Click here to switch to the map view.

The map label for this gene is hhoB [H]

Identifier: 158338252

GI number: 158338252

Start: 5210785

End: 5211975

Strand: Reverse

Name: hhoB [H]

Synonym: AM1_5148

Alternate gene names: 158338252

Gene position: 5211975-5210785 (Counterclockwise)

Preceding gene: 158338257

Following gene: 158338249

Centisome position: 80.14

GC content: 49.54

Gene sequence:

>1191_bases
ATGTCAGCGAAATTTTCAGTCCAAAGGTCCGCGACCTATCTATCTTTATTGTTAGTCGGTTCCTTAGGTACACTCCTGGG
AACACAGGTTATTCCGAGTAACAGTCTTTTACCTCAACCGAGTGTCGCTCAATTGCCGAAGCCGCTCCCGGGGCAAACGG
ATACCAATTTTATCGCCCGTGCGGTGGAAAAGGTAGGACCAGCCGTGGTCCGGATTGACTCTGCTCGCACCGTGAGCCGT
CGTCGATCCAGGCTGTTTGACGATCCCTTCTTCCGGGAGTTTTTTGGCCGAGATATTCCTAGACAACAACCTCGCACACG
GGTTCAACGGGGAACAGGGTCTGGATTTATCATCAGTGATGATGGCTTAGTCCTCACCAATGCCCACGTGGTGAATGGGG
CGGATAAAGTTACAGTCGTTCTCAAAGATGGCCGTAGCTATGAAGGCACCGTGATGGGAGAAGATTCCTTGACGGATGTT
GCAGTCATTAAAATTAAAGCCAAAGATCTGCCCACGGTAAAAATGGGCAAGTCAGATGAGCTACAGCCGGGTGAATGGGC
GATCGCTATTGGTAACCCCCTCGGCTTGGATAACACCGTGACCGCAGGCATTATCAGTGCGACAGGGCGTACCAGCAATG
ACGTGGGCGTTCCAGATAAGCGGGTTGGATTTATTCAAACGGACGCGGCCATTAATCCCGGTAATTCCGGGGGACCCTTG
CTTAACCAGGCTGGTGAAGTCATTGGTATGAACACCGCCATTATTGGGGGAGCTCAAGGCCTGGGATTTGCCATTCCCAT
CAAAACAGCCCAGCGGATTGCTGATCAACTGATTGCCAAAGGTAAAGTGGATCATCCCTTCCTGGGTATTCGGATGGCTG
GTTTGACCCCTGAACTAAAAGAGCGCATCAACAGCAGCCCAGATGTGGATTTTCAAGTCAAAGACGAGAAAGGTGTCTTA
ATCTTTGAAGTGATTCCTAAGTCTCCTGCAGCAGCAGCAGGCTTGCGTCCTGGAGACATTATTCGTGAAATTGATGGCCA
ATCCATTAGTAAGGCTAGCCAAGTTCAGCAGAAGGTTGATGCCACATCCTTAGGAAACTCTCTAAAATTAGGAATTACAC
GTAATGGGAAGGAGCAAACCATTGCCGTTAAACCTGGACCTCTACCTGCTCAATTAAGTAAGAATAACTAA

Upstream 100 bases:

>100_bases
GAGCACTCTCTCCCTTAAAGGCTAAGTTTTTATTCCCCACATGATCCATTCTGTTCCTTTAAGTCACTGCTATCCCATAG
TCCTTTAGTTATCGTTCGAT

Downstream 100 bases:

>100_bases
GAGTATTTAGGGCAAGGGGCCGATTTAGGAGGCAGTCCAGTTTAGCCAGGGGGGGATCAGGGCAACCGCACATAGTTCTT
CATGAAGAAGGTATTCCCTT

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSAKFSVQRSATYLSLLLVGSLGTLLGTQVIPSNSLLPQPSVAQLPKPLPGQTDTNFIARAVEKVGPAVVRIDSARTVSR
RRSRLFDDPFFREFFGRDIPRQQPRTRVQRGTGSGFIISDDGLVLTNAHVVNGADKVTVVLKDGRSYEGTVMGEDSLTDV
AVIKIKAKDLPTVKMGKSDELQPGEWAIAIGNPLGLDNTVTAGIISATGRTSNDVGVPDKRVGFIQTDAAINPGNSGGPL
LNQAGEVIGMNTAIIGGAQGLGFAIPIKTAQRIADQLIAKGKVDHPFLGIRMAGLTPELKERINSSPDVDFQVKDEKGVL
IFEVIPKSPAAAAGLRPGDIIREIDGQSISKASQVQQKVDATSLGNSLKLGITRNGKEQTIAVKPGPLPAQLSKNN

Sequences:

>Translated_396_residues
MSAKFSVQRSATYLSLLLVGSLGTLLGTQVIPSNSLLPQPSVAQLPKPLPGQTDTNFIARAVEKVGPAVVRIDSARTVSR
RRSRLFDDPFFREFFGRDIPRQQPRTRVQRGTGSGFIISDDGLVLTNAHVVNGADKVTVVLKDGRSYEGTVMGEDSLTDV
AVIKIKAKDLPTVKMGKSDELQPGEWAIAIGNPLGLDNTVTAGIISATGRTSNDVGVPDKRVGFIQTDAAINPGNSGGPL
LNQAGEVIGMNTAIIGGAQGLGFAIPIKTAQRIADQLIAKGKVDHPFLGIRMAGLTPELKERINSSPDVDFQVKDEKGVL
IFEVIPKSPAAAAGLRPGDIIREIDGQSISKASQVQQKVDATSLGNSLKLGITRNGKEQTIAVKPGPLPAQLSKNN
>Mature_395_residues
SAKFSVQRSATYLSLLLVGSLGTLLGTQVIPSNSLLPQPSVAQLPKPLPGQTDTNFIARAVEKVGPAVVRIDSARTVSRR
RSRLFDDPFFREFFGRDIPRQQPRTRVQRGTGSGFIISDDGLVLTNAHVVNGADKVTVVLKDGRSYEGTVMGEDSLTDVA
VIKIKAKDLPTVKMGKSDELQPGEWAIAIGNPLGLDNTVTAGIISATGRTSNDVGVPDKRVGFIQTDAAINPGNSGGPLL
NQAGEVIGMNTAIIGGAQGLGFAIPIKTAQRIADQLIAKGKVDHPFLGIRMAGLTPELKERINSSPDVDFQVKDEKGVLI
FEVIPKSPAAAAGLRPGDIIREIDGQSISKASQVQQKVDATSLGNSLKLGITRNGKEQTIAVKPGPLPAQLSKNN

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=340, Percent_Identity=41.1764705882353, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI22129776, Length=340, Percent_Identity=38.5294117647059, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI7019477, Length=344, Percent_Identity=38.953488372093, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI24308541, Length=346, Percent_Identity=35.2601156069364, Blast_Score=185, Evalue=8e-47,
Organism=Escherichia coli, GI1789629, Length=351, Percent_Identity=39.031339031339, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786356, Length=352, Percent_Identity=36.9318181818182, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=37.5, Blast_Score=172, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646839, Length=380, Percent_Identity=35.5263157894737, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41874; Mature: 41742

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKFSVQRSATYLSLLLVGSLGTLLGTQVIPSNSLLPQPSVAQLPKPLPGQTDTNFIAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHCCCCCCCCCCHHHHHH
AVEKVGPAVVRIDSARTVSRRRSRLFDDPFFREFFGRDIPRQQPRTRVQRGTGSGFIISD
HHHHCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCCCEEEECC
DGLVLTNAHVVNGADKVTVVLKDGRSYEGTVMGEDSLTDVAVIKIKAKDLPTVKMGKSDE
CCEEEEEEEEECCCCEEEEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCEEECCCCCC
LQPGEWAIAIGNPLGLDNTVTAGIISATGRTSNDVGVPDKRVGFIQTDAAINPGNSGGPL
CCCCCEEEEECCCCCCCCCHHEEEEEECCCCCCCCCCCCCCEEEEEECCEECCCCCCCCH
LNQAGEVIGMNTAIIGGAQGLGFAIPIKTAQRIADQLIAKGKVDHPFLGIRMAGLTPELK
HHHCCCEEECCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
ERINSSPDVDFQVKDEKGVLIFEVIPKSPAAAAGLRPGDIIREIDGQSISKASQVQQKVD
HHCCCCCCCCEEEECCCCEEEEEECCCCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATSLGNSLKLGITRNGKEQTIAVKPGPLPAQLSKNN
HHHCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SAKFSVQRSATYLSLLLVGSLGTLLGTQVIPSNSLLPQPSVAQLPKPLPGQTDTNFIAR
CCCCCHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHCCCCCCCCCCHHHHHH
AVEKVGPAVVRIDSARTVSRRRSRLFDDPFFREFFGRDIPRQQPRTRVQRGTGSGFIISD
HHHHCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCCCEEEECC
DGLVLTNAHVVNGADKVTVVLKDGRSYEGTVMGEDSLTDVAVIKIKAKDLPTVKMGKSDE
CCEEEEEEEEECCCCEEEEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCEEECCCCCC
LQPGEWAIAIGNPLGLDNTVTAGIISATGRTSNDVGVPDKRVGFIQTDAAINPGNSGGPL
CCCCCEEEEECCCCCCCCCHHEEEEEECCCCCCCCCCCCCCEEEEEECCEECCCCCCCCH
LNQAGEVIGMNTAIIGGAQGLGFAIPIKTAQRIADQLIAKGKVDHPFLGIRMAGLTPELK
HHHCCCEEECCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
ERINSSPDVDFQVKDEKGVLIFEVIPKSPAAAAGLRPGDIIREIDGQSISKASQVQQKVD
HHCCCCCCCCEEEECCCCEEEEEECCCCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATSLGNSLKLGITRNGKEQTIAVKPGPLPAQLSKNN
HHHCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]