Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 158337734

GI number: 158337734

Start: 4651219

End: 4652085

Strand: Reverse

Name: nadC [H]

Synonym: AM1_4618

Alternate gene names: 158337734

Gene position: 4652085-4651219 (Counterclockwise)

Preceding gene: 158337735

Following gene: 158337733

Centisome position: 71.53

GC content: 52.36

Gene sequence:

>867_bases
GTGGCAACCTTACCTCCTTGGCTGATTCTGGACCCCCTTTTGCAGACCTGGCTAGCTGAAGATATTGGCCGAGGCGATCG
CACCACCCAAGCCCTCTGGCCTGAAGGATCAGAAGCCCATTGGGGGCAAGCTGAACTTCGCTTAAAGCAGTCGGGGGTAG
TTGCCGGTCTACCTTTGTTTCAGCGCGTATTTCATCTCCTAAGCTCCCAGGTAGCGATAAATCCTCTCGTTCCAGAGGGA
AAGAACAGCCCCTCTGGAACCGTCGTTGCTCAGCTCCAAGGGCCAATGGGAGCTTTACTGATGGGAGAGCGTGTTGCCCT
TAACCTGATCATGCCGTTAAGTGGCATCGCATCTCTCACTCGCACCTATGCCGAGAAAATTGCGGATCTGCCCACCCAGC
TTGTTGATACCCGCAAAACGACCCCAGGTTTACGCATCTTAGAAAAATATGCCACCCAGGTCGGAGGGGCCGTCAATCAT
CGTATGGGCTTGGATGATGCGGTGATGATAAAGGACAACCATATTTTTGCTGCTGGGGGTATCGGTGAGGCTATTCGTCG
CGTGCGTCAGCACATTCCGTTTCCCCTGGCCATTGAAGTGGAAACAGAGACCCTGGAGCAGGTTCAGCAGGCCGTAGACC
ATCAGGCCGATATCATTATGCTCGACAATATGGCGGTTGAGCAGATGCAATCTGCCGTCAAACTCATTCGATCTCAGTGT
GCCAACACGGTCAAAATTGAAGCGTCGGGGAATATCAATTTGCAAACCATTAGGGCTGTTGCTGAAACAGGCGTGGACTA
TATCTCTACGAGCGCCACGATTACCCAAGCGAGTTGGTTGGATCTAAGCCTTAAGTTTAGGGACTAA

Upstream 100 bases:

>100_bases
AAACCAGCCATTTTGGGATTGAAGCTACCGAAGTTTATTGGCACTTTGTGGATGTTATTTGGATTGTTTTATTCCTGATT
TTGTATCTTCTCTAGAATCT

Downstream 100 bases:

>100_bases
TTCCAGGCTTTTGCAGGGTTGAGTGACCCGTTAGGAAACAAAACTTAAAGATTGCGCTTCACCAACCCTAAATATCTAAC
ATGAGTAGTCTTAGAAAGGT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRLKQSGVVAGLPLFQRVFHLLSSQVAINPLVPEG
KNSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIASLTRTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNH
RMGLDDAVMIKDNHIFAAGGIGEAIRRVRQHIPFPLAIEVETETLEQVQQAVDHQADIIMLDNMAVEQMQSAVKLIRSQC
ANTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLKFRD

Sequences:

>Translated_288_residues
MATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRLKQSGVVAGLPLFQRVFHLLSSQVAINPLVPEG
KNSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIASLTRTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNH
RMGLDDAVMIKDNHIFAAGGIGEAIRRVRQHIPFPLAIEVETETLEQVQQAVDHQADIIMLDNMAVEQMQSAVKLIRSQC
ANTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLKFRD
>Mature_287_residues
ATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRLKQSGVVAGLPLFQRVFHLLSSQVAINPLVPEGK
NSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIASLTRTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNHR
MGLDDAVMIKDNHIFAAGGIGEAIRRVRQHIPFPLAIEVETETLEQVQQAVDHQADIIMLDNMAVEQMQSAVKLIRSQCA
NTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLKFRD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=288, Percent_Identity=38.1944444444444, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=40.9420289855072, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=286, Percent_Identity=35.6643356643357, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31369; Mature: 31237

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRLKQSGVVAGLPLF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEECCHHH
QRVFHLLSSQVAINPLVPEGKNSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIASLT
HHHHHHHHCCCEECCCCCCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHH
RTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNHRMGLDDAVMIKDNHIFAAGG
HHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCEEEEECC
IGEAIRRVRQHIPFPLAIEVETETLEQVQQAVDHQADIIMLDNMAVEQMQSAVKLIRSQC
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHC
ANTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLKFRD
CCEEEEEECCCCCHHHHHHHHHCCHHHHCCCCEEEEEEEEEEEEEECC
>Mature Secondary Structure 
ATLPPWLILDPLLQTWLAEDIGRGDRTTQALWPEGSEAHWGQAELRLKQSGVVAGLPLF
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEECCHHH
QRVFHLLSSQVAINPLVPEGKNSPSGTVVAQLQGPMGALLMGERVALNLIMPLSGIASLT
HHHHHHHHCCCEECCCCCCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHH
RTYAEKIADLPTQLVDTRKTTPGLRILEKYATQVGGAVNHRMGLDDAVMIKDNHIFAAGG
HHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCEEEEECC
IGEAIRRVRQHIPFPLAIEVETETLEQVQQAVDHQADIIMLDNMAVEQMQSAVKLIRSQC
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHC
ANTVKIEASGNINLQTIRAVAETGVDYISTSATITQASWLDLSLKFRD
CCEEEEEECCCCCHHHHHHHHHCCHHHHCCCCEEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]