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The map label for this gene is ahpC [C]

Identifier: 158335840

GI number: 158335840

Start: 2730218

End: 2730826

Strand: Direct

Name: ahpC [C]

Synonym: AM1_2698

Alternate gene names: 158335840

Gene position: 2730218-2730826 (Clockwise)

Preceding gene: 158335839

Following gene: 158335842

Centisome position: 41.98

GC content: 45.81

Gene sequence:

>609_bases
ATGTCGCAACACGAAGCACATGAATGTTTAAGAGTCGGCCAAGCCGCACCTGACTTTACAGCAACGGCTGTTTACGACCA
AGAATTTAGTGAAGTCAAACTCTCCAATTATCGGGGCAAGTACGTCGTCATCTTTTTCTATCCGCTTGATTTCACCTTCG
TGTGTCCTACTGAAATTACGGCGTTTAGCGATCGCTATGATGCTTTTAAAGACTTAAATACTGAAGTTCTCGGTATTTCT
GTAGACAGCGAATTCTCCCACCTAGCTTGGACCCAGACCGATCGCAAATCTGGAGGAGTCGGCGATCTCAACTACCCCTT
GGTTTCGGACATTAAAAAAGAAATTAGCACTGCCTATAACGTTCTAGATCCAGATGCTGGTGTTGCCTTAAGAGGTCTCT
TTATCATCGATAAAGAAGGCGTTGTCCAACATGCCACCATTAACAACCTTGCCTTTGGCCGCAATGTTGATGAAACCTTG
CGCACCTTACAGGCAATTCAACATGTTCAGTCTCATCCGGATGAGGTTTGTCCCGCAGGCTGGCAGCCAGGAGACAAGAC
CATGAACCCTGATCCAGTCAAATCCAAGGTTTACTTCGAATCTGTCTAA

Upstream 100 bases:

>100_bases
ATTTATACCGTAGATACACTCATTTTTTTGCACGCAGTCGATTGATCTTTGCAAATTCTGATATCTACAAAGATCAACAT
CCTATAGGAGTAATTTGGTT

Downstream 100 bases:

>100_bases
AGATTTAGACAGATTCGTGTTGCCTGATCGCCCTCAAATACACAAGCTCCATGAGTATTTGAGGGCTATGTTATTGGCAC
TTCCCAGATCCTATACACTC

Product: 2-cys peroxiredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSQHEAHECLRVGQAAPDFTATAVYDQEFSEVKLSNYRGKYVVIFFYPLDFTFVCPTEITAFSDRYDAFKDLNTEVLGIS
VDSEFSHLAWTQTDRKSGGVGDLNYPLVSDIKKEISTAYNVLDPDAGVALRGLFIIDKEGVVQHATINNLAFGRNVDETL
RTLQAIQHVQSHPDEVCPAGWQPGDKTMNPDPVKSKVYFESV

Sequences:

>Translated_202_residues
MSQHEAHECLRVGQAAPDFTATAVYDQEFSEVKLSNYRGKYVVIFFYPLDFTFVCPTEITAFSDRYDAFKDLNTEVLGIS
VDSEFSHLAWTQTDRKSGGVGDLNYPLVSDIKKEISTAYNVLDPDAGVALRGLFIIDKEGVVQHATINNLAFGRNVDETL
RTLQAIQHVQSHPDEVCPAGWQPGDKTMNPDPVKSKVYFESV
>Mature_201_residues
SQHEAHECLRVGQAAPDFTATAVYDQEFSEVKLSNYRGKYVVIFFYPLDFTFVCPTEITAFSDRYDAFKDLNTEVLGISV
DSEFSHLAWTQTDRKSGGVGDLNYPLVSDIKKEISTAYNVLDPDAGVALRGLFIIDKEGVVQHATINNLAFGRNVDETLR
TLQAIQHVQSHPDEVCPAGWQPGDKTMNPDPVKSKVYFESV

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=189, Percent_Identity=59.7883597883598, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI4505591, Length=190, Percent_Identity=58.421052631579, Blast_Score=234, Evalue=3e-62,
Organism=Homo sapiens, GI32455266, Length=190, Percent_Identity=58.421052631579, Blast_Score=234, Evalue=3e-62,
Organism=Homo sapiens, GI32455264, Length=190, Percent_Identity=58.421052631579, Blast_Score=234, Evalue=3e-62,
Organism=Homo sapiens, GI5802974, Length=191, Percent_Identity=55.4973821989529, Blast_Score=229, Evalue=1e-60,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=54.1666666666667, Blast_Score=227, Evalue=6e-60,
Organism=Homo sapiens, GI32483377, Length=187, Percent_Identity=55.6149732620321, Blast_Score=226, Evalue=7e-60,
Organism=Homo sapiens, GI33188454, Length=86, Percent_Identity=67.4418604651163, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=25.3968253968254, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=34.8837209302326, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565831, Length=189, Percent_Identity=56.6137566137566, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193204376, Length=189, Percent_Identity=56.6137566137566, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=51.0752688172043, Blast_Score=203, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25153706, Length=191, Percent_Identity=26.1780104712042, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=51.3089005235602, Blast_Score=191, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320661, Length=190, Percent_Identity=48.9473684210526, Blast_Score=185, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319407, Length=193, Percent_Identity=28.4974093264249, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17738015, Length=201, Percent_Identity=56.7164179104478, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24656348, Length=188, Percent_Identity=55.3191489361702, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17864676, Length=188, Percent_Identity=55.3191489361702, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17157991, Length=191, Percent_Identity=51.8324607329843, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24641739, Length=191, Percent_Identity=51.8324607329843, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI21357347, Length=191, Percent_Identity=47.6439790575916, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=34.3915343915344, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=34.3915343915344, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=34.3915343915344, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581278, Length=198, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22557; Mature: 22426

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHEAHECLRVGQAAPDFTATAVYDQEFSEVKLSNYRGKYVVIFFYPLDFTFVCPTEIT
CCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCEEEECCCHHH
AFSDRYDAFKDLNTEVLGISVDSEFSHLAWTQTDRKSGGVGDLNYPLVSDIKKEISTAYN
HHHHHHHHHHCCCCEEEEEEECCCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLDPDAGVALRGLFIIDKEGVVQHATINNLAFGRNVDETLRTLQAIQHVQSHPDEVCPAG
CCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCC
WQPGDKTMNPDPVKSKVYFESV
CCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SQHEAHECLRVGQAAPDFTATAVYDQEFSEVKLSNYRGKYVVIFFYPLDFTFVCPTEIT
CCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCEEEECCCHHH
AFSDRYDAFKDLNTEVLGISVDSEFSHLAWTQTDRKSGGVGDLNYPLVSDIKKEISTAYN
HHHHHHHHHHCCCCEEEEEEECCCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLDPDAGVALRGLFIIDKEGVVQHATINNLAFGRNVDETLRTLQAIQHVQSHPDEVCPAG
CCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCC
WQPGDKTMNPDPVKSKVYFESV
CCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]