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The map label for this gene is ubiE [H]

Identifier: 158336953

GI number: 158336953

Start: 3871836

End: 3872597

Strand: Reverse

Name: ubiE [H]

Synonym: AM1_3823

Alternate gene names: 158336953

Gene position: 3872597-3871836 (Counterclockwise)

Preceding gene: 158336955

Following gene: 158336950

Centisome position: 59.54

GC content: 50.66

Gene sequence:

>762_bases
TTGCCAGATCGTCATCGTTTTTCGTTCTCCATTGGTCAACGGTTGCCCCCCATGAGCCCCACTCCTCTATCCTCTGATAT
TCAAGACATTTTTAACCGCATTGCCCCTGTTTATGATGACCTGAATCAATGGTTGAGCTTGGGCCAGCACCGAATTTGGA
AAATGATGGCGGTCAAATGGGCCAATCCCAAACCGGGTGATCAGGGGTTGGATATTTGCTGTGGCAGTGGGGACTTAGCC
AGACTGTTAGCTCAAAAAGTCTCTCCGGGTAAAGTGACCGGAGTCGATTTTTCCTCAGAGCAATTAGCCGTTGCCGAGCA
ACGCAGCAAGACTCAATACCCCCATTTATCCTTGGACTGGGTGGAAGGGGATGCTCTAGAACTCCCGTTTGCCACCAACC
AGTTTGACTGCATCACCATGGGATATGGCCTGCGCAACGTCACCGATATTCCTCGATGTCTGGGTGAAATTTATCGTGTG
CTGAAGCCCAGTGCCCGGGTGGCGATTCTAGACTTTCATCAACCTCAACAAGCTTGGATCCAGCAGTTTCAAAATTGGTA
TTTGCAATCGGTGGTGGTGCCCGTGGCTCAACGCTATGGCCTCACGGATGAATATGCCTATATCACCCCCAGTCTAGAGC
GGTTTCCGCCTGGATCAGAGCAGGAAAGACTGGCAAAGGAAGCTGGATTAACTGAGGTGACCCACTACCCAATTGCAGGA
GGTTTAATGGGAGTATTAGTGGCCAGGAAACCGACGGTCTAA

Upstream 100 bases:

>100_bases
AGAGCCGATGGCAGGCCATTTGGGTTTGCGGATCATAAACGGTGAGTTCCCAGAGGGGATAGTCCTCAGTATTCTTAAGA
GGACGGCGATCAAAGTCTAC

Downstream 100 bases:

>100_bases
GGGTGATAATTGGCGCTGGGCCATAACTCGTTTATTTCTTCAGCTTGTTGGCCTGCGGTAAAGTGCTCCCAGGTAATACC
GTTCGTATCAACTTCTGCTG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MPDRHRFSFSIGQRLPPMSPTPLSSDIQDIFNRIAPVYDDLNQWLSLGQHRIWKMMAVKWANPKPGDQGLDICCGSGDLA
RLLAQKVSPGKVTGVDFSSEQLAVAEQRSKTQYPHLSLDWVEGDALELPFATNQFDCITMGYGLRNVTDIPRCLGEIYRV
LKPSARVAILDFHQPQQAWIQQFQNWYLQSVVVPVAQRYGLTDEYAYITPSLERFPPGSEQERLAKEAGLTEVTHYPIAG
GLMGVLVARKPTV

Sequences:

>Translated_253_residues
MPDRHRFSFSIGQRLPPMSPTPLSSDIQDIFNRIAPVYDDLNQWLSLGQHRIWKMMAVKWANPKPGDQGLDICCGSGDLA
RLLAQKVSPGKVTGVDFSSEQLAVAEQRSKTQYPHLSLDWVEGDALELPFATNQFDCITMGYGLRNVTDIPRCLGEIYRV
LKPSARVAILDFHQPQQAWIQQFQNWYLQSVVVPVAQRYGLTDEYAYITPSLERFPPGSEQERLAKEAGLTEVTHYPIAG
GLMGVLVARKPTV
>Mature_252_residues
PDRHRFSFSIGQRLPPMSPTPLSSDIQDIFNRIAPVYDDLNQWLSLGQHRIWKMMAVKWANPKPGDQGLDICCGSGDLAR
LLAQKVSPGKVTGVDFSSEQLAVAEQRSKTQYPHLSLDWVEGDALELPFATNQFDCITMGYGLRNVTDIPRCLGEIYRVL
KPSARVAILDFHQPQQAWIQQFQNWYLQSVVVPVAQRYGLTDEYAYITPSLERFPPGSEQERLAKEAGLTEVTHYPIAGG
LMGVLVARKPTV

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:
GO:0008168: Demethylmenaquinone methyltransferase
GO:0009234: Demethylmenaquinone methyltransferase
GO:0016740: Demethylmenaquinone methyltransferase
GO:0032259: Demethylmenaquinone methyltransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=267, Percent_Identity=30.3370786516854, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI48994983, Length=221, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557039, Length=230, Percent_Identity=29.1304347826087, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323526, Length=242, Percent_Identity=28.099173553719, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24641702, Length=234, Percent_Identity=29.9145299145299, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28415; Mature: 28284

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRHRFSFSIGQRLPPMSPTPLSSDIQDIFNRIAPVYDDLNQWLSLGQHRIWKMMAVKW
CCCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ANPKPGDQGLDICCGSGDLARLLAQKVSPGKVTGVDFSSEQLAVAEQRSKTQYPHLSLDW
CCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCCEEEE
VEGDALELPFATNQFDCITMGYGLRNVTDIPRCLGEIYRVLKPSARVAILDFHQPQQAWI
ECCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
QQFQNWYLQSVVVPVAQRYGLTDEYAYITPSLERFPPGSEQERLAKEAGLTEVTHYPIAG
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCHHHHHHHHCCCCHHHCCCHHH
GLMGVLVARKPTV
HHHHHHHHCCCCC
>Mature Secondary Structure 
PDRHRFSFSIGQRLPPMSPTPLSSDIQDIFNRIAPVYDDLNQWLSLGQHRIWKMMAVKW
CCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ANPKPGDQGLDICCGSGDLARLLAQKVSPGKVTGVDFSSEQLAVAEQRSKTQYPHLSLDW
CCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCCEEEE
VEGDALELPFATNQFDCITMGYGLRNVTDIPRCLGEIYRVLKPSARVAILDFHQPQQAWI
ECCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
QQFQNWYLQSVVVPVAQRYGLTDEYAYITPSLERFPPGSEQERLAKEAGLTEVTHYPIAG
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCHHHHHHHHCCCCHHHCCCHHH
GLMGVLVARKPTV
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA