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The map label for this gene is hemD

Identifier: 158334561

GI number: 158334561

Start: 1368130

End: 1368993

Strand: Direct

Name: hemD

Synonym: AM1_1388

Alternate gene names: NA

Gene position: 1368130-1368993 (Clockwise)

Preceding gene: 158334556

Following gene: 158334562

Centisome position: 21.04

GC content: 52.66

Gene sequence:

>864_bases
ATGACGGATCTACTGCTATCGACAGCACGCCTGCCTCTGGGCAATAAACGGATTGTCATTACGGCTCCTCGACCCTATGC
CGGACGTCTAGCGACGGCAATCATCCAGCAAGGGGGGTTGCCCATCGTCATGCCCACGATAGAGACCTATGCATTAGACC
CTGCTCCCGATTTGGATCACGCCTTGCAACAGCTCAGGGATTTTTCGTGGGTTGCTTTCACCAGTCGCACAGGTATTCAA
GCCGTTATGCTGCGGTTACAACAGCTCGATATCCCCTTATTTCTTCTCAATCAATGCCATATTTGCGCCATCGGCCAAGA
TGCAGACCAACTGCAAACGTTAGGCGTTCGTGTTGATCTAATTCCCAAGGAATCGAGTCCTGCGGGCCTTGTGGCAGAGC
TGGCACAAATCCCTGACATAGACACCCGGCGAATTTTTGTACCGATTCCCCAGGTGGAGCGGATACCGGAGCCAGATATC
GTGCCCAAATTCCTTGCCGATCTGGAGCAATTGGGATTAACCGTTGTATCAGTGCCCGCTTATGTCACACGTCGGCTGGA
GGCCACGGCCTATGCCGTCGAGGTGGAACAGATTCGCCAGGGTAAGGTGGATGCGATCGCATTTAGCAGTACCGCTGAAA
TCTCGGCCTTGCTGCAGATGGTGGATGCCGAAACCCTAATGAAGCATTGTGTGATCGCCTGTTTTGGTCCCTATACCGCT
GGGAACGCAAAAGACTTAGGGCTATCCGTTGATATCGTGTCCCAGGACTTTAGTTCATTTACAGGCTTTACCGCAGCCAT
CGCTCAATTTTTCCACCCAGCTTCCGCAGATATCCCTAGGCAGGACCCCGTAATTTTGCCGTAA

Upstream 100 bases:

>100_bases
ACCTTAATCCGATTTTTCTCAACCTCACCTGGACGAATATCCACTTTTGAGACTGGCTATCAACGTCTGGCAGAATAGGT
CGTAGTCTTCGATGGATAGA

Downstream 100 bases:

>100_bases
ACTGTAAATACGTAAATACGCCCCTGGCCAATCTTCTGTGAGCAAGGCCAGTACCTGGAGTTTTTGAGACACCATGTATC
AGACCGCCGACCTGCATGTC

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase; Uroporphyrin-III C/Tetrapyrrole Methyltransferase; Uroporphyrinogen III Synthase/Methyltransferase; Porphyrin Biosynthesis Protein; Porphobilinogen Deaminase; Uroporphyrinogen III Synthase; Uroporphyrin-III C-Methyltransferase CysG; Uroporphyrin-III Synthase/Methyltransferase; Uroporphyrinogen-III Methylase; Uroporphyrin-III Synthase; Uroporphyrinogen-III C-Methyltransferase; Uroporphiryn-III C-Methyltransferase; Uroporphyrin-III C-Methyltransferase Domain Protein; Uroporphyrin-III C-Methyltransferase HemD; Porphyrin Biosynthesis Protein HemD; Siroheme Synthase; Uroporphyrinogen-III Synthase HemD

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTDLLLSTARLPLGNKRIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDHALQQLRDFSWVAFTSRTGIQ
AVMLRLQQLDIPLFLLNQCHICAIGQDADQLQTLGVRVDLIPKESSPAGLVAELAQIPDIDTRRIFVPIPQVERIPEPDI
VPKFLADLEQLGLTVVSVPAYVTRRLEATAYAVEVEQIRQGKVDAIAFSSTAEISALLQMVDAETLMKHCVIACFGPYTA
GNAKDLGLSVDIVSQDFSSFTGFTAAIAQFFHPASADIPRQDPVILP

Sequences:

>Translated_287_residues
MTDLLLSTARLPLGNKRIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDHALQQLRDFSWVAFTSRTGIQ
AVMLRLQQLDIPLFLLNQCHICAIGQDADQLQTLGVRVDLIPKESSPAGLVAELAQIPDIDTRRIFVPIPQVERIPEPDI
VPKFLADLEQLGLTVVSVPAYVTRRLEATAYAVEVEQIRQGKVDAIAFSSTAEISALLQMVDAETLMKHCVIACFGPYTA
GNAKDLGLSVDIVSQDFSSFTGFTAAIAQFFHPASADIPRQDPVILP
>Mature_286_residues
TDLLLSTARLPLGNKRIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDHALQQLRDFSWVAFTSRTGIQA
VMLRLQQLDIPLFLLNQCHICAIGQDADQLQTLGVRVDLIPKESSPAGLVAELAQIPDIDTRRIFVPIPQVERIPEPDIV
PKFLADLEQLGLTVVSVPAYVTRRLEATAYAVEVEQIRQGKVDAIAFSSTAEISALLQMVDAETLMKHCVIACFGPYTAG
NAKDLGLSVDIVSQDFSSFTGFTAAIAQFFHPASADIPRQDPVILP

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:
GO:0004852: Uroporphyrinogen-III synthase
GO:0033014: Uroporphyrinogen-III synthase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 31207; Mature: 31075

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLLSTARLPLGNKRIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDH
CCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHEECCCCCCHHH
ALQQLRDFSWVAFTSRTGIQAVMLRLQQLDIPLFLLNQCHICAIGQDADQLQTLGVRVDL
HHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHCEEEEE
IPKESSPAGLVAELAQIPDIDTRRIFVPIPQVERIPEPDIVPKFLADLEQLGLTVVSVPA
EECCCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCEEEEHHH
YVTRRLEATAYAVEVEQIRQGKVDAIAFSSTAEISALLQMVDAETLMKHCVIACFGPYTA
HHHHHHHHHHHHEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GNAKDLGLSVDIVSQDFSSFTGFTAAIAQFFHPASADIPRQDPVILP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLLLSTARLPLGNKRIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDH
CCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHEECCCCCCHHH
ALQQLRDFSWVAFTSRTGIQAVMLRLQQLDIPLFLLNQCHICAIGQDADQLQTLGVRVDL
HHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHCEEEEE
IPKESSPAGLVAELAQIPDIDTRRIFVPIPQVERIPEPDIVPKFLADLEQLGLTVVSVPA
EECCCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCEEEEHHH
YVTRRLEATAYAVEVEQIRQGKVDAIAFSSTAEISALLQMVDAETLMKHCVIACFGPYTA
HHHHHHHHHHHHEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GNAKDLGLSVDIVSQDFSSFTGFTAAIAQFFHPASADIPRQDPVILP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA