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The map label for this gene is acr1 [H]

Identifier: 158334423

GI number: 158334423

Start: 1229534

End: 1230349

Strand: Reverse

Name: acr1 [H]

Synonym: AM1_1244

Alternate gene names: 158334423

Gene position: 1230349-1229534 (Counterclockwise)

Preceding gene: 158334425

Following gene: 158334422

Centisome position: 18.92

GC content: 51.35

Gene sequence:

>816_bases
ATGGATTTATTGTTCTTTCCCTGTCTTAGGGTTAATCAGCGTAGACTCGAACGATTGCTGGTAGGAAAAACGGTTCTGAT
TACCGGAGCGAGCTATGGAATCGGAGAATGTTTGGCTTTACGGCTAGCCTTGCCCATGACTCAGTTAATCTTAGTGGCGC
GGACTGAAGAGAAACTATTGGCCGTTCAAGCTCAGGTAGAGGCCCGTGGCGGACAGGCAGATATTTTTCCCTGCGATCTG
AGACAGCCGACAGAAGTTGAAGCGTTGCTAGAGCAGCTTCCCCATCCCATTGATATTCTGGTGAGCAATGCGGGGAAGTC
GATTCGGCGATCCCTGTTTGATTCTCTGGATCGGTTCCATGACTTTACCCGGACCATGAACATCAACTACTTTGGTCCTG
TCCAGTTGATGCTGGCCTTGACCCCCACCCTGGTGGCTCAACAGGGTCATATGATTAATATCTCGGCAATCAATGTGCTG
CTCTTGCCTGCCCCCCAATGGGCAGCCTATCAGGCTTCGAAAACGGCCTTTGACCAATGGTTCCGCTGTGCCGCCCCTGA
ACTCAATGCCCAAGGGGTCAAGACCACTTCAATCTATTTACCTTTGGTACGCACTCGGATGATTGCGCCGACGAAAGCCT
ATCAGAATATGCCTGCCTTGAGTCCAGATCAGGTGGCTAAACTGATTTGCAAAGCAATGGTTACCCGTTCTCGGACCATT
GCCCCTTGGTGGTTGATGATGGGGGAGTTGGTATCTGTCCTGCTGCGATGGCCGGGAGAAGTAATTTGGAGTGGGGTGAT
GAGGTGGAGACGATAG

Upstream 100 bases:

>100_bases
CTATAACTGTATGTCTTGCTAGGCCAGCTCAAACTAACCCAGCTCTATCCAGCAGACTTCCTTTGGTAGATGCGCGCCTG
GGCGAACGAGGGGCAGCCTA

Downstream 100 bases:

>100_bases
AGCCATGATCTTTACTCTGCTGAGAAAACTGCATCGGACGCGCCTATTAACCTTGGTTGGTTTGTATCGTTTGCTGGAAG
CGATCTGGACGACGGGGGTT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MDLLFFPCLRVNQRRLERLLVGKTVLITGASYGIGECLALRLALPMTQLILVARTEEKLLAVQAQVEARGGQADIFPCDL
RQPTEVEALLEQLPHPIDILVSNAGKSIRRSLFDSLDRFHDFTRTMNINYFGPVQLMLALTPTLVAQQGHMINISAINVL
LLPAPQWAAYQASKTAFDQWFRCAAPELNAQGVKTTSIYLPLVRTRMIAPTKAYQNMPALSPDQVAKLICKAMVTRSRTI
APWWLMMGELVSVLLRWPGEVIWSGVMRWRR

Sequences:

>Translated_271_residues
MDLLFFPCLRVNQRRLERLLVGKTVLITGASYGIGECLALRLALPMTQLILVARTEEKLLAVQAQVEARGGQADIFPCDL
RQPTEVEALLEQLPHPIDILVSNAGKSIRRSLFDSLDRFHDFTRTMNINYFGPVQLMLALTPTLVAQQGHMINISAINVL
LLPAPQWAAYQASKTAFDQWFRCAAPELNAQGVKTTSIYLPLVRTRMIAPTKAYQNMPALSPDQVAKLICKAMVTRSRTI
APWWLMMGELVSVLLRWPGEVIWSGVMRWRR
>Mature_271_residues
MDLLFFPCLRVNQRRLERLLVGKTVLITGASYGIGECLALRLALPMTQLILVARTEEKLLAVQAQVEARGGQADIFPCDL
RQPTEVEALLEQLPHPIDILVSNAGKSIRRSLFDSLDRFHDFTRTMNINYFGPVQLMLALTPTLVAQQGHMINISAINVL
LLPAPQWAAYQASKTAFDQWFRCAAPELNAQGVKTTSIYLPLVRTRMIAPTKAYQNMPALSPDQVAKLICKAMVTRSRTI
APWWLMMGELVSVLLRWPGEVIWSGVMRWRR

Specific function: Catalyzes the NADPH-dependent reduction of long chain acyl-CoA to the corresponding aldehyde [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=224, Percent_Identity=29.9107142857143, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7705855, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI32455239, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031765, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=235, Percent_Identity=29.3617021276596, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI87082100, Length=239, Percent_Identity=31.7991631799163, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787820, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=226, Percent_Identity=28.3185840707965, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=197, Percent_Identity=28.4263959390863, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=27.0935960591133, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=229, Percent_Identity=26.2008733624454, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=204, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=240, Percent_Identity=25.8333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=257, Percent_Identity=28.7937743190661, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=189, Percent_Identity=32.2751322751323, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=194, Percent_Identity=25.7731958762887, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=195, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=192, Percent_Identity=28.6458333333333, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=180, Percent_Identity=29.4444444444444, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=252, Percent_Identity=27.3809523809524, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28571526, Length=187, Percent_Identity=34.7593582887701, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=219, Percent_Identity=30.5936073059361, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=32.9842931937173, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24644339, Length=184, Percent_Identity=32.6086956521739, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21358495, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30526; Mature: 30526

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLFFPCLRVNQRRLERLLVGKTVLITGASYGIGECLALRLALPMTQLILVARTEEKLL
CCCEEHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
AVQAQVEARGGQADIFPCDLRQPTEVEALLEQLPHPIDILVSNAGKSIRRSLFDSLDRFH
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
DFTRTMNINYFGPVQLMLALTPTLVAQQGHMINISAINVLLLPAPQWAAYQASKTAFDQW
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHH
FRCAAPELNAQGVKTTSIYLPLVRTRMIAPTKAYQNMPALSPDQVAKLICKAMVTRSRTI
HHHCCCCCCCCCCEEHHEEHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
APWWLMMGELVSVLLRWPGEVIWSGVMRWRR
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDLLFFPCLRVNQRRLERLLVGKTVLITGASYGIGECLALRLALPMTQLILVARTEEKLL
CCCEEHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
AVQAQVEARGGQADIFPCDLRQPTEVEALLEQLPHPIDILVSNAGKSIRRSLFDSLDRFH
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
DFTRTMNINYFGPVQLMLALTPTLVAQQGHMINISAINVLLLPAPQWAAYQASKTAFDQW
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHH
FRCAAPELNAQGVKTTSIYLPLVRTRMIAPTKAYQNMPALSPDQVAKLICKAMVTRSRTI
HHHCCCCCCCCCCEEHHEEHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
APWWLMMGELVSVLLRWPGEVIWSGVMRWRR
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA