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The map label for this gene is proC [H]

Identifier: 158338465

GI number: 158338465

Start: 5425657

End: 5426472

Strand: Direct

Name: proC [H]

Synonym: AM1_5367

Alternate gene names: 158338465

Gene position: 5425657-5426472 (Clockwise)

Preceding gene: 158338464

Following gene: 158338467

Centisome position: 83.42

GC content: 51.96

Gene sequence:

>816_bases
GTGAGTCAGTTTCGCGATCAGCTTGGCATCATTGGCGGTGGTGTTATGGCTGAAGCCATTTTGTCACGGCTGCTTTCCCA
AAAAATCTGTTCACCAAAGCAGATTCAAGTAAGTGATATCTCCAAAGAGCGATTAGAGGTTCTAATCGGTCGCTATCAGA
TTCAGGGATCTACCCTTAATGATGCGGTTGCCTCCAACGCTCGGGTCTTGCTGTTGGCCATCAAACCCCAAATATTTGCA
AAGGTCGCTGTTCCCCTCGCATCATCCATACCCGCTGGATGTTTAATCCTTTCTATTTTGGCGGGGGTAACTTTAGGGAC
GTTAGAAGCAGCTTTTCCAGGATCCCCTGTGATTCGAGTTATGCCAAACACACCGGCTACAGTTGGGGCTGGAATAGCTG
CGATCGCAGCGGGTAACCATGCACATCAGACTCACCTAGATCTCGCTCATCAGCTCTTTGGCGCCGTTGGGCAAACGGTT
ACCGTACCTGAATCATTGATGGATGCAGTCACCGGGTTGTCGGGATCAGGGCCAGCTTATGTCGCCTTGGTGCTGGAAGC
CCTCACGGATGGCGGCGTTTCTGTCGGTTTGCCTCGCCCCATTGCCGCTCAATTAGCCTTACAAACCCTTTTGGGTACGG
CCAAATTAGTGGATGAAACGGGACTGCACCCAGCCCAACTCAAGGATCAGGTTACGAGTCCAGGTGGTACAACGATCGCT
GGAGTTGCGGCTTTAGAGCAAGCGGGACTTCGATCAGCCCTGGTCAAAGCTGTTCAGGCCGCTTACCATCGTTCCTGTGA
ACTTGGTCAAGGCTAA

Upstream 100 bases:

>100_bases
GCCACTTTGGGTTTTTCGAAAAACTAAATACAGCAAGGAATCTCGACTAAGCTTTGGTAGACTGGTGCATTGTTTCTGCC
ATCAGTTTAGGGGTGTTTTA

Downstream 100 bases:

>100_bases
AACCTACCATGGGGACTGTAAGGCTGGCGTTGTTAACTCGAAAGCCAAAAAATCTGCTAGCCAATTTTTGATTTGATAGG
TGGCTTGGCAATCATCCTCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSQFRDQLGIIGGGVMAEAILSRLLSQKICSPKQIQVSDISKERLEVLIGRYQIQGSTLNDAVASNARVLLLAIKPQIFA
KVAVPLASSIPAGCLILSILAGVTLGTLEAAFPGSPVIRVMPNTPATVGAGIAAIAAGNHAHQTHLDLAHQLFGAVGQTV
TVPESLMDAVTGLSGSGPAYVALVLEALTDGGVSVGLPRPIAAQLALQTLLGTAKLVDETGLHPAQLKDQVTSPGGTTIA
GVAALEQAGLRSALVKAVQAAYHRSCELGQG

Sequences:

>Translated_271_residues
MSQFRDQLGIIGGGVMAEAILSRLLSQKICSPKQIQVSDISKERLEVLIGRYQIQGSTLNDAVASNARVLLLAIKPQIFA
KVAVPLASSIPAGCLILSILAGVTLGTLEAAFPGSPVIRVMPNTPATVGAGIAAIAAGNHAHQTHLDLAHQLFGAVGQTV
TVPESLMDAVTGLSGSGPAYVALVLEALTDGGVSVGLPRPIAAQLALQTLLGTAKLVDETGLHPAQLKDQVTSPGGTTIA
GVAALEQAGLRSALVKAVQAAYHRSCELGQG
>Mature_270_residues
SQFRDQLGIIGGGVMAEAILSRLLSQKICSPKQIQVSDISKERLEVLIGRYQIQGSTLNDAVASNARVLLLAIKPQIFAK
VAVPLASSIPAGCLILSILAGVTLGTLEAAFPGSPVIRVMPNTPATVGAGIAAIAAGNHAHQTHLDLAHQLFGAVGQTVT
VPESLMDAVTGLSGSGPAYVALVLEALTDGGVSVGLPRPIAAQLALQTLLGTAKLVDETGLHPAQLKDQVTSPGGTTIAG
VAALEQAGLRSALVKAVQAAYHRSCELGQG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:
GO:0004735: Pyrroline-5-carboxylate reductase
GO:0005488: Pyrroline-5-carboxylate reductase
GO:0006561: Pyrroline-5-carboxylate reductase
GO:0008652: Pyrroline-5-carboxylate reductase
GO:0016491: Pyrroline-5-carboxylate reductase
GO:0016616: Pyrroline-5-carboxylate reductase
GO:0055114: Pyrroline-5-carboxylate reductase

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=41.4179104477612, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=39.4736842105263, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=39.4736842105263, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=38.4328358208955, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=38.1481481481481, Blast_Score=163, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=43.2835820895522, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=32.6241134751773, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320861, Length=282, Percent_Identity=35.4609929078014, Blast_Score=146, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24648116, Length=285, Percent_Identity=43.859649122807, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=39.2452830188679, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24647700, Length=164, Percent_Identity=47.5609756097561, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27578; Mature: 27447

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFRDQLGIIGGGVMAEAILSRLLSQKICSPKQIQVSDISKERLEVLIGRYQIQGSTLN
CCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHEECCCCHH
DAVASNARVLLLAIKPQIFAKVAVPLASSIPAGCLILSILAGVTLGTLEAAFPGSPVIRV
HHHHCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
MPNTPATVGAGIAAIAAGNHAHQTHLDLAHQLFGAVGQTVTVPESLMDAVTGLSGSGPAY
CCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCCCCHHH
VALVLEALTDGGVSVGLPRPIAAQLALQTLLGTAKLVDETGLHPAQLKDQVTSPGGTTIA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
GVAALEQAGLRSALVKAVQAAYHRSCELGQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQFRDQLGIIGGGVMAEAILSRLLSQKICSPKQIQVSDISKERLEVLIGRYQIQGSTLN
CCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHEECCCCHH
DAVASNARVLLLAIKPQIFAKVAVPLASSIPAGCLILSILAGVTLGTLEAAFPGSPVIRV
HHHHCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
MPNTPATVGAGIAAIAAGNHAHQTHLDLAHQLFGAVGQTVTVPESLMDAVTGLSGSGPAY
CCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCCCCHHH
VALVLEALTDGGVSVGLPRPIAAQLALQTLLGTAKLVDETGLHPAQLKDQVTSPGGTTIA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
GVAALEQAGLRSALVKAVQAAYHRSCELGQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]