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The map label for this gene is pepA

Identifier: 158336127

GI number: 158336127

Start: 3018825

End: 3020303

Strand: Direct

Name: pepA

Synonym: AM1_2989

Alternate gene names: 158336127

Gene position: 3018825-3020303 (Clockwise)

Preceding gene: 158336126

Following gene: 158336128

Centisome position: 46.42

GC content: 51.32

Gene sequence:

>1479_bases
ATGAAGATTCAGGCAATTGAGACAGTGGCGGCCGACTGGTCAGGCGATTATTTAGGCATTGGTTTTTTCGAAGATTCCGC
AGCAATAGACGCTGGTTTGACCCAGCTAGACCAATCCCTCCAGGACATCCTCCAAGATCTGGTGAGCGAAACTGAATTTC
AAGGCAAAGTGGGGGAACAGCCCTGGACTCGAATTGCAGGACCCGGCTCCATCCGCAAAGTTATGCTGATTGGCCTTGGC
TCCCCAGATGCATTTACATTAGACAGTCTGCGCCAAGCTGCCGCCGCCTTTGCCAAAGCTGCTCAAAAACAGAAAGCTGC
CTCTGCGGGTCTGCAGTTGCCCTCATGGGACGATGATGCCGCAGCTTCAACTCAAGCTATGGCAGAAGGAATTGAACTTG
CTTTACATCAAGAGATTCGTTTTAAGTCTGATCCTGATGCGAAAAAGCCTGGCGAATTTCCGCAAGAGGTCCACCTACTA
GGTCTTGCCAATCAAGCTGCCGCCATTGAAAAAGCCCAACAGATTTGTGCAGGGGTCATTCTGACCCGTGAACTTGTAGC
AGCCCCTGCCAACGTGGTCACTCCCAGTGCTTTAGCAGAAACTGCAGCCCAAATCGCTGAGGACCACGGTTTGACCCTAG
AAGTTCTAGAGCGAGAAGAATGCGAAGCCCAAGGCATGGGCGCTTTTCTGGGCGTTTCTCTAGCATCTGAGCTGCCTCCC
AAATTTATCCACCTGACTTACAAGCCCAGCGGCACTCCTCGCCGCAAACTTGCCATTGTGGGTAAAGGGGTTACGTTTGA
CTCCGGTGGCCTCAACCTCAAAGTTGGGGGCAGCGGCATCGAAACCATGAAAATGGATATGGCAGGATCTGGTGCGACGT
TAGGAGCGGCCAAAGCCATTGGTCAACTCAAGCCTGATGTGGAAGTTCATTTCATCGTCGCAGCAGCTGAGAATATGATT
AGCGGCCATGCCCTCCATCCTGGCGATATCCTGACTGCATCCAATGGCAAAACTATCGAGATCAATAATACTGATGCGGA
AGGGCGGCTCACCCTTGCCGATGCTTTAGTCTTTGCGGAAAAGCAAGGCGTCGACGCCATTGTTGACTTGGCCACCTTAA
CTGGAGCCTGCATCGTCGCCTTAGGCAATGATATTGCTGGCATGTGGACCCCAGAAGATAGCTTGGCAGAAGAGCTGAGC
CAAGCGTCTGAACAGGCAGGAGAAAAGTTTTGGCGGATGCCCTTAGAAGAAAAATATTTTGAAGGACTGAAATCTCCCAT
CGCCGATATGAAAAACACTGGACCTCGTCCAGGGGGTTCCATTACCGCCGCTTTATTTCTCAAACAATATATTGAGAACA
CGCCCTGGGCTCACTTAGATGTGGCAGGCCCCGTCTGGACTGAGAAAGAGAACGGTTATCTCAATGTGGGTGCGACAGGG
TTTGCAGTCCGGACTTTAGTCAATTGGGTAATGGGTTAA

Upstream 100 bases:

>100_bases
TTGCTATGATCAGAACGACGGATTGGCTTGTGGGAGGAAAAACTCGCAAAGTCAGCAACTTACAGTTTGAACATTCAGCG
TTGAAGGATATGGGTTGAGG

Downstream 100 bases:

>100_bases
TGGCCTTCCTCCATCGATAGAAGCCACTTCGGCAAAATCTAAATCCACCTCACGCCACACCTCGGACAGGCCTTAGCGGC
GTATTTCACACTGATCATCT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKIQAIETVAADWSGDYLGIGFFEDSAAIDAGLTQLDQSLQDILQDLVSETEFQGKVGEQPWTRIAGPGSIRKVMLIGLG
SPDAFTLDSLRQAAAAFAKAAQKQKAASAGLQLPSWDDDAAASTQAMAEGIELALHQEIRFKSDPDAKKPGEFPQEVHLL
GLANQAAAIEKAQQICAGVILTRELVAAPANVVTPSALAETAAQIAEDHGLTLEVLEREECEAQGMGAFLGVSLASELPP
KFIHLTYKPSGTPRRKLAIVGKGVTFDSGGLNLKVGGSGIETMKMDMAGSGATLGAAKAIGQLKPDVEVHFIVAAAENMI
SGHALHPGDILTASNGKTIEINNTDAEGRLTLADALVFAEKQGVDAIVDLATLTGACIVALGNDIAGMWTPEDSLAEELS
QASEQAGEKFWRMPLEEKYFEGLKSPIADMKNTGPRPGGSITAALFLKQYIENTPWAHLDVAGPVWTEKENGYLNVGATG
FAVRTLVNWVMG

Sequences:

>Translated_492_residues
MKIQAIETVAADWSGDYLGIGFFEDSAAIDAGLTQLDQSLQDILQDLVSETEFQGKVGEQPWTRIAGPGSIRKVMLIGLG
SPDAFTLDSLRQAAAAFAKAAQKQKAASAGLQLPSWDDDAAASTQAMAEGIELALHQEIRFKSDPDAKKPGEFPQEVHLL
GLANQAAAIEKAQQICAGVILTRELVAAPANVVTPSALAETAAQIAEDHGLTLEVLEREECEAQGMGAFLGVSLASELPP
KFIHLTYKPSGTPRRKLAIVGKGVTFDSGGLNLKVGGSGIETMKMDMAGSGATLGAAKAIGQLKPDVEVHFIVAAAENMI
SGHALHPGDILTASNGKTIEINNTDAEGRLTLADALVFAEKQGVDAIVDLATLTGACIVALGNDIAGMWTPEDSLAEELS
QASEQAGEKFWRMPLEEKYFEGLKSPIADMKNTGPRPGGSITAALFLKQYIENTPWAHLDVAGPVWTEKENGYLNVGATG
FAVRTLVNWVMG
>Mature_492_residues
MKIQAIETVAADWSGDYLGIGFFEDSAAIDAGLTQLDQSLQDILQDLVSETEFQGKVGEQPWTRIAGPGSIRKVMLIGLG
SPDAFTLDSLRQAAAAFAKAAQKQKAASAGLQLPSWDDDAAASTQAMAEGIELALHQEIRFKSDPDAKKPGEFPQEVHLL
GLANQAAAIEKAQQICAGVILTRELVAAPANVVTPSALAETAAQIAEDHGLTLEVLEREECEAQGMGAFLGVSLASELPP
KFIHLTYKPSGTPRRKLAIVGKGVTFDSGGLNLKVGGSGIETMKMDMAGSGATLGAAKAIGQLKPDVEVHFIVAAAENMI
SGHALHPGDILTASNGKTIEINNTDAEGRLTLADALVFAEKQGVDAIVDLATLTGACIVALGNDIAGMWTPEDSLAEELS
QASEQAGEKFWRMPLEEKYFEGLKSPIADMKNTGPRPGGSITAALFLKQYIENTPWAHLDVAGPVWTEKENGYLNVGATG
FAVRTLVNWVMG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=434, Percent_Identity=36.405529953917, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=36.1370716510903, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1790710, Length=306, Percent_Identity=39.8692810457516, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=38.2911392405063, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=294, Percent_Identity=37.0748299319728, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=30.1204819277108, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355725, Length=408, Percent_Identity=31.1274509803922, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24661038, Length=405, Percent_Identity=31.358024691358, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI20129969, Length=512, Percent_Identity=28.3203125, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21357381, Length=303, Percent_Identity=34.3234323432343, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI221379063, Length=303, Percent_Identity=34.3234323432343, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221379062, Length=303, Percent_Identity=34.3234323432343, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355645, Length=492, Percent_Identity=26.0162601626016, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662223, Length=492, Percent_Identity=26.0162601626016, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161077148, Length=315, Percent_Identity=30.1587301587302, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20130057, Length=315, Percent_Identity=30.1587301587302, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20129963, Length=473, Percent_Identity=27.906976744186, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922386, Length=383, Percent_Identity=29.242819843342, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24662227, Length=464, Percent_Identity=24.7844827586207, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646701, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ACAM1 (B0CCF6)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517301.1
- ProteinModelPortal:   B0CCF6
- SMR:   B0CCF6
- MEROPS:   M17.002
- GeneID:   5681797
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2989
- HOGENOM:   HBG742580
- OMA:   GELIWRM
- ProtClustDB:   PRK00913
- BioCyc:   AMAR329726:AM1_2989-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51870; Mature: 51870

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 274-274 ACT_SITE 349-349

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQAIETVAADWSGDYLGIGFFEDSAAIDAGLTQLDQSLQDILQDLVSETEFQGKVGEQ
CCCCHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PWTRIAGPGSIRKVMLIGLGSPDAFTLDSLRQAAAAFAKAAQKQKAASAGLQLPSWDDDA
CCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
AASTQAMAEGIELALHQEIRFKSDPDAKKPGEFPQEVHLLGLANQAAAIEKAQQICAGVI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCHHHHHHHHHHHHHHHHH
LTRELVAAPANVVTPSALAETAAQIAEDHGLTLEVLEREECEAQGMGAFLGVSLASELPP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCHHHHHHHHHHCCC
KFIHLTYKPSGTPRRKLAIVGKGVTFDSGGLNLKVGGSGIETMKMDMAGSGATLGAAKAI
EEEEEEECCCCCCCEEEEEEECCEEECCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHH
GQLKPDVEVHFIVAAAENMISGHALHPGDILTASNGKTIEINNTDAEGRLTLADALVFAE
HHCCCCCEEEEEEEEHHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHH
KQGVDAIVDLATLTGACIVALGNDIAGMWTPEDSLAEELSQASEQAGEKFWRMPLEEKYF
HCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EGLKSPIADMKNTGPRPGGSITAALFLKQYIENTPWAHLDVAGPVWTEKENGYLNVGATG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEEECCHH
FAVRTLVNWVMG
HHHHHHHHHHCC
>Mature Secondary Structure
MKIQAIETVAADWSGDYLGIGFFEDSAAIDAGLTQLDQSLQDILQDLVSETEFQGKVGEQ
CCCCHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PWTRIAGPGSIRKVMLIGLGSPDAFTLDSLRQAAAAFAKAAQKQKAASAGLQLPSWDDDA
CCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
AASTQAMAEGIELALHQEIRFKSDPDAKKPGEFPQEVHLLGLANQAAAIEKAQQICAGVI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCHHHHHHHHHHHHHHHHH
LTRELVAAPANVVTPSALAETAAQIAEDHGLTLEVLEREECEAQGMGAFLGVSLASELPP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCHHHHHHHHHHCCC
KFIHLTYKPSGTPRRKLAIVGKGVTFDSGGLNLKVGGSGIETMKMDMAGSGATLGAAKAI
EEEEEEECCCCCCCEEEEEEECCEEECCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHH
GQLKPDVEVHFIVAAAENMISGHALHPGDILTASNGKTIEINNTDAEGRLTLADALVFAE
HHCCCCCEEEEEEEEHHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHH
KQGVDAIVDLATLTGACIVALGNDIAGMWTPEDSLAEELSQASEQAGEKFWRMPLEEKYF
HCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EGLKSPIADMKNTGPRPGGSITAALFLKQYIENTPWAHLDVAGPVWTEKENGYLNVGATG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEEECCHH
FAVRTLVNWVMG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA