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The map label for this gene is psaA [H]

Identifier: 158338066

GI number: 158338066

Start: 4990847

End: 4991824

Strand: Direct

Name: psaA [H]

Synonym: AM1_4953

Alternate gene names: 158338066

Gene position: 4990847-4991824 (Clockwise)

Preceding gene: 158338062

Following gene: 158338070

Centisome position: 76.74

GC content: 48.77

Gene sequence:

>978_bases
ATGACAACTTCCTTCCTAAAGCGCCAATTTGATTCCTGGGCATGGGCGATCGGCGGATTATTTCTGGGGTTGAGTTTGGT
CGGATGTACCGGAGGTCAAGACACTGAACCATCAGGGAAGCCCAAGGTTGTCGCGACCAACACGATTTTGCAAGATTGGA
CGGCAGAAGTCGCCGGGGATGAAGTTGAACTGGTGGGTATCCTGCAGCCCGGGGCAGACCCCCACGTTTATGAACCCGTC
CCGGCAGATAATTTAAGAATTGAACAAGCGGATCTGATTTTCTACAACGGCTACAACTTAGAACCAGGCTTGATTAAGCT
AATTGAATCGACCCAGAAATCTAAAGTGTTTGCTGTGGGGGAAGTGGTGACGCCCCTGGATTTCGATTATGAGGGTAAGC
GAGAGCCCGATCCTCATGTTTGGGGCGATGCCAAAAATGCCATCAAAATGGTGAACGCTATTCGCGACCAGCTAATTGAG
CTATCCCCGGAGGATAAAGAAGAATTTACTCAAAATGCAGCTGAATTTACGAAAGAACTGGCAGCGGTGGATCAATGGAT
TGGCCAACAGATGCAAACTATTCCCAGCCAACAACGACAGTTAGTCACGACCCATGATGCCTTTCAATACTATGCCAAAG
CCTATGGCCTCACGGTTGCAGGCACCCTGATTGGCATGAGTACGGAAGAGCAACCCAGCGCTCAAACCGTCAAACGGCTT
TCGGATGATATTGAAAAAGCCAAGGTACCGGCTATTTTTGCGGAAACTACCATTAACCCAGCTTTGATCAAAACCGTAGC
GGCGGAAGCCAAGGTAAAGCTAGCGGAGCAAGAGCTGTACTCAGATTCCATTGGTGCCTCGGGAACTGAAGCCGATACTT
ATATCAAGATGCTTCAGGTGAATACTCGCACGATTGTGGAAGCGTTAGGGGGCAACTACACCGAATTTCAGGCAGCATTA
TCTGAGGAAAAGAAATAA

Upstream 100 bases:

>100_bases
ACACCTGAGAAATGAAAGGAATGCAATTAAAGATGAAACGATTATGAAAATACTGTAGCATCAAAAAGTGAAAGCATTAT
GAAAAATTGATGGAAACGCC

Downstream 100 bases:

>100_bases
TGCCTCACCCAATTGATGCAGGCCAGCATACCCTACCAAGGCAACAGACTACCATCCCAGGAAAAGAACTGGCCACTGTC
TTCTTTTCCCAGCCCGTCCA

Product: ABC transporter periplasmic solute-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTTSFLKRQFDSWAWAIGGLFLGLSLVGCTGGQDTEPSGKPKVVATNTILQDWTAEVAGDEVELVGILQPGADPHVYEPV
PADNLRIEQADLIFYNGYNLEPGLIKLIESTQKSKVFAVGEVVTPLDFDYEGKREPDPHVWGDAKNAIKMVNAIRDQLIE
LSPEDKEEFTQNAAEFTKELAAVDQWIGQQMQTIPSQQRQLVTTHDAFQYYAKAYGLTVAGTLIGMSTEEQPSAQTVKRL
SDDIEKAKVPAIFAETTINPALIKTVAAEAKVKLAEQELYSDSIGASGTEADTYIKMLQVNTRTIVEALGGNYTEFQAAL
SEEKK

Sequences:

>Translated_325_residues
MTTSFLKRQFDSWAWAIGGLFLGLSLVGCTGGQDTEPSGKPKVVATNTILQDWTAEVAGDEVELVGILQPGADPHVYEPV
PADNLRIEQADLIFYNGYNLEPGLIKLIESTQKSKVFAVGEVVTPLDFDYEGKREPDPHVWGDAKNAIKMVNAIRDQLIE
LSPEDKEEFTQNAAEFTKELAAVDQWIGQQMQTIPSQQRQLVTTHDAFQYYAKAYGLTVAGTLIGMSTEEQPSAQTVKRL
SDDIEKAKVPAIFAETTINPALIKTVAAEAKVKLAEQELYSDSIGASGTEADTYIKMLQVNTRTIVEALGGNYTEFQAAL
SEEKK
>Mature_324_residues
TTSFLKRQFDSWAWAIGGLFLGLSLVGCTGGQDTEPSGKPKVVATNTILQDWTAEVAGDEVELVGILQPGADPHVYEPVP
ADNLRIEQADLIFYNGYNLEPGLIKLIESTQKSKVFAVGEVVTPLDFDYEGKREPDPHVWGDAKNAIKMVNAIRDQLIEL
SPEDKEEFTQNAAEFTKELAAVDQWIGQQMQTIPSQQRQLVTTHDAFQYYAKAYGLTVAGTLIGMSTEEQPSAQTVKRLS
DDIEKAKVPAIFAETTINPALIKTVAAEAKVKLAEQELYSDSIGASGTEADTYIKMLQVNTRTIVEALGGNYTEFQAALS
EEKK

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=267, Percent_Identity=24.3445692883895, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 35637; Mature: 35506

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSFLKRQFDSWAWAIGGLFLGLSLVGCTGGQDTEPSGKPKVVATNTILQDWTAEVAGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCC
EVELVGILQPGADPHVYEPVPADNLRIEQADLIFYNGYNLEPGLIKLIESTQKSKVFAVG
CEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEC
EVVTPLDFDYEGKREPDPHVWGDAKNAIKMVNAIRDQLIELSPEDKEEFTQNAAEFTKEL
CEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AAVDQWIGQQMQTIPSQQRQLVTTHDAFQYYAKAYGLTVAGTLIGMSTEEQPSAQTVKRL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHEECCCCCCCHHHHHHHH
SDDIEKAKVPAIFAETTINPALIKTVAAEAKVKLAEQELYSDSIGASGTEADTYIKMLQV
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
NTRTIVEALGGNYTEFQAALSEEKK
CHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTSFLKRQFDSWAWAIGGLFLGLSLVGCTGGQDTEPSGKPKVVATNTILQDWTAEVAGD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCC
EVELVGILQPGADPHVYEPVPADNLRIEQADLIFYNGYNLEPGLIKLIESTQKSKVFAVG
CEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEC
EVVTPLDFDYEGKREPDPHVWGDAKNAIKMVNAIRDQLIELSPEDKEEFTQNAAEFTKEL
CEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AAVDQWIGQQMQTIPSQQRQLVTTHDAFQYYAKAYGLTVAGTLIGMSTEEQPSAQTVKRL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHEECCCCCCCHHHHHHHH
SDDIEKAKVPAIFAETTINPALIKTVAAEAKVKLAEQELYSDSIGASGTEADTYIKMLQV
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
NTRTIVEALGGNYTEFQAALSEEKK
CHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]