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The map label for this gene is mutY [H]

Identifier: 158337045

GI number: 158337045

Start: 3970539

End: 3971645

Strand: Reverse

Name: mutY [H]

Synonym: AM1_3918

Alternate gene names: 158337045

Gene position: 3971645-3970539 (Counterclockwise)

Preceding gene: 158337052

Following gene: 158337044

Centisome position: 61.07

GC content: 51.4

Gene sequence:

>1107_bases
ATGCCAGAAACTAAACTAAAGAAGTTACCCATCGCGAAATTAAGAACTGCTTTGCGAACTTGGTATCAAGAGTCAGGGCG
AGATCTCCCCTGGAGGCAAACACAAGACCCTTATGCCATCTGGGTCTCAGAGATCATGCTCCAGCAAACCCAGGTCAAAA
CCGTCATTCCCTATTACCAGCGCTGGTTAGCCCAATTCCCCACTATTGCCAGCCTAGCAGCCGCTCCCCAACAAGACGTC
TTGAAAGTTTGGCAGGGACTGGGTTACTATGCTCGGGCGCGGAACTTGCATCGAGCTGCCCAACAAGTCGTCGCAGACTG
GGATGGAACCTTCCCAGAGCAATTTGACCAAGTGATGAGCTTACCCGGCATCGGTCGAACCACTGCTGGAGGCATTCTTA
GCGCCGCCTTTAATCAGCCCACCCCTATTTTGGATGGTAATGTTAAGCGCATCCTAGTCCGGCTACTCGCCATCCAACAG
CCTCCCAAAAAAGTGTTGGCAGATCTATGGGAAGCCTCCACAGCACTCCTCGATCCAGAGTATCCTAGGGAATTCAACCA
GGCATTTATGGACCTAGGGGCCACCCTATGTACCCCCAAGCAACCCCAGTGCGATCGCTGTCCCTGGAGGTCCGACTGCC
AAGCCTACCGTCATCAACTGCAAACCACCTTACCCATGACCGAACAGAAAGCCCCAGTCCCCCATAAACAAATTGGCGTT
GCCGTGATCTGGAACGACCAAAACCAGATTCTGATCGATAAACGACCTCAAAAAGGTCTGCTGGGTGGCCTATGGGAATT
TCCAGGAGGAAAAGTAGAACCCCAAGAATCTGTGGAAGACTGCATTCGCCGGGAAATAAAAGAAGAACTAGGGATTGAGA
TTGGCGTTGACGATCATTTGATTACCGTGAATCATGCCTACACCCACTTCAAAGTCACCCTGATGGTGCATCACTGCCAC
CATATCCAAGGGGAGCCCCAGGCCATTGAATGTGATGAAATTCGCTGGGTGACCTTAGCAGAGCTAGATGAGTATCCCTT
TCCCAAAGCCAATCAAGAAATCATTGCCGCCCTACGGGCTTCTAAACAACCAGCCCCCAAAGGCTAA

Upstream 100 bases:

>100_bases
AGCAATCAATCTCTCATTATGGGCTAGCGCTCTCGTTATCCTACTCAACGCTCAACATTCCTTTATCCTGATCAAGGAAA
TATAGGGTCATTTGGAGTTG

Downstream 100 bases:

>100_bases
AATAATGACCTCCACTCCATCCCTACTGAGAGGCACCCGACTGTGAGTACGGTTTATACCCGGCCCCTAGCCCGACTGGT
TGAGCAGCTCCAACGACTCC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MPETKLKKLPIAKLRTALRTWYQESGRDLPWRQTQDPYAIWVSEIMLQQTQVKTVIPYYQRWLAQFPTIASLAAAPQQDV
LKVWQGLGYYARARNLHRAAQQVVADWDGTFPEQFDQVMSLPGIGRTTAGGILSAAFNQPTPILDGNVKRILVRLLAIQQ
PPKKVLADLWEASTALLDPEYPREFNQAFMDLGATLCTPKQPQCDRCPWRSDCQAYRHQLQTTLPMTEQKAPVPHKQIGV
AVIWNDQNQILIDKRPQKGLLGGLWEFPGGKVEPQESVEDCIRREIKEELGIEIGVDDHLITVNHAYTHFKVTLMVHHCH
HIQGEPQAIECDEIRWVTLAELDEYPFPKANQEIIAALRASKQPAPKG

Sequences:

>Translated_368_residues
MPETKLKKLPIAKLRTALRTWYQESGRDLPWRQTQDPYAIWVSEIMLQQTQVKTVIPYYQRWLAQFPTIASLAAAPQQDV
LKVWQGLGYYARARNLHRAAQQVVADWDGTFPEQFDQVMSLPGIGRTTAGGILSAAFNQPTPILDGNVKRILVRLLAIQQ
PPKKVLADLWEASTALLDPEYPREFNQAFMDLGATLCTPKQPQCDRCPWRSDCQAYRHQLQTTLPMTEQKAPVPHKQIGV
AVIWNDQNQILIDKRPQKGLLGGLWEFPGGKVEPQESVEDCIRREIKEELGIEIGVDDHLITVNHAYTHFKVTLMVHHCH
HIQGEPQAIECDEIRWVTLAELDEYPFPKANQEIIAALRASKQPAPKG
>Mature_367_residues
PETKLKKLPIAKLRTALRTWYQESGRDLPWRQTQDPYAIWVSEIMLQQTQVKTVIPYYQRWLAQFPTIASLAAAPQQDVL
KVWQGLGYYARARNLHRAAQQVVADWDGTFPEQFDQVMSLPGIGRTTAGGILSAAFNQPTPILDGNVKRILVRLLAIQQP
PKKVLADLWEASTALLDPEYPREFNQAFMDLGATLCTPKQPQCDRCPWRSDCQAYRHQLQTTLPMTEQKAPVPHKQIGVA
VIWNDQNQILIDKRPQKGLLGGLWEFPGGKVEPQESVEDCIRREIKEELGIEIGVDDHLITVNHAYTHFKVTLMVHHCHH
IQGEPQAIECDEIRWVTLAELDEYPFPKANQEIIAALRASKQPAPKG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:
GO:0003677: A/G-specific adenine glycosylase
GO:0003824: A/G-specific adenine glycosylase
GO:0004519: A/G-specific adenine glycosylase
GO:0005622: A/G-specific adenine glycosylase
GO:0006281: A/G-specific adenine glycosylase
GO:0006284: A/G-specific adenine glycosylase
GO:0008413: A/G-specific adenine glycosylase
GO:0016787: A/G-specific adenine glycosylase
GO:0019104: A/G-specific adenine glycosylase
GO:0051539: A/G-specific adenine glycosylase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI190358497, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI6912520, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI115298654, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI115298652, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI115298650, Length=405, Percent_Identity=35.3086419753086, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789331, Length=300, Percent_Identity=42.6666666666667, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788056, Length=126, Percent_Identity=35.7142857142857, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=32.520325203252, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41856; Mature: 41724

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00893 NUDIX ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETKLKKLPIAKLRTALRTWYQESGRDLPWRQTQDPYAIWVSEIMLQQTQVKTVIPYYQ
CCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RWLAQFPTIASLAAAPQQDVLKVWQGLGYYARARNLHRAAQQVVADWDGTFPEQFDQVMS
HHHHHCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
LPGIGRTTAGGILSAAFNQPTPILDGNVKRILVRLLAIQQPPKKVLADLWEASTALLDPE
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
YPREFNQAFMDLGATLCTPKQPQCDRCPWRSDCQAYRHQLQTTLPMTEQKAPVPHKQIGV
CCHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCE
AVIWNDQNQILIDKRPQKGLLGGLWEFPGGKVEPQESVEDCIRREIKEELGIEIGVDDHL
EEEECCCCEEEEECCCCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCE
ITVNHAYTHFKVTLMVHHCHHIQGEPQAIECDEIRWVTLAELDEYPFPKANQEIIAALRA
EEEECCEEEEEEEHEEHHHHHCCCCCCEECCCCEEEEEHHHHCCCCCCCCCHHHHHHHHH
SKQPAPKG
CCCCCCCC
>Mature Secondary Structure 
PETKLKKLPIAKLRTALRTWYQESGRDLPWRQTQDPYAIWVSEIMLQQTQVKTVIPYYQ
CCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RWLAQFPTIASLAAAPQQDVLKVWQGLGYYARARNLHRAAQQVVADWDGTFPEQFDQVMS
HHHHHCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
LPGIGRTTAGGILSAAFNQPTPILDGNVKRILVRLLAIQQPPKKVLADLWEASTALLDPE
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
YPREFNQAFMDLGATLCTPKQPQCDRCPWRSDCQAYRHQLQTTLPMTEQKAPVPHKQIGV
CCHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCE
AVIWNDQNQILIDKRPQKGLLGGLWEFPGGKVEPQESVEDCIRREIKEELGIEIGVDDHL
EEEECCCCEEEEECCCCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCE
ITVNHAYTHFKVTLMVHHCHHIQGEPQAIECDEIRWVTLAELDEYPFPKANQEIIAALRA
EEEECCEEEEEEEHEEHHHHHCCCCCCEECCCCEEEEEHHHHCCCCCCCCCHHHHHHHHH
SKQPAPKG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]