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The map label for this gene is lpxB [H]

Identifier: 158333774

GI number: 158333774

Start: 568724

End: 569899

Strand: Reverse

Name: lpxB [H]

Synonym: AM1_0581

Alternate gene names: 158333774

Gene position: 569899-568724 (Counterclockwise)

Preceding gene: 158333775

Following gene: 158333772

Centisome position: 8.76

GC content: 54.68

Gene sequence:

>1176_bases
ATGGATCGGCCCTACCGAATTTTTATCAGTACCGGCGAGGTCTCTGGCGATCTCCAGGGCAGTTTACTGATTCCTGCCTT
GATGGCAGAAGCCCAGTCCCGAGGATATGCCCTAGAGATCTGGGCTTTGGGGGGTCCACGAATGGCTGCAGTAGGCGCTC
GACTCCTAGGGGATACCAGCCAGATCGGCGCGATTGGTCCCGTCAATGCATTACCCTTTGTCTGGCCCACCCTGAAGCTA
CACAAGCAGGTGATGGATCAGTTCAAACAGGTCCCTCCCGATCTCACGGTTTTGATTGATTACATCGGCCCCAACCTTCG
TTTAGGTCAACATCTCAAGCAGGCCTGCCCCAACCCGGTGGTCTACTATATTGCGCCCTCCGAATGGGTCTGGTCCCAAG
GGTTAGGGGTCACCCGGCAAGTCGTGGACCTCAGCGATAAAATGCTGGCTATTTTTCCCCAGGAAGCCACGTATTACCAA
GAGATGGGGGCAGATATCAATTGGGTGGGCCATCCTCTGGTGGATCACATCCATCAGTTTCCCCCACGAGAACAGGCCCG
TCAGCAGTTGGGGCTGCATCCTCACCAACCCATGATGGCGCTGATGCCTGCCTCTCGTCATCAAGAGCTGGCTCATCTGT
TGCCGGTGATGCTCACCGCCGCACAGCAGATCTGCCGCCAGGTGCCAGACATTCAGTTTTGGATACCTCTGGCCCTACCG
GCCTATCGTGGCGAGGTCACCCAAGCCCTACAAAGGACAGGACTCCCCATTTCGCTCTTTCCAGATTCTCAAACGGTGGT
CGCCGCCGCAGATGTGGTGATTACTAAATCCGGAACCGCTAACCTGGAAGCAGCCCTTCTCAATGTCCCGCAAGTGGTGG
TCTATCGGGTGGGAGCCATTAGTGCTTGGCTGTATCAGCATCTGCTTCACTTTGAGGTTGAGTTTATTTCGCCGGTCAAT
CTTGTGGTTGGACGAGAAATTGTACCCGAGCTACTGCAACAGGAGGTAACTCCAGAAAAGATTGCAGAACTTGCCTACTC
ACTACTAGAGAAAGGGGAGGCTCGACACACCATGATGGCCGGATATCAGGAGTTGCGATCTCACCTTGGTCTTCCAGGGG
TTCTCCAGCGAGCGGCAGAAGCTATCCTAAATGTTTTAGAGCAGTCCCTTAGGTAG

Upstream 100 bases:

>100_bases
GCATCCCCTGATTCAACATTTGTGCCAGTTTATGCGGGCAGCCCAAACCAGGCGCGGCCTCACCCCTGGGCGTCAGCGCT
GGGCTTCGGTCTAAGGCACG

Downstream 100 bases:

>100_bases
ACTCTAGATCAGCCGGTAGCTCACCAATAATGGTTTGGCGGCTATTAAAGGTAGATGTCGTCAGGCTAGGTTTAATCGCT
AAGAGCGCAGAGGATAGAGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDRPYRIFISTGEVSGDLQGSLLIPALMAEAQSRGYALEIWALGGPRMAAVGARLLGDTSQIGAIGPVNALPFVWPTLKL
HKQVMDQFKQVPPDLTVLIDYIGPNLRLGQHLKQACPNPVVYYIAPSEWVWSQGLGVTRQVVDLSDKMLAIFPQEATYYQ
EMGADINWVGHPLVDHIHQFPPREQARQQLGLHPHQPMMALMPASRHQELAHLLPVMLTAAQQICRQVPDIQFWIPLALP
AYRGEVTQALQRTGLPISLFPDSQTVVAAADVVITKSGTANLEAALLNVPQVVVYRVGAISAWLYQHLLHFEVEFISPVN
LVVGREIVPELLQQEVTPEKIAELAYSLLEKGEARHTMMAGYQELRSHLGLPGVLQRAAEAILNVLEQSLR

Sequences:

>Translated_391_residues
MDRPYRIFISTGEVSGDLQGSLLIPALMAEAQSRGYALEIWALGGPRMAAVGARLLGDTSQIGAIGPVNALPFVWPTLKL
HKQVMDQFKQVPPDLTVLIDYIGPNLRLGQHLKQACPNPVVYYIAPSEWVWSQGLGVTRQVVDLSDKMLAIFPQEATYYQ
EMGADINWVGHPLVDHIHQFPPREQARQQLGLHPHQPMMALMPASRHQELAHLLPVMLTAAQQICRQVPDIQFWIPLALP
AYRGEVTQALQRTGLPISLFPDSQTVVAAADVVITKSGTANLEAALLNVPQVVVYRVGAISAWLYQHLLHFEVEFISPVN
LVVGREIVPELLQQEVTPEKIAELAYSLLEKGEARHTMMAGYQELRSHLGLPGVLQRAAEAILNVLEQSLR
>Mature_391_residues
MDRPYRIFISTGEVSGDLQGSLLIPALMAEAQSRGYALEIWALGGPRMAAVGARLLGDTSQIGAIGPVNALPFVWPTLKL
HKQVMDQFKQVPPDLTVLIDYIGPNLRLGQHLKQACPNPVVYYIAPSEWVWSQGLGVTRQVVDLSDKMLAIFPQEATYYQ
EMGADINWVGHPLVDHIHQFPPREQARQQLGLHPHQPMMALMPASRHQELAHLLPVMLTAAQQICRQVPDIQFWIPLALP
AYRGEVTQALQRTGLPISLFPDSQTVVAAADVVITKSGTANLEAALLNVPQVVVYRVGAISAWLYQHLLHFEVEFISPVN
LVVGREIVPELLQQEVTPEKIAELAYSLLEKGEARHTMMAGYQELRSHLGLPGVLQRAAEAILNVLEQSLR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=386, Percent_Identity=29.7927461139896, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43306; Mature: 43306

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPYRIFISTGEVSGDLQGSLLIPALMAEAQSRGYALEIWALGGPRMAAVGARLLGDTS
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCH
QIGAIGPVNALPFVWPTLKLHKQVMDQFKQVPPDLTVLIDYIGPNLRLGQHLKQACPNPV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCCHHHHHHHHHCCCCE
VYYIAPSEWVWSQGLGVTRQVVDLSDKMLAIFPQEATYYQEMGADINWVGHPLVDHIHQF
EEEECCCCHHHHCCCCHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHCC
PPREQARQQLGLHPHQPMMALMPASRHQELAHLLPVMLTAAQQICRQVPDIQFWIPLALP
CCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
AYRGEVTQALQRTGLPISLFPDSQTVVAAADVVITKSGTANLEAALLNVPQVVVYRVGAI
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHH
SAWLYQHLLHFEVEFISPVNLVVGREIVPELLQQEVTPEKIAELAYSLLEKGEARHTMMA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
GYQELRSHLGLPGVLQRAAEAILNVLEQSLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRPYRIFISTGEVSGDLQGSLLIPALMAEAQSRGYALEIWALGGPRMAAVGARLLGDTS
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCH
QIGAIGPVNALPFVWPTLKLHKQVMDQFKQVPPDLTVLIDYIGPNLRLGQHLKQACPNPV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCCHHHHHHHHHCCCCE
VYYIAPSEWVWSQGLGVTRQVVDLSDKMLAIFPQEATYYQEMGADINWVGHPLVDHIHQF
EEEECCCCHHHHCCCCHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHCC
PPREQARQQLGLHPHQPMMALMPASRHQELAHLLPVMLTAAQQICRQVPDIQFWIPLALP
CCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
AYRGEVTQALQRTGLPISLFPDSQTVVAAADVVITKSGTANLEAALLNVPQVVVYRVGAI
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHH
SAWLYQHLLHFEVEFISPVNLVVGREIVPELLQQEVTPEKIAELAYSLLEKGEARHTMMA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
GYQELRSHLGLPGVLQRAAEAILNVLEQSLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA