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The map label for this gene is gyrA [H]

Identifier: 158336251

GI number: 158336251

Start: 3141716

End: 3144331

Strand: Reverse

Name: gyrA [H]

Synonym: AM1_3113

Alternate gene names: 158336251

Gene position: 3144331-3141716 (Counterclockwise)

Preceding gene: 158336255

Following gene: 158336250

Centisome position: 48.35

GC content: 50.69

Gene sequence:

>2616_bases
ATGACCTTCTCCTCTGATCCAGCGCAGGACCGCATTATTCTCACAGATCTACGGGATGAGATGTCGCGCTCCTACCTGGA
ATACGCCATGAGCGTCATTGTTGGTCGGGCCTTGCCAGATGCTAGAGATGGCCTCAAACCCGTGCATCGACGTATCTTAT
ACGCCATGTATGAGTTGGGTTTAACCCCTGATCGCCCCTTCCGGAAATGCGCTCGTGTGGTTGGGGAAGTATTGGGTAAA
TATCATCCCCATGGTGATACGGCGGTATATGACGCCTTAGTACGCATGGCGCAGGACTTCTCCATGCGCATGCCTCTGAT
TAATGGCCATGGAAACTTTGGATCGATTGATAACGATCCACCTGCGGCCATGCGATATACAGAATGTCGCTTACAGGCCC
TCAGTACGGACTCGCTTCTACCCGATATTGAGCAAGAAACCGTTGACTTTGGCGATAACTTTGATGGGTCACAACAAGAA
CCTCTCGTTCTGCCTGCTCGCATCCCTCAACTTTTAATCAACGGATCTTCAGGGATTGCGGTGGGAATGGCAACCAATAT
TCCTCCCCATAATCTGGGAGAAGTCATTGATGGCCTAGTGGCTCTCATTCATAATCCTGAGATTACCGATCTGGAGTTGA
TGAAAATCATTCCAGGTCCCGATTTCCCCACAGGGGGCCGGATTTTAGGAACAGCTGGTATTCGTGAAGCCTATACCACC
GGCCGTGGCTCCATCACCATGCGTGGGGTGGCTGAGATTGAAACCTTAGAACAATCTGGGCGTCCTGATCGGGAAGCCAT
TATCATCACAGAGCTACCGTTTCAAACCAATAAAGCTGCCCTGATTGAGCGAATTGCCGAAAACGTCAATGACAAGCGCT
TAGAAGGCATTTCAGATATTCGCGATGAAAGCGATCGCGACGGGATGCGGATTGTGATTGAACTGAAGCGGGATGCTTAT
CCCCAGGTGGTTCTTAACAATCTTTATAAACAAACCCCCATCCAAACGAATTTTGGGGCCAATATGTTGGCGCTAGTGGG
CGGCGATCCGCAGCTTCTCACCCTAAGGCAGTTCCTGAGCGTCTTTTTGGAGTTCCGGGAAGATGCAATCTTGCGCCGCA
CTCGTTTCCAGCTGCGCAAAGCCCAAGAACGCGATCACCTGTTACAGGGATTACTCATTGCTTTAGACAATCTAGATGCA
GTCATTCAGCTCATTCGCCAAGCGGCAGATTCTGCAGTAGCTCGTCAAGAACTGATGGATGGATTTGGGCTATCTGATAC
CCAGGCCGATGCCATTCTGCAAATGCAGCTTCGCCGACTCACTGCTTTAGAAGCTGAAAAAATCGAGCGAGAGCATCAAG
ATTTACAAGAGCGAATCGCTGATCTAGAAGATATTCTGGCCCGTCGCGAGCGAGTGCTAGAAATTATCGAAACGGAAGTC
ACCGAACTTAAAACCAAGTTTGCCAGCCCCCGTCGCACCTTAATTGAGGCTAATCTAGCAGACCTAGACGATATTGACCT
GATTGCCAACGATCAGGCCGTGATTTTGGTGACAGAACAGGGCTACGTGAAGCGGATGCCTGTGGATACCTTTAATGCTC
AAAGCCGAGCCACTCGAGGTCGAGCCGGGGCCAAAATTAAAGAAGATGATGCGGTAGAGCATTTCTTTGGCTGCTGCGAC
CATGACAGTGTGTTATTTTTTAGCGATCGCGGCGTCGTATACTGCCTGCGTGCCTATCAAATCCCCGTCAGTTCCCGCAC
AGCCAGGGGTGTGCCTTTAGTGCAGCTCTTACCCATTCCGCGAGAAGAAAAAATTACCTCCGTCATCCCCGTCAGCGAAT
TTAGTGAAGACGAATATCTAGTTATGATGACTGCTGGCGGCTTTATCAAGAAAACTGCTCTAGCGGCCTTCAGCAATATT
CGGGCCAATGGCCTAATTGCCATTTCCCTAGAAGAAGGAGATTTACTGCGCTGGGTGCGGTTAACCCGAGCAGAAGACAG
TATCGTCATTGGCTCTCGCCGAGGCATGTCCATCCATTTCCGGGCGGATCATCAACAGCTTCGGCCCTTAGGACGAGCTA
CGCGAGGGGTACGGGCCATGCGTCTGCGGGAAGGCGATGAATTTATCGGTATGGACATCCTATCGAGTGCCGTTGTAGAG
ACATTAGGCAACGCAACGGATGCAGACGATGAAGAGACGGATGATCCAGATGTTTTGGTCGAGGACGACGGCAATGAAGA
AGAATCTGAAACCGTTGAACAGCCCGGACCTTGGGTCTTAGTCATTACCACCAATGGCTTTGGTAAGCGGGTGCCTGTGG
CTCAATTCAGGCTGCAAAATCGGGCCGGTAAAGGGGTCACCGCTACCAAGTTCAAAAAGCTGAAGACGCCCGATCAGTTA
GCCGCACTTCGGATCGTCAATGCTGAAGATGAGTTGATGTTGGTCACTAGCCGAGGCATTGTGATTCGACAAGCGGTAAC
AGATATTTCATCCCAGTCTCGCGCAGCTACTGGCGTCCGAGTCCAACGATTGGATGAAGATGACTATATTGCGGCAGTTG
CGCTAGTCCCCCCCGAGGATCTCTCTGATGAGGAAGGTGAAACTGAATTAGAGTAA

Upstream 100 bases:

>100_bases
CGGGGGTAAATAGCTTAATTTTTTAATGATATTAATGGTAAGTCGTTATTGATCAAGCTATTTCTCAACTAAGCATCTTT
TTAGGAGTTTTTCAAACCAT

Downstream 100 bases:

>100_bases
TTCACAGGAAACAATGCCATCTAAGAATCTGTTCCTCAGTGCCGCTCTTGATCCGTAGATGCTAAAGCCCGTAACAAAAC
AACACTGTTACGAATACCGT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 871; Mature: 870

Protein sequence:

>871_residues
MTFSSDPAQDRIILTDLRDEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGK
YHPHGDTAVYDALVRMAQDFSMRMPLINGHGNFGSIDNDPPAAMRYTECRLQALSTDSLLPDIEQETVDFGDNFDGSQQE
PLVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGLVALIHNPEITDLELMKIIPGPDFPTGGRILGTAGIREAYTT
GRGSITMRGVAEIETLEQSGRPDREAIIITELPFQTNKAALIERIAENVNDKRLEGISDIRDESDRDGMRIVIELKRDAY
PQVVLNNLYKQTPIQTNFGANMLALVGGDPQLLTLRQFLSVFLEFREDAILRRTRFQLRKAQERDHLLQGLLIALDNLDA
VIQLIRQAADSAVARQELMDGFGLSDTQADAILQMQLRRLTALEAEKIEREHQDLQERIADLEDILARRERVLEIIETEV
TELKTKFASPRRTLIEANLADLDDIDLIANDQAVILVTEQGYVKRMPVDTFNAQSRATRGRAGAKIKEDDAVEHFFGCCD
HDSVLFFSDRGVVYCLRAYQIPVSSRTARGVPLVQLLPIPREEKITSVIPVSEFSEDEYLVMMTAGGFIKKTALAAFSNI
RANGLIAISLEEGDLLRWVRLTRAEDSIVIGSRRGMSIHFRADHQQLRPLGRATRGVRAMRLREGDEFIGMDILSSAVVE
TLGNATDADDEETDDPDVLVEDDGNEEESETVEQPGPWVLVITTNGFGKRVPVAQFRLQNRAGKGVTATKFKKLKTPDQL
AALRIVNAEDELMLVTSRGIVIRQAVTDISSQSRAATGVRVQRLDEDDYIAAVALVPPEDLSDEEGETELE

Sequences:

>Translated_871_residues
MTFSSDPAQDRIILTDLRDEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGK
YHPHGDTAVYDALVRMAQDFSMRMPLINGHGNFGSIDNDPPAAMRYTECRLQALSTDSLLPDIEQETVDFGDNFDGSQQE
PLVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGLVALIHNPEITDLELMKIIPGPDFPTGGRILGTAGIREAYTT
GRGSITMRGVAEIETLEQSGRPDREAIIITELPFQTNKAALIERIAENVNDKRLEGISDIRDESDRDGMRIVIELKRDAY
PQVVLNNLYKQTPIQTNFGANMLALVGGDPQLLTLRQFLSVFLEFREDAILRRTRFQLRKAQERDHLLQGLLIALDNLDA
VIQLIRQAADSAVARQELMDGFGLSDTQADAILQMQLRRLTALEAEKIEREHQDLQERIADLEDILARRERVLEIIETEV
TELKTKFASPRRTLIEANLADLDDIDLIANDQAVILVTEQGYVKRMPVDTFNAQSRATRGRAGAKIKEDDAVEHFFGCCD
HDSVLFFSDRGVVYCLRAYQIPVSSRTARGVPLVQLLPIPREEKITSVIPVSEFSEDEYLVMMTAGGFIKKTALAAFSNI
RANGLIAISLEEGDLLRWVRLTRAEDSIVIGSRRGMSIHFRADHQQLRPLGRATRGVRAMRLREGDEFIGMDILSSAVVE
TLGNATDADDEETDDPDVLVEDDGNEEESETVEQPGPWVLVITTNGFGKRVPVAQFRLQNRAGKGVTATKFKKLKTPDQL
AALRIVNAEDELMLVTSRGIVIRQAVTDISSQSRAATGVRVQRLDEDDYIAAVALVPPEDLSDEEGETELE
>Mature_870_residues
TFSSDPAQDRIILTDLRDEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKY
HPHGDTAVYDALVRMAQDFSMRMPLINGHGNFGSIDNDPPAAMRYTECRLQALSTDSLLPDIEQETVDFGDNFDGSQQEP
LVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGLVALIHNPEITDLELMKIIPGPDFPTGGRILGTAGIREAYTTG
RGSITMRGVAEIETLEQSGRPDREAIIITELPFQTNKAALIERIAENVNDKRLEGISDIRDESDRDGMRIVIELKRDAYP
QVVLNNLYKQTPIQTNFGANMLALVGGDPQLLTLRQFLSVFLEFREDAILRRTRFQLRKAQERDHLLQGLLIALDNLDAV
IQLIRQAADSAVARQELMDGFGLSDTQADAILQMQLRRLTALEAEKIEREHQDLQERIADLEDILARRERVLEIIETEVT
ELKTKFASPRRTLIEANLADLDDIDLIANDQAVILVTEQGYVKRMPVDTFNAQSRATRGRAGAKIKEDDAVEHFFGCCDH
DSVLFFSDRGVVYCLRAYQIPVSSRTARGVPLVQLLPIPREEKITSVIPVSEFSEDEYLVMMTAGGFIKKTALAAFSNIR
ANGLIAISLEEGDLLRWVRLTRAEDSIVIGSRRGMSIHFRADHQQLRPLGRATRGVRAMRLREGDEFIGMDILSSAVVET
LGNATDADDEETDDPDVLVEDDGNEEESETVEQPGPWVLVITTNGFGKRVPVAQFRLQNRAGKGVTATKFKKLKTPDQLA
ALRIVNAEDELMLVTSRGIVIRQAVTDISSQSRAATGVRVQRLDEDDYIAAVALVPPEDLSDEEGETELE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:
GO:0000166: DNA gyrase, A subunit
GO:0003677: DNA gyrase, A subunit
GO:0003916: DNA gyrase, A subunit
GO:0003918: DNA gyrase, A subunit
GO:0005524: DNA gyrase, A subunit
GO:0005694: DNA gyrase, A subunit
GO:0006259: DNA gyrase, A subunit
GO:0006265: DNA gyrase, A subunit
GO:0006355: DNA gyrase, A subunit
GO:0016853: DNA gyrase, A subunit
GO:0005737: DNA gyrase, A subunit

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=355, Percent_Identity=26.4788732394366, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI19913406, Length=355, Percent_Identity=25.3521126760563, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1788562, Length=886, Percent_Identity=44.1309255079007, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=614, Percent_Identity=38.599348534202, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=291, Percent_Identity=25.4295532646048, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=388, Percent_Identity=24.7422680412371, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136538, Length=391, Percent_Identity=22.7621483375959, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96880; Mature: 96748

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSSDPAQDRIILTDLRDEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELG
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHC
LTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLINGHGNFGSIDNDP
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
PAAMRYTECRLQALSTDSLLPDIEQETVDFGDNFDGSQQEPLVLPARIPQLLINGSSGIA
CCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCEEECCCCEE
VGMATNIPPHNLGEVIDGLVALIHNPEITDLELMKIIPGPDFPTGGRILGTAGIREAYTT
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHC
GRGSITMRGVAEIETLEQSGRPDREAIIITELPFQTNKAALIERIAENVNDKRLEGISDI
CCCCEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHCHHHH
RDESDRDGMRIVIELKRDAYPQVVLNNLYKQTPIQTNFGANMLALVGGDPQLLTLRQFLS
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHH
VFLEFREDAILRRTRFQLRKAQERDHLLQGLLIALDNLDAVIQLIRQAADSAVARQELMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GFGLSDTQADAILQMQLRRLTALEAEKIEREHQDLQERIADLEDILARRERVLEIIETEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELKTKFASPRRTLIEANLADLDDIDLIANDQAVILVTEQGYVKRMPVDTFNAQSRATRG
HHHHHHHCCCCHHEEECCCCCCCCCEEEECCCEEEEEECCCCEEECCCCCCCCHHHHCCC
RAGAKIKEDDAVEHFFGCCDHDSVLFFSDRGVVYCLRAYQIPVSSRTARGVPLVQLLPIP
CCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEECCC
REEKITSVIPVSEFSEDEYLVMMTAGGFIKKTALAAFSNIRANGLIAISLEEGDLLRWVR
CHHCHHEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
LTRAEDSIVIGSRRGMSIHFRADHQQLRPLGRATRGVRAMRLREGDEFIGMDILSSAVVE
HHCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TLGNATDADDEETDDPDVLVEDDGNEEESETVEQPGPWVLVITTNGFGKRVPVAQFRLQN
HHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHH
RAGKGVTATKFKKLKTPDQLAALRIVNAEDELMLVTSRGIVIRQAVTDISSQSRAATGVR
CCCCCCCHHHHHHCCCCHHHEEEEEECCCCCEEEEECCCEEEHHHHHHHHHCCHHHCCCE
VQRLDEDDYIAAVALVPPEDLSDEEGETELE
EEECCCCCEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TFSSDPAQDRIILTDLRDEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELG
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHC
LTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLINGHGNFGSIDNDP
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
PAAMRYTECRLQALSTDSLLPDIEQETVDFGDNFDGSQQEPLVLPARIPQLLINGSSGIA
CCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCEEECCCCEE
VGMATNIPPHNLGEVIDGLVALIHNPEITDLELMKIIPGPDFPTGGRILGTAGIREAYTT
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHC
GRGSITMRGVAEIETLEQSGRPDREAIIITELPFQTNKAALIERIAENVNDKRLEGISDI
CCCCEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHCHHHH
RDESDRDGMRIVIELKRDAYPQVVLNNLYKQTPIQTNFGANMLALVGGDPQLLTLRQFLS
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHH
VFLEFREDAILRRTRFQLRKAQERDHLLQGLLIALDNLDAVIQLIRQAADSAVARQELMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GFGLSDTQADAILQMQLRRLTALEAEKIEREHQDLQERIADLEDILARRERVLEIIETEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELKTKFASPRRTLIEANLADLDDIDLIANDQAVILVTEQGYVKRMPVDTFNAQSRATRG
HHHHHHHCCCCHHEEECCCCCCCCCEEEECCCEEEEEECCCCEEECCCCCCCCHHHHCCC
RAGAKIKEDDAVEHFFGCCDHDSVLFFSDRGVVYCLRAYQIPVSSRTARGVPLVQLLPIP
CCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEECCC
REEKITSVIPVSEFSEDEYLVMMTAGGFIKKTALAAFSNIRANGLIAISLEEGDLLRWVR
CHHCHHEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
LTRAEDSIVIGSRRGMSIHFRADHQQLRPLGRATRGVRAMRLREGDEFIGMDILSSAVVE
HHCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TLGNATDADDEETDDPDVLVEDDGNEEESETVEQPGPWVLVITTNGFGKRVPVAQFRLQN
HHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHH
RAGKGVTATKFKKLKTPDQLAALRIVNAEDELMLVTSRGIVIRQAVTDISSQSRAATGVR
CCCCCCCHHHHHHCCCCHHHEEEEEECCCCCEEEEECCCEEEHHHHHHHHHCCHHHCCCE
VQRLDEDDYIAAVALVPPEDLSDEEGETELE
EEECCCCCEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]