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The map label for this gene is loxA [H]

Identifier: 158336696

GI number: 158336696

Start: 3606628

End: 3608640

Strand: Reverse

Name: loxA [H]

Synonym: AM1_3564

Alternate gene names: 158336696

Gene position: 3608640-3606628 (Counterclockwise)

Preceding gene: 158336702

Following gene: 158336695

Centisome position: 55.49

GC content: 51.32

Gene sequence:

>2013_bases
ATGACGCATCAGTACTCCCTCACTGGCCTGCCGACCCAAATCACACCTGTAGAAATTCAACAGGACAAACATCAACCCAC
TCTGGCCCCCACTCGTCCTAATCCGACCCAGCCGGAGCCTATCCCCGCAGCGCTAAAAGCAGCTCGACGCAAATATCAAT
ACAACTATAGTCACATTGCCCCTGTGGCCATGGTGGATCGCTTACCCAAAGAGGAACTCCCCTCTAGGGCTTGGTGGTCA
AAGTTGATCCGTACCATGTTCAAGATTCTCTCGAATGCCATTGTTGGCGCCCATAATCACCACCATGAGCATGAAGCAGA
GCAGCATGCTTCTCGCCTCATTCGCAAAACCTTGGTGGATATCTTGAGACAACGCCCCGAGGTGCGGTGGCGTCTCATCT
GGCATCTGCTGAAAACAGCGCCAACGACTTTGCTTAACGGTTTACGGTTGTCGTTTTCTGATGCCGAAAGCTTGCTGCAC
AGTTTAGCCGCCCATTTAGAGCATGATCTATTACGGATTCTGCACTTGAACTTAAAAGAACATCTAGCCCATGAATGTGG
ACAAGATCGCCCTACCTCAATAGCAGACTTTAATCAGCAGTTTGCAACGATTCCGTTACCGGAGTGTGCCGAATACTTTC
AAGAAGATGAGTTTTTTGCTTACTTGCGAGTAGCCGGTCCTAATCCTGTTTTGCTGCAACAAGTCCGCCATTTATCGGGA
GACATCCTCTGCTCTCATTTCCCAGTTACCAATCAGCATTATCAGACCGTAATGGGAGAAGACGATTCTCTGCAAATAGC
AATCACCGAAGGCCGTCTATACATCGCCGATTATGCTATTTTGGCTGGTGCGATCAATGGTAACTACCCCGATCAGCAAA
AATATATTTCGGCTCCCATCGCCCTTTTTGCCGTTCCCTCAGCTGATGCCCCCTGCCGAAATCTCCAGCCCATCGCTATT
CAATGCCGCCAATCTCCAGGGCCTGAAACACCGATTCTGACGCCGCCTACGGATCAGAATCCAGACCAAAAACAGGCCTG
GGACATGGCGAAGACCTGCGTGCAAGTTGCAGACAGCAATTACCATGAGGCCGTCACCCATTTGGGTCGAACCCATCTGT
TTATTAGCCCGTTTGTAATTGCCACCCATCGCCAACTACTGCCGTCTCATCCCGTGAGTGTCCTGCTTCGGCCTCACTTT
GAAGGCACCTTAAGTATCAACAACGGTGCTCAAAGCATGTTAATGGCGCCAGAAGGTGGAGTGGATACGGTCTTGGCTGC
CACTATCGACTGTGCCAGGGTCTTAGCCGTAAAGGGAGTACAAAGCTATTCCTTTAATCAGGCCATGCTGCCCCAACAAT
TGCGGCAACTGGGTTTGGATAATGCAGAGGCGCTTCCCATCCACCCCTATCGAGACGATGCATTGCTGATTTGGCAGGCC
ATCGAAACTTGGGTCACTGATTATGTGAGCTTGTACTACCCAACAGATGACTCCGTGCAAACAGATGCGGCCCTTCAGGC
TTGGGCGCAGGAGCTACAGGCTGAAGAGGGTGGCCGAGTCCCAGATTTTGGTGAGGATGGACAATTGCGAACCCAGGCCT
ACTTGATTCAAGCCCTCACGCTGATCATCTTTACCGCGAGTGCCCAACATGCCGCTGTGAATTTTCCCCAGGGCGACATC
ATGGTCTATACCCCAGGGATGCCATTAGCAGGCTACCAGCCCGCTCCCAACTCGACAGCTATGTCTTCCCAGGATCGGCT
CAACCAACTGCCCTCCTTACACCAGGCCTTAAATCAGCTGGAGTTAACGTATTTGCTCGGGCAGATTTACCATACGCAAC
TCGGTCAATACGAAAAGTCTTGGTTCTCTGATCAGCGAGTGCAAGCTCCGCTGCATCGGTTTCAAGCCAATTTACTGGAT
ATCGAAACTGCGATCGCAGAACGAAACCGCCATCGCCCCTACCCTTACCGCTACCTACAGCCGTCCAACATTCCCCAGAG
CATCAATATCTAA

Upstream 100 bases:

>100_bases
GAACACTAGAGCTGAATCGGTAGCTGCTACGGATTATCCCTACACCCCTGATCACAGGCAGTTGCCATTTACGTCAGAAC
ACACATAGACCGGATCAACA

Downstream 100 bases:

>100_bases
AGTCTACTCGCCATCAAAAATGCACTTGCCAACGCGATGGGCCCTGGCAGGTTACCTCGTGGCAACCGCAACCATTCAGC
ATAATCAGCATAAGAGGATA

Product: lipoxygenase

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MTHQYSLTGLPTQITPVEIQQDKHQPTLAPTRPNPTQPEPIPAALKAARRKYQYNYSHIAPVAMVDRLPKEELPSRAWWS
KLIRTMFKILSNAIVGAHNHHHEHEAEQHASRLIRKTLVDILRQRPEVRWRLIWHLLKTAPTTLLNGLRLSFSDAESLLH
SLAAHLEHDLLRILHLNLKEHLAHECGQDRPTSIADFNQQFATIPLPECAEYFQEDEFFAYLRVAGPNPVLLQQVRHLSG
DILCSHFPVTNQHYQTVMGEDDSLQIAITEGRLYIADYAILAGAINGNYPDQQKYISAPIALFAVPSADAPCRNLQPIAI
QCRQSPGPETPILTPPTDQNPDQKQAWDMAKTCVQVADSNYHEAVTHLGRTHLFISPFVIATHRQLLPSHPVSVLLRPHF
EGTLSINNGAQSMLMAPEGGVDTVLAATIDCARVLAVKGVQSYSFNQAMLPQQLRQLGLDNAEALPIHPYRDDALLIWQA
IETWVTDYVSLYYPTDDSVQTDAALQAWAQELQAEEGGRVPDFGEDGQLRTQAYLIQALTLIIFTASAQHAAVNFPQGDI
MVYTPGMPLAGYQPAPNSTAMSSQDRLNQLPSLHQALNQLELTYLLGQIYHTQLGQYEKSWFSDQRVQAPLHRFQANLLD
IETAIAERNRHRPYPYRYLQPSNIPQSINI

Sequences:

>Translated_670_residues
MTHQYSLTGLPTQITPVEIQQDKHQPTLAPTRPNPTQPEPIPAALKAARRKYQYNYSHIAPVAMVDRLPKEELPSRAWWS
KLIRTMFKILSNAIVGAHNHHHEHEAEQHASRLIRKTLVDILRQRPEVRWRLIWHLLKTAPTTLLNGLRLSFSDAESLLH
SLAAHLEHDLLRILHLNLKEHLAHECGQDRPTSIADFNQQFATIPLPECAEYFQEDEFFAYLRVAGPNPVLLQQVRHLSG
DILCSHFPVTNQHYQTVMGEDDSLQIAITEGRLYIADYAILAGAINGNYPDQQKYISAPIALFAVPSADAPCRNLQPIAI
QCRQSPGPETPILTPPTDQNPDQKQAWDMAKTCVQVADSNYHEAVTHLGRTHLFISPFVIATHRQLLPSHPVSVLLRPHF
EGTLSINNGAQSMLMAPEGGVDTVLAATIDCARVLAVKGVQSYSFNQAMLPQQLRQLGLDNAEALPIHPYRDDALLIWQA
IETWVTDYVSLYYPTDDSVQTDAALQAWAQELQAEEGGRVPDFGEDGQLRTQAYLIQALTLIIFTASAQHAAVNFPQGDI
MVYTPGMPLAGYQPAPNSTAMSSQDRLNQLPSLHQALNQLELTYLLGQIYHTQLGQYEKSWFSDQRVQAPLHRFQANLLD
IETAIAERNRHRPYPYRYLQPSNIPQSINI
>Mature_669_residues
THQYSLTGLPTQITPVEIQQDKHQPTLAPTRPNPTQPEPIPAALKAARRKYQYNYSHIAPVAMVDRLPKEELPSRAWWSK
LIRTMFKILSNAIVGAHNHHHEHEAEQHASRLIRKTLVDILRQRPEVRWRLIWHLLKTAPTTLLNGLRLSFSDAESLLHS
LAAHLEHDLLRILHLNLKEHLAHECGQDRPTSIADFNQQFATIPLPECAEYFQEDEFFAYLRVAGPNPVLLQQVRHLSGD
ILCSHFPVTNQHYQTVMGEDDSLQIAITEGRLYIADYAILAGAINGNYPDQQKYISAPIALFAVPSADAPCRNLQPIAIQ
CRQSPGPETPILTPPTDQNPDQKQAWDMAKTCVQVADSNYHEAVTHLGRTHLFISPFVIATHRQLLPSHPVSVLLRPHFE
GTLSINNGAQSMLMAPEGGVDTVLAATIDCARVLAVKGVQSYSFNQAMLPQQLRQLGLDNAEALPIHPYRDDALLIWQAI
ETWVTDYVSLYYPTDDSVQTDAALQAWAQELQAEEGGRVPDFGEDGQLRTQAYLIQALTLIIFTASAQHAAVNFPQGDIM
VYTPGMPLAGYQPAPNSTAMSSQDRLNQLPSLHQALNQLELTYLLGQIYHTQLGQYEKSWFSDQRVQAPLHRFQANLLDI
ETAIAERNRHRPYPYRYLQPSNIPQSINI

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI182765464, Length=464, Percent_Identity=36.6379310344828, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI260166612, Length=463, Percent_Identity=37.1490280777538, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI4502057, Length=506, Percent_Identity=31.6205533596838, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI85067501, Length=464, Percent_Identity=34.051724137931, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI4502053, Length=464, Percent_Identity=30.8189655172414, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI85067499, Length=464, Percent_Identity=31.6810344827586, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI40316937, Length=491, Percent_Identity=29.7352342158859, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI154426292, Length=486, Percent_Identity=28.6008230452675, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI85067503, Length=464, Percent_Identity=28.2327586206897, Blast_Score=154, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 75405; Mature: 75274

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00081 LIPOXYGENASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHQYSLTGLPTQITPVEIQQDKHQPTLAPTRPNPTQPEPIPAALKAARRKYQYNYSHIA
CCCCEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
PVAMVDRLPKEELPSRAWWSKLIRTMFKILSNAIVGAHNHHHEHEAEQHASRLIRKTLVD
HHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ILRQRPEVRWRLIWHLLKTAPTTLLNGLRLSFSDAESLLHSLAAHLEHDLLRILHLNLKE
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAHECGQDRPTSIADFNQQFATIPLPECAEYFQEDEFFAYLRVAGPNPVLLQQVRHLSG
HHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCC
DILCSHFPVTNQHYQTVMGEDDSLQIAITEGRLYIADYAILAGAINGNYPDQQKYISAPI
CEEEECCCCCCCHHHHHCCCCCCEEEEEECCEEEEEEHHHHHCCCCCCCCCHHHHHHCCE
ALFAVPSADAPCRNLQPIAIQCRQSPGPETPILTPPTDQNPDQKQAWDMAKTCVQVADSN
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCC
YHEAVTHLGRTHLFISPFVIATHRQLLPSHPVSVLLRPHFEGTLSINNGAQSMLMAPEGG
HHHHHHHCCCHHEEECHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCEEEECCCCC
VDTVLAATIDCARVLAVKGVQSYSFNQAMLPQQLRQLGLDNAEALPIHPYRDDALLIWQA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
IETWVTDYVSLYYPTDDSVQTDAALQAWAQELQAEEGGRVPDFGEDGQLRTQAYLIQALT
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LIIFTASAQHAAVNFPQGDIMVYTPGMPLAGYQPAPNSTAMSSQDRLNQLPSLHQALNQL
HHHHCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHH
ELTYLLGQIYHTQLGQYEKSWFSDQRVQAPLHRFQANLLDIETAIAERNRHRPYPYRYLQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PSNIPQSINI
CCCCCCCCCC
>Mature Secondary Structure 
THQYSLTGLPTQITPVEIQQDKHQPTLAPTRPNPTQPEPIPAALKAARRKYQYNYSHIA
CCCEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
PVAMVDRLPKEELPSRAWWSKLIRTMFKILSNAIVGAHNHHHEHEAEQHASRLIRKTLVD
HHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ILRQRPEVRWRLIWHLLKTAPTTLLNGLRLSFSDAESLLHSLAAHLEHDLLRILHLNLKE
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAHECGQDRPTSIADFNQQFATIPLPECAEYFQEDEFFAYLRVAGPNPVLLQQVRHLSG
HHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCC
DILCSHFPVTNQHYQTVMGEDDSLQIAITEGRLYIADYAILAGAINGNYPDQQKYISAPI
CEEEECCCCCCCHHHHHCCCCCCEEEEEECCEEEEEEHHHHHCCCCCCCCCHHHHHHCCE
ALFAVPSADAPCRNLQPIAIQCRQSPGPETPILTPPTDQNPDQKQAWDMAKTCVQVADSN
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCC
YHEAVTHLGRTHLFISPFVIATHRQLLPSHPVSVLLRPHFEGTLSINNGAQSMLMAPEGG
HHHHHHHCCCHHEEECHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCEEEECCCCC
VDTVLAATIDCARVLAVKGVQSYSFNQAMLPQQLRQLGLDNAEALPIHPYRDDALLIWQA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
IETWVTDYVSLYYPTDDSVQTDAALQAWAQELQAEEGGRVPDFGEDGQLRTQAYLIQALT
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LIIFTASAQHAAVNFPQGDIMVYTPGMPLAGYQPAPNSTAMSSQDRLNQLPSLHQALNQL
HHHHCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHH
ELTYLLGQIYHTQLGQYEKSWFSDQRVQAPLHRFQANLLDIETAIAERNRHRPYPYRYLQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PSNIPQSINI
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]