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The map label for this gene is tetA [H]

Identifier: 158335707

GI number: 158335707

Start: 2593178

End: 2594347

Strand: Reverse

Name: tetA [H]

Synonym: AM1_2557

Alternate gene names: 158335707

Gene position: 2594347-2593178 (Counterclockwise)

Preceding gene: 158335708

Following gene: 158335705

Centisome position: 39.89

GC content: 49.91

Gene sequence:

>1170_bases
ATGAAGCGCGAAGTTTGGATCGTCTCTGCCATTGCCTTAGTCAACTCCCTTAGTTTTACGGTTTTGCTGCCGACCCTGTA
TCCCTACGGTCGGCAGTTTGGGCTCAATGATTTTGAGACCAGCTTCCTCTTTTCGATATTTTCGATTGCTCAATTTATCG
CCACCCCTGTGATTGGACAGCTCTCGGATCGTTGGGGGCGACGACCTTTATTACTGGTGAGTTTGGCGGGGACAATGTTG
GCCAACCTGATGGCAGGTCTGGCGACGGCGGCATGGGTGTTATTTTTGGCCCGGTTTTTAGACGGGATTACTGGAGGCAA
CAATTCCGTGATTCAGGCCGTGATTGCGGATGTCACGGATGCCGAGAATCGGGCGCGGGGCTTTAGTCTGTTTGGAGCTG
CCTTTGGCGTCGGCTTTGTCCTCGGCCCCCTTATTAGCTTGGGCGCCCAAGCGATTTCCCTGGGGGCTAGTTTTTTAGTA
TCTGCCTGGATCGCTGGGATAGCCTTAGGGGTGACCTACTTCTTCTTACCAGAAACCTTAGAAGAGCGATCGCAACCGCG
TCGGTTTGAGTTGGGATTGGCCAAATTAGTCACAGGATTGACGATTCCCAAAGTGGGCATTCTCTTGTTGATCAATTTTT
TGATTGGCACGACCTTTACGATTTTCACCTACGCATTTCAGCCGTACTTCCTCAACGTCCTTAACCAAACTCCCCAGTCT
TTGGCCCTGATATTTATCGTTTACGGAGTACTCGGGGTGCTAATGCAGACCTTCGGGGTGCCTAACCTGACTAAAAGATT
TAATTTGCTGTTGATCTTATTTGTGGCCTTACTGATTCGGAGTGTGGCTTTCTTGGCGATGCCCATCTGGCCCAATGTGA
CCTATTTTGTCTCGATTACCATTTTCTTTTCCATCTTTAACTCCCTGGTCCAACCCATTATCAATACCCTGATTTCCCTG
AATGTGGATGCTCAGCAGCAGGGGATGGCGATGGGCTTAAATTCCTCGTATCTCAGTATTTCTAATGGTATTGGCCCCGT
CATTGCTGGTGTGCTGATTCATCAGTCCAACCTGGCCAGCTATGGCTATCCCCTCTATTTAGCGGGTGCCTGTACTTTTG
GGGTGCTCCTGTTGGCGATTCAGACCCGCACAAAATATGCCCCCAGTTGA

Upstream 100 bases:

>100_bases
AAGTGGCCGATCTGATTTACCACAGTCTCGTGGCCCTGGCCCACCATGATGTAGATATCAAGGACGTCTACCGCAAACTG
CAAGAGCGGCGACGCTAGGC

Downstream 100 bases:

>100_bases
GTTGGGGGCATCAGGCGTCTTGATATGATGCGTTGGAATTTAGCCGGGGTGGAAGATAAAGCTGACCTTATCTTCTTTGC
CCAGGGAAATGCGATCGCCC

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKREVWIVSAIALVNSLSFTVLLPTLYPYGRQFGLNDFETSFLFSIFSIAQFIATPVIGQLSDRWGRRPLLLVSLAGTML
ANLMAGLATAAWVLFLARFLDGITGGNNSVIQAVIADVTDAENRARGFSLFGAAFGVGFVLGPLISLGAQAISLGASFLV
SAWIAGIALGVTYFFLPETLEERSQPRRFELGLAKLVTGLTIPKVGILLLINFLIGTTFTIFTYAFQPYFLNVLNQTPQS
LALIFIVYGVLGVLMQTFGVPNLTKRFNLLLILFVALLIRSVAFLAMPIWPNVTYFVSITIFFSIFNSLVQPIINTLISL
NVDAQQQGMAMGLNSSYLSISNGIGPVIAGVLIHQSNLASYGYPLYLAGACTFGVLLLAIQTRTKYAPS

Sequences:

>Translated_389_residues
MKREVWIVSAIALVNSLSFTVLLPTLYPYGRQFGLNDFETSFLFSIFSIAQFIATPVIGQLSDRWGRRPLLLVSLAGTML
ANLMAGLATAAWVLFLARFLDGITGGNNSVIQAVIADVTDAENRARGFSLFGAAFGVGFVLGPLISLGAQAISLGASFLV
SAWIAGIALGVTYFFLPETLEERSQPRRFELGLAKLVTGLTIPKVGILLLINFLIGTTFTIFTYAFQPYFLNVLNQTPQS
LALIFIVYGVLGVLMQTFGVPNLTKRFNLLLILFVALLIRSVAFLAMPIWPNVTYFVSITIFFSIFNSLVQPIINTLISL
NVDAQQQGMAMGLNSSYLSISNGIGPVIAGVLIHQSNLASYGYPLYLAGACTFGVLLLAIQTRTKYAPS
>Mature_389_residues
MKREVWIVSAIALVNSLSFTVLLPTLYPYGRQFGLNDFETSFLFSIFSIAQFIATPVIGQLSDRWGRRPLLLVSLAGTML
ANLMAGLATAAWVLFLARFLDGITGGNNSVIQAVIADVTDAENRARGFSLFGAAFGVGFVLGPLISLGAQAISLGASFLV
SAWIAGIALGVTYFFLPETLEERSQPRRFELGLAKLVTGLTIPKVGILLLINFLIGTTFTIFTYAFQPYFLNVLNQTPQS
LALIFIVYGVLGVLMQTFGVPNLTKRFNLLLILFVALLIRSVAFLAMPIWPNVTYFVSITIFFSIFNSLVQPIINTLISL
NVDAQQQGMAMGLNSSYLSISNGIGPVIAGVLIHQSNLASYGYPLYLAGACTFGVLLLAIQTRTKYAPS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=312, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225703104, Length=151, Percent_Identity=37.7483443708609, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI225703102, Length=151, Percent_Identity=37.7483443708609, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI94721311, Length=317, Percent_Identity=24.9211356466877, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081738, Length=405, Percent_Identity=25.1851851851852, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551570, Length=148, Percent_Identity=33.7837837837838, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996331, Length=328, Percent_Identity=24.0853658536585, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17738085, Length=355, Percent_Identity=27.0422535211268, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357569, Length=333, Percent_Identity=27.3273273273273, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656463, Length=347, Percent_Identity=27.0893371757925, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656468, Length=347, Percent_Identity=27.0893371757925, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161080926, Length=347, Percent_Identity=27.0893371757925, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161080924, Length=347, Percent_Identity=27.0893371757925, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221513297, Length=327, Percent_Identity=25.6880733944954, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42155; Mature: 42155

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]