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The map label for this gene is moeA [H]

Identifier: 158334554

GI number: 158334554

Start: 1360384

End: 1361631

Strand: Direct

Name: moeA [H]

Synonym: AM1_1382

Alternate gene names: 158334554

Gene position: 1360384-1361631 (Clockwise)

Preceding gene: 158334552

Following gene: 158334556

Centisome position: 20.92

GC content: 51.12

Gene sequence:

>1248_bases
ATGCTCTCAGTTGACCAAGCAGAGTCTCTTATCCTCAAAACGGCTCAACCCCTCGCAGATCAAGAAATCTCTACTCTCCT
CAACGCGCAACAGCGCATTCTGGCCACAGATATTTCCAGTACATTGGATTTTCCCTATTGGGATAATTCGGCGATGGATG
GGTATGCAGTGCGCTATGTAGATGTCCAAGCTTGTGGGCCTGATACTCCAGCTATCCTCGATGTGGTGACGGAAATACCC
GCCGGGACGTGTCCCAGTCTCTCCTTAGCCCCTGGACAAGCGGCCCGCATCTTTACGGGGGCTATGGTGCCTCAGGGGGC
AGATACAGTGGTGATGCAGGAGAATACCCTTCGGCAAGGTGACCAGGTTCATATCCTTCAATGCCCTCAACCCCAAGCCT
TTGTCAGAAAGCGAGGTGCCTATTACCAAGCAGGAGCGCCAGTTTTAAAGCAAGGCATGACTTTAACGCCCCCAGATATC
GCCATTTTGGCAACGGTTCAGTGCACAGAAATTCCTGTTTATCGTCGACCCGTGGTTGCGATTTTATCGACGGGTAATGA
ACTGGTTGCGCCGGATCAACCATTGGAGGCCGGACAAATTGTTGACTCCAATCGGTATGCTTTGGCGGCTCTAGTACAGG
CAACGGGAGCCGAAGTTCAGCTGATAGACCCCGTGGGGGACACAGTGGAGGATTTGAAAGCTGCGATCGCATCTACAATT
CTTCAGGCCGATATCGTTATTTCTTCTGGGGGAGTCTCGGTGGGAGATTACGATTATGTTGACCAAGTACTAGCAGAGTT
AAATGCTGATATCTATATTCGGTCTGTGGCCGTTAAACCCGGTAAACCTCTGACCTTTGCTACTTTCCCTGCTACAGGCG
GAAACCAGCCTGTTCTCTATTTTGGTCTACCGGGAAATCCAGTGTCCGCGTTGGTCAGCTTTTGGCGATTTGTGCAGCCT
GCTCTCCGCAAAGTGTCCGGTCAGTCAGGCAGTTGGCGACCGCATTTTGTAAAGGCTAGAACTTTACACCCTTTACCTGC
GGGAGGACGGAGAGAGATTTATCTCTGGGGGCAGTTGAGCCTAAACGACGGCCAATATGAATTTACCCTCGCTGGCGGAA
GTCATAGCTCTGGAAATTTAATGAATCTATCCCAAACCAACGGTTTAGTCATGATTCCTGTTGATCATCCAGCAATGGAG
GCTGGAGAGTCGGTATCGGTGATGCAGGTGGGGGAAGCCAGCACCTAA

Upstream 100 bases:

>100_bases
AAATACTATTATTTTTTGCAAAATAAAGGTGGGTCAGCCTAACTTGTAGGGGCAACCACAGAAACCGCTCCCCTATCGTC
ATTGCGCCCAAAGGTATCTC

Downstream 100 bases:

>100_bases
GCCATCCCAGCAGGCTCGATCAAATGAGAAATAACCCTTGATTCATAGCAAATCAAAGACAACCATTGGCATTCTGGGGT
CCTCAGTCTAAACTGTTGCC

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLSVDQAESLILKTAQPLADQEISTLLNAQQRILATDISSTLDFPYWDNSAMDGYAVRYVDVQACGPDTPAILDVVTEIP
AGTCPSLSLAPGQAARIFTGAMVPQGADTVVMQENTLRQGDQVHILQCPQPQAFVRKRGAYYQAGAPVLKQGMTLTPPDI
AILATVQCTEIPVYRRPVVAILSTGNELVAPDQPLEAGQIVDSNRYALAALVQATGAEVQLIDPVGDTVEDLKAAIASTI
LQADIVISSGGVSVGDYDYVDQVLAELNADIYIRSVAVKPGKPLTFATFPATGGNQPVLYFGLPGNPVSALVSFWRFVQP
ALRKVSGQSGSWRPHFVKARTLHPLPAGGRREIYLWGQLSLNDGQYEFTLAGGSHSSGNLMNLSQTNGLVMIPVDHPAME
AGESVSVMQVGEAST

Sequences:

>Translated_415_residues
MLSVDQAESLILKTAQPLADQEISTLLNAQQRILATDISSTLDFPYWDNSAMDGYAVRYVDVQACGPDTPAILDVVTEIP
AGTCPSLSLAPGQAARIFTGAMVPQGADTVVMQENTLRQGDQVHILQCPQPQAFVRKRGAYYQAGAPVLKQGMTLTPPDI
AILATVQCTEIPVYRRPVVAILSTGNELVAPDQPLEAGQIVDSNRYALAALVQATGAEVQLIDPVGDTVEDLKAAIASTI
LQADIVISSGGVSVGDYDYVDQVLAELNADIYIRSVAVKPGKPLTFATFPATGGNQPVLYFGLPGNPVSALVSFWRFVQP
ALRKVSGQSGSWRPHFVKARTLHPLPAGGRREIYLWGQLSLNDGQYEFTLAGGSHSSGNLMNLSQTNGLVMIPVDHPAME
AGESVSVMQVGEAST
>Mature_415_residues
MLSVDQAESLILKTAQPLADQEISTLLNAQQRILATDISSTLDFPYWDNSAMDGYAVRYVDVQACGPDTPAILDVVTEIP
AGTCPSLSLAPGQAARIFTGAMVPQGADTVVMQENTLRQGDQVHILQCPQPQAFVRKRGAYYQAGAPVLKQGMTLTPPDI
AILATVQCTEIPVYRRPVVAILSTGNELVAPDQPLEAGQIVDSNRYALAALVQATGAEVQLIDPVGDTVEDLKAAIASTI
LQADIVISSGGVSVGDYDYVDQVLAELNADIYIRSVAVKPGKPLTFATFPATGGNQPVLYFGLPGNPVSALVSFWRFVQP
ALRKVSGQSGSWRPHFVKARTLHPLPAGGRREIYLWGQLSLNDGQYEFTLAGGSHSSGNLMNLSQTNGLVMIPVDHPAME
AGESVSVMQVGEAST

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=429, Percent_Identity=37.5291375291375, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI66932975, Length=429, Percent_Identity=37.5291375291375, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1787049, Length=392, Percent_Identity=40.0510204081633, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI25147659, Length=306, Percent_Identity=31.6993464052288, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=317, Percent_Identity=27.1293375394322, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136978, Length=418, Percent_Identity=32.0574162679426, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24638841, Length=418, Percent_Identity=32.0574162679426, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44142; Mature: 44142

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVDQAESLILKTAQPLADQEISTLLNAQQRILATDISSTLDFPYWDNSAMDGYAVRYV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
DVQACGPDTPAILDVVTEIPAGTCPSLSLAPGQAARIFTGAMVPQGADTVVMQENTLRQG
EEEECCCCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEECCCCCCCC
DQVHILQCPQPQAFVRKRGAYYQAGAPVLKQGMTLTPPDIAILATVQCTEIPVYRRPVVA
CEEEEEECCCCHHHHHHCCCEEECCCHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCEEE
ILSTGNELVAPDQPLEAGQIVDSNRYALAALVQATGAEVQLIDPVGDTVEDLKAAIASTI
EEECCCCEECCCCCCCCCCEECCCCCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHH
LQADIVISSGGVSVGDYDYVDQVLAELNADIYIRSVAVKPGKPLTFATFPATGGNQPVLY
HHEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEE
FGLPGNPVSALVSFWRFVQPALRKVSGQSGSWRPHFVKARTLHPLPAGGRREIYLWGQLS
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEE
LNDGQYEFTLAGGSHSSGNLMNLSQTNGLVMIPVDHPAMEAGESVSVMQVGEAST
ECCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCHHHCCCCEEEEECCCCCC
>Mature Secondary Structure
MLSVDQAESLILKTAQPLADQEISTLLNAQQRILATDISSTLDFPYWDNSAMDGYAVRYV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
DVQACGPDTPAILDVVTEIPAGTCPSLSLAPGQAARIFTGAMVPQGADTVVMQENTLRQG
EEEECCCCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEECCCCCCCC
DQVHILQCPQPQAFVRKRGAYYQAGAPVLKQGMTLTPPDIAILATVQCTEIPVYRRPVVA
CEEEEEECCCCHHHHHHCCCEEECCCHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCEEE
ILSTGNELVAPDQPLEAGQIVDSNRYALAALVQATGAEVQLIDPVGDTVEDLKAAIASTI
EEECCCCEECCCCCCCCCCEECCCCCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHH
LQADIVISSGGVSVGDYDYVDQVLAELNADIYIRSVAVKPGKPLTFATFPATGGNQPVLY
HHEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEE
FGLPGNPVSALVSFWRFVQPALRKVSGQSGSWRPHFVKARTLHPLPAGGRREIYLWGQLS
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEE
LNDGQYEFTLAGGSHSSGNLMNLSQTNGLVMIPVDHPAMEAGESVSVMQVGEAST
ECCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]