFYDAFRTGDRSLTSCPGSRIEGIGRPRVEPSFIPEVIDHMI
HHHHHHHCEEEEECCCCCEEEHHHHCCCCCHHCCCCHHHCCCCCCCCCHHHHHHHHHHHH
RVPDAASIAAMRVLARRLGRKVGPSTGTAFHALCMLAAEMMGRGETGSLVTLICDRGERY
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHH
LRSYYDDAWVAAQGFELGSHEARMETFLDQGGPF
HHHHCCCHHEEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]