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The map label for this gene is frdB [H]

Identifier: 158336799

GI number: 158336799

Start: 3723489

End: 3724538

Strand: Direct

Name: frdB [H]

Synonym: AM1_3667

Alternate gene names: 158336799

Gene position: 3723489-3724538 (Clockwise)

Preceding gene: 158336797

Following gene: 158336800

Centisome position: 57.25

GC content: 47.81

Gene sequence:

>1050_bases
ATGCAAGTTCTGTTCAAAATATCCCGTCAACAGCAACAAAGTGCAGTTAAAGTCCAGACGTATTCATTAGATGTAGATCC
GAGTACCACGATTCTGGACTGTTTGAATTTGATTAAATGGCAGCAGGATGGGTCTCTAGCCTTTCGAAAAAACTGTCGCA
ATACCATTTGTGGTAGCTGCAGTATGCGGATTAATCATCGGGCGGCTTTGGCCTGTCAACAGAATGTGAAAGCAGAAGTG
GCCCGTTCTTATTCAGCCTGGAACAAACAGAATGGTGCCGACTCAGATCGAGAAAATCCAGACTCAATTCCCGTGATAGA
AATTGCGCCTATGGGGAATATGCCAGTCATTAAAGACTTGGTTGTGGAAATGGATCAGTTTTGGCAAAAGTTGGACCAGG
TTGAACCTTATGTCAGTTCTGCCAGCCGACAAGTCCCTGAACGGGAGTTTCTCCAGTCTCCAGAAGATCGCAGCAAGCTT
GATCAAATGGGGAATTGTATTTTATGTGGGGCTTGTTATTCTGACTGTAATGCCCTCCCGGCAAATGGGTCTTTTGTGGG
TCCCCATGCGTTGGCAAAAGCCCACCGATTGTTAGCCGATACTCGTGATCAAGCGACGGAACATCGCCTTGAACAATATA
ACCAGGATATCCAAGGGGTCTGGGGTTGTACCCGTTGTTTTAATTGCAATACGGTATGCCCTATGGGTGTGGCTCCCCTG
GATCAGATCAGTAAAATCAAATCTCAGGTCCTGGCGAACCCAACTCTTCCTGACAGTCGCCCCCTGCGCCATCGGCGGGT
CTTGGTGGATTTAGTTCAAGAGGGGGGCTGGATCGATGAACGGAAATTTGGATTGAAAGTGGTGGGCAATAACTTTAAAG
ATTTGCCAGGGCTTTTTAGTCTGGTGCCTTTGGCTGGACAAATGCTCCGGCGTCAAAAACTGCCGATTAAATTTGATGCT
TCAACCGGGACAGATGAAGTGCGAGGGCTGATTGAGGCCGTTAAAAAGCGGCAGTCTAAGACGGCTTCTCAGAGCGAGTC
AACGCGCTAA

Upstream 100 bases:

>100_bases
TATACCTTTACTAAAGGTAATCTTTCTTTAGACTTTCCAGAAAACTCGACAAATATAACAGAAAAATTGATAATCTCTCA
AAGTTCTTAGGCATGAAATC

Downstream 100 bases:

>100_bases
TTCTGAATGAAGTCAGAATCAGACAGGGGGGATAGATACAGATTGCTAGGGTTTCTTCAGTGCGATCGCAAGGGAATTCC
GTTAAGATCCTGAAGTCCTT

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQVLFKISRQQQQSAVKVQTYSLDVDPSTTILDCLNLIKWQQDGSLAFRKNCRNTICGSCSMRINHRAALACQQNVKAEV
ARSYSAWNKQNGADSDRENPDSIPVIEIAPMGNMPVIKDLVVEMDQFWQKLDQVEPYVSSASRQVPEREFLQSPEDRSKL
DQMGNCILCGACYSDCNALPANGSFVGPHALAKAHRLLADTRDQATEHRLEQYNQDIQGVWGCTRCFNCNTVCPMGVAPL
DQISKIKSQVLANPTLPDSRPLRHRRVLVDLVQEGGWIDERKFGLKVVGNNFKDLPGLFSLVPLAGQMLRRQKLPIKFDA
STGTDEVRGLIEAVKKRQSKTASQSESTR

Sequences:

>Translated_349_residues
MQVLFKISRQQQQSAVKVQTYSLDVDPSTTILDCLNLIKWQQDGSLAFRKNCRNTICGSCSMRINHRAALACQQNVKAEV
ARSYSAWNKQNGADSDRENPDSIPVIEIAPMGNMPVIKDLVVEMDQFWQKLDQVEPYVSSASRQVPEREFLQSPEDRSKL
DQMGNCILCGACYSDCNALPANGSFVGPHALAKAHRLLADTRDQATEHRLEQYNQDIQGVWGCTRCFNCNTVCPMGVAPL
DQISKIKSQVLANPTLPDSRPLRHRRVLVDLVQEGGWIDERKFGLKVVGNNFKDLPGLFSLVPLAGQMLRRQKLPIKFDA
STGTDEVRGLIEAVKKRQSKTASQSESTR
>Mature_349_residues
MQVLFKISRQQQQSAVKVQTYSLDVDPSTTILDCLNLIKWQQDGSLAFRKNCRNTICGSCSMRINHRAALACQQNVKAEV
ARSYSAWNKQNGADSDRENPDSIPVIEIAPMGNMPVIKDLVVEMDQFWQKLDQVEPYVSSASRQVPEREFLQSPEDRSKL
DQMGNCILCGACYSDCNALPANGSFVGPHALAKAHRLLADTRDQATEHRLEQYNQDIQGVWGCTRCFNCNTVCPMGVAPL
DQISKIKSQVLANPTLPDSRPLRHRRVLVDLVQEGGWIDERKFGLKVVGNNFKDLPGLFSLVPLAGQMLRRQKLPIKFDA
STGTDEVRGLIEAVKKRQSKTASQSESTR

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=236, Percent_Identity=34.3220338983051, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786943, Length=256, Percent_Identity=35.546875, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=32.3144104803493, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17533915, Length=261, Percent_Identity=28.735632183908, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322987, Length=251, Percent_Identity=33.0677290836653, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137106, Length=251, Percent_Identity=31.4741035856574, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24643156, Length=247, Percent_Identity=31.9838056680162, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 39021; Mature: 39021

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLFKISRQQQQSAVKVQTYSLDVDPSTTILDCLNLIKWQQDGSLAFRKNCRNTICGSC
CCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCC
SMRINHRAALACQQNVKAEVARSYSAWNKQNGADSDRENPDSIPVIEIAPMGNMPVIKDL
CEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
VVEMDQFWQKLDQVEPYVSSASRQVPEREFLQSPEDRSKLDQMGNCILCGACYSDCNALP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCEEEEECHHHCCCCCC
ANGSFVGPHALAKAHRLLADTRDQATEHRLEQYNQDIQGVWGCTRCFNCNTVCPMGVAPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCH
DQISKIKSQVLANPTLPDSRPLRHRRVLVDLVQEGGWIDERKFGLKVVGNNFKDLPGLFS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHCCEEEECCCCCHHHHHHH
LVPLAGQMLRRQKLPIKFDASTGTDEVRGLIEAVKKRQSKTASQSESTR
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQVLFKISRQQQQSAVKVQTYSLDVDPSTTILDCLNLIKWQQDGSLAFRKNCRNTICGSC
CCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCC
SMRINHRAALACQQNVKAEVARSYSAWNKQNGADSDRENPDSIPVIEIAPMGNMPVIKDL
CEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
VVEMDQFWQKLDQVEPYVSSASRQVPEREFLQSPEDRSKLDQMGNCILCGACYSDCNALP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCEEEEECHHHCCCCCC
ANGSFVGPHALAKAHRLLADTRDQATEHRLEQYNQDIQGVWGCTRCFNCNTVCPMGVAPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCH
DQISKIKSQVLANPTLPDSRPLRHRRVLVDLVQEGGWIDERKFGLKVVGNNFKDLPGLFS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHCCEEEECCCCCHHHHHHH
LVPLAGQMLRRQKLPIKFDASTGTDEVRGLIEAVKKRQSKTASQSESTR
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]