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The map label for this gene is fadA [H]

Identifier: 158335305

GI number: 158335305

Start: 2143045

End: 2144226

Strand: Direct

Name: fadA [H]

Synonym: AM1_2149

Alternate gene names: 158335305

Gene position: 2143045-2144226 (Clockwise)

Preceding gene: 158335304

Following gene: 158335306

Centisome position: 32.95

GC content: 53.55

Gene sequence:

>1182_bases
ATGAATAACGCATATATCGTCAGTAGTGTCCGCACTGCCGTTGGCAAAGCCCCCAAAGGTGCACTGCACCATAGCCGCCC
CGATGACTTGGGTGCCGTTGCTGTTAAGGGCGCACTAGATACCGTCCCCAAACTTGAGATCGATCAAGTTGATGATCTGA
TAATCGGCTGTTCCTTCCCTGAAGCTGAACAGGGGTTCAACTTGGGGCGCGTGATTGCCCTGCGGGCAGGGCTTCCCCAC
TCCGTTGCTGGCTGCACCGTGAATCGCTTTTGTTCGTCGGGGTTACAAACCATTGTTATGGCCACGCAAGCGATTATGAC
AGGTCAGGCAGAGGTGATCGTGGCTGGGGGAGCTGAATCTATGAGTCTGATCCCGATGGGGGGACATTACCTGACGCCCA
ATCCAGATCTACTGTCTGAGATTCCTGAAGCCTATTTATCGATGGGGCTAACGGCAGAGAATGTGGCCGAAGAATTCCAG
ATTTCTAGAACTGATCAGGATGCTTTTGCCTTGCGATCGCATCAAAAAGCCCTGGCTGCCCTTGAGAAGGGACGGTTCAA
AGACGAGATTATTCCCTTTATGGTCAAGGCAACCACCTTAGTAGAAGGACAACTCCACACCACCCAAACCGTGTTCGACG
TCGATGAAGGCCCCCGTGCTGACACCAGCCTTGAAGCCTTAGCTCAGCTCAAGCCGGTCTTTAAGGTCGATGGTACCGTC
ACGGCGGGCACCTCTTCCCAAATGTCGGATGGGGCAGCAGCAACAGTTGTAATGAGTGAGCGTAAGGTCAGAGAATTGGC
CCTTGCACCGCTAGGCCGAATGCTGGGCTACTCCGTGGTAGGGGTACCACCGGAACTGATGGGTATGGGTCCAGTGGAGG
CAGTACCCAAGGTACTGAAGCAGGTGGGGTTATCCCTCAGTGATATTGGCTTGATTGAGCTGAATGAAGCCTTTGCGGCC
CAGGCCTTAGCGGTTATGCGAAAGCTAGGTTTGGATGAAGGCATTGTCAATGTGAATGGTGGTGCGATCGCACTTGGTCA
CCCATTGGGCTGCACAGGAGCAAAATTGACTGCCACCCTACTGCATGAGATGAAGCGTCGGGGCATTCGCTATGGTCTGG
TGACTATGTGTGTTGGAGGCGGCATGGGTGCTGCAGGTGTCTTTGAAAACTTGATGTTGTAG

Upstream 100 bases:

>100_bases
AGAAAACTCAGGAACGGATTCTGCATACGTTGAAAACGAAAAAGTCTTTACGGAATTAGGAGACTCAACCTTAGCCCTCA
CAAGAGACGAGGTACATCAA

Downstream 100 bases:

>100_bases
TTGTTTTGCTGTCTATGCTCAATGCTTTGCACTGGCCCCCTACCCCCCCAATCCTGGGGGGAAAGATGCATAGACCTGAG
ACTTCGCTTTTCCTTCTCTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNNAYIVSSVRTAVGKAPKGALHHSRPDDLGAVAVKGALDTVPKLEIDQVDDLIIGCSFPEAEQGFNLGRVIALRAGLPH
SVAGCTVNRFCSSGLQTIVMATQAIMTGQAEVIVAGGAESMSLIPMGGHYLTPNPDLLSEIPEAYLSMGLTAENVAEEFQ
ISRTDQDAFALRSHQKALAALEKGRFKDEIIPFMVKATTLVEGQLHTTQTVFDVDEGPRADTSLEALAQLKPVFKVDGTV
TAGTSSQMSDGAAATVVMSERKVRELALAPLGRMLGYSVVGVPPELMGMGPVEAVPKVLKQVGLSLSDIGLIELNEAFAA
QALAVMRKLGLDEGIVNVNGGAIALGHPLGCTGAKLTATLLHEMKRRGIRYGLVTMCVGGGMGAAGVFENLML

Sequences:

>Translated_393_residues
MNNAYIVSSVRTAVGKAPKGALHHSRPDDLGAVAVKGALDTVPKLEIDQVDDLIIGCSFPEAEQGFNLGRVIALRAGLPH
SVAGCTVNRFCSSGLQTIVMATQAIMTGQAEVIVAGGAESMSLIPMGGHYLTPNPDLLSEIPEAYLSMGLTAENVAEEFQ
ISRTDQDAFALRSHQKALAALEKGRFKDEIIPFMVKATTLVEGQLHTTQTVFDVDEGPRADTSLEALAQLKPVFKVDGTV
TAGTSSQMSDGAAATVVMSERKVRELALAPLGRMLGYSVVGVPPELMGMGPVEAVPKVLKQVGLSLSDIGLIELNEAFAA
QALAVMRKLGLDEGIVNVNGGAIALGHPLGCTGAKLTATLLHEMKRRGIRYGLVTMCVGGGMGAAGVFENLML
>Mature_393_residues
MNNAYIVSSVRTAVGKAPKGALHHSRPDDLGAVAVKGALDTVPKLEIDQVDDLIIGCSFPEAEQGFNLGRVIALRAGLPH
SVAGCTVNRFCSSGLQTIVMATQAIMTGQAEVIVAGGAESMSLIPMGGHYLTPNPDLLSEIPEAYLSMGLTAENVAEEFQ
ISRTDQDAFALRSHQKALAALEKGRFKDEIIPFMVKATTLVEGQLHTTQTVFDVDEGPRADTSLEALAQLKPVFKVDGTV
TAGTSSQMSDGAAATVVMSERKVRELALAPLGRMLGYSVVGVPPELMGMGPVEAVPKVLKQVGLSLSDIGLIELNEAFAA
QALAVMRKLGLDEGIVNVNGGAIALGHPLGCTGAKLTATLLHEMKRRGIRYGLVTMCVGGGMGAAGVFENLML

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=44.4444444444444, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=41.2935323383085, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=38.5786802030457, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=37.5621890547264, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=32.579185520362, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI194353979, Length=388, Percent_Identity=33.2474226804124, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=47.3417721518987, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=44.8275862068966, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=42.1307506053269, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=46.6666666666667, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=32.7014218009479, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=42.75, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=34.75, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=34.9127182044888, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=411, Percent_Identity=30.1703163017032, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=29.873417721519, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=40.1515151515151, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=37.3464373464373, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=40.2985074626866, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17648125, Length=399, Percent_Identity=40.3508771929825, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=34.9246231155779, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI17137578, Length=393, Percent_Identity=32.824427480916, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41145; Mature: 41145

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNAYIVSSVRTAVGKAPKGALHHSRPDDLGAVAVKGALDTVPKLEIDQVDDLIIGCSFP
CCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCEEEECCCC
EAEQGFNLGRVIALRAGLPHSVAGCTVNRFCSSGLQTIVMATQAIMTGQAEVIVAGGAES
CHHHCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
MSLIPMGGHYLTPNPDLLSEIPEAYLSMGLTAENVAEEFQISRTDQDAFALRSHQKALAA
EEEEECCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LEKGRFKDEIIPFMVKATTLVEGQLHTTQTVFDVDEGPRADTSLEALAQLKPVFKVDGTV
HHHCCCHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECCEE
TAGTSSQMSDGAAATVVMSERKVRELALAPLGRMLGYSVVGVPPELMGMGPVEAVPKVLK
ECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCEEECCCHHHHCCCCHHHHHHHHH
QVGLSLSDIGLIELNEAFAAQALAVMRKLGLDEGIVNVNGGAIALGHPLGCTGAKLTATL
HHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCHHHHHHH
LHEMKRRGIRYGLVTMCVGGGMGAAGVFENLML
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNNAYIVSSVRTAVGKAPKGALHHSRPDDLGAVAVKGALDTVPKLEIDQVDDLIIGCSFP
CCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCEEEECCCC
EAEQGFNLGRVIALRAGLPHSVAGCTVNRFCSSGLQTIVMATQAIMTGQAEVIVAGGAES
CHHHCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
MSLIPMGGHYLTPNPDLLSEIPEAYLSMGLTAENVAEEFQISRTDQDAFALRSHQKALAA
EEEEECCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LEKGRFKDEIIPFMVKATTLVEGQLHTTQTVFDVDEGPRADTSLEALAQLKPVFKVDGTV
HHHCCCHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECCEE
TAGTSSQMSDGAAATVVMSERKVRELALAPLGRMLGYSVVGVPPELMGMGPVEAVPKVLK
ECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCEEECCCHHHHCCCCHHHHHHHHH
QVGLSLSDIGLIELNEAFAAQALAVMRKLGLDEGIVNVNGGAIALGHPLGCTGAKLTATL
HHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCHHHHHHH
LHEMKRRGIRYGLVTMCVGGGMGAAGVFENLML
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]