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The map label for this gene is pgi

Identifier: 158337393

GI number: 158337393

Start: 4291137

End: 4292726

Strand: Direct

Name: pgi

Synonym: AM1_4272

Alternate gene names: 158337393

Gene position: 4291137-4292726 (Clockwise)

Preceding gene: 158337389

Following gene: 158337394

Centisome position: 65.98

GC content: 49.81

Gene sequence:

>1590_bases
ATGGATGCAGCCGCCCTTTGGCAACGCTATCAAGACTGGCTTTATTACCACGAGCAGCTGGGTATCTATGTAGACATCAG
CCGCATGAGTTTTGATGATGCATTCGTGGAACGCTTGGAGCCTAAGTTTGTAAAGGCGTTCAAAGAAATGGATGCCCTGG
AAGCGGGTGCGATCGCAAATCCTGACGAAAATCGCATGGTGGGCCATTATTGGCTCCGAGACTCCAATCTCGCCCCCACT
CCTGAATTAAAAAAAGAAATTATTACCACCTTAGAAAAAATAGAAGCCTTTGCGGCAGATGTTCATGCCGGACGGATCAA
GCCCGCCACCGCCCCTCGCTTTACCGACGTGATTTCCATTGGCATTGGTGGGTCTTCTTTGGGACCTCAGTTTGTGTCTC
AGGCCTTGGCCGTGCTCCATCCTGCTTTAGAGCTGCATTTTATCGATAATACCGATCCAGCGGGCATCGATTATATTTTG
GACCGGGTCCAAGATCGCCTAGATACTACCCTCGTAGTTACCATTTCTAAGTCTGGCGGTACACCTGAAACGCGCAATGG
CATGTTAGAAGCGAAAAACCGCTTCAAAAATTTGGGATTAGATTTTCCCAAACATGCTGTTGCCGTTACCGGGTATGGCA
GTAAACTGGCCCAAATTGCTGAAGAGGAGGGCTGGTTAGCCATGCTCCCCATGCATGACTGGGTTGGCGGACGAACCTCT
GAACTGTCTGCGGTGGGCTTGGTGCCCGCTTCCTTGCAGGGCATTGCTATTCGGGAGATGCTGGCCGGGGCCAAAGCCAT
GGATGAAGCCACCCGCGTGCATGATCTCAAAACCAATCCTGCTGCCTTGTTAGCCTTGTCTTGGTATTTTGCCGGGGAAG
GGGCAGGCAAAAAAGATATGGTGATTTTGCCCTATAAGGACAGCTTGATGCTGTTTAGCCGCTATCTCCAGCAGCTGGTG
ATGGAGTCCTTAGGTAAAGAAAAAGATCTGGACGACAAAATTGTGCACCAAGGCATTGCCGTTTATGGCAACAAAGGTTC
AACGGATCAACATGCCTATGTCCAAGAACTGCGGGAAGGTATTCCTAACTTCTTCCTGACCTTTATCGAAGTTTTAAAAG
ATCGCGATGGCACTCGCTTTGAAGTGGAACCCGGTGTGACCTCTGGGGATTACCTATCAGGGTTTCTCTTAGGGACTCGG
GAAGCGCTGTATGAAAAACGGCGTGATTCCATTACCGTGACTTTGCCAGAAGTGACCTCCAAACAGGTGGGGGCTTTGAT
TGCTCTATATGAGCGGGCAGTGGGTCTCTATGCGTCCTTAATTAATGTCAACGCCTATCACCAACCTGGTGTAGAGGCAG
GTAAGAAAGCCGCAACGGATACCATTGCGTTGCAAAATAAAATTGTGCAAATCCTCAGAAATACCCTAACACCTTTACCT
ATCACCAGTTTGGCTGATAAAGCCGAAGCCCCGGACAAAATAGAGACGGTCTATAAAATTGTCCGGCATCTCGCCGCCAA
TAAACGGGGGGTTGAGCTATACGGTAATCCAGCTGAGCCAGGAAGCCTCCAGGTCACGCTCAAGGGCTAG

Upstream 100 bases:

>100_bases
CTGCTCAGAAATGCTAAAGCCCATCCGAATATTTGGTCACCTTTTCAGGCCACACGCTATGGTTTAATCATCAACAAATC
ATTGCACTCAGGAACGATAT

Downstream 100 bases:

>100_bases
TCAGTCTAACCTTAAATAACCGCATCAACGGGCCTCTGCATACAGAGACCCGTTTTTATTTTGGTTGCGGTATGGCAAAA
ATCATCCGGAATCTTTCTCT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MDAAALWQRYQDWLYYHEQLGIYVDISRMSFDDAFVERLEPKFVKAFKEMDALEAGAIANPDENRMVGHYWLRDSNLAPT
PELKKEIITTLEKIEAFAADVHAGRIKPATAPRFTDVISIGIGGSSLGPQFVSQALAVLHPALELHFIDNTDPAGIDYIL
DRVQDRLDTTLVVTISKSGGTPETRNGMLEAKNRFKNLGLDFPKHAVAVTGYGSKLAQIAEEEGWLAMLPMHDWVGGRTS
ELSAVGLVPASLQGIAIREMLAGAKAMDEATRVHDLKTNPAALLALSWYFAGEGAGKKDMVILPYKDSLMLFSRYLQQLV
MESLGKEKDLDDKIVHQGIAVYGNKGSTDQHAYVQELREGIPNFFLTFIEVLKDRDGTRFEVEPGVTSGDYLSGFLLGTR
EALYEKRRDSITVTLPEVTSKQVGALIALYERAVGLYASLINVNAYHQPGVEAGKKAATDTIALQNKIVQILRNTLTPLP
ITSLADKAEAPDKIETVYKIVRHLAANKRGVELYGNPAEPGSLQVTLKG

Sequences:

>Translated_529_residues
MDAAALWQRYQDWLYYHEQLGIYVDISRMSFDDAFVERLEPKFVKAFKEMDALEAGAIANPDENRMVGHYWLRDSNLAPT
PELKKEIITTLEKIEAFAADVHAGRIKPATAPRFTDVISIGIGGSSLGPQFVSQALAVLHPALELHFIDNTDPAGIDYIL
DRVQDRLDTTLVVTISKSGGTPETRNGMLEAKNRFKNLGLDFPKHAVAVTGYGSKLAQIAEEEGWLAMLPMHDWVGGRTS
ELSAVGLVPASLQGIAIREMLAGAKAMDEATRVHDLKTNPAALLALSWYFAGEGAGKKDMVILPYKDSLMLFSRYLQQLV
MESLGKEKDLDDKIVHQGIAVYGNKGSTDQHAYVQELREGIPNFFLTFIEVLKDRDGTRFEVEPGVTSGDYLSGFLLGTR
EALYEKRRDSITVTLPEVTSKQVGALIALYERAVGLYASLINVNAYHQPGVEAGKKAATDTIALQNKIVQILRNTLTPLP
ITSLADKAEAPDKIETVYKIVRHLAANKRGVELYGNPAEPGSLQVTLKG
>Mature_529_residues
MDAAALWQRYQDWLYYHEQLGIYVDISRMSFDDAFVERLEPKFVKAFKEMDALEAGAIANPDENRMVGHYWLRDSNLAPT
PELKKEIITTLEKIEAFAADVHAGRIKPATAPRFTDVISIGIGGSSLGPQFVSQALAVLHPALELHFIDNTDPAGIDYIL
DRVQDRLDTTLVVTISKSGGTPETRNGMLEAKNRFKNLGLDFPKHAVAVTGYGSKLAQIAEEEGWLAMLPMHDWVGGRTS
ELSAVGLVPASLQGIAIREMLAGAKAMDEATRVHDLKTNPAALLALSWYFAGEGAGKKDMVILPYKDSLMLFSRYLQQLV
MESLGKEKDLDDKIVHQGIAVYGNKGSTDQHAYVQELREGIPNFFLTFIEVLKDRDGTRFEVEPGVTSGDYLSGFLLGTR
EALYEKRRDSITVTLPEVTSKQVGALIALYERAVGLYASLINVNAYHQPGVEAGKKAATDTIALQNKIVQILRNTLTPLP
ITSLADKAEAPDKIETVYKIVRHLAANKRGVELYGNPAEPGSLQVTLKG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:
GO:0004347: Glucose-6-phosphate isomerase
GO:0005737: Glucose-6-phosphate isomerase
GO:0006094: Glucose-6-phosphate isomerase
GO:0006096: Glucose-6-phosphate isomerase
GO:0016853: Glucose-6-phosphate isomerase

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=481, Percent_Identity=29.7297297297297, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI296080693, Length=481, Percent_Identity=26.6112266112266, Blast_Score=106, Evalue=6e-23,
Organism=Escherichia coli, GI1790457, Length=453, Percent_Identity=30.242825607064, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71996708, Length=482, Percent_Identity=28.2157676348548, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71996703, Length=481, Percent_Identity=27.6507276507277, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319673, Length=434, Percent_Identity=28.110599078341, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24651916, Length=447, Percent_Identity=29.5302013422819, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24651914, Length=447, Percent_Identity=29.5302013422819, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17737445, Length=447, Percent_Identity=29.5302013422819, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ACAM1 (B0CCT9)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518568.1
- ProteinModelPortal:   B0CCT9
- SMR:   B0CCT9
- GeneID:   5683075
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_4272
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   AMAR329726:AM1_4272-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 58213; Mature: 58213

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 322-322 ACT_SITE 351-351 ACT_SITE 455-455

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAALWQRYQDWLYYHEQLGIYVDISRMSFDDAFVERLEPKFVKAFKEMDALEAGAIAN
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRDSNLAPTPELKKEIITTLEKIEAFAADVHAGRIKPATAPRFTDVISI
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEE
GIGGSSLGPQFVSQALAVLHPALELHFIDNTDPAGIDYILDRVQDRLDTTLVVTISKSGG
ECCCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCC
TPETRNGMLEAKNRFKNLGLDFPKHAVAVTGYGSKLAQIAEEEGWLAMLPMHDWVGGRTS
CCHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEECCHHCCCCCCC
ELSAVGLVPASLQGIAIREMLAGAKAMDEATRVHDLKTNPAALLALSWYFAGEGAGKKDM
CCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCE
VILPYKDSLMLFSRYLQQLVMESLGKEKDLDDKIVHQGIAVYGNKGSTDQHAYVQELREG
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEECCCCCCHHHHHHHHHHHH
IPNFFLTFIEVLKDRDGTRFEVEPGVTSGDYLSGFLLGTREALYEKRRDSITVTLPEVTS
CHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
KQVGALIALYERAVGLYASLINVNAYHQPGVEAGKKAATDTIALQNKIVQILRNTLTPLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCCC
ITSLADKAEAPDKIETVYKIVRHLAANKRGVELYGNPAEPGSLQVTLKG
CHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEECC
>Mature Secondary Structure
MDAAALWQRYQDWLYYHEQLGIYVDISRMSFDDAFVERLEPKFVKAFKEMDALEAGAIAN
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRDSNLAPTPELKKEIITTLEKIEAFAADVHAGRIKPATAPRFTDVISI
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEE
GIGGSSLGPQFVSQALAVLHPALELHFIDNTDPAGIDYILDRVQDRLDTTLVVTISKSGG
ECCCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCC
TPETRNGMLEAKNRFKNLGLDFPKHAVAVTGYGSKLAQIAEEEGWLAMLPMHDWVGGRTS
CCHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEECCHHCCCCCCC
ELSAVGLVPASLQGIAIREMLAGAKAMDEATRVHDLKTNPAALLALSWYFAGEGAGKKDM
CCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCE
VILPYKDSLMLFSRYLQQLVMESLGKEKDLDDKIVHQGIAVYGNKGSTDQHAYVQELREG
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEECCCCCCHHHHHHHHHHHH
IPNFFLTFIEVLKDRDGTRFEVEPGVTSGDYLSGFLLGTREALYEKRRDSITVTLPEVTS
CHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
KQVGALIALYERAVGLYASLINVNAYHQPGVEAGKKAATDTIALQNKIVQILRNTLTPLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCCC
ITSLADKAEAPDKIETVYKIVRHLAANKRGVELYGNPAEPGSLQVTLKG
CHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA