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The map label for this gene is clpP [H]

Identifier: 158336585

GI number: 158336585

Start: 3479141

End: 3479857

Strand: Direct

Name: clpP [H]

Synonym: AM1_3449

Alternate gene names: 158336585

Gene position: 3479141-3479857 (Clockwise)

Preceding gene: 158336584

Following gene: 158336586

Centisome position: 53.49

GC content: 46.16

Gene sequence:

>717_bases
ATGATCTTGTCTCATTCTTCTGATCACTTCTATCCTGGTCTGTCTGGTGAGTCCAGTCCTACCTATATGCCGCCTCGCAA
TATCGTACCGATGGTTGTTGAACAGTCTGGTCGAGGCGAGCGGGCGTTTGATATATACTCTCGCTTACTCCGTGAGCGAA
TTGTCTTCTTAGGTGGAGGTGGCTCTGCCAATGGGGGCGGCATTGATGATGCTGTTGCGGATGCAATTGTGGCTCAGCTC
CTGTTTCTAGAATCAGAAAACCCCGAACAGGATATTTACCTTTACATTAATTCACCTGGCGGTTCGATCACGGCAGGAAT
GGCTATTTACGACACCATTCAGCATATTCGCCCCGATGTTTGTACCATTTGTTTTGGTTTAGCAGCTAGTATGGGTGCGT
TCCTTTTATGTGCAGGTACTGCAGGCAAACGAATGGCATTGCCAAATGCGCGAATTATGATCCATCAGCCTTTGGGCGGT
GCTCAAGGTCAAGCGGTAGATATTGAAATTCGAGCTAAAGAAATTTTGTACCTCAAAAACAATCTTAATCATCTTATGGC
AGGCCATACAGGGCAGCCGTTTGAGCGGATTGAAGCAGACACCGAGAGAGATTTCTTTATGTCTGCAGAAGAGGCACAAA
AATATGGTTTGATTGATCAAGTCCTCACTAGACAAAATCTTCCTAACCACTCTGAAGCCGTCAGTGAAGTCCACTAA

Upstream 100 bases:

>100_bases
CATAATATAACTGGTTGACAAGGTGAAAGGGTAATCGCCTTAGATCCCTACACCTAGATATCGCTAATACTACCCATTGA
TACGATTAACGTTGAGGTCC

Downstream 100 bases:

>100_bases
GAGAAAGCCATGTCTAAATATGACTCCCATCTCAAATGTTCATTTTGTGGTAAATCTCAAGAACAGGTCCGCAAATTAAT
TGCTGGGCCGGGGGTCTATA

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MILSHSSDHFYPGLSGESSPTYMPPRNIVPMVVEQSGRGERAFDIYSRLLRERIVFLGGGGSANGGGIDDAVADAIVAQL
LFLESENPEQDIYLYINSPGGSITAGMAIYDTIQHIRPDVCTICFGLAASMGAFLLCAGTAGKRMALPNARIMIHQPLGG
AQGQAVDIEIRAKEILYLKNNLNHLMAGHTGQPFERIEADTERDFFMSAEEAQKYGLIDQVLTRQNLPNHSEAVSEVH

Sequences:

>Translated_238_residues
MILSHSSDHFYPGLSGESSPTYMPPRNIVPMVVEQSGRGERAFDIYSRLLRERIVFLGGGGSANGGGIDDAVADAIVAQL
LFLESENPEQDIYLYINSPGGSITAGMAIYDTIQHIRPDVCTICFGLAASMGAFLLCAGTAGKRMALPNARIMIHQPLGG
AQGQAVDIEIRAKEILYLKNNLNHLMAGHTGQPFERIEADTERDFFMSAEEAQKYGLIDQVLTRQNLPNHSEAVSEVH
>Mature_238_residues
MILSHSSDHFYPGLSGESSPTYMPPRNIVPMVVEQSGRGERAFDIYSRLLRERIVFLGGGGSANGGGIDDAVADAIVAQL
LFLESENPEQDIYLYINSPGGSITAGMAIYDTIQHIRPDVCTICFGLAASMGAFLLCAGTAGKRMALPNARIMIHQPLGG
AQGQAVDIEIRAKEILYLKNNLNHLMAGHTGQPFERIEADTERDFFMSAEEAQKYGLIDQVLTRQNLPNHSEAVSEVH

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=58.1632653061224, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1786641, Length=212, Percent_Identity=64.622641509434, Blast_Score=280, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=195, Percent_Identity=55.8974358974359, Blast_Score=220, Evalue=5e-58,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=55.6122448979592, Blast_Score=227, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25878; Mature: 25878

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSHSSDHFYPGLSGESSPTYMPPRNIVPMVVEQSGRGERAFDIYSRLLRERIVFLGGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEECC
GSANGGGIDDAVADAIVAQLLFLESENPEQDIYLYINSPGGSITAGMAIYDTIQHIRPDV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCHHH
CTICFGLAASMGAFLLCAGTAGKRMALPNARIMIHQPLGGAQGQAVDIEIRAKEILYLKN
HHHHHHHHHHHCEEEEEECCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECEEEEEECC
NLNHLMAGHTGQPFERIEADTERDFFMSAEEAQKYGLIDQVLTRQNLPNHSEAVSEVH
CCHHHHCCCCCCCHHHHHCCCCHHHHHCHHHHHHHCHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MILSHSSDHFYPGLSGESSPTYMPPRNIVPMVVEQSGRGERAFDIYSRLLRERIVFLGGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEECC
GSANGGGIDDAVADAIVAQLLFLESENPEQDIYLYINSPGGSITAGMAIYDTIQHIRPDV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCHHH
CTICFGLAASMGAFLLCAGTAGKRMALPNARIMIHQPLGGAQGQAVDIEIRAKEILYLKN
HHHHHHHHHHHCEEEEEECCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECEEEEEECC
NLNHLMAGHTGQPFERIEADTERDFFMSAEEAQKYGLIDQVLTRQNLPNHSEAVSEVH
CCHHHHCCCCCCCHHHHHCCCCHHHHHCHHHHHHHCHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]