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The map label for this gene is aroB

Identifier: 158338471

GI number: 158338471

Start: 5431566

End: 5432684

Strand: Reverse

Name: aroB

Synonym: AM1_5373

Alternate gene names: 158338471

Gene position: 5432684-5431566 (Counterclockwise)

Preceding gene: 158338473

Following gene: 158338466

Centisome position: 83.53

GC content: 50.67

Gene sequence:

>1119_bases
ATGCAGCAGACATTTATCCCCGTCCCTTTACCACAACAGCCGTATCAAATTGCGATCGCATCCGGTGGCCTCACCCAATT
AGGCTCCTGGCTCCAGGATCGATCCCTGCAGTCAGTAAAGCTAGGACAGAAAGTCCTAGTCGTTTCTAACCCCCAGATTT
GGAAACACTACGGGGAGATTGTCCAAGATTCTTTAGCCCAGGCGGGCTTCCAGGTTGAGCATTTTCTCTTGCCAGCAGGG
GAACGCTACAAAACCCCCCGCTCTATTCAAAAGATTTACGATTATGCCCTGGACCTGAAACTAGAGCGCTCGTCCACCCT
TGTCGCCCTTGGGGGAGGTGTGATTGGTGATATGACGGGGTTTGCAGCCGCGACCTGGTTGCGTGGCATTAACTTTGTCC
AAGTTCCCACAAGTTTGTTGGCCATGGTTGATGCCTCCATTGGCGGTAAAACTGGTGTCAATCATCCGAAGGGGAAAAAC
TTGATTGGGGCATTTTATCAGCCTCGGTTGGTTTTGATCGATCCCGATACCTTAAAAACCTTGGCCAGCCGAGAATTTAG
GGCGGGAATGGCTGAGGTGATTAAATATGGTGTGATTTGGGATCTAGAGCTGTTTGAGGTGTTGGAGGGTTGCGATCGCA
CCAACCAATACCGTTACATGCCCCCGCATATCCTCACAGAAATTCTCACCCGCTCCGCTCAAGCCAAAGCAGATGTCGTC
ACTCAGGACGAAAAAGAAGCTGGGCTTAGGGCTATCCTTAACTACGGTCATACCATTGGCCATGCGATTGAAAGTCTAAC
GGGGTACCGTTTGTTTAATCATGGCGAGGCCGTTGCTTTAGGCATGGTAGCTGCTGCCGATATCGCCGTCCAACTAGATT
GGTGGTCTGTTGAAGACGCGCAACGTCAGCACCAACTGATTCAGAAAACCGGATTACCCACTGAACTCCCGGCTGACTTT
GCCATTGAAGCTGTGGCAGATGTGCTGCTGACGGATAAAAAAGTCAAAGACGGCAAAGTCCGGTTTATCTTGCCCACTCA
GCTCGGTAAGATTGACATCACGGATCAGGTGCCAGGACAGGTGATCGTAAGTGCCCTAAAAGGAATGATAGGGCAATAG

Upstream 100 bases:

>100_bases
TATCAATCGATTAAATGGGGAATAAAACTCACCCCAAAAAGTTGCTAGTGACAGAAGGGGTTCCTGTAAGGCACACTGGC
AAGGGAGTTCCAGGAGTGGC

Downstream 100 bases:

>100_bases
TTTAGATAAGAGAGAGCTCAACAATGACAGCAACTCTAGTTAGCTAGGAAGAAAATAGAGTAAACAGCCCTGGATAACGC
TTATGGGTGGAGTTTTGACG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQQTFIPVPLPQQPYQIAIASGGLTQLGSWLQDRSLQSVKLGQKVLVVSNPQIWKHYGEIVQDSLAQAGFQVEHFLLPAG
ERYKTPRSIQKIYDYALDLKLERSSTLVALGGGVIGDMTGFAAATWLRGINFVQVPTSLLAMVDASIGGKTGVNHPKGKN
LIGAFYQPRLVLIDPDTLKTLASREFRAGMAEVIKYGVIWDLELFEVLEGCDRTNQYRYMPPHILTEILTRSAQAKADVV
TQDEKEAGLRAILNYGHTIGHAIESLTGYRLFNHGEAVALGMVAAADIAVQLDWWSVEDAQRQHQLIQKTGLPTELPADF
AIEAVADVLLTDKKVKDGKVRFILPTQLGKIDITDQVPGQVIVSALKGMIGQ

Sequences:

>Translated_372_residues
MQQTFIPVPLPQQPYQIAIASGGLTQLGSWLQDRSLQSVKLGQKVLVVSNPQIWKHYGEIVQDSLAQAGFQVEHFLLPAG
ERYKTPRSIQKIYDYALDLKLERSSTLVALGGGVIGDMTGFAAATWLRGINFVQVPTSLLAMVDASIGGKTGVNHPKGKN
LIGAFYQPRLVLIDPDTLKTLASREFRAGMAEVIKYGVIWDLELFEVLEGCDRTNQYRYMPPHILTEILTRSAQAKADVV
TQDEKEAGLRAILNYGHTIGHAIESLTGYRLFNHGEAVALGMVAAADIAVQLDWWSVEDAQRQHQLIQKTGLPTELPADF
AIEAVADVLLTDKKVKDGKVRFILPTQLGKIDITDQVPGQVIVSALKGMIGQ
>Mature_372_residues
MQQTFIPVPLPQQPYQIAIASGGLTQLGSWLQDRSLQSVKLGQKVLVVSNPQIWKHYGEIVQDSLAQAGFQVEHFLLPAG
ERYKTPRSIQKIYDYALDLKLERSSTLVALGGGVIGDMTGFAAATWLRGINFVQVPTSLLAMVDASIGGKTGVNHPKGKN
LIGAFYQPRLVLIDPDTLKTLASREFRAGMAEVIKYGVIWDLELFEVLEGCDRTNQYRYMPPHILTEILTRSAQAKADVV
TQDEKEAGLRAILNYGHTIGHAIESLTGYRLFNHGEAVALGMVAAADIAVQLDWWSVEDAQRQHQLIQKTGLPTELPADF
AIEAVADVLLTDKKVKDGKVRFILPTQLGKIDITDQVPGQVIVSALKGMIGQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=361, Percent_Identity=44.0443213296399, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6320332, Length=319, Percent_Identity=38.2445141065831, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_ACAM1 (B0CBS9)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001519648.1
- ProteinModelPortal:   B0CBS9
- SMR:   B0CBS9
- GeneID:   5684165
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5373
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- BioCyc:   AMAR329726:AM1_5373-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40822; Mature: 40822

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQTFIPVPLPQQPYQIAIASGGLTQLGSWLQDRSLQSVKLGQKVLVVSNPQIWKHYGEI
CCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHHHHHH
VQDSLAQAGFQVEHFLLPAGERYKTPRSIQKIYDYALDLKLERSSTLVALGGGVIGDMTG
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCEEEECCCEEEEECCCHHHHHHH
FAAATWLRGINFVQVPTSLLAMVDASIGGKTGVNHPKGKNLIGAFYQPRLVLIDPDTLKT
HHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHH
LASREFRAGMAEVIKYGVIWDLELFEVLEGCDRTNQYRYMPPHILTEILTRSAQAKADVV
HHHHHHHHHHHHHHHHCCEECHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHCC
TQDEKEAGLRAILNYGHTIGHAIESLTGYRLFNHGEAVALGMVAAADIAVQLDWWSVEDA
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCHHHHHHHHHEEEEEEEEECCCHHH
QRQHQLIQKTGLPTELPADFAIEAVADVLLTDKKVKDGKVRFILPTQLGKIDITDQVPGQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCCCHH
VIVSALKGMIGQ
HHHHHHHHHHCC
>Mature Secondary Structure
MQQTFIPVPLPQQPYQIAIASGGLTQLGSWLQDRSLQSVKLGQKVLVVSNPQIWKHYGEI
CCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHHHHHH
VQDSLAQAGFQVEHFLLPAGERYKTPRSIQKIYDYALDLKLERSSTLVALGGGVIGDMTG
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCEEEECCCEEEEECCCHHHHHHH
FAAATWLRGINFVQVPTSLLAMVDASIGGKTGVNHPKGKNLIGAFYQPRLVLIDPDTLKT
HHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHH
LASREFRAGMAEVIKYGVIWDLELFEVLEGCDRTNQYRYMPPHILTEILTRSAQAKADVV
HHHHHHHHHHHHHHHHCCEECHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHCC
TQDEKEAGLRAILNYGHTIGHAIESLTGYRLFNHGEAVALGMVAAADIAVQLDWWSVEDA
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCHHHHHHHHHEEEEEEEEECCCHHH
QRQHQLIQKTGLPTELPADFAIEAVADVLLTDKKVKDGKVRFILPTQLGKIDITDQVPGQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCCCHH
VIVSALKGMIGQ
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA