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The map label for this gene is dxs

Identifier: 158338290

GI number: 158338290

Start: 5249504

End: 5251411

Strand: Reverse

Name: dxs

Synonym: AM1_5186

Alternate gene names: 158338290

Gene position: 5251411-5249504 (Counterclockwise)

Preceding gene: 158338291

Following gene: 158338289

Centisome position: 80.74

GC content: 51.89

Gene sequence:

>1908_bases
ATGCATCTGAGTGAAATTGTCCACCCTAACCAGTTGCACGGGTTATCTATTTCGGAACTGAAGCAAATTGCCAATCAGAT
CCGTGAGAAGCATTTAGACACTGTGGCGACGAGCGGTGGCCATTTAGGACCGGGGTTAGGGGTTGTTGAACTGACCCTAG
CGCTCTATCAAACCTTAGATTTAGATCAAGATAAAGTGGTGTGGGATGTCGGACACCAAGCCTATCCCCACAAACTGATT
ACGGGACGATACGAGCGGTTCCATACCCTACGCCAAAAAGATGGGGTTGCCGGATATTTAAATCGTCGGGAAAGCAAGTT
TGATCACTTTGGTGCAGGACATGCGTCTACCAGTATTTCATCCGTCCTAGGGATGGCCTTGGCTCGAGATGCCAAGGGAG
AAAACTTTAAAACAGTCGCAGTCATTGGCGACGGAGCGATGACGGGTGGGATGGCTCTGGAAGCCATTAACCATGCGGGT
CACCTCCCTCATACTCGGATGCTCGTGATTTTAAATGATAACGACATGTCCATTTCTCCGAATGTGGGCGCCATGTCTCG
TTATCTGAATAAGATGCGCCTCAGTCCTCCGATTCAGTTCTTGTCCGATAACTTTGAAGAACAGCTCAAGCAGCTCCCTT
TTGGAGAGCAGGTCGCTCCCGATTTGAAGCGCCTCAAAGGCGGCATGAAGCGCCTGGCGGTGTCTAAGGTTGGTGCGGTA
TTTGAAGAGCTGGGCTTTACCTATATAGGGCCTGTAGATGGCCATAGCCTGGAGGAGTTGCTGGCAACCTTTAAGGAAGC
CCATTTGCATGAAGGCCCTGTGCTGGTGCATGTGGCCACCACGAAGGGTAAGGGATATGCGATCGCAGAGCAAGACCAAG
TCAGCTACCATGCCCAAAGTCCGTTCAACCTAGAAACGGGTAAAGCGAAGCCATCCAACAAACCCAAGCCACCCAGCTAT
TCCAAAGTGTTTGCCGAAACCCTAATCAAAATGGCGGAAAACGACATTCGGGTCGTGGGCATCACCGCAGCCATGGCTAC
GGGAACAGGGTTAGACAAATTACAAGCCAAACTACCAAAACAATATATTGATGTCGGTATTGCTGAACAGCATGCCGTTA
CCCTAGCTGCTGGGATGGCCTGTGAAGGGATGCGACCTGTTGTCGCTATCTATTCCACCTTTTTGCAGCGAGGCTACGAC
CAAATTATTCATGATGTCTGCATCCAAAACCTGCCCGTCTTTTTCTGCTTAGATCGGGCCGGTATCGTCGGTGCCGATGG
ACCCACCCACCAAGGTATGTACGATATCGCCTACCTACGCTGCCTCCCAAATATGGTGATGATGGCGCCTAAGGATGAAG
CCGAACTGCAGCAAATGTTAGTGACGGGCATCAACTATACCGATGGCCCGATTGCCATGCGCTATCCCCGAGGCAGTGGC
CTGGGGGTAGGCCTAATGGAAGAAGGGTGGGAACCGTTACCCATTGGTAAAGCGGAAACCCTGCGCCATGGCGACGATGT
CTTGCTGCTGGCCTATGGCACGATGGTGAACTTGGCGTCTCAAGTGGCAGATATGCTGACGGAGCATGGTGTACGGGCCA
CCGTGGTGAATGCTCGATTTGCCAAGCCCTTGGATACAGAGTTAATTATTCCTTTGGCTCAGAAGATTGGCCAAGTGGTC
ACCCTTGAGGAAGGCTGTTTACCCGGTGGCTTCGGCTCGGCTGTCTTAGAAGCCCTGATGGACCATCAAGTGATGGCCCC
TGTGACCCGCATTGGCGTTCCGGATCAATTGGTAGAGCATGCCACACCGGATCAATCCAAAGCGGAGCTGGGACTTACCC
CTGCTCAAGTGGCAGAAAGAGTGTTAGGGTTGCTGAAGCAGAAACCAGCACCTAGCTACGTTTCCTAA

Upstream 100 bases:

>100_bases
GGATGGGGATCAATTCTCAAAATGTAATCAACGCGACGGCCTGAAATCGACTACAGTAGAGGATAGCGAAACAAGCAAAT
TGACGGGAGACGACTCCGGT

Downstream 100 bases:

>100_bases
TACTTGTCCACTGATTCCCAAAAATTGAACTCTGATGACTGCATCGGTTGCCAATCCCGTTTACCCTGTTGTTTGGCGTG
GCGACCACGTTGAACTGATT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLDLDQDKVVWDVGHQAYPHKLI
TGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSISSVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAG
HLPHTRMLVILNDNDMSISPNVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAV
FEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQSPFNLETGKAKPSNKPKPPSY
SKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPKQYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYD
QIIHDVCIQNLPVFFCLDRAGIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSG
LGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARFAKPLDTELIIPLAQKIGQVV
TLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEHATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS

Sequences:

>Translated_635_residues
MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLDLDQDKVVWDVGHQAYPHKLI
TGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSISSVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAG
HLPHTRMLVILNDNDMSISPNVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAV
FEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQSPFNLETGKAKPSNKPKPPSY
SKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPKQYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYD
QIIHDVCIQNLPVFFCLDRAGIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSG
LGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARFAKPLDTELIIPLAQKIGQVV
TLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEHATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS
>Mature_635_residues
MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLDLDQDKVVWDVGHQAYPHKLI
TGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSISSVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAG
HLPHTRMLVILNDNDMSISPNVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAV
FEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQSPFNLETGKAKPSNKPKPPSY
SKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPKQYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYD
QIIHDVCIQNLPVFFCLDRAGIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSG
LGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARFAKPLDTELIIPLAQKIGQVV
TLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEHATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=424, Percent_Identity=25.2358490566038, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=424, Percent_Identity=25.2358490566038, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637459, Length=383, Percent_Identity=26.8929503916449, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637461, Length=383, Percent_Identity=26.8929503916449, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI133778974, Length=381, Percent_Identity=25.4593175853018, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637463, Length=383, Percent_Identity=26.8929503916449, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI156564403, Length=280, Percent_Identity=23.2142857142857, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786622, Length=615, Percent_Identity=46.5040650406504, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17539652, Length=414, Percent_Identity=29.4685990338164, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17538422, Length=250, Percent_Identity=25.6, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=269, Percent_Identity=24.5353159851301, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551847, Length=652, Percent_Identity=25, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45550715, Length=652, Percent_Identity=25, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24645119, Length=608, Percent_Identity=25.4934210526316, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666278, Length=660, Percent_Identity=25, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI21358145, Length=298, Percent_Identity=26.8456375838926, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650940, Length=298, Percent_Identity=26.8456375838926, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ACAM1 (B0C8J3)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001519467.1
- ProteinModelPortal:   B0C8J3
- SMR:   B0C8J3
- GeneID:   5683982
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5186
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   AMAR329726:AM1_5186-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68791; Mature: 68791

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLD
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LDQDKVVWDVGHQAYPHKLITGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHH
SVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAGHLPHTRMLVILNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEECC
NVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAV
CHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQS
HHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCEECCC
PFNLETGKAKPSNKPKPPSYSKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCHHHHHHHCCH
QYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYDQIIHDVCIQNLPVFFCLDRA
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSG
CEECCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCC
LGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARF
CCCCHHHCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCHH
AKPLDTELIIPLAQKIGQVVTLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEH
CCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHC
ATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS
CCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLD
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LDQDKVVWDVGHQAYPHKLITGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHH
SVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAGHLPHTRMLVILNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEECC
NVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAV
CHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQS
HHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCEECCC
PFNLETGKAKPSNKPKPPSYSKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCHHHHHHHCCH
QYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYDQIIHDVCIQNLPVFFCLDRA
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSG
CEECCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCC
LGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARF
CCCCHHHCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCHH
AKPLDTELIIPLAQKIGQVVTLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEH
CCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHC
ATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS
CCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA