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The map label for this gene is yciC [H]

Identifier: 158336152

GI number: 158336152

Start: 3042485

End: 3043603

Strand: Direct

Name: yciC [H]

Synonym: AM1_3014

Alternate gene names: 158336152

Gene position: 3042485-3043603 (Clockwise)

Preceding gene: 158336151

Following gene: 158336156

Centisome position: 46.78

GC content: 46.65

Gene sequence:

>1119_bases
TTGACTAATTCAACTGCAAACGTTCAGACATCCCAATCCCTGGATATCAATCTGCCCAAAAAAGGCATGCCCGTGACGAT
TATTACGGGGTTCTTGGGGAGTGGCAAAACCACGCTCCTCAACCATATTCTCAATACCAGCCAAGACCTCAAGGTGGCTG
TACTGGTCAATGAGTTTGGTGATATTGATATTGACAGTCAGTTACTGACCACCATTGATCAAGATATGGTGCAGCTGACC
AATGGCTGCATCTGCTGCACGATCAATGACGACCTGGTGGAGGCGGTCTATTCCGTCCTAGAACGTGAGGAAAAAATTGA
TCATGTCGTTATCGAAACCACGGGGGTGGCTGATCCGCTACCGATTATTCTCACCTTTGTCAGCTCTCAACTGAAAGACG
TAACGACGTTAGATTCCATTATTACCTTGGTAGATTCAGAAACCTTTACCCCTGAATGTTTTCAGAGTGAGGCGGCCCTA
AATCAAATTACCTTTGGCGATATTGTCGTTCTCAACAAAACCGACCTGACCACCGATCAAAAGGTAGAAGAACTAGAGGA
GTGGATTCGTGAACGCAAATGGGGTGCACGGCTCTTGCGATCGCAACAAGGTCAGGTCCCTCTGCCACTAATTCTGGATA
CTGCTCTCTTTGATCCAAAGGCTTATGAAGCGGAAGCCAAAGCCTTTGCAGAGGAGGAGGCTCATCACGATCATGACGAT
CACCATCACCACGATCATGACCACCATGATCATGGCCACCACCATCACGGAGATCATGATCATCATCACCATGACGATCA
TGATCATCACCACCATCATTCGGATCATCTCACCGTCGACGGCTTCTCATCTATGGTCTTTGAAAGCGATCGGCCCTTTA
TCCTAGAAAAAATGCAGGCTTTCGTGACCGATCATCTACCAGAAGAAGTCTTTCGAGCCAAAGGTTTTATGTGGTTTGAG
AAAAATACATCCCGCTATATTTTTCAGCTCAGTGGCAAGCGCTATACAATGGATGCTGATCAGTGGCCGGATGCCCCAAA
AAATCAGTTAGTCTTTATTGGCCGCAACATTGACAAAGCACAGCTTAACCAACTGCTAACGGATTGTTTAGCTCCCTAA

Upstream 100 bases:

>100_bases
AATGGATTTTACAACATCTTCACCACTCTGCAGCAGCTCGCCCTGACGCTCTCAGCTGCATCATCAGATTCTTTCCCCAC
TCAGCAATTGGAGGACACCG

Downstream 100 bases:

>100_bases
CACACCACAATCACAAAATCCGCTCCATCAGAACGCTCGGTATGCTGTGACCCAAGACCAGCGGAACGTCGAGTCGCCGC
ACTGATCTAAAACCCAAAGC

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTNSTANVQTSQSLDINLPKKGMPVTIITGFLGSGKTTLLNHILNTSQDLKVAVLVNEFGDIDIDSQLLTTIDQDMVQLT
NGCICCTINDDLVEAVYSVLEREEKIDHVVIETTGVADPLPIILTFVSSQLKDVTTLDSIITLVDSETFTPECFQSEAAL
NQITFGDIVVLNKTDLTTDQKVEELEEWIRERKWGARLLRSQQGQVPLPLILDTALFDPKAYEAEAKAFAEEEAHHDHDD
HHHHDHDHHDHGHHHHGDHDHHHHDDHDHHHHHSDHLTVDGFSSMVFESDRPFILEKMQAFVTDHLPEEVFRAKGFMWFE
KNTSRYIFQLSGKRYTMDADQWPDAPKNQLVFIGRNIDKAQLNQLLTDCLAP

Sequences:

>Translated_372_residues
MTNSTANVQTSQSLDINLPKKGMPVTIITGFLGSGKTTLLNHILNTSQDLKVAVLVNEFGDIDIDSQLLTTIDQDMVQLT
NGCICCTINDDLVEAVYSVLEREEKIDHVVIETTGVADPLPIILTFVSSQLKDVTTLDSIITLVDSETFTPECFQSEAAL
NQITFGDIVVLNKTDLTTDQKVEELEEWIRERKWGARLLRSQQGQVPLPLILDTALFDPKAYEAEAKAFAEEEAHHDHDD
HHHHDHDHHDHGHHHHGDHDHHHHDDHDHHHHHSDHLTVDGFSSMVFESDRPFILEKMQAFVTDHLPEEVFRAKGFMWFE
KNTSRYIFQLSGKRYTMDADQWPDAPKNQLVFIGRNIDKAQLNQLLTDCLAP
>Mature_371_residues
TNSTANVQTSQSLDINLPKKGMPVTIITGFLGSGKTTLLNHILNTSQDLKVAVLVNEFGDIDIDSQLLTTIDQDMVQLTN
GCICCTINDDLVEAVYSVLEREEKIDHVVIETTGVADPLPIILTFVSSQLKDVTTLDSIITLVDSETFTPECFQSEAALN
QITFGDIVVLNKTDLTTDQKVEELEEWIRERKWGARLLRSQQGQVPLPLILDTALFDPKAYEAEAKAFAEEEAHHDHDDH
HHHDHDHHDHGHHHHGDHDHHHHDDHDHHHHHSDHLTVDGFSSMVFESDRPFILEKMQAFVTDHLPEEVFRAKGFMWFEK
NTSRYIFQLSGKRYTMDADQWPDAPKNQLVFIGRNIDKAQLNQLLTDCLAP

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=372, Percent_Identity=29.0322580645161, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI126722884, Length=361, Percent_Identity=29.6398891966759, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148727351, Length=371, Percent_Identity=29.3800539083558, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI146231952, Length=362, Percent_Identity=29.8342541436464, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI223941779, Length=194, Percent_Identity=36.0824742268041, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI223941776, Length=362, Percent_Identity=27.6243093922652, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI119120938, Length=131, Percent_Identity=40.4580152671756, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=342, Percent_Identity=31.2865497076023, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788499, Length=213, Percent_Identity=32.8638497652582, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324356, Length=226, Percent_Identity=33.1858407079646, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 42280; Mature: 42148

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSTANVQTSQSLDINLPKKGMPVTIITGFLGSGKTTLLNHILNTSQDLKVAVLVNEFG
CCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCC
DIDIDSQLLTTIDQDMVQLTNGCICCTINDDLVEAVYSVLEREEKIDHVVIETTGVADPL
CCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
PIILTFVSSQLKDVTTLDSIITLVDSETFTPECFQSEAALNQITFGDIVVLNKTDLTTDQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
KVEELEEWIRERKWGARLLRSQQGQVPLPLILDTALFDPKAYEAEAKAFAEEEAHHDHDD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
HHHHDHDHHDHGHHHHGDHDHHHHDDHDHHHHHSDHLTVDGFSSMVFESDRPFILEKMQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCCHHHHHHHH
FVTDHLPEEVFRAKGFMWFEKNTSRYIFQLSGKRYTMDADQWPDAPKNQLVFIGRNIDKA
HHHHCCHHHHHHHCCEEEEECCCCEEEEEECCCEEEECHHCCCCCCCCCEEEEECCCCHH
QLNQLLTDCLAP
HHHHHHHHHCCC
>Mature Secondary Structure 
TNSTANVQTSQSLDINLPKKGMPVTIITGFLGSGKTTLLNHILNTSQDLKVAVLVNEFG
CCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCC
DIDIDSQLLTTIDQDMVQLTNGCICCTINDDLVEAVYSVLEREEKIDHVVIETTGVADPL
CCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
PIILTFVSSQLKDVTTLDSIITLVDSETFTPECFQSEAALNQITFGDIVVLNKTDLTTDQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
KVEELEEWIRERKWGARLLRSQQGQVPLPLILDTALFDPKAYEAEAKAFAEEEAHHDHDD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
HHHHDHDHHDHGHHHHGDHDHHHHDDHDHHHHHSDHLTVDGFSSMVFESDRPFILEKMQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCCHHHHHHHH
FVTDHLPEEVFRAKGFMWFEKNTSRYIFQLSGKRYTMDADQWPDAPKNQLVFIGRNIDKA
HHHHCCHHHHHHHCCEEEEECCCCEEEEEECCCEEEECHHCCCCCCCCCEEEEECCCCHH
QLNQLLTDCLAP
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]