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The map label for this gene is rpfC [H]

Identifier: 158337935

GI number: 158337935

Start: 4856075

End: 4858129

Strand: Direct

Name: rpfC [H]

Synonym: AM1_4822

Alternate gene names: 158337935

Gene position: 4856075-4858129 (Clockwise)

Preceding gene: 158337932

Following gene: 158337936

Centisome position: 74.67

GC content: 46.81

Gene sequence:

>2055_bases
GTGCGTGCTGATGGCATTATGGTGGCCATGAACGGCTTTTTATGCCTTGTTTGTTTTGCCCTTGCTCCCCTACGCAATAC
AGGAGCTGCAGCATTAGCGATTGGAGTTCCGACATTGCTCATCTCCCTTTGGCTAAAACATCGCCATTCGGGTGAGTTAG
GGACGCGACTCTATATGGCCTGTGGCTTTATGATCTACACGGCTTTAATTATTCATCAGAACGGAGGTGTGACCGAAGCC
CATTTTTCTGCCTTTGGACTGATTGGGGTTCTCCTCTATTATCGAGACTGGCGCACCATTCTTACTGCTACCGTATTTAT
CTACTTACATCATTTCGTCTTGGGTTATGGCCAAACATTAGGTTGGCCCATTTATGTGTTTGCTGACTCCCATTTTTGGC
GGATGTTTGTCAGTCATGTGCTCTATTTCCTTCCCTTTGTGGGGATGATGTCTTATCTCTCTATTTGGCTGCGACGAGAA
GGCTATGAAAACCAACAGGATCTAATTGCCCTTAGACAGGCAGAACAGGAATTAACTCAATTTAATGAAGTCCTAGAAAA
GCGGGTTGAAGAACGGACGTTTGAATTGCAAGCCGCAAAACTGGAAGCGGATCGTGCCAACCAGGCTAAAAGCGAATTTC
TAGCCAACATGAGCCATGAACTTCGTACGCCTCTCAACGGCATCCTCGGTTACGCCCAAATTCTTAGCCGTTCCAAAACA
CTATCCGCTGAAGATAAAAATGGGGTAGGTGTCATATTAGATAGCGGTTCCCACCTATTGTCACTGATCAACGATGTCCT
TGACTTAGCCAAAATCGAAGCCGGTAAACTGGAGCTTTTCCCGACCACCACCTCTTTGCCCAGCCTCTTACAAAGGGTCG
TGGATATCTGCCAAATCAAGGCTACGCAGAAGGGACTTCAGTTTTTGTATAAACCTAGCCAGCTACCTGAAGGAATATTG
GCTGACGAGAAATTGCTTTCTCAGGTACTGATCAATCTCATCGGCAACGCGATTAAGTTTACCGATGCGGGGACAGTGAC
CTTCCAGATTGAAGTTCACAAGGGGAGTGATGGCCAGGTTTCTCTCATGTTCAAGGTAATCGATACAGGCAGGGGCATTG
CTGAAGAAGATATAGACAAACTATTTGAGGCATTTGAACAAGTTGGAGATCATCACAAACAGTCTGAAGGAACTGGATTA
GGTCTCGCCATTAGCCAACGCATTGTGCAATTGATGGGGGGGACGATTCATATCAACAGCAAGCCGGGGGATGGTAGTGA
ATTCTGGTTCATACTAGACTTCCCACTGGTCGAAAGTGGGGAAAAGCGACAGCCCTTCCGATTTAGTCAGCGGATCATCG
GCTACCAAACTCCCCACAACCGACAGGGCGAGATTCCCCTTACCCTTCTGGTTGTAGATGACCGTTGGGAGAATCGAGCT
GTTTTGCTCAATCTGCTTGAGCCCCTTGGATTTACTGTAATCGAAGCAGAAGACGGTCAAGTTGGGTTAGAGCAAATCCG
CCGACACCGCCCTGATTTAATCATCACCGATCTCGCCATGCCCATCATGGATGGTTTTGAGTTTCTGCAGCATATTCGTG
AAGACGAGGACTTTAAAGCAACGAAAGTGATTGTCTCTTCCGCTTCAGTATCCCGGTCAGATCAGCAGATGGCCTTGGAT
CAAGGTGGAGATGCCTTTTTAGCCAAACCGATTGAGGCCAGCTTACTCTTTCAAATGATCACTGAACAATTAAACATCAG
CTGGCTCTATGAGGAGGGGGAACGACCTCTTGCATCTGAGACGGTCCCAACTGAGATCATCCTACCCTCGACTCAAGTCC
TCGAAGAGCTATTCGCTTTATCCCAATACGGTGACGTATTTCGTCTAAAGGAAAAACTGAATGGGTTAGTGGAATCAGAT
CCGATTTATACTCCTTTCGCTCAACCCATTTTGGAATTGACCCAGTTATTTATGGTCGAAGAAATTGCAGAGATGCTAAG
CACTCAGTTAGAAGAGAAACTGGCTCTATCGGGTGCGAGTAACCCAACAGATTAA

Upstream 100 bases:

>100_bases
CAACGAGTCCTTACCGAAACGCTGGAAATTCAGAGCCCAAGTCATTCCTGCGCTCTTTGCATCCGAAGCAGACTGTGACC
TTCTTTTGCAGTCGTATCGT

Downstream 100 bases:

>100_bases
AAAAACAGGCGTTCTTCACTACACGTTCCTAGCCCTTTAGTAATGAAGCTGGCAAATCATGACGCGTGTAAGGATCAATC
TCATATTTTTTGGCTAAGAT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MRADGIMVAMNGFLCLVCFALAPLRNTGAAALAIGVPTLLISLWLKHRHSGELGTRLYMACGFMIYTALIIHQNGGVTEA
HFSAFGLIGVLLYYRDWRTILTATVFIYLHHFVLGYGQTLGWPIYVFADSHFWRMFVSHVLYFLPFVGMMSYLSIWLRRE
GYENQQDLIALRQAEQELTQFNEVLEKRVEERTFELQAAKLEADRANQAKSEFLANMSHELRTPLNGILGYAQILSRSKT
LSAEDKNGVGVILDSGSHLLSLINDVLDLAKIEAGKLELFPTTTSLPSLLQRVVDICQIKATQKGLQFLYKPSQLPEGIL
ADEKLLSQVLINLIGNAIKFTDAGTVTFQIEVHKGSDGQVSLMFKVIDTGRGIAEEDIDKLFEAFEQVGDHHKQSEGTGL
GLAISQRIVQLMGGTIHINSKPGDGSEFWFILDFPLVESGEKRQPFRFSQRIIGYQTPHNRQGEIPLTLLVVDDRWENRA
VLLNLLEPLGFTVIEAEDGQVGLEQIRRHRPDLIITDLAMPIMDGFEFLQHIREDEDFKATKVIVSSASVSRSDQQMALD
QGGDAFLAKPIEASLLFQMITEQLNISWLYEEGERPLASETVPTEIILPSTQVLEELFALSQYGDVFRLKEKLNGLVESD
PIYTPFAQPILELTQLFMVEEIAEMLSTQLEEKLALSGASNPTD

Sequences:

>Translated_684_residues
MRADGIMVAMNGFLCLVCFALAPLRNTGAAALAIGVPTLLISLWLKHRHSGELGTRLYMACGFMIYTALIIHQNGGVTEA
HFSAFGLIGVLLYYRDWRTILTATVFIYLHHFVLGYGQTLGWPIYVFADSHFWRMFVSHVLYFLPFVGMMSYLSIWLRRE
GYENQQDLIALRQAEQELTQFNEVLEKRVEERTFELQAAKLEADRANQAKSEFLANMSHELRTPLNGILGYAQILSRSKT
LSAEDKNGVGVILDSGSHLLSLINDVLDLAKIEAGKLELFPTTTSLPSLLQRVVDICQIKATQKGLQFLYKPSQLPEGIL
ADEKLLSQVLINLIGNAIKFTDAGTVTFQIEVHKGSDGQVSLMFKVIDTGRGIAEEDIDKLFEAFEQVGDHHKQSEGTGL
GLAISQRIVQLMGGTIHINSKPGDGSEFWFILDFPLVESGEKRQPFRFSQRIIGYQTPHNRQGEIPLTLLVVDDRWENRA
VLLNLLEPLGFTVIEAEDGQVGLEQIRRHRPDLIITDLAMPIMDGFEFLQHIREDEDFKATKVIVSSASVSRSDQQMALD
QGGDAFLAKPIEASLLFQMITEQLNISWLYEEGERPLASETVPTEIILPSTQVLEELFALSQYGDVFRLKEKLNGLVESD
PIYTPFAQPILELTQLFMVEEIAEMLSTQLEEKLALSGASNPTD
>Mature_684_residues
MRADGIMVAMNGFLCLVCFALAPLRNTGAAALAIGVPTLLISLWLKHRHSGELGTRLYMACGFMIYTALIIHQNGGVTEA
HFSAFGLIGVLLYYRDWRTILTATVFIYLHHFVLGYGQTLGWPIYVFADSHFWRMFVSHVLYFLPFVGMMSYLSIWLRRE
GYENQQDLIALRQAEQELTQFNEVLEKRVEERTFELQAAKLEADRANQAKSEFLANMSHELRTPLNGILGYAQILSRSKT
LSAEDKNGVGVILDSGSHLLSLINDVLDLAKIEAGKLELFPTTTSLPSLLQRVVDICQIKATQKGLQFLYKPSQLPEGIL
ADEKLLSQVLINLIGNAIKFTDAGTVTFQIEVHKGSDGQVSLMFKVIDTGRGIAEEDIDKLFEAFEQVGDHHKQSEGTGL
GLAISQRIVQLMGGTIHINSKPGDGSEFWFILDFPLVESGEKRQPFRFSQRIIGYQTPHNRQGEIPLTLLVVDDRWENRA
VLLNLLEPLGFTVIEAEDGQVGLEQIRRHRPDLIITDLAMPIMDGFEFLQHIREDEDFKATKVIVSSASVSRSDQQMALD
QGGDAFLAKPIEASLLFQMITEQLNISWLYEEGERPLASETVPTEIILPSTQVLEELFALSQYGDVFRLKEKLNGLVESD
PIYTPFAQPILELTQLFMVEEIAEMLSTQLEEKLALSGASNPTD

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=264, Percent_Identity=40.9090909090909, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994928, Length=385, Percent_Identity=33.2467532467532, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1788713, Length=385, Percent_Identity=31.4285714285714, Blast_Score=182, Evalue=9e-47,
Organism=Escherichia coli, GI87081816, Length=377, Percent_Identity=30.7692307692308, Blast_Score=152, Evalue=8e-38,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=38.5593220338983, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=31.4893617021277, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=30.4526748971193, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=30.2325581395349, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=30.5785123966942, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=27.6995305164319, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=206, Percent_Identity=29.6116504854369, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=331, Percent_Identity=27.7945619335347, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=243, Percent_Identity=26.7489711934156, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=266, Percent_Identity=25.9398496240602, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786911, Length=103, Percent_Identity=42.7184466019417, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=29.1479820627803, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76641; Mature: 76641

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADGIMVAMNGFLCLVCFALAPLRNTGAAALAIGVPTLLISLWLKHRHSGELGTRLYMA
CCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
CGFMIYTALIIHQNGGVTEAHFSAFGLIGVLLYYRDWRTILTATVFIYLHHFVLGYGQTL
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GWPIYVFADSHFWRMFVSHVLYFLPFVGMMSYLSIWLRREGYENQQDLIALRQAEQELTQ
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FNEVLEKRVEERTFELQAAKLEADRANQAKSEFLANMSHELRTPLNGILGYAQILSRSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LSAEDKNGVGVILDSGSHLLSLINDVLDLAKIEAGKLELFPTTTSLPSLLQRVVDICQIK
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ATQKGLQFLYKPSQLPEGILADEKLLSQVLINLIGNAIKFTDAGTVTFQIEVHKGSDGQV
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCCE
SLMFKVIDTGRGIAEEDIDKLFEAFEQVGDHHKQSEGTGLGLAISQRIVQLMGGTIHINS
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEC
KPGDGSEFWFILDFPLVESGEKRQPFRFSQRIIGYQTPHNRQGEIPLTLLVVDDRWENRA
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHH
VLLNLLEPLGFTVIEAEDGQVGLEQIRRHRPDLIITDLAMPIMDGFEFLQHIREDEDFKA
HHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHH
TKVIVSSASVSRSDQQMALDQGGDAFLAKPIEASLLFQMITEQLNISWLYEEGERPLASE
HHHHHCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCC
TVPTEIILPSTQVLEELFALSQYGDVFRLKEKLNGLVESDPIYTPFAQPILELTQLFMVE
CCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
EIAEMLSTQLEEKLALSGASNPTD
HHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRADGIMVAMNGFLCLVCFALAPLRNTGAAALAIGVPTLLISLWLKHRHSGELGTRLYMA
CCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
CGFMIYTALIIHQNGGVTEAHFSAFGLIGVLLYYRDWRTILTATVFIYLHHFVLGYGQTL
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GWPIYVFADSHFWRMFVSHVLYFLPFVGMMSYLSIWLRREGYENQQDLIALRQAEQELTQ
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FNEVLEKRVEERTFELQAAKLEADRANQAKSEFLANMSHELRTPLNGILGYAQILSRSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LSAEDKNGVGVILDSGSHLLSLINDVLDLAKIEAGKLELFPTTTSLPSLLQRVVDICQIK
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ATQKGLQFLYKPSQLPEGILADEKLLSQVLINLIGNAIKFTDAGTVTFQIEVHKGSDGQV
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCCE
SLMFKVIDTGRGIAEEDIDKLFEAFEQVGDHHKQSEGTGLGLAISQRIVQLMGGTIHINS
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEC
KPGDGSEFWFILDFPLVESGEKRQPFRFSQRIIGYQTPHNRQGEIPLTLLVVDDRWENRA
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHH
VLLNLLEPLGFTVIEAEDGQVGLEQIRRHRPDLIITDLAMPIMDGFEFLQHIREDEDFKA
HHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHH
TKVIVSSASVSRSDQQMALDQGGDAFLAKPIEASLLFQMITEQLNISWLYEEGERPLASE
HHHHHCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCC
TVPTEIILPSTQVLEELFALSQYGDVFRLKEKLNGLVESDPIYTPFAQPILELTQLFMVE
CCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
EIAEMLSTQLEEKLALSGASNPTD
HHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]