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The map label for this gene is yciC [H]

Identifier: 158336195

GI number: 158336195

Start: 3079450

End: 3080424

Strand: Direct

Name: yciC [H]

Synonym: AM1_3057

Alternate gene names: 158336195

Gene position: 3079450-3080424 (Clockwise)

Preceding gene: 158336194

Following gene: 158336196

Centisome position: 47.35

GC content: 49.33

Gene sequence:

>975_bases
ATGCTTCCCGTCCCTGGACTCTTTGAATACCGTCTGCCCGTCACCCTGATCACGGGCTTTTTGGGGAGTGGTAAAACCAC
TCTGCTGAACCATCTAATGCGCCATCTGAGGGATCGACGCGCGGCGGTGTTTGTCAATGAATTTGGAGCCATTGACATTG
ATAGCCAAATTCTGGTGACCGTAGATGAAGATCTGGTGGCCTTGTCTAACGGCTGTATCTGCTGCCAGATCAGAGATGAT
TTTCTGATGGCCTTCCGACGGGTTTTGGCCTATAACCAAATGCAAACGTCTGCCGGAAAACGGGGGCTAGATGCCATTTT
CTTGGAAACATCTGGGGTGGCCGATCCCTATCCACTGATGCTCACCTTTAGAGCGACTGAACTCTGGAGCTTAACCCGGT
TGGATGCAATCCTGACCGTTGTGGATGCTGAGACCTTTACAGCTGAGTATTTCCAAAGTCAGGCTGCTCTTGCCCAAATT
CAACATGGCGACATCATCCTGCTGAATAAAACTGATCTAGTGGATGACGAACAGCTTAGGTCTGTAGAAACAGAAATTCA
GCGCTTCAAGCCCCAGGCCAGGATATTACCGATGACCTATGGTCAAGTTCCTCTTTCCAGCGTTTTGGATGTGGATCTCT
ATTCCGAGGACATGTCAACAGACTCCCCCTCAGGAGTCCAGCATCTGCAGAATGACGGGTTTGTCGCTGTCCCCTTTGAA
AGCGATCGCCCCTTTAGCTTAAGAAAATTTCAGAAATTTTTGGACTATCAGCTCCCCTCAGAAGTCTTTCGAGCAAAAGG
GGTTCTCTGGTTTGACGAAAGTCCCCACAGACATCTCTTTCAACTCAGTGGTAAGCGGAGCCAACTTCAGGATGAGGCTT
GGCAAGATCCTCCCAGAAACCAACTGGTGTGCATTGGCCGTAACCTAGATGAAGAAGAATTACAACATCAGCTCCATCAG
TGTCTTGCCCCATGA

Upstream 100 bases:

>100_bases
AGGCGTCTTTTCCAGTGATGCCCGCACCCGCCAAGAGTTCTTTAACTTGGTTGCCCACGCACCCGCCATTCGCTAGTTCC
GGCTTCAGCCGATCAGCACT

Downstream 100 bases:

>100_bases
ATAGTCCTTCTGTTATAGCCGTCGCTGGCCCCTGTGGCAGTGGTAAAACCACCTGGATTAACCAGTTTTTAAAAATTGAA
ACGGCTCCCTTCTTTTATTT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLPVPGLFEYRLPVTLITGFLGSGKTTLLNHLMRHLRDRRAAVFVNEFGAIDIDSQILVTVDEDLVALSNGCICCQIRDD
FLMAFRRVLAYNQMQTSAGKRGLDAIFLETSGVADPYPLMLTFRATELWSLTRLDAILTVVDAETFTAEYFQSQAALAQI
QHGDIILLNKTDLVDDEQLRSVETEIQRFKPQARILPMTYGQVPLSSVLDVDLYSEDMSTDSPSGVQHLQNDGFVAVPFE
SDRPFSLRKFQKFLDYQLPSEVFRAKGVLWFDESPHRHLFQLSGKRSQLQDEAWQDPPRNQLVCIGRNLDEEELQHQLHQ
CLAP

Sequences:

>Translated_324_residues
MLPVPGLFEYRLPVTLITGFLGSGKTTLLNHLMRHLRDRRAAVFVNEFGAIDIDSQILVTVDEDLVALSNGCICCQIRDD
FLMAFRRVLAYNQMQTSAGKRGLDAIFLETSGVADPYPLMLTFRATELWSLTRLDAILTVVDAETFTAEYFQSQAALAQI
QHGDIILLNKTDLVDDEQLRSVETEIQRFKPQARILPMTYGQVPLSSVLDVDLYSEDMSTDSPSGVQHLQNDGFVAVPFE
SDRPFSLRKFQKFLDYQLPSEVFRAKGVLWFDESPHRHLFQLSGKRSQLQDEAWQDPPRNQLVCIGRNLDEEELQHQLHQ
CLAP
>Mature_324_residues
MLPVPGLFEYRLPVTLITGFLGSGKTTLLNHLMRHLRDRRAAVFVNEFGAIDIDSQILVTVDEDLVALSNGCICCQIRDD
FLMAFRRVLAYNQMQTSAGKRGLDAIFLETSGVADPYPLMLTFRATELWSLTRLDAILTVVDAETFTAEYFQSQAALAQI
QHGDIILLNKTDLVDDEQLRSVETEIQRFKPQARILPMTYGQVPLSSVLDVDLYSEDMSTDSPSGVQHLQNDGFVAVPFE
SDRPFSLRKFQKFLDYQLPSEVFRAKGVLWFDESPHRHLFQLSGKRSQLQDEAWQDPPRNQLVCIGRNLDEEELQHQLHQ
CLAP

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727351, Length=346, Percent_Identity=31.5028901734104, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI126722884, Length=346, Percent_Identity=31.2138728323699, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI33469141, Length=346, Percent_Identity=30.9248554913295, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI146231952, Length=346, Percent_Identity=30.9248554913295, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI223941779, Length=334, Percent_Identity=29.6407185628743, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI223941776, Length=329, Percent_Identity=29.483282674772, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI119120938, Length=328, Percent_Identity=28.6585365853659, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI87082430, Length=314, Percent_Identity=30.5732484076433, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788499, Length=264, Percent_Identity=26.8939393939394, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324356, Length=373, Percent_Identity=25.4691689008043, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36820; Mature: 36820

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVPGLFEYRLPVTLITGFLGSGKTTLLNHLMRHLRDRRAAVFVNEFGAIDIDSQILVT
CCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCEEECCEEEEE
VDEDLVALSNGCICCQIRDDFLMAFRRVLAYNQMQTSAGKRGLDAIFLETSGVADPYPLM
ECCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEE
LTFRATELWSLTRLDAILTVVDAETFTAEYFQSQAALAQIQHGDIILLNKTDLVDDEQLR
EEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
SVETEIQRFKPQARILPMTYGQVPLSSVLDVDLYSEDMSTDSPSGVQHLQNDGFVAVPFE
HHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHCCCCCCCCCHHHHHHCCCCEEEEECC
SDRPFSLRKFQKFLDYQLPSEVFRAKGVLWFDESPHRHLFQLSGKRSQLQDEAWQDPPRN
CCCCCHHHHHHHHHCCCCCHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHCCCCCC
QLVCIGRNLDEEELQHQLHQCLAP
CEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPVPGLFEYRLPVTLITGFLGSGKTTLLNHLMRHLRDRRAAVFVNEFGAIDIDSQILVT
CCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCEEECCEEEEE
VDEDLVALSNGCICCQIRDDFLMAFRRVLAYNQMQTSAGKRGLDAIFLETSGVADPYPLM
ECCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEE
LTFRATELWSLTRLDAILTVVDAETFTAEYFQSQAALAQIQHGDIILLNKTDLVDDEQLR
EEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
SVETEIQRFKPQARILPMTYGQVPLSSVLDVDLYSEDMSTDSPSGVQHLQNDGFVAVPFE
HHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHCCCCCCCCCHHHHHHCCCCEEEEECC
SDRPFSLRKFQKFLDYQLPSEVFRAKGVLWFDESPHRHLFQLSGKRSQLQDEAWQDPPRN
CCCCCHHHHHHHHHCCCCCHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHCCCCCC
QLVCIGRNLDEEELQHQLHQCLAP
CEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]