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The map label for this gene is mtnA

Identifier: 158338289

GI number: 158338289

Start: 5248402

End: 5249469

Strand: Reverse

Name: mtnA

Synonym: AM1_5185

Alternate gene names: 158338289

Gene position: 5249469-5248402 (Counterclockwise)

Preceding gene: 158338290

Following gene: 158338288

Centisome position: 80.71

GC content: 51.97

Gene sequence:

>1068_bases
ATGACTGCATCGGTTGCCAATCCCGTTTACCCTGTTGTTTGGCGTGGCGACCACGTTGAACTGATTGATCAGACTCGCTT
GCCGCAACAATTTAGCGTTGTAGAGATCCGCCGCTCAGAAGATATGGCGACGGCGATCAAAACCATGATTGTTCGGGGTG
CTCCAGCTATCGGAGTGGCTGCTGCCTATGGCATGTACTTAGGAAGTTGCGAAGTTACCACTGACAATCGGGATGGATTC
TTGAGTGAACTGGCTGGTGTCGGTGATACCCTCAAAGCCACCCGACCGACGGCAGTGAACTTGTTTTGGGCAGTAGATCG
GATGCTGAAAGTGGCTCGCCAAACCTTAGGCCCCATTTCCCAGATTCAAGACCAGCTGTTAACGACGGCTCAAGAGATTG
GGGCGGATGATGTCCGCACTTGCAAGGCGATTGGCGATCATGGCCTCAGTGTTTTACCTAAAGATCCGGAAAAGCTTTGT
CTTCTGACCCATTGTAATGCTGGAGCCTTAGCGACGGCAGGCTATGGTACTGCATTGGGGGTGGTTCGCTCCGCTTGGAC
CGCAGGTCGATTGGCCAGGGTCTATGCAGATGAGACTCGGCCTCGTTTGCAGGGGGCCAAGTTAACCACTTGGGAATGCG
TACAAGAAGAGATTCCTGTGACGCTGATCTCTGATGGCATGGCGGCCCATTGTATGCAGCAGAACCTGATCGATGTGGTG
GTGGTTGGCGCTGATCGCATTGCCGCGAATGGTGATGCGGCCAACAAAATTGGTACTTATAGCGTTGCCCTTTGTGCTAA
AGCCCACAATTTGCCTTTTTACGTCGCAGCGCCCCTCTCTACGATTGATTTTGATCTAGCGGATGGCGGGGGGATTCCGA
TTGAAGAGCGACATCCATCGGAAATTTATCAAATTGGGACAACGGATATTTGTCCAAAAGGGGTTGAGTTCTATAACCCT
GCCTTTGATGTGACTCCCGCTGAATTGATTACCGGCATTATTACGGAGCATGGTGTGTTTGCCCCAGGAGATATCCGAGA
GAAGCTCAGCCATCACCGCTCTGCTTAA

Upstream 100 bases:

>100_bases
GCTCAAGTGGCAGAAAGAGTGTTAGGGTTGCTGAAGCAGAAACCAGCACCTAGCTACGTTTCCTAATACTTGTCCACTGA
TTCCCAAAAATTGAACTCTG

Downstream 100 bases:

>100_bases
CTTTGCTCCGTCATCCCAGAGATGTGGTCAATGGGGATGCCTATTTGTTATCACAGGAATTGGTGCTGGTTTTGGGATGC
GATCGCAAAGTCGCATCTAA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTASVANPVYPVVWRGDHVELIDQTRLPQQFSVVEIRRSEDMATAIKTMIVRGAPAIGVAAAYGMYLGSCEVTTDNRDGF
LSELAGVGDTLKATRPTAVNLFWAVDRMLKVARQTLGPISQIQDQLLTTAQEIGADDVRTCKAIGDHGLSVLPKDPEKLC
LLTHCNAGALATAGYGTALGVVRSAWTAGRLARVYADETRPRLQGAKLTTWECVQEEIPVTLISDGMAAHCMQQNLIDVV
VVGADRIAANGDAANKIGTYSVALCAKAHNLPFYVAAPLSTIDFDLADGGGIPIEERHPSEIYQIGTTDICPKGVEFYNP
AFDVTPAELITGIITEHGVFAPGDIREKLSHHRSA

Sequences:

>Translated_355_residues
MTASVANPVYPVVWRGDHVELIDQTRLPQQFSVVEIRRSEDMATAIKTMIVRGAPAIGVAAAYGMYLGSCEVTTDNRDGF
LSELAGVGDTLKATRPTAVNLFWAVDRMLKVARQTLGPISQIQDQLLTTAQEIGADDVRTCKAIGDHGLSVLPKDPEKLC
LLTHCNAGALATAGYGTALGVVRSAWTAGRLARVYADETRPRLQGAKLTTWECVQEEIPVTLISDGMAAHCMQQNLIDVV
VVGADRIAANGDAANKIGTYSVALCAKAHNLPFYVAAPLSTIDFDLADGGGIPIEERHPSEIYQIGTTDICPKGVEFYNP
AFDVTPAELITGIITEHGVFAPGDIREKLSHHRSA
>Mature_354_residues
TASVANPVYPVVWRGDHVELIDQTRLPQQFSVVEIRRSEDMATAIKTMIVRGAPAIGVAAAYGMYLGSCEVTTDNRDGFL
SELAGVGDTLKATRPTAVNLFWAVDRMLKVARQTLGPISQIQDQLLTTAQEIGADDVRTCKAIGDHGLSVLPKDPEKLCL
LTHCNAGALATAGYGTALGVVRSAWTAGRLARVYADETRPRLQGAKLTTWECVQEEIPVTLISDGMAAHCMQQNLIDVVV
VGADRIAANGDAANKIGTYSVALCAKAHNLPFYVAAPLSTIDFDLADGGGIPIEERHPSEIYQIGTTDICPKGVEFYNPA
FDVTPAELITGIITEHGVFAPGDIREKLSHHRSA

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:
GO:0008652: Methylthioribose-1-phosphate isomerase
GO:0009086: Methylthioribose-1-phosphate isomerase
GO:0016853: Methylthioribose-1-phosphate isomerase
GO:0044237: Methylthioribose-1-phosphate isomerase
GO:0044249: Methylthioribose-1-phosphate isomerase
GO:0046523: Methylthioribose-1-phosphate isomerase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=345, Percent_Identity=42.6086956521739, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI23943880, Length=339, Percent_Identity=37.4631268436578, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI4503503, Length=222, Percent_Identity=28.8288288288288, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17557462, Length=346, Percent_Identity=36.7052023121387, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17557123, Length=193, Percent_Identity=29.5336787564767, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=381, Percent_Identity=34.9081364829396, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322878, Length=266, Percent_Identity=27.0676691729323, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357667, Length=347, Percent_Identity=42.0749279538905, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24651647, Length=347, Percent_Identity=42.0749279538905, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_ACAM1 (B0C8J2)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001519466.1
- ProteinModelPortal:   B0C8J2
- SMR:   B0C8J2
- GeneID:   5683981
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5185
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- BioCyc:   AMAR329726:AM1_5185-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38037; Mature: 37906

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: ACT_SITE 245-245 BINDING 95-95 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASVANPVYPVVWRGDHVELIDQTRLPQQFSVVEIRRSEDMATAIKTMIVRGAPAIGVA
CCCCCCCCCEEEEECCCCEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHH
AAYGMYLGSCEVTTDNRDGFLSELAGVGDTLKATRPTAVNLFWAVDRMLKVARQTLGPIS
HHHHHHCCCEEEEECCCCHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
QIQDQLLTTAQEIGADDVRTCKAIGDHGLSVLPKDPEKLCLLTHCNAGALATAGYGTALG
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEECCCHHHHH
VVRSAWTAGRLARVYADETRPRLQGAKLTTWECVQEEIPVTLISDGMAAHCMQQNLIDVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHCCEEEE
VVGADRIAANGDAANKIGTYSVALCAKAHNLPFYVAAPLSTIDFDLADGGGIPIEERHPS
EECCCCEECCCCCCCCCCCCCEEEEHHHCCCCEEEECCCCEEEEEECCCCCCCCCCCCCH
EIYQIGTTDICPKGVEFYNPAFDVTPAELITGIITEHGVFAPGDIREKLSHHRSA
HHEECCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TASVANPVYPVVWRGDHVELIDQTRLPQQFSVVEIRRSEDMATAIKTMIVRGAPAIGVA
CCCCCCCCEEEEECCCCEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHH
AAYGMYLGSCEVTTDNRDGFLSELAGVGDTLKATRPTAVNLFWAVDRMLKVARQTLGPIS
HHHHHHCCCEEEEECCCCHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
QIQDQLLTTAQEIGADDVRTCKAIGDHGLSVLPKDPEKLCLLTHCNAGALATAGYGTALG
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEECCCHHHHH
VVRSAWTAGRLARVYADETRPRLQGAKLTTWECVQEEIPVTLISDGMAAHCMQQNLIDVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHCCEEEE
VVGADRIAANGDAANKIGTYSVALCAKAHNLPFYVAAPLSTIDFDLADGGGIPIEERHPS
EECCCCEECCCCCCCCCCCCCEEEEHHHCCCCEEEECCCCEEEEEECCCCCCCCCCCCCH
EIYQIGTTDICPKGVEFYNPAFDVTPAELITGIITEHGVFAPGDIREKLSHHRSA
HHEECCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA