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The map label for this gene is fadN [H]

Identifier: 158335304

GI number: 158335304

Start: 2140619

End: 2143003

Strand: Direct

Name: fadN [H]

Synonym: AM1_2148

Alternate gene names: 158335304

Gene position: 2140619-2143003 (Clockwise)

Preceding gene: 158335303

Following gene: 158335305

Centisome position: 32.91

GC content: 50.78

Gene sequence:

>2385_bases
ATGTTGAAACCATTTCGGACCGCTGCTGTTCTCGGTGCAGGGGTGATGGGCACTCAAATTGCCGCCCATCTCGCCAATGC
AGGTTTAGTGGTTTATCTCCTGGATCTGCCTGGGCCTGGCGTCCATAAAAACGCGATTGTAGAAGCTGCTTTCAAAAAAG
GTCTGCAGCAAAAACCGCCGATTTTCTTTACCGAAAAAACAGCCCGCCGCGTTCTTCTGGGCAACTTTGAGGATGACTGG
CATCGCCTAACCCATGTGGATTGGGTGATTGAGGCGGTAGTCGAAAAGTTAGAGGTCAAGCAACAGCTGATGGCCCGTTT
AGAAGGCCACATTCGCGATGATGCAGTGGTGTCAACCAATACCAGTGGGTTATCCATTCAAGCGATTACTGCAGGTCGCT
CCGATTCGTTCCGACGACGATTTCTAGGAACACACTTTTTTAATCCTCCGCGTTACCTGAAGCTCTTGGAACTGATTCCC
ACCATAGAAACGGATCCACAAATTGTGGAGCGGCTGAAGTGGTTTGGACATCTCCATCTGGGGAAAGGGGTCGTGGTCGC
CAAAGATACCCCTAACTTTATCGGCAATCGGATTGGTGTGTTTATCAGTATGTTAGGCATCCGAGCCTTTACGGAACAGG
GGTACACCATTGAAGAAATTGATACGCTCACAGGAACCCTGGTGGGTCGTCCTAAATCTGCAACCTTCCGAACTGCAGAT
ATTGTGGGTCTCGATACCTTACTGTATGTAGCTGAAAATCTCTATCCTGCCATCCCCGACGATGAAAATCGTGATGTTTT
CCAGGTGCCAGAGATTCTGAGGCGCTTAGTTGAGGCAGGACATCTCGGGTCCAAAACGGGTCAGGGCTTCTATCAAAAAG
TGGGTAAACATATTCTCTCCGTTAACCCACAGACCCTGGCATACGAAAAGGCCCAGTCTCTGCATCTAAGGAACTGGAAG
GCCATTGCCAAAATAAAACCCCTTCCCGAACGCCTGCGAACCCTCTATCAAGATTCCGGTCGAGCGGGAACATTTTTCCG
GCAAATGATGCTGAAGATCTTGAGCTACAGTGCCCATCGGATTCCTGAAATTGCCGATCATCCCCTCGACATTGATCAGG
CTATGCGCTGGGGATTTGGTTGGCAGTTGGGTCCCTTTGAAATCTGGGATGCAATTGGTTTCAGTCAGGTGATCCAAGAT
ATGCAGGCCGCCGGGATTGTTGTACCCCAGTGGGTAGAGAAAATGCAGCTTGCCGAGATTGATAGCTTCTATCAAAACAT
TGGTCCTAACGGGGAGCGGTTTGTCTATCAACCCCTGCATGGCTATCTACCCACGGAAGGGCCTCAAGATGAATTGACGG
TGGCCCAGTTCAAGACTGATCCAGCCCGAACACTGTGGCAGAACGCCGAGGCGGCTTTGCTTGATATTGGCGATGGTGTA
ACGCTGTTTGAGTTTCGCTCTAAGGGCAATACCCTCGGTCAAGTGGTAGTAGACGGTTTCTCAGAAGCCTTAGATATCGT
TGAGGCGGGCGACTATCGCGGCTTGGTGATTGGTAATGACGGGGAGCATTTTTCTGCTGGGGCCAACCTAGCAGACATGA
TCAAGTTCTCGCACCAAGACAAGGTCAATGTCTTTACAGATTGTGAGCATGGTGCCATTGCCCATCTCCTCGATCAGTTT
CAGGCCCTGATGCTGCGAATTCACTATTTTCCCAAGCCGATTGTGGCAGCGATTCGAGGGCGAATCTTAGGGGGTGGCTG
TGAGCTGGTGATGGCTTCTCCCCATGTGGTGGTAGCGGCTGAGACCTACATTGGTTTGGTGGAACTCAGCGTCGGTCTTA
TCCCCGGTGCAGGTGGCATTATGACCATGGCGACTTGGGCTGCTGAACAGGCTGCCAGTGATGCCCCCAGAGATATTCAG
CCGTTTTTAAAGCAGGCTTTTGAGCATATTGGTATGGCAAAGGTGGCAAGCAGCGCCCATGAAGCTCAAGCGTGGGGATA
TTTACCTCCAACAGCTCAGATTGTTATGAATAGCGATCGCCGTTTGTACGTCGCCAAGGAAGAAGTGTTGCGCCTAGATC
ATGAGAGCTACGTCCCCCCACCCAAACGCAATGCAATCCAGGTGTTGGGCAAACCAGCCCGCGCCCTGTTTGAAACGGCG
GCCTACCAGATGCAGCAAGGAGGCTATATCTCTGACTATGATCGCTTCCTCGCCAATCGGTTGGCCTATGTATTGACAGG
CGGTGATCTGTCAGCACCAACGTTGGTCTCTGATGATTATCTGCTGGGCTTAGAACGTGACATGTTCTTACCCCTGTTCT
CAGAGAAGAAAACTCAGGAACGGATTCTGCATACGTTGAAAACGAAAAAGTCTTTACGGAATTAG

Upstream 100 bases:

>100_bases
ACCCAGCCAGTTTCTCCCACTATTCCACCAACATCTGCATCGCTGAGGTTGGAAGCTTCTTAGGGATTTATTCCTTCCTA
ATTTATGGAGGTTTGCTGTT

Downstream 100 bases:

>100_bases
GAGACTCAACCTTAGCCCTCACAAGAGACGAGGTACATCAAATGAATAACGCATATATCGTCAGTAGTGTCCGCACTGCC
GTTGGCAAAGCCCCCAAAGG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MLKPFRTAAVLGAGVMGTQIAAHLANAGLVVYLLDLPGPGVHKNAIVEAAFKKGLQQKPPIFFTEKTARRVLLGNFEDDW
HRLTHVDWVIEAVVEKLEVKQQLMARLEGHIRDDAVVSTNTSGLSIQAITAGRSDSFRRRFLGTHFFNPPRYLKLLELIP
TIETDPQIVERLKWFGHLHLGKGVVVAKDTPNFIGNRIGVFISMLGIRAFTEQGYTIEEIDTLTGTLVGRPKSATFRTAD
IVGLDTLLYVAENLYPAIPDDENRDVFQVPEILRRLVEAGHLGSKTGQGFYQKVGKHILSVNPQTLAYEKAQSLHLRNWK
AIAKIKPLPERLRTLYQDSGRAGTFFRQMMLKILSYSAHRIPEIADHPLDIDQAMRWGFGWQLGPFEIWDAIGFSQVIQD
MQAAGIVVPQWVEKMQLAEIDSFYQNIGPNGERFVYQPLHGYLPTEGPQDELTVAQFKTDPARTLWQNAEAALLDIGDGV
TLFEFRSKGNTLGQVVVDGFSEALDIVEAGDYRGLVIGNDGEHFSAGANLADMIKFSHQDKVNVFTDCEHGAIAHLLDQF
QALMLRIHYFPKPIVAAIRGRILGGGCELVMASPHVVVAAETYIGLVELSVGLIPGAGGIMTMATWAAEQAASDAPRDIQ
PFLKQAFEHIGMAKVASSAHEAQAWGYLPPTAQIVMNSDRRLYVAKEEVLRLDHESYVPPPKRNAIQVLGKPARALFETA
AYQMQQGGYISDYDRFLANRLAYVLTGGDLSAPTLVSDDYLLGLERDMFLPLFSEKKTQERILHTLKTKKSLRN

Sequences:

>Translated_794_residues
MLKPFRTAAVLGAGVMGTQIAAHLANAGLVVYLLDLPGPGVHKNAIVEAAFKKGLQQKPPIFFTEKTARRVLLGNFEDDW
HRLTHVDWVIEAVVEKLEVKQQLMARLEGHIRDDAVVSTNTSGLSIQAITAGRSDSFRRRFLGTHFFNPPRYLKLLELIP
TIETDPQIVERLKWFGHLHLGKGVVVAKDTPNFIGNRIGVFISMLGIRAFTEQGYTIEEIDTLTGTLVGRPKSATFRTAD
IVGLDTLLYVAENLYPAIPDDENRDVFQVPEILRRLVEAGHLGSKTGQGFYQKVGKHILSVNPQTLAYEKAQSLHLRNWK
AIAKIKPLPERLRTLYQDSGRAGTFFRQMMLKILSYSAHRIPEIADHPLDIDQAMRWGFGWQLGPFEIWDAIGFSQVIQD
MQAAGIVVPQWVEKMQLAEIDSFYQNIGPNGERFVYQPLHGYLPTEGPQDELTVAQFKTDPARTLWQNAEAALLDIGDGV
TLFEFRSKGNTLGQVVVDGFSEALDIVEAGDYRGLVIGNDGEHFSAGANLADMIKFSHQDKVNVFTDCEHGAIAHLLDQF
QALMLRIHYFPKPIVAAIRGRILGGGCELVMASPHVVVAAETYIGLVELSVGLIPGAGGIMTMATWAAEQAASDAPRDIQ
PFLKQAFEHIGMAKVASSAHEAQAWGYLPPTAQIVMNSDRRLYVAKEEVLRLDHESYVPPPKRNAIQVLGKPARALFETA
AYQMQQGGYISDYDRFLANRLAYVLTGGDLSAPTLVSDDYLLGLERDMFLPLFSEKKTQERILHTLKTKKSLRN
>Mature_794_residues
MLKPFRTAAVLGAGVMGTQIAAHLANAGLVVYLLDLPGPGVHKNAIVEAAFKKGLQQKPPIFFTEKTARRVLLGNFEDDW
HRLTHVDWVIEAVVEKLEVKQQLMARLEGHIRDDAVVSTNTSGLSIQAITAGRSDSFRRRFLGTHFFNPPRYLKLLELIP
TIETDPQIVERLKWFGHLHLGKGVVVAKDTPNFIGNRIGVFISMLGIRAFTEQGYTIEEIDTLTGTLVGRPKSATFRTAD
IVGLDTLLYVAENLYPAIPDDENRDVFQVPEILRRLVEAGHLGSKTGQGFYQKVGKHILSVNPQTLAYEKAQSLHLRNWK
AIAKIKPLPERLRTLYQDSGRAGTFFRQMMLKILSYSAHRIPEIADHPLDIDQAMRWGFGWQLGPFEIWDAIGFSQVIQD
MQAAGIVVPQWVEKMQLAEIDSFYQNIGPNGERFVYQPLHGYLPTEGPQDELTVAQFKTDPARTLWQNAEAALLDIGDGV
TLFEFRSKGNTLGQVVVDGFSEALDIVEAGDYRGLVIGNDGEHFSAGANLADMIKFSHQDKVNVFTDCEHGAIAHLLDQF
QALMLRIHYFPKPIVAAIRGRILGGGCELVMASPHVVVAAETYIGLVELSVGLIPGAGGIMTMATWAAEQAASDAPRDIQ
PFLKQAFEHIGMAKVASSAHEAQAWGYLPPTAQIVMNSDRRLYVAKEEVLRLDHESYVPPPKRNAIQVLGKPARALFETA
AYQMQQGGYISDYDRFLANRLAYVLTGGDLSAPTLVSDDYLLGLERDMFLPLFSEKKTQERILHTLKTKKSLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=34.3642611683849, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=32.7922077922078, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI20127408, Length=291, Percent_Identity=31.6151202749141, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI261878539, Length=423, Percent_Identity=27.6595744680851, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI68989263, Length=423, Percent_Identity=27.6595744680851, Blast_Score=101, Evalue=3e-21,
Organism=Escherichia coli, GI1787661, Length=460, Percent_Identity=26.304347826087, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790281, Length=217, Percent_Identity=29.0322580645161, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI1788682, Length=335, Percent_Identity=27.4626865671642, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=29.8657718120805, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=304, Percent_Identity=31.25, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17558304, Length=423, Percent_Identity=29.3144208037825, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508951, Length=295, Percent_Identity=31.864406779661, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=295, Percent_Identity=31.864406779661, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=295, Percent_Identity=31.864406779661, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=300, Percent_Identity=31.3333333333333, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=305, Percent_Identity=26.2295081967213, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71985930, Length=299, Percent_Identity=24.4147157190635, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583077, Length=410, Percent_Identity=28.2926829268293, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583079, Length=410, Percent_Identity=28.2926829268293, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921000, Length=410, Percent_Identity=28.2926829268293, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 88250; Mature: 88250

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPFRTAAVLGAGVMGTQIAAHLANAGLVVYLLDLPGPGVHKNAIVEAAFKKGLQQKPP
CCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
IFFTEKTARRVLLGNFEDDWHRLTHVDWVIEAVVEKLEVKQQLMARLEGHIRDDAVVSTN
EEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
TSGLSIQAITAGRSDSFRRRFLGTHFFNPPRYLKLLELIPTIETDPQIVERLKWFGHLHL
CCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEC
GKGVVVAKDTPNFIGNRIGVFISMLGIRAFTEQGYTIEEIDTLTGTLVGRPKSATFRTAD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEHH
IVGLDTLLYVAENLYPAIPDDENRDVFQVPEILRRLVEAGHLGSKTGQGFYQKVGKHILS
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
VNPQTLAYEKAQSLHLRNWKAIAKIKPLPERLRTLYQDSGRAGTFFRQMMLKILSYSAHR
CCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
IPEIADHPLDIDQAMRWGFGWQLGPFEIWDAIGFSQVIQDMQAAGIVVPQWVEKMQLAEI
CCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
DSFYQNIGPNGERFVYQPLHGYLPTEGPQDELTVAQFKTDPARTLWQNAEAALLDIGDGV
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEECCCCE
TLFEFRSKGNTLGQVVVDGFSEALDIVEAGDYRGLVIGNDGEHFSAGANLADMIKFSHQD
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCC
KVNVFTDCEHGAIAHLLDQFQALMLRIHYFPKPIVAAIRGRILGGGCELVMASPHVVVAA
CCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECCCEEEEEECCCEEEEE
ETYIGLVELSVGLIPGAGGIMTMATWAAEQAASDAPRDIQPFLKQAFEHIGMAKVASSAH
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EAQAWGYLPPTAQIVMNSDRRLYVAKEEVLRLDHESYVPPPKRNAIQVLGKPARALFETA
HHHCCCCCCCCHHEEECCCCEEEEEHHHHHHHCCCCCCCCCCCCHHHHHCHHHHHHHHHH
AYQMQQGGYISDYDRFLANRLAYVLTGGDLSAPTLVSDDYLLGLERDMFLPLFSEKKTQE
HHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCEEECCCEEEECCCCCCCCCCCCCHHHH
RILHTLKTKKSLRN
HHHHHHHHHHHHCC
>Mature Secondary Structure
MLKPFRTAAVLGAGVMGTQIAAHLANAGLVVYLLDLPGPGVHKNAIVEAAFKKGLQQKPP
CCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
IFFTEKTARRVLLGNFEDDWHRLTHVDWVIEAVVEKLEVKQQLMARLEGHIRDDAVVSTN
EEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
TSGLSIQAITAGRSDSFRRRFLGTHFFNPPRYLKLLELIPTIETDPQIVERLKWFGHLHL
CCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEC
GKGVVVAKDTPNFIGNRIGVFISMLGIRAFTEQGYTIEEIDTLTGTLVGRPKSATFRTAD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEHH
IVGLDTLLYVAENLYPAIPDDENRDVFQVPEILRRLVEAGHLGSKTGQGFYQKVGKHILS
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
VNPQTLAYEKAQSLHLRNWKAIAKIKPLPERLRTLYQDSGRAGTFFRQMMLKILSYSAHR
CCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
IPEIADHPLDIDQAMRWGFGWQLGPFEIWDAIGFSQVIQDMQAAGIVVPQWVEKMQLAEI
CCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
DSFYQNIGPNGERFVYQPLHGYLPTEGPQDELTVAQFKTDPARTLWQNAEAALLDIGDGV
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEECCCCE
TLFEFRSKGNTLGQVVVDGFSEALDIVEAGDYRGLVIGNDGEHFSAGANLADMIKFSHQD
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCC
KVNVFTDCEHGAIAHLLDQFQALMLRIHYFPKPIVAAIRGRILGGGCELVMASPHVVVAA
CCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECCCEEEEEECCCEEEEE
ETYIGLVELSVGLIPGAGGIMTMATWAAEQAASDAPRDIQPFLKQAFEHIGMAKVASSAH
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EAQAWGYLPPTAQIVMNSDRRLYVAKEEVLRLDHESYVPPPKRNAIQVLGKPARALFETA
HHHCCCCCCCCHHEEECCCCEEEEEHHHHHHHCCCCCCCCCCCCHHHHHCHHHHHHHHHH
AYQMQQGGYISDYDRFLANRLAYVLTGGDLSAPTLVSDDYLLGLERDMFLPLFSEKKTQE
HHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCEEECCCEEEECCCCCCCCCCCCCHHHH
RILHTLKTKKSLRN
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]