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The map label for this gene is lktA [H]

Identifier: 158337389

GI number: 158337389

Start: 4285499

End: 4287241

Strand: Direct

Name: lktA [H]

Synonym: AM1_4268

Alternate gene names: 158337389

Gene position: 4285499-4287241 (Clockwise)

Preceding gene: 158337387

Following gene: 158337393

Centisome position: 65.89

GC content: 49.34

Gene sequence:

>1743_bases
ATGCGTCAATCATTTCAGCTTAATTTTGAGCATGAGTTGGAATCTCCAATTGAAAGCTTGAATGACCTGAAAGTTGGTTC
AACCTCACAAGCATCTGTCGATATCAAAAGTGACAATATTGATATTGCCCCGCAGCAAATCCTAGAACTTTCTGAGTTAG
GTACTAAAGTCAATCTTCCTGATATTCAGACTTTTATCTCGATACCACTTTTTTCGTCTGAGCCATCTACACAAGACACT
ACATTAGAAGAAAATGTGGGAACTCAAGCCCCAAAGACGCTAGAAAGTGGTTATTGCTGTTTATGTACTGCTTGCGGAAC
TGCACATAGCCATGGTGCAAGGTTTCAGACAGGTGGATCGTTCGCTCAATTTAATGACAGTGGCGGACGATTCAAATGGA
ACCAGCCTGGAGGAAGCGGGAACGCAGTCAATATTACATACAGCTTTGCACCTAGTTTTCAATTAAATGGGTTATCGAAT
AACGAAGCAAGATCGCTCTTCCGCGAGGCTCTGGGCGTTTGGGCAAAGTATGCTCCATTAAATTTTCAAGAAGTTCAAGA
TCCTGGCAATGGAAGCGACGTTGATATCCGGGTCGGAGCTGAGTTTATTGATGGTCGTAGTGGTACCTTGGCCTTCGCAT
TTTTCCCGCGAGGCGGTGATCAAACCTACGATACTGGCGAAACTTGGAATGCTGGCTTATTTCTAGAAACCGCTGTTCAT
GAAACGGGCCATAGTCTTGGTCTTGGGCATGAATCGGGAGTGGATGCGATTATGAATCCCTCAATTCAGCGGCGGTTTAG
TGGGGCGGGCACTGCGTTCTTGCTACAGGATGATATCAATGGTGTTCACAGCCTCTATGGCAGTGGTACAGGATCTGTTA
GTCCCCTATCACCTTCTCCGACTCCAGTCCCGGCTCCGGCCCCAGCTCCAGCTCCAGCTCCAGCTCCGGCTCCAGCCCCA
GCCCCAGTGCCAACACCCACCCCGACTCCGACTCCAACACCAACACCGACTCCAACACCGACTCCATCACCAAGCCCAAC
ACCAACTCCATCACCGAGTCCTACGCCTGGTGACAACCGGATTGATGGCACCAATCGGAATGATGTCTTACGGGGTGGCT
CCCGTAATGATGTGATTCGGGGATTTGGTGGTAATGATTTGATCAGTGGTCGAAGGGGAAATGATCGCCTCTTTGGGGGA
AGTGGCAACGATCGTATGTTTGGTGGCTCAGGTAACGATGTGATGTCTGGCGATGGTGGTAGCGATCGTATGAGTGGTGG
CTCGGGTAATGACCGTATGTTTGGCGGCTCAGGCAATGACCGTATCGACGGCAACTCGGGCAACGATGTATTGAATGGTG
GCTCAGGCAATGACTCTCTGTTTGGGGGAAATGGTCGCGATCGATTAATTGGTGTCAATATCAGTGATGCTAAACCCGGT
GTCGGAGAGATTGATTTCCTGCGAGGGGGAAGAGATGCAGATGTCTTTGTCTTGGGAGATAGCCAAAAGGTTTATTATGC
TGACGGTCCAGCAACCAGTAATTATGCTGTGGTGCAGGACTTCACACCCAATCAGGGAGATGTATTGCAACTGAATGGCT
CAGCCAGCGATTACTCATTAGGGGTTTCACAGCCCAGTGGAACCGCCCTGATTTATGAAGGGGGGAGTTCTCGTGAAGTC
ATCGCGATTATCCAAGGTGCGACTAACTTCAGTCTGAACAGTAGTGCGGTCCGGTACGTGTAG

Upstream 100 bases:

>100_bases
AGGTGTATCAACTATATGATAAAACCTCTAAGGATATACGGATTTAAAGGGGGAGCTTATGTCTCTAAAACTTGTAAGTT
ACTGATCCTTAGGAGGATAT

Downstream 100 bases:

>100_bases
GTAATCGCCGATAGGGGCCATCGGGTCTCGATTCAGTAAGACTGGCTGGAGTAACGAATCTTATACATTGGTTTGCTACT
CCAGCAATATGGATAGTTTG

Product: type I secretion target repeat-containing protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MRQSFQLNFEHELESPIESLNDLKVGSTSQASVDIKSDNIDIAPQQILELSELGTKVNLPDIQTFISIPLFSSEPSTQDT
TLEENVGTQAPKTLESGYCCLCTACGTAHSHGARFQTGGSFAQFNDSGGRFKWNQPGGSGNAVNITYSFAPSFQLNGLSN
NEARSLFREALGVWAKYAPLNFQEVQDPGNGSDVDIRVGAEFIDGRSGTLAFAFFPRGGDQTYDTGETWNAGLFLETAVH
ETGHSLGLGHESGVDAIMNPSIQRRFSGAGTAFLLQDDINGVHSLYGSGTGSVSPLSPSPTPVPAPAPAPAPAPAPAPAP
APVPTPTPTPTPTPTPTPTPTPSPSPTPTPSPSPTPGDNRIDGTNRNDVLRGGSRNDVIRGFGGNDLISGRRGNDRLFGG
SGNDRMFGGSGNDVMSGDGGSDRMSGGSGNDRMFGGSGNDRIDGNSGNDVLNGGSGNDSLFGGNGRDRLIGVNISDAKPG
VGEIDFLRGGRDADVFVLGDSQKVYYADGPATSNYAVVQDFTPNQGDVLQLNGSASDYSLGVSQPSGTALIYEGGSSREV
IAIIQGATNFSLNSSAVRYV

Sequences:

>Translated_580_residues
MRQSFQLNFEHELESPIESLNDLKVGSTSQASVDIKSDNIDIAPQQILELSELGTKVNLPDIQTFISIPLFSSEPSTQDT
TLEENVGTQAPKTLESGYCCLCTACGTAHSHGARFQTGGSFAQFNDSGGRFKWNQPGGSGNAVNITYSFAPSFQLNGLSN
NEARSLFREALGVWAKYAPLNFQEVQDPGNGSDVDIRVGAEFIDGRSGTLAFAFFPRGGDQTYDTGETWNAGLFLETAVH
ETGHSLGLGHESGVDAIMNPSIQRRFSGAGTAFLLQDDINGVHSLYGSGTGSVSPLSPSPTPVPAPAPAPAPAPAPAPAP
APVPTPTPTPTPTPTPTPTPTPSPSPTPTPSPSPTPGDNRIDGTNRNDVLRGGSRNDVIRGFGGNDLISGRRGNDRLFGG
SGNDRMFGGSGNDVMSGDGGSDRMSGGSGNDRMFGGSGNDRIDGNSGNDVLNGGSGNDSLFGGNGRDRLIGVNISDAKPG
VGEIDFLRGGRDADVFVLGDSQKVYYADGPATSNYAVVQDFTPNQGDVLQLNGSASDYSLGVSQPSGTALIYEGGSSREV
IAIIQGATNFSLNSSAVRYV
>Mature_580_residues
MRQSFQLNFEHELESPIESLNDLKVGSTSQASVDIKSDNIDIAPQQILELSELGTKVNLPDIQTFISIPLFSSEPSTQDT
TLEENVGTQAPKTLESGYCCLCTACGTAHSHGARFQTGGSFAQFNDSGGRFKWNQPGGSGNAVNITYSFAPSFQLNGLSN
NEARSLFREALGVWAKYAPLNFQEVQDPGNGSDVDIRVGAEFIDGRSGTLAFAFFPRGGDQTYDTGETWNAGLFLETAVH
ETGHSLGLGHESGVDAIMNPSIQRRFSGAGTAFLLQDDINGVHSLYGSGTGSVSPLSPSPTPVPAPAPAPAPAPAPAPAP
APVPTPTPTPTPTPTPTPTPTPSPSPTPTPSPSPTPGDNRIDGTNRNDVLRGGSRNDVIRGFGGNDLISGRRGNDRLFGG
SGNDRMFGGSGNDVMSGDGGSDRMSGGSGNDRMFGGSGNDRIDGNSGNDVLNGGSGNDSLFGGNGRDRLIGVNISDAKPG
VGEIDFLRGGRDADVFVLGDSQKVYYADGPATSNYAVVQDFTPNQGDVLQLNGSASDYSLGVSQPSGTALIYEGGSSREV
IAIIQGATNFSLNSSAVRYV

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

Organism=Homo sapiens, GI5729929, Length=223, Percent_Identity=32.7354260089686, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI149999365, Length=243, Percent_Identity=32.5102880658436, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4505209, Length=191, Percent_Identity=32.9842931937173, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI13027802, Length=243, Percent_Identity=32.5102880658436, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI11968059, Length=171, Percent_Identity=35.0877192982456, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI58331148, Length=177, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4505211, Length=221, Percent_Identity=31.6742081447964, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI5902004, Length=190, Percent_Identity=30, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4505221, Length=162, Percent_Identity=35.8024691358025, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI73858572, Length=136, Percent_Identity=41.9117647058824, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI73808266, Length=186, Percent_Identity=34.4086021505376, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4826834, Length=163, Percent_Identity=33.7423312883436, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4505215, Length=192, Percent_Identity=30.7291666666667, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI225543094, Length=192, Percent_Identity=30.7291666666667, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4505205, Length=204, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4505219, Length=144, Percent_Identity=38.1944444444444, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI112382270, Length=156, Percent_Identity=36.5384615384615, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4505213, Length=148, Percent_Identity=33.7837837837838, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI45359865, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI4505217, Length=170, Percent_Identity=32.9411764705882, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558356, Length=177, Percent_Identity=32.7683615819209, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45552531, Length=157, Percent_Identity=36.3057324840764, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221468755, Length=115, Percent_Identity=38.2608695652174, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221468756, Length=115, Percent_Identity=38.2608695652174, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 60292; Mature: 60292

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSFQLNFEHELESPIESLNDLKVGSTSQASVDIKSDNIDIAPQQILELSELGTKVNLP
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCC
DIQTFISIPLFSSEPSTQDTTLEENVGTQAPKTLESGYCCLCTACGTAHSHGARFQTGGS
CCCHHEEEEEECCCCCCCCCCHHHHCCCCCCHHHCCCCEEEEEECCCCCCCCCEECCCCC
FAQFNDSGGRFKWNQPGGSGNAVNITYSFAPSFQLNGLSNNEARSLFREALGVWAKYAPL
EEEECCCCCEEEECCCCCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCC
NFQEVQDPGNGSDVDIRVGAEFIDGRSGTLAFAFFPRGGDQTYDTGETWNAGLFLETAVH
CHHHHCCCCCCCEEEEEECCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEHHH
ETGHSLGLGHESGVDAIMNPSIQRRFSGAGTAFLLQDDINGVHSLYGSGTGSVSPLSPSP
HCCCCCCCCCCCCCHHHHCCHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCC
TPVPAPAPAPAPAPAPAPAPAPVPTPTPTPTPTPTPTPTPTPSPSPTPTPSPSPTPGDNR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IDGTNRNDVLRGGSRNDVIRGFGGNDLISGRRGNDRLFGGSGNDRMFGGSGNDVMSGDGG
CCCCCCCHHCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCCCCCCCC
SDRMSGGSGNDRMFGGSGNDRIDGNSGNDVLNGGSGNDSLFGGNGRDRLIGVNISDAKPG
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCC
VGEIDFLRGGRDADVFVLGDSQKVYYADGPATSNYAVVQDFTPNQGDVLQLNGSASDYSL
CCCEEEECCCCCCEEEEEECCCEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCEEE
GVSQPSGTALIYEGGSSREVIAIIQGATNFSLNSSAVRYV
ECCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCEEECC
>Mature Secondary Structure
MRQSFQLNFEHELESPIESLNDLKVGSTSQASVDIKSDNIDIAPQQILELSELGTKVNLP
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCC
DIQTFISIPLFSSEPSTQDTTLEENVGTQAPKTLESGYCCLCTACGTAHSHGARFQTGGS
CCCHHEEEEEECCCCCCCCCCHHHHCCCCCCHHHCCCCEEEEEECCCCCCCCCEECCCCC
FAQFNDSGGRFKWNQPGGSGNAVNITYSFAPSFQLNGLSNNEARSLFREALGVWAKYAPL
EEEECCCCCEEEECCCCCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCC
NFQEVQDPGNGSDVDIRVGAEFIDGRSGTLAFAFFPRGGDQTYDTGETWNAGLFLETAVH
CHHHHCCCCCCCEEEEEECCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEHHH
ETGHSLGLGHESGVDAIMNPSIQRRFSGAGTAFLLQDDINGVHSLYGSGTGSVSPLSPSP
HCCCCCCCCCCCCCHHHHCCHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCC
TPVPAPAPAPAPAPAPAPAPAPVPTPTPTPTPTPTPTPTPTPSPSPTPTPSPSPTPGDNR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IDGTNRNDVLRGGSRNDVIRGFGGNDLISGRRGNDRLFGGSGNDRMFGGSGNDVMSGDGG
CCCCCCCHHCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCCCCCCCC
SDRMSGGSGNDRMFGGSGNDRIDGNSGNDVLNGGSGNDSLFGGNGRDRLIGVNISDAKPG
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCC
VGEIDFLRGGRDADVFVLGDSQKVYYADGPATSNYAVVQDFTPNQGDVLQLNGSASDYSL
CCCEEEECCCCCCEEEEEECCCEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCEEE
GVSQPSGTALIYEGGSSREVIAIIQGATNFSLNSSAVRYV
ECCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]