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The map label for this gene is xseA

Identifier: 158336480

GI number: 158336480

Start: 3376109

End: 3377365

Strand: Reverse

Name: xseA

Synonym: AM1_3344

Alternate gene names: 158336480

Gene position: 3377365-3376109 (Counterclockwise)

Preceding gene: 158336481

Following gene: 158336479

Centisome position: 51.93

GC content: 51.79

Gene sequence:

>1257_bases
ATGACATCTTATCAACCCAATTTATTAGTTCCACCGGAAGTTTTGTCCGTTAAAGGGTTAACGGACTATATTCAGACACT
GCTAGAAGATGATTCATATTTAGTTCAAGTTTGGGTCGAAGGCGAGGTCTCCAGTGCAGCCCGGCATCGCAGTGGCTTCT
TCTTTACCCTCCAAGATCAGCAAGAAGCTGCCTCTATTCACTGTGTGATTTGGAATAGCTACTGTGACCAGCTCGTCATC
GAACCAGAGGTAGGTGAGCAGATTCTGGCGTTAGGCCGTATTCGCGTGTACCCTCAACGGGGCCAGTATCAGCTGATGGC
CTGGCAATTATTTCCCGCCGGGGAAGGATTACGCTCCCTGCGCTACCAGCAGCTCCGAGAACGCTTAACCCGTGAAGGTC
TATTCGACCCTCTCCAAAAGCAAGCCCTCCCGACCTACCCCCAAACGGTTGGGGTGGTCACATCTCATCAAGCTGCGGCT
TGGGGCGATATTAAACGCACTCTGAAGGCTCAGCATCCTGGGTTAAAGGTGCTGTTCTCTCCCACCAAAGTGCAGGGTAA
ACAAGCGCCAGAAGCGATCGTGCTGGCCATTGAACGGGTGATTAAAGACGGCAGAGCCGAGGTCTTGATTGTGGCCCGAG
GCGGAGGCGCAACCGAAGACTTAGCTTGTTTCAATGATGAGCGGGTGGTGCGGGCCATTGCAGAATGCCCCATTCCAGTC
ATTTCTGGCATTGGTCATCAACGAGATGAGACCCTAGCTGATCTGGTGGCCGATGTATGTGCCCATACCCCGACAGCCGC
CGCTGAGTGCATTCCCCGTCTAACAGACTGGCAAACAGACTATCGCAATTGTATTGCCCGACTCTACATTATTCTCACGC
GCCAGCTCGATGTTGCCCATGAGCATTTGCTGTATCAAAAAACGCGCCTACGGCGGCTGCAGATAGATCGTCAGTTTGAA
CGGGAACAGGTATTGCGATCGCGACTGCAAAACCACCTTCTCCACGCCATTAAACATCGATTAGGGCAGGCTCAGCAACA
TCAACAGCTTTTACAGCAACAGCTCACTTCTCTAGACCCCACCCAAGTGCTTAAACGGGGATATGCTCTCGTCCAAACCA
CCGACCAGCAAATTGTTCGAAGTACACAACAGTTACAAGTCGATCAAGAACTCAAGGTAGAGTTAGCAGAAGGCCACTTT
ACTGCTCGCGTCACGGCATTGCAGTCTTCACCCCAGGAAGCGGATGATGAAAGGTAA

Upstream 100 bases:

>100_bases
CAAGCCTGGCGGTTAGTTTAGGCCAGATGTCATGGGTCTAACAGGCTAGAAGGCTAGATAGCCTGCTTTATAGTTCTATC
GACGGAACGCGAAACCTGCG

Downstream 100 bases:

>100_bases
CAGCGATACATCGACGGCTCCCAGCGGAGTTGAACTTCCCCAAGACTGGCGGTATGAAGAGACTATCCGCGAAGTCGAAA
CCATCATTACGGAAATTGAG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQQEAASIHCVIWNSYCDQLVI
EPEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSLRYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAA
WGDIKRTLKAQHPGLKVLFSPTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPV
ISGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAHEHLLYQKTRLRRLQIDRQFE
REQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDPTQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHF
TARVTALQSSPQEADDER

Sequences:

>Translated_418_residues
MTSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQQEAASIHCVIWNSYCDQLVI
EPEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSLRYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAA
WGDIKRTLKAQHPGLKVLFSPTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPV
ISGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAHEHLLYQKTRLRRLQIDRQFE
REQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDPTQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHF
TARVTALQSSPQEADDER
>Mature_417_residues
TSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQQEAASIHCVIWNSYCDQLVIE
PEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSLRYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAAW
GDIKRTLKAQHPGLKVLFSPTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPVI
SGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAHEHLLYQKTRLRRLQIDRQFER
EQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDPTQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHFT
ARVTALQSSPQEADDER

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:
GO:0003676: Exodeoxyribonuclease 7 large subunit
GO:0004518: Exodeoxyribonuclease 7 large subunit
GO:0004527: Exodeoxyribonuclease 7 large subunit
GO:0005737: Exodeoxyribonuclease 7 large subunit
GO:0006308: Exodeoxyribonuclease 7 large subunit
GO:0008855: Exodeoxyribonuclease 7 large subunit
GO:0009318: Exodeoxyribonuclease 7 large subunit
GO:0016787: Exodeoxyribonuclease 7 large subunit

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=451, Percent_Identity=34.8115299334812, Blast_Score=225, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_ACAM1 (B0BZ38)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517654.1
- GeneID:   5682152
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3344
- HOGENOM:   HBG634411
- OMA:   THQTAYL
- ProtClustDB:   PRK00286
- BioCyc:   AMAR329726:AM1_3344-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47405; Mature: 47274

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQ
CCCCCCCEECCHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEECCC
QEAASIHCVIWNSYCDQLVIEPEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSL
CCCCEEEEEEECCHHCCEEECCHHHHHHHHHHHEEEECCCCCEEEEEEEECCCCCHHHHH
RYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAAWGDIKRTLKAQHPGLKVLFS
HHHHHHHHHHHCCCCCHHHHHCCCCCCCHHCEEECCCHHHHHHHHHHHHHCCCCCEEEEC
PTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPV
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHCCCHH
ISGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAH
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
EHLLYQKTRLRRLQIDRQFEREQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCH
TQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHFTARVTALQSSPQEADDER
HHHHHCCCCEEEECHHHHHHHHHHHCCCHHHHHEECCCCEEEEEEEHHCCCCCCCCCC
>Mature Secondary Structure 
TSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQ
CCCCCCEECCHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEECCC
QEAASIHCVIWNSYCDQLVIEPEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSL
CCCCEEEEEEECCHHCCEEECCHHHHHHHHHHHEEEECCCCCEEEEEEEECCCCCHHHHH
RYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAAWGDIKRTLKAQHPGLKVLFS
HHHHHHHHHHHCCCCCHHHHHCCCCCCCHHCEEECCCHHHHHHHHHHHHHCCCCCEEEEC
PTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPV
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHCCCHH
ISGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAH
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
EHLLYQKTRLRRLQIDRQFEREQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCH
TQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHFTARVTALQSSPQEADDER
HHHHHCCCCEEEECHHHHHHHHHHHCCCHHHHHEECCCCEEEEEEEHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA