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The map label for this gene is luxQ [H]

Identifier: 158333826

GI number: 158333826

Start: 621355

End: 623316

Strand: Direct

Name: luxQ [H]

Synonym: AM1_0635

Alternate gene names: 158333826

Gene position: 621355-623316 (Clockwise)

Preceding gene: 158333825

Following gene: 158333828

Centisome position: 9.55

GC content: 41.18

Gene sequence:

>1962_bases
ATGTGTTCTCAGTCACCTATCAGCCCTAGTCATCAGACTCTTTTCTTTCGGCATAGTTTACCGCCAGGGCAATTTGCCAC
TGCCTTCCCATTCCATTTCGTTCTCAATTCAGATTTAGAGATTATTCAAGCTGGAGACTCTCTTCAGCATTTACTCCCTA
AAATCTGTGGGAGTCAGTTTGAACAGCAATTTGCGATTCAAAGACCCCCTTTGTCACCAGATTTTGCTAGTCTCAGCGAG
CCTTGCCGTTCGTTGTTGATTTTAGATTGCCTTGCTATAAATATGCAGTTGCAAGGGCAGATGGTGTATGTTGTCGAGAC
TAATTTAATTTTCTTCCTCGGCTCTCTCTGGGTAACAGAAATCCATGAGCTTAAACCTCTGGGGTTACGGCTTAACCATT
TTGCTGTTCATGATCGGGTCTCAGATTTTCTGTTTCTTTTACAGGCCAAAAATACAGCTTTAAATGAAGCCCATAAGTTG
GCGGATGAACGGGCTCAAAAATTAGTGGCTGCTAAGGAGATGGCTGAAAGTGCGAATTTAGCTAAAAGCACCTTTCTTGC
CAATATGAGTCATGAATTGCGAACACCTCTAAATGCAATTTTAGGCTTTTCGCAACTATTGAGTCGGGATTCAACATTGA
CGGCGGCTCATCTTCATAAGCTAAGCATCATCAATAATAGTGGTGAACATCTCCTGGCTCTTCTCAACGACATTTTAGAA
ATGTCGAAAATTGAGGCTGGTCAAATTACTCTAGATCCCACCAATTTCAACCTTCATCACTTTTTGGAAGGCCTATATAA
TTTGTTCCAGCAGAAGGTTTTTTCCAAGAAAATTAATTTAAAGTTTCAATATTCTAAAACGGTTCCCCAATATATTCAAG
CTGATATCAAAAAGCTTCGTCAAGTACTAATTAATTTACTAGGGAATGCAATTAAATTTACTAATGAAGGGCAAGTTTAT
CTGAAAGTAGCCAGTCGTATTTATCTCGATGATGCTTACTCTGTAAACCTTCAGGAGCCGACTTGTTTATTAACCTTCTC
AGTAGAGGATACGGGGCCTGGTGTCTCGGAAGAGGATCAAGAGAAGATTTTTCATCCTTTTTACCAAACTGAGTATGGCA
AACAGTCCCATCAGGGGGTTCATGGGACAGGCTTAGGACTGTCAATTAGTCGTCAATTTGTCAATTTAATGGGGGGAGAA
CTATCCATATCGAGTCAACTGAATAAGGGAGCGACTTTTTCTTTTTCAATTCCCGTTAAAGTAAGTACTGCCAGTGCATT
GGTACCCACCCTCGAACAGCGTATTCTTCAGGTTCACCCTCATCAACCGATTTTTCGGATCTTGGTAGTGGAAGATCATG
CAGATAATCGATGTTTGTTAGTCACATTACTGGCCACCATTGGCTTTTTGGTGAAATCTGCACAAAACGGCCAAGAAGCT
TTGGAAATTTGCCAAGAGTGGCATCCCCATTTAATTTGGATGGATATTAAGATGCCTTTAATGGATGGCCTGGAGGCGAC
TCAACGGATTAGAGCAATGCCTCAGATCCCACAACCAGTGATTATTGCTTTAACGGCTAATGCCTTCGATGAAGATAAAG
AACGAGCCCTGACGTGTGGCTGTGATGATTTTCTCCATAAACCCTGTAATGAGACGATTATCTTGGAGAAAATGACGCAG
CATTTAGGGGTGAAGTATTTATATGAAGAATTGACTCCTCCGTTGACCCATTGCGACTCTTTGTCCCTACCTAAACGGAA
TGATCTTAAGGCTCAATTGCAGGAAGTGATGTCTGAATCATGGCTGAACCATTTGCAGAGTAAGGCCATTAATTTAGATA
CGGATGGAATTTTTGACTTGCTAGAAGACATCTCACCTGAATATGAGCATTTAAAAAACCTTTTGGCCTCCCTGGCCAAT
AATTATCGATGTGATGTAATCCTGGAATTGACTCAGCAATAA

Upstream 100 bases:

>100_bases
GCTCCGATGGTATCTGGATTGGTGGAAGGGCTAGGGGAGCGATTTGACACAGCAGTAGAAGTAACCCAAGTCCAAGATCG
AGAGCAGGGAGCTGATCACG

Downstream 100 bases:

>100_bases
TCGAGACAGGGCATCTGAGATGGTGTTGTGTGGCCATTCTTAGAGAAGGACGCCTTCACCTAAGGAATAACCATGACAGG
GCAAGGGGCTAAATTAATCA

Product: two-component hybrid sensor and regulator histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MCSQSPISPSHQTLFFRHSLPPGQFATAFPFHFVLNSDLEIIQAGDSLQHLLPKICGSQFEQQFAIQRPPLSPDFASLSE
PCRSLLILDCLAINMQLQGQMVYVVETNLIFFLGSLWVTEIHELKPLGLRLNHFAVHDRVSDFLFLLQAKNTALNEAHKL
ADERAQKLVAAKEMAESANLAKSTFLANMSHELRTPLNAILGFSQLLSRDSTLTAAHLHKLSIINNSGEHLLALLNDILE
MSKIEAGQITLDPTNFNLHHFLEGLYNLFQQKVFSKKINLKFQYSKTVPQYIQADIKKLRQVLINLLGNAIKFTNEGQVY
LKVASRIYLDDAYSVNLQEPTCLLTFSVEDTGPGVSEEDQEKIFHPFYQTEYGKQSHQGVHGTGLGLSISRQFVNLMGGE
LSISSQLNKGATFSFSIPVKVSTASALVPTLEQRILQVHPHQPIFRILVVEDHADNRCLLVTLLATIGFLVKSAQNGQEA
LEICQEWHPHLIWMDIKMPLMDGLEATQRIRAMPQIPQPVIIALTANAFDEDKERALTCGCDDFLHKPCNETIILEKMTQ
HLGVKYLYEELTPPLTHCDSLSLPKRNDLKAQLQEVMSESWLNHLQSKAINLDTDGIFDLLEDISPEYEHLKNLLASLAN
NYRCDVILELTQQ

Sequences:

>Translated_653_residues
MCSQSPISPSHQTLFFRHSLPPGQFATAFPFHFVLNSDLEIIQAGDSLQHLLPKICGSQFEQQFAIQRPPLSPDFASLSE
PCRSLLILDCLAINMQLQGQMVYVVETNLIFFLGSLWVTEIHELKPLGLRLNHFAVHDRVSDFLFLLQAKNTALNEAHKL
ADERAQKLVAAKEMAESANLAKSTFLANMSHELRTPLNAILGFSQLLSRDSTLTAAHLHKLSIINNSGEHLLALLNDILE
MSKIEAGQITLDPTNFNLHHFLEGLYNLFQQKVFSKKINLKFQYSKTVPQYIQADIKKLRQVLINLLGNAIKFTNEGQVY
LKVASRIYLDDAYSVNLQEPTCLLTFSVEDTGPGVSEEDQEKIFHPFYQTEYGKQSHQGVHGTGLGLSISRQFVNLMGGE
LSISSQLNKGATFSFSIPVKVSTASALVPTLEQRILQVHPHQPIFRILVVEDHADNRCLLVTLLATIGFLVKSAQNGQEA
LEICQEWHPHLIWMDIKMPLMDGLEATQRIRAMPQIPQPVIIALTANAFDEDKERALTCGCDDFLHKPCNETIILEKMTQ
HLGVKYLYEELTPPLTHCDSLSLPKRNDLKAQLQEVMSESWLNHLQSKAINLDTDGIFDLLEDISPEYEHLKNLLASLAN
NYRCDVILELTQQ
>Mature_653_residues
MCSQSPISPSHQTLFFRHSLPPGQFATAFPFHFVLNSDLEIIQAGDSLQHLLPKICGSQFEQQFAIQRPPLSPDFASLSE
PCRSLLILDCLAINMQLQGQMVYVVETNLIFFLGSLWVTEIHELKPLGLRLNHFAVHDRVSDFLFLLQAKNTALNEAHKL
ADERAQKLVAAKEMAESANLAKSTFLANMSHELRTPLNAILGFSQLLSRDSTLTAAHLHKLSIINNSGEHLLALLNDILE
MSKIEAGQITLDPTNFNLHHFLEGLYNLFQQKVFSKKINLKFQYSKTVPQYIQADIKKLRQVLINLLGNAIKFTNEGQVY
LKVASRIYLDDAYSVNLQEPTCLLTFSVEDTGPGVSEEDQEKIFHPFYQTEYGKQSHQGVHGTGLGLSISRQFVNLMGGE
LSISSQLNKGATFSFSIPVKVSTASALVPTLEQRILQVHPHQPIFRILVVEDHADNRCLLVTLLATIGFLVKSAQNGQEA
LEICQEWHPHLIWMDIKMPLMDGLEATQRIRAMPQIPQPVIIALTANAFDEDKERALTCGCDDFLHKPCNETIILEKMTQ
HLGVKYLYEELTPPLTHCDSLSLPKRNDLKAQLQEVMSESWLNHLQSKAINLDTDGIFDLLEDISPEYEHLKNLLASLAN
NYRCDVILELTQQ

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI194595482, Length=175, Percent_Identity=25.1428571428571, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI194595474, Length=175, Percent_Identity=25.1428571428571, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194595476, Length=175, Percent_Identity=25.1428571428571, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194595472, Length=175, Percent_Identity=25.1428571428571, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI67763816, Length=175, Percent_Identity=25.1428571428571, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194595478, Length=175, Percent_Identity=25.1428571428571, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=439, Percent_Identity=33.9407744874715, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI48994928, Length=378, Percent_Identity=34.1269841269841, Blast_Score=202, Evalue=8e-53,
Organism=Escherichia coli, GI87081816, Length=395, Percent_Identity=32.6582278481013, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=38.8663967611336, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=34.8178137651822, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=28.1368821292776, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=28.2945736434109, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=27.6, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1786912, Length=268, Percent_Identity=27.9850746268657, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=25, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787894, Length=254, Percent_Identity=27.9527559055118, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082128, Length=249, Percent_Identity=26.1044176706827, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=40.9523809523809, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=236, Percent_Identity=26.6949152542373, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=22.5296442687747, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323034, Length=145, Percent_Identity=33.1034482758621, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322044, Length=95, Percent_Identity=41.0526315789474, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73501; Mature: 73501

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSQSPISPSHQTLFFRHSLPPGQFATAFPFHFVLNSDLEIIQAGDSLQHLLPKICGSQF
CCCCCCCCCCCCEEEEEECCCCCCCCHHCCEEEEECCCCCEEECCCHHHHHHHHHHHHHH
EQQFAIQRPPLSPDFASLSEPCRSLLILDCLAINMQLQGQMVYVVETNLIFFLGSLWVTE
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCEEEEEEECHHHHHHHHHHHHH
IHELKPLGLRLNHFAVHDRVSDFLFLLQAKNTALNEAHKLADERAQKLVAAKEMAESANL
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSTFLANMSHELRTPLNAILGFSQLLSRDSTLTAAHLHKLSIINNSGEHLLALLNDILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHH
MSKIEAGQITLDPTNFNLHHFLEGLYNLFQQKVFSKKINLKFQYSKTVPQYIQADIKKLR
HHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
QVLINLLGNAIKFTNEGQVYLKVASRIYLDDAYSVNLQEPTCLLTFSVEDTGPGVSEEDQ
HHHHHHHCCCEEECCCCEEEEEEEHHHEECCCEEEECCCCEEEEEEEECCCCCCCCCCHH
EKIFHPFYQTEYGKQSHQGVHGTGLGLSISRQFVNLMGGELSISSQLNKGATFSFSIPVK
HHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCEEEEEEEEE
VSTASALVPTLEQRILQVHPHQPIFRILVVEDHADNRCLLVTLLATIGFLVKSAQNGQEA
ECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
LEICQEWHPHLIWMDIKMPLMDGLEATQRIRAMPQIPQPVIIALTANAFDEDKERALTCG
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHEEECC
CDDFLHKPCNETIILEKMTQHLGVKYLYEELTPPLTHCDSLSLPKRNDLKAQLQEVMSES
CHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
WLNHLQSKAINLDTDGIFDLLEDISPEYEHLKNLLASLANNYRCDVILELTQQ
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MCSQSPISPSHQTLFFRHSLPPGQFATAFPFHFVLNSDLEIIQAGDSLQHLLPKICGSQF
CCCCCCCCCCCCEEEEEECCCCCCCCHHCCEEEEECCCCCEEECCCHHHHHHHHHHHHHH
EQQFAIQRPPLSPDFASLSEPCRSLLILDCLAINMQLQGQMVYVVETNLIFFLGSLWVTE
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCEEEEEEECHHHHHHHHHHHHH
IHELKPLGLRLNHFAVHDRVSDFLFLLQAKNTALNEAHKLADERAQKLVAAKEMAESANL
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSTFLANMSHELRTPLNAILGFSQLLSRDSTLTAAHLHKLSIINNSGEHLLALLNDILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHH
MSKIEAGQITLDPTNFNLHHFLEGLYNLFQQKVFSKKINLKFQYSKTVPQYIQADIKKLR
HHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
QVLINLLGNAIKFTNEGQVYLKVASRIYLDDAYSVNLQEPTCLLTFSVEDTGPGVSEEDQ
HHHHHHHCCCEEECCCCEEEEEEEHHHEECCCEEEECCCCEEEEEEEECCCCCCCCCCHH
EKIFHPFYQTEYGKQSHQGVHGTGLGLSISRQFVNLMGGELSISSQLNKGATFSFSIPVK
HHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCEEEEEEEEE
VSTASALVPTLEQRILQVHPHQPIFRILVVEDHADNRCLLVTLLATIGFLVKSAQNGQEA
ECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
LEICQEWHPHLIWMDIKMPLMDGLEATQRIRAMPQIPQPVIIALTANAFDEDKERALTCG
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHEEECC
CDDFLHKPCNETIILEKMTQHLGVKYLYEELTPPLTHCDSLSLPKRNDLKAQLQEVMSES
CHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
WLNHLQSKAINLDTDGIFDLLEDISPEYEHLKNLLASLANNYRCDVILELTQQ
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA