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The map label for this gene is ilvC

Identifier: 158338651

GI number: 158338651

Start: 5608166

End: 5609161

Strand: Reverse

Name: ilvC

Synonym: AM1_5555

Alternate gene names: 158338651

Gene position: 5609161-5608166 (Counterclockwise)

Preceding gene: 158338652

Following gene: 158338649

Centisome position: 86.25

GC content: 49.1

Gene sequence:

>996_bases
ATGGCCCGCCTGTATTACGATGCCGATGCCAATTTAGATTTATTGGCAAATAAAACCGTTGCCATTATTGGCTATGGTTC
TCAGGGGCATGCCCATGCCTTAAACCTAAAGGATAGCGGTGTTCAGGTCATTGTGGGCCTATATGAAGGGAGCAAATCTG
CAGCAAAGGCCCAGGAAGCAGGACTAACGGTGAAGTCAGCTGCAGACGCTGCAAAAGCTGCTGACTTAATTATGATTTTG
CTGCCAGATGAAGTGCAGAGAACCGTCTACACCCAGGATATTCAACCCCATTTGAGTGCAGATAAGGTATTGGCATTTGC
CCACGGCTTTAACATCCATTTTGCCCAAGTGGTCCCCCCTAGCGACGTTGATGTCGTCATGGTGGCTCCGAAAGGTCCTG
GGCATCTGGTGCGTCGGACTTATACCCAAGGGCAAGGCGTTCCCTGCTTATTTGCTGTGTACCAAGACGCCTCAGGCCAA
GCACGAGATCGGGCAATGGCCTATGCCAAAGGGATAGGAGGAACCCGAGCAGGTATCCTCGAGACCACTTTTCGGGAAGA
AACAGAGACGGATTTATTTGGAGAACAAGCTGTTCTATGTGGTGGGTTGACTGCCCTCATTAAGGCAGGTTTTGAAACTC
TAGTAGAAGCTGGATATCAGCCTGAGCTGGCCTATTTCGAATGTATGCATGAAGTGAAGCTAATTGTGGATCTCATTGTG
GAAGGCGGGCTTGCCAAAATGCGAGATAGCATCTCTAATACAGCAGAGTATGGAGACTACACCCGTGGACCTCGCATTGT
TGATGACAGAACAAAGGCTGAAATGCGCCGAGTTCTGCATGAAATTCAAACGGGGCAGTTTGCCAAGGAGTTTGTGCTAG
AGAATATGTCCGGCAAGGCAGGATTTACAGCAACTCGTCGGCGTGAATCTGAACATGCGATTGAAGAGGTCGGCAAAGAT
TTACGAGCGATGTTCAGCTGGACAGATAAGGCATAA

Upstream 100 bases:

>100_bases
GCTCTTTGTTGACGTGTTCGTAGTATGATTCACCAGCGATTAATTGTAGAATTAGAAGCCAGCAGATAGCCCCTGGCTGT
TAAGGAGAGAGCAAAATATT

Downstream 100 bases:

>100_bases
TTAGCCCTTAGTTTGAGTTCCACTGAAACCTTTATGCAATTTTGCTCCGGCAAAGAAATGCCGGAGCGACAAATTCGAGT
TGAAGTTTTTAGTCCACTTC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MARLYYDADANLDLLANKTVAIIGYGSQGHAHALNLKDSGVQVIVGLYEGSKSAAKAQEAGLTVKSAADAAKAADLIMIL
LPDEVQRTVYTQDIQPHLSADKVLAFAHGFNIHFAQVVPPSDVDVVMVAPKGPGHLVRRTYTQGQGVPCLFAVYQDASGQ
ARDRAMAYAKGIGGTRAGILETTFREETETDLFGEQAVLCGGLTALIKAGFETLVEAGYQPELAYFECMHEVKLIVDLIV
EGGLAKMRDSISNTAEYGDYTRGPRIVDDRTKAEMRRVLHEIQTGQFAKEFVLENMSGKAGFTATRRRESEHAIEEVGKD
LRAMFSWTDKA

Sequences:

>Translated_331_residues
MARLYYDADANLDLLANKTVAIIGYGSQGHAHALNLKDSGVQVIVGLYEGSKSAAKAQEAGLTVKSAADAAKAADLIMIL
LPDEVQRTVYTQDIQPHLSADKVLAFAHGFNIHFAQVVPPSDVDVVMVAPKGPGHLVRRTYTQGQGVPCLFAVYQDASGQ
ARDRAMAYAKGIGGTRAGILETTFREETETDLFGEQAVLCGGLTALIKAGFETLVEAGYQPELAYFECMHEVKLIVDLIV
EGGLAKMRDSISNTAEYGDYTRGPRIVDDRTKAEMRRVLHEIQTGQFAKEFVLENMSGKAGFTATRRRESEHAIEEVGKD
LRAMFSWTDKA
>Mature_330_residues
ARLYYDADANLDLLANKTVAIIGYGSQGHAHALNLKDSGVQVIVGLYEGSKSAAKAQEAGLTVKSAADAAKAADLIMILL
PDEVQRTVYTQDIQPHLSADKVLAFAHGFNIHFAQVVPPSDVDVVMVAPKGPGHLVRRTYTQGQGVPCLFAVYQDASGQA
RDRAMAYAKGIGGTRAGILETTFREETETDLFGEQAVLCGGLTALIKAGFETLVEAGYQPELAYFECMHEVKLIVDLIVE
GGLAKMRDSISNTAEYGDYTRGPRIVDDRTKAEMRRVLHEIQTGQFAKEFVLENMSGKAGFTATRRRESEHAIEEVGKDL
RAMFSWTDKA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:
GO:0004455: Ketol-acid reductoisomerase
GO:0008652: Ketol-acid reductoisomerase
GO:0009082: Ketol-acid reductoisomerase
GO:0016491: Ketol-acid reductoisomerase
GO:0016616: Ketol-acid reductoisomerase
GO:0050662: Ketol-acid reductoisomerase
GO:0055114: Ketol-acid reductoisomerase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=253, Percent_Identity=37.9446640316205, Blast_Score=144, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=37.6470588235294, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ACAM1 (B0CE35)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001519828.1
- ProteinModelPortal:   B0CE35
- SMR:   B0CE35
- GeneID:   5684346
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5555
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   CLSK2475886
- BioCyc:   AMAR329726:AM1_5555-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35989; Mature: 35858

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLYYDADANLDLLANKTVAIIGYGSQGHAHALNLKDSGVQVIVGLYEGSKSAAKAQEA
CCEEEECCCCCEEEEECCEEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHH
GLTVKSAADAAKAADLIMILLPDEVQRTVYTQDIQPHLSADKVLAFAHGFNIHFAQVVPP
CCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCHHHEEEEEECCCEEEEEECCC
SDVDVVMVAPKGPGHLVRRTYTQGQGVPCLFAVYQDASGQARDRAMAYAKGIGGTRAGIL
CCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHH
ETTFREETETDLFGEQAVLCGGLTALIKAGFETLVEAGYQPELAYFECMHEVKLIVDLIV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLAKMRDSISNTAEYGDYTRGPRIVDDRTKAEMRRVLHEIQTGQFAKEFVLENMSGKA
CCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GFTATRRRESEHAIEEVGKDLRAMFSWTDKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARLYYDADANLDLLANKTVAIIGYGSQGHAHALNLKDSGVQVIVGLYEGSKSAAKAQEA
CEEEECCCCCEEEEECCEEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHH
GLTVKSAADAAKAADLIMILLPDEVQRTVYTQDIQPHLSADKVLAFAHGFNIHFAQVVPP
CCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCHHHEEEEEECCCEEEEEECCC
SDVDVVMVAPKGPGHLVRRTYTQGQGVPCLFAVYQDASGQARDRAMAYAKGIGGTRAGIL
CCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHH
ETTFREETETDLFGEQAVLCGGLTALIKAGFETLVEAGYQPELAYFECMHEVKLIVDLIV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLAKMRDSISNTAEYGDYTRGPRIVDDRTKAEMRRVLHEIQTGQFAKEFVLENMSGKA
CCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GFTATRRRESEHAIEEVGKDLRAMFSWTDKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA