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The map label for this gene is cysC

Identifier: 158333605

GI number: 158333605

Start: 380125

End: 380742

Strand: Reverse

Name: cysC

Synonym: AM1_0406

Alternate gene names: 158333605

Gene position: 380742-380125 (Counterclockwise)

Preceding gene: 158333606

Following gene: 158333604

Centisome position: 5.85

GC content: 44.17

Gene sequence:

>618_bases
ATGATTATGAAATCTTCTAATGTTGTCTGGCATAAGTCTACCGTCACACGCCAGAACCGACAGGAGCAAAATGGCCACCT
GAGTACTATCCTTTGGTTTACGGGACTATCTGGTGCGGGTAAATCGACGCTGGCTCACACCGTTGAAGATGCCCTATCTA
AGATGAACTGCCGAACTTTTGTTATCGATGGAGATAATATTCGCCACGGCTTGTGTGCAGATCTTGGTTTTTCGAGTGAA
GATCGAGTTGAAAATATTCGCCGAATTGGTGAAGTCGCTAAACTATTTACGGAAGCAGGCATCATTGTTTTGTCGGCATT
TATTTCTCCATTTCGGGCTGATCGAGATCGTGTTCGTGAATTGGTTCCAGAAGGTGACTTTATTGAAATATATTGCCAAG
CTAGTCTAGAAGTTTGTGAAGAGCGAGATGTAAAAGGGTTATATAAGAAGGCTAGATCGGGAGAAATCCCTAACTTTACA
GGTATTTCTTCTCCCTATGAGCCACCTGAAGAACCAGAGATTATCGTGAAGACGGGGGAAGATTCCCTAGAGGTTTGTGC
ACAGCAGGTGATTGAATTTTTACAGGAGCGGGGGATTGTTCAACCCACCTCTGCTTAG

Upstream 100 bases:

>100_bases
ATTATGGAGAGAATTCCGGGGGCAAACAGTCGAAAGCCAAGAAAAAGAAGAAAAAAGCTGATGTTAATGCCGTAGAGCGC
TCCTAAATTCCTCACTGATT

Downstream 100 bases:

>100_bases
CTAAGGTAAATTGACGAGTCAATTACTAAAAAACAAAATATCATGACGATTCTGGTTACGGGGGGAGCCGGTTTTATTGG
CGCAAACTATGTTTTGCGCA

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIMKSSNVVWHKSTVTRQNRQEQNGHLSTILWFTGLSGAGKSTLAHTVEDALSKMNCRTFVIDGDNIRHGLCADLGFSSE
DRVENIRRIGEVAKLFTEAGIIVLSAFISPFRADRDRVRELVPEGDFIEIYCQASLEVCEERDVKGLYKKARSGEIPNFT
GISSPYEPPEEPEIIVKTGEDSLEVCAQQVIEFLQERGIVQPTSA

Sequences:

>Translated_205_residues
MIMKSSNVVWHKSTVTRQNRQEQNGHLSTILWFTGLSGAGKSTLAHTVEDALSKMNCRTFVIDGDNIRHGLCADLGFSSE
DRVENIRRIGEVAKLFTEAGIIVLSAFISPFRADRDRVRELVPEGDFIEIYCQASLEVCEERDVKGLYKKARSGEIPNFT
GISSPYEPPEEPEIIVKTGEDSLEVCAQQVIEFLQERGIVQPTSA
>Mature_205_residues
MIMKSSNVVWHKSTVTRQNRQEQNGHLSTILWFTGLSGAGKSTLAHTVEDALSKMNCRTFVIDGDNIRHGLCADLGFSSE
DRVENIRRIGEVAKLFTEAGIIVLSAFISPFRADRDRVRELVPEGDFIEIYCQASLEVCEERDVKGLYKKARSGEIPNFT
GISSPYEPPEEPEIIVKTGEDSLEVCAQQVIEFLQERGIVQPTSA

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:
GO:0000103: Adenylyl-sulfate kinase
GO:0000166: Adenylyl-sulfate kinase
GO:0004020: Adenylyl-sulfate kinase
GO:0005524: Adenylyl-sulfate kinase
GO:0016301: Adenylyl-sulfate kinase
GO:0016310: Adenylyl-sulfate kinase
GO:0016740: Adenylyl-sulfate kinase
GO:0016772: Adenylyl-sulfate kinase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=206, Percent_Identity=48.5436893203884, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI34447231, Length=206, Percent_Identity=48.5436893203884, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI62912492, Length=206, Percent_Identity=48.5436893203884, Blast_Score=197, Evalue=6e-51,
Organism=Escherichia coli, GI1789107, Length=201, Percent_Identity=55.2238805970149, Blast_Score=236, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17542422, Length=203, Percent_Identity=48.7684729064039, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6322852, Length=199, Percent_Identity=48.2412060301507, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24667032, Length=202, Percent_Identity=43.5643564356436, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24667028, Length=202, Percent_Identity=43.5643564356436, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24667036, Length=202, Percent_Identity=43.5643564356436, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI116007838, Length=202, Percent_Identity=43.5643564356436, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24667044, Length=202, Percent_Identity=43.5643564356436, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24667040, Length=202, Percent_Identity=43.5643564356436, Blast_Score=174, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_ACAM1 (B0CAX3)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001514777.1
- ProteinModelPortal:   B0CAX3
- SMR:   B0CAX3
- GeneID:   5679237
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_0406
- HOGENOM:   HBG309946
- OMA:   DFIEIYC
- ProtClustDB:   CLSK2475753
- BioCyc:   AMAR329726:AM1_0406-MONOMER
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 22861; Mature: 22861

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMKSSNVVWHKSTVTRQNRQEQNGHLSTILWFTGLSGAGKSTLAHTVEDALSKMNCRTF
CCCCCCCEEEECHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEE
VIDGDNIRHGLCADLGFSSEDRVENIRRIGEVAKLFTEAGIIVLSAFISPFRADRDRVRE
EEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LVPEGDFIEIYCQASLEVCEERDVKGLYKKARSGEIPNFTGISSPYEPPEEPEIIVKTGE
HCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
DSLEVCAQQVIEFLQERGIVQPTSA
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIMKSSNVVWHKSTVTRQNRQEQNGHLSTILWFTGLSGAGKSTLAHTVEDALSKMNCRTF
CCCCCCCEEEECHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEE
VIDGDNIRHGLCADLGFSSEDRVENIRRIGEVAKLFTEAGIIVLSAFISPFRADRDRVRE
EEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LVPEGDFIEIYCQASLEVCEERDVKGLYKKARSGEIPNFTGISSPYEPPEEPEIIVKTGE
HCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
DSLEVCAQQVIEFLQERGIVQPTSA
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA