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The map label for this gene is loxA [H]

Identifier: 158337030

GI number: 158337030

Start: 3951725

End: 3953668

Strand: Reverse

Name: loxA [H]

Synonym: AM1_3903

Alternate gene names: 158337030

Gene position: 3953668-3951725 (Counterclockwise)

Preceding gene: 158337032

Following gene: 158337023

Centisome position: 60.79

GC content: 47.43

Gene sequence:

>1944_bases
ATGACGCCACAATATGAATATCGATACGATGCCCTGAAAGACGTTTCCCCTGAATTGAAATATCCAATGGCCAAGGAGGT
GTTTCCAGCAGACCAATCTTTGACAAAATGGCCCTGGACTCGAGACCTCGTTTCCGTTGTACTCAGAATTATTGCCAATC
AGGCCATGCAGGATATATCCGTCCGCCGAGGATCAGCCTGTCGTCTGATTACGTTTATCCGCTTGTATCGAATTCTAGAA
AATCCCCTCTATCAGTCAGGTCTGGAGCGGGTTTTCAATGCTATCAATAATCTCGTACGGGGTCTCTCCAATATTTTTGG
CAACAGAGCCCAGTCTCAAAATATCAAGCATGATGTAAAGGACGAGCAACATCCTGAAAAAGTCTCCGCCCGCATTTCCG
CCATAGCCAAGGATATCCAAGAAACGGCTGAGTCGAGAGAGGCAAGAGAGCAAACTTCTTTAGCTGACTATCGCGATCTC
TTTCAGATCATTTACTTACCGGACATTAGCAACCATTTCCTAGAAGATCGTGCCTTTGCCGCTCAACGGGTTGCCGGAGC
CAACCCCCTCGTGATTAACCGCATTTCTGAACTCCCAGACCATTTCCAAGTCACTGACCAACAGTTTAAAGCTGTGATGG
GAGATAGTGAGTCCCTCCAAGCAGCTTTGAATGATGGCCGAGTCTATCTGGCAGACTATCAAATTCTAGAAGAAATTGAT
GCGGGTACTGTTGAGGTAAAGGATCGCGAAATTCCAAAGTATAGATATGCGCCGTTGGCCTTATTTGCGATCGCATCCGG
AAATTGTCCCGGTCGCCTCCTCCAACCGATTGCCATTCAATGCCACCAAGAAGCAGGCAGCCCGATATTTACACCACCCA
GTCTAGAAGCCGATAAAGAGGAGCGGCTCGCTTGGCGCATGGCCAAGACCGTCGTTCAAATCGCCGATGGTAACTACCAT
GAATTGATTTCTCATTTAGGGCGGACTCATCTCTGGATTGAGCCCATTGCTTTAGGCACTTACCGACGCCTAGGAACAGA
GCATCCACTGGGTAAATTGCTCCTCCCCCACTTCGAAGGCACCTTATTTATCAACAATGCGGCAGCCAATAGCTTAATTG
CTCCAGGTGGCACCGTAGACAAAATCTTATTTGGCACCTTAAAGTCATCTGTTCAGCTCAGCGTCAAAGGCGCTAAGGGT
TACCCCTTTTCTTTCAATGACTCCATGCTCCCCCAAACCTTTGCATCGCGAGGCGTGGACGACCTACAAAAGCTACCGGA
CTACCCGTATCGAGATGATGCATTACTGATTTGGCACGCCATTCACGATTGGGTTGAGGCCTATCTTCAGATCTACTACA
AAGATGATGATGCAGTCCTCAAGGATGACATCCTCCAGGATTGGTTAGCCGAGCTACGAGCTGAAGATGGAGGCCAGATG
ACTGAAATCGGTGAATCAACTCCAGAAGAACCCGAGCCTAAAATTCGCACCTTGGATTACCTCATTAATGCGACAACGCT
CATTATTTTTACCTGCAGTGCCCAACATGCATCTGTCAACTTCCCTCAAGCATCATTGATGACGTTCGTCCCCAATATGC
CCCTAGCAGGGTTCAATGAAGGTCCGACGGCAGAGAAAGCCAGTGAAGCAGATTATTTCTCTTTACTACCACCCCTGAGT
TTGGCCGAACAACAGTTGGATCTAGGGTATACCTTGGGTTCGGTCTACTATACTCAGCTCGGATATTACAAAGCCAATGA
TGTGGATTTAGATGATATTAACGACCATACCTACTTCAAGGACCTCCAAGTTAAACAGGCCCTCCGAGACTTCCAACAAA
GATTAGAAGAAATTGAGTTGATCATTCAAGACCGGAACGAAACCCGACCCACTTATTACGACATCTTGCTCCCATCCAAG
ATTCCCCAAAGTACCAACATTTAA

Upstream 100 bases:

>100_bases
CTTTGCAATTCGCATAAGGTCCTGCGCCATATCTGATGATTCTAGTAGCCCCAAACATTTTTAAAGTTCTATTAGAATAA
CGTCTCAAATAGGAGTGAAT

Downstream 100 bases:

>100_bases
GGTAGATCACCTGAGTTCAGGTTAAGTACATTTTTTGAAATCCTTATACAGACATATAAAGCCGTCAACTCATATAAAAA
ATAAGGGTTTCAGCTTATCC

Product: lipoxygenase

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MTPQYEYRYDALKDVSPELKYPMAKEVFPADQSLTKWPWTRDLVSVVLRIIANQAMQDISVRRGSACRLITFIRLYRILE
NPLYQSGLERVFNAINNLVRGLSNIFGNRAQSQNIKHDVKDEQHPEKVSARISAIAKDIQETAESREAREQTSLADYRDL
FQIIYLPDISNHFLEDRAFAAQRVAGANPLVINRISELPDHFQVTDQQFKAVMGDSESLQAALNDGRVYLADYQILEEID
AGTVEVKDREIPKYRYAPLALFAIASGNCPGRLLQPIAIQCHQEAGSPIFTPPSLEADKEERLAWRMAKTVVQIADGNYH
ELISHLGRTHLWIEPIALGTYRRLGTEHPLGKLLLPHFEGTLFINNAAANSLIAPGGTVDKILFGTLKSSVQLSVKGAKG
YPFSFNDSMLPQTFASRGVDDLQKLPDYPYRDDALLIWHAIHDWVEAYLQIYYKDDDAVLKDDILQDWLAELRAEDGGQM
TEIGESTPEEPEPKIRTLDYLINATTLIIFTCSAQHASVNFPQASLMTFVPNMPLAGFNEGPTAEKASEADYFSLLPPLS
LAEQQLDLGYTLGSVYYTQLGYYKANDVDLDDINDHTYFKDLQVKQALRDFQQRLEEIELIIQDRNETRPTYYDILLPSK
IPQSTNI

Sequences:

>Translated_647_residues
MTPQYEYRYDALKDVSPELKYPMAKEVFPADQSLTKWPWTRDLVSVVLRIIANQAMQDISVRRGSACRLITFIRLYRILE
NPLYQSGLERVFNAINNLVRGLSNIFGNRAQSQNIKHDVKDEQHPEKVSARISAIAKDIQETAESREAREQTSLADYRDL
FQIIYLPDISNHFLEDRAFAAQRVAGANPLVINRISELPDHFQVTDQQFKAVMGDSESLQAALNDGRVYLADYQILEEID
AGTVEVKDREIPKYRYAPLALFAIASGNCPGRLLQPIAIQCHQEAGSPIFTPPSLEADKEERLAWRMAKTVVQIADGNYH
ELISHLGRTHLWIEPIALGTYRRLGTEHPLGKLLLPHFEGTLFINNAAANSLIAPGGTVDKILFGTLKSSVQLSVKGAKG
YPFSFNDSMLPQTFASRGVDDLQKLPDYPYRDDALLIWHAIHDWVEAYLQIYYKDDDAVLKDDILQDWLAELRAEDGGQM
TEIGESTPEEPEPKIRTLDYLINATTLIIFTCSAQHASVNFPQASLMTFVPNMPLAGFNEGPTAEKASEADYFSLLPPLS
LAEQQLDLGYTLGSVYYTQLGYYKANDVDLDDINDHTYFKDLQVKQALRDFQQRLEEIELIIQDRNETRPTYYDILLPSK
IPQSTNI
>Mature_646_residues
TPQYEYRYDALKDVSPELKYPMAKEVFPADQSLTKWPWTRDLVSVVLRIIANQAMQDISVRRGSACRLITFIRLYRILEN
PLYQSGLERVFNAINNLVRGLSNIFGNRAQSQNIKHDVKDEQHPEKVSARISAIAKDIQETAESREAREQTSLADYRDLF
QIIYLPDISNHFLEDRAFAAQRVAGANPLVINRISELPDHFQVTDQQFKAVMGDSESLQAALNDGRVYLADYQILEEIDA
GTVEVKDREIPKYRYAPLALFAIASGNCPGRLLQPIAIQCHQEAGSPIFTPPSLEADKEERLAWRMAKTVVQIADGNYHE
LISHLGRTHLWIEPIALGTYRRLGTEHPLGKLLLPHFEGTLFINNAAANSLIAPGGTVDKILFGTLKSSVQLSVKGAKGY
PFSFNDSMLPQTFASRGVDDLQKLPDYPYRDDALLIWHAIHDWVEAYLQIYYKDDDAVLKDDILQDWLAELRAEDGGQMT
EIGESTPEEPEPKIRTLDYLINATTLIIFTCSAQHASVNFPQASLMTFVPNMPLAGFNEGPTAEKASEADYFSLLPPLSL
AEQQLDLGYTLGSVYYTQLGYYKANDVDLDDINDHTYFKDLQVKQALRDFQQRLEEIELIIQDRNETRPTYYDILLPSKI
PQSTNI

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI4502053, Length=494, Percent_Identity=33.4008097165992, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI4502057, Length=509, Percent_Identity=30.2554027504912, Blast_Score=209, Evalue=7e-54,
Organism=Homo sapiens, GI182765464, Length=485, Percent_Identity=32.7835051546392, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI260166612, Length=485, Percent_Identity=32.7835051546392, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI85067501, Length=501, Percent_Identity=32.7345309381238, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI40316937, Length=524, Percent_Identity=29.0076335877863, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI85067499, Length=501, Percent_Identity=30.3393213572854, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI154426292, Length=486, Percent_Identity=30.0411522633745, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI85067503, Length=501, Percent_Identity=27.7445109780439, Blast_Score=129, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 73254; Mature: 73122

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQYEYRYDALKDVSPELKYPMAKEVFPADQSLTKWPWTRDLVSVVLRIIANQAMQDIS
CCCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRRGSACRLITFIRLYRILENPLYQSGLERVFNAINNLVRGLSNIFGNRAQSQNIKHDVK
HCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
DEQHPEKVSARISAIAKDIQETAESREAREQTSLADYRDLFQIIYLPDISNHFLEDRAFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AQRVAGANPLVINRISELPDHFQVTDQQFKAVMGDSESLQAALNDGRVYLADYQILEEID
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEHHHHHHHCC
AGTVEVKDREIPKYRYAPLALFAIASGNCPGRLLQPIAIQCHQEAGSPIFTPPSLEADKE
CCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ERLAWRMAKTVVQIADGNYHELISHLGRTHLWIEPIALGTYRRLGTEHPLGKLLLPHFEG
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCC
TLFINNAAANSLIAPGGTVDKILFGTLKSSVQLSVKGAKGYPFSFNDSMLPQTFASRGVD
EEEEECCCCCCEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHCCHH
DLQKLPDYPYRDDALLIWHAIHDWVEAYLQIYYKDDDAVLKDDILQDWLAELRAEDGGQM
HHHHCCCCCCCCCCEEHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
TEIGESTPEEPEPKIRTLDYLINATTLIIFTCSAQHASVNFPQASLMTFVPNMPLAGFNE
HHCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCC
GPTAEKASEADYFSLLPPLSLAEQQLDLGYTLGSVYYTQLGYYKANDVDLDDINDHTYFK
CCCCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCCCCCCHHHH
DLQVKQALRDFQQRLEEIELIIQDRNETRPTYYDILLPSKIPQSTNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TPQYEYRYDALKDVSPELKYPMAKEVFPADQSLTKWPWTRDLVSVVLRIIANQAMQDIS
CCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRRGSACRLITFIRLYRILENPLYQSGLERVFNAINNLVRGLSNIFGNRAQSQNIKHDVK
HCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
DEQHPEKVSARISAIAKDIQETAESREAREQTSLADYRDLFQIIYLPDISNHFLEDRAFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AQRVAGANPLVINRISELPDHFQVTDQQFKAVMGDSESLQAALNDGRVYLADYQILEEID
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEHHHHHHHCC
AGTVEVKDREIPKYRYAPLALFAIASGNCPGRLLQPIAIQCHQEAGSPIFTPPSLEADKE
CCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ERLAWRMAKTVVQIADGNYHELISHLGRTHLWIEPIALGTYRRLGTEHPLGKLLLPHFEG
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCC
TLFINNAAANSLIAPGGTVDKILFGTLKSSVQLSVKGAKGYPFSFNDSMLPQTFASRGVD
EEEEECCCCCCEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHCCHH
DLQKLPDYPYRDDALLIWHAIHDWVEAYLQIYYKDDDAVLKDDILQDWLAELRAEDGGQM
HHHHCCCCCCCCCCEEHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
TEIGESTPEEPEPKIRTLDYLINATTLIIFTCSAQHASVNFPQASLMTFVPNMPLAGFNE
HHCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCC
GPTAEKASEADYFSLLPPLSLAEQQLDLGYTLGSVYYTQLGYYKANDVDLDDINDHTYFK
CCCCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCCCCCCHHHH
DLQVKQALRDFQQRLEEIELIIQDRNETRPTYYDILLPSKIPQSTNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]