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The map label for this gene is malL [H]

Identifier: 158333370

GI number: 158333370

Start: 140063

End: 141742

Strand: Direct

Name: malL [H]

Synonym: AM1_0142

Alternate gene names: 158333370

Gene position: 140063-141742 (Clockwise)

Preceding gene: 158333369

Following gene: 158333371

Centisome position: 2.15

GC content: 48.63

Gene sequence:

>1680_bases
ATGTCCTTAGCATTAGATTGCGATCGCAAGTGGTGGCACGGGGGAGTAATTTACCAGATCTATCCCCTGACCTTTGCGGA
TGGGAATGGGGATGGGGTAGGTGATTTACGGGGAATTATTCAACGACTGGATTACCTAAACGATGGTGACCCGGATAAAA
CGGCTGACTTGGGCGTCGACGCCATTTGGCTGTCTCCCGTTAATCAGTCACCGATGGTGGATAACGGCTACGATATCAGC
GACTACCGAGATATTTGCCCCATCTTTGGCACCTTAGCAGAATTCAAAGAACTGCTAGAGCAATGCCATATCCGAGGGAT
CCGGGTAATTATGGATATGGTACTGAACCATACCTCTAATCAGCATCCTTGGTTTATCGAATCCAGCGCTAGCCGGGACA
ATCCCAAAAGCGATTGGTACCTCTGGCAAGATCCAGGCTATAAGGACGGGCTTCCCAATAACTGGTTATCCTATTTTGGC
GGGTCGGGCTGGACCTTTAATGAAGACCGTCAACAATATTACTTTCACGTTTTTAATGAAAACCAACCTGACTTAAATTG
GCGCAATCCTGAGGTGAAGGCCGCCATTTATGACATGCTGCGCTATTGGCTTGATATGGGGGTTGATGGCTTTCGCCTAG
ATGCGTCTAGTGTCTATAGCAAGGACCAATATTATCGGGATAACCCCGTCAAATTCGGGGCAACGGATAAGAATGCCTAC
TATAACCAGGATCACCTCTACGACAAAGATCTGCCCGATAACCATGGAATTATTCGGGAAATTCGTGCTCTGATGGACGA
GTACGAAGACCGGGTCCTGATTGGTGAAACTTTTATCGACAGTCGTTTATATGACTCCAATAGCTTTTATGGGGTCAATA
ATGATGAGCTGCATCTTCCCTTTGCCTTCGAATTCCCCTTTAGTCCTTGGTATCCCGGTTATTTACAACGGGAAATCGAA
AAGAAGGAGCGCATTACCCCGGCTGGGGCTTGGCCCACTTATTTTCTGGATAACCACGATTTACCCCGCCATTTATCTCG
CTGGATTGAATGTGCTTTATGCACGAACCCCACGGAAATTGCTAAAGCCGCAGCCACTCTGCTGTTAACAGTGCGGGGGA
CGCCTGTACTGTACTACGGTCAAGAAATTGGCATGGTAGATAACCAAGATATCCCCCCGGAGCTACAGCGAGATCAAGCT
GTGGTGGCTAGCCCCACGGGAGAGTTGCCTCCCAACCGAGATGGCTCCCGCACCCCGATGCAATGGGACGCGTCTGCGAA
TGCTGGATTTAGCTTTGGCAAGGAGGTTACCCCTTGGCTCCCGGTTCATGCCAACTATCAGGAAGTCAATGTCGAAACCA
CCTTAAAAGATGATGCATCGATTTTGAACTTCTATCGCAAGTTACTCTACGTGCGGGCGCAAAGTGAGGCGCTTCGGTTT
GGTAGTTGGCGAACGCTGATTCATTACCCCTACGAGCATATGGCCTATATGCGAGAAACGGCCTCTGAGCAGGTGCTGAT
CTTGATCAATTTCGCCTATGAGAAGCCCCTAGAACTAGATAAGCCGATCACCAAAGGGGGTTGGACGGTTTTAGCTTCCA
ACAAATGGGAGTCGGGTAAAACCTTGGCACTTCCTGAGAATTTGCAATCCTTTGAAATTGATGTGTTGAGGAAAGCATAA

Upstream 100 bases:

>100_bases
CGCCAGCTCAAGAACTCCAAAAATATTTGGCGCGTTCTTCTGTCCAGTTACAACTGGGCAGTATGTTTGGATGTTGTTAT
CTGTAACAAGGAAGACCTGA

Downstream 100 bases:

>100_bases
AGCTTAGGTGAATATTTCAAAATGATGCGAATATTTCAGTCCAACCACTATCTGCATAAGTGCGATCGCAAGCTGCAAAA
AAAGAAGATATAGCATCTAG

Product: alpha amylase catalytic subunit

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MSLALDCDRKWWHGGVIYQIYPLTFADGNGDGVGDLRGIIQRLDYLNDGDPDKTADLGVDAIWLSPVNQSPMVDNGYDIS
DYRDICPIFGTLAEFKELLEQCHIRGIRVIMDMVLNHTSNQHPWFIESSASRDNPKSDWYLWQDPGYKDGLPNNWLSYFG
GSGWTFNEDRQQYYFHVFNENQPDLNWRNPEVKAAIYDMLRYWLDMGVDGFRLDASSVYSKDQYYRDNPVKFGATDKNAY
YNQDHLYDKDLPDNHGIIREIRALMDEYEDRVLIGETFIDSRLYDSNSFYGVNNDELHLPFAFEFPFSPWYPGYLQREIE
KKERITPAGAWPTYFLDNHDLPRHLSRWIECALCTNPTEIAKAAATLLLTVRGTPVLYYGQEIGMVDNQDIPPELQRDQA
VVASPTGELPPNRDGSRTPMQWDASANAGFSFGKEVTPWLPVHANYQEVNVETTLKDDASILNFYRKLLYVRAQSEALRF
GSWRTLIHYPYEHMAYMRETASEQVLILINFAYEKPLELDKPITKGGWTVLASNKWESGKTLALPENLQSFEIDVLRKA

Sequences:

>Translated_559_residues
MSLALDCDRKWWHGGVIYQIYPLTFADGNGDGVGDLRGIIQRLDYLNDGDPDKTADLGVDAIWLSPVNQSPMVDNGYDIS
DYRDICPIFGTLAEFKELLEQCHIRGIRVIMDMVLNHTSNQHPWFIESSASRDNPKSDWYLWQDPGYKDGLPNNWLSYFG
GSGWTFNEDRQQYYFHVFNENQPDLNWRNPEVKAAIYDMLRYWLDMGVDGFRLDASSVYSKDQYYRDNPVKFGATDKNAY
YNQDHLYDKDLPDNHGIIREIRALMDEYEDRVLIGETFIDSRLYDSNSFYGVNNDELHLPFAFEFPFSPWYPGYLQREIE
KKERITPAGAWPTYFLDNHDLPRHLSRWIECALCTNPTEIAKAAATLLLTVRGTPVLYYGQEIGMVDNQDIPPELQRDQA
VVASPTGELPPNRDGSRTPMQWDASANAGFSFGKEVTPWLPVHANYQEVNVETTLKDDASILNFYRKLLYVRAQSEALRF
GSWRTLIHYPYEHMAYMRETASEQVLILINFAYEKPLELDKPITKGGWTVLASNKWESGKTLALPENLQSFEIDVLRKA
>Mature_558_residues
SLALDCDRKWWHGGVIYQIYPLTFADGNGDGVGDLRGIIQRLDYLNDGDPDKTADLGVDAIWLSPVNQSPMVDNGYDISD
YRDICPIFGTLAEFKELLEQCHIRGIRVIMDMVLNHTSNQHPWFIESSASRDNPKSDWYLWQDPGYKDGLPNNWLSYFGG
SGWTFNEDRQQYYFHVFNENQPDLNWRNPEVKAAIYDMLRYWLDMGVDGFRLDASSVYSKDQYYRDNPVKFGATDKNAYY
NQDHLYDKDLPDNHGIIREIRALMDEYEDRVLIGETFIDSRLYDSNSFYGVNNDELHLPFAFEFPFSPWYPGYLQREIEK
KERITPAGAWPTYFLDNHDLPRHLSRWIECALCTNPTEIAKAAATLLLTVRGTPVLYYGQEIGMVDNQDIPPELQRDQAV
VASPTGELPPNRDGSRTPMQWDASANAGFSFGKEVTPWLPVHANYQEVNVETTLKDDASILNFYRKLLYVRAQSEALRFG
SWRTLIHYPYEHMAYMRETASEQVLILINFAYEKPLELDKPITKGGWTVLASNKWESGKTLALPENLQSFEIDVLRKA

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=537, Percent_Identity=32.7746741154562, Blast_Score=269, Evalue=6e-72,
Organism=Escherichia coli, GI1790687, Length=575, Percent_Identity=36, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1786604, Length=531, Percent_Identity=23.5404896421846, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081873, Length=245, Percent_Identity=24.8979591836735, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565753, Length=495, Percent_Identity=28.0808080808081, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25147709, Length=519, Percent_Identity=23.6994219653179, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321726, Length=508, Percent_Identity=36.0236220472441, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322245, Length=582, Percent_Identity=32.8178694158076, Blast_Score=283, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6324416, Length=513, Percent_Identity=36.2573099415205, Blast_Score=279, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6322241, Length=513, Percent_Identity=36.2573099415205, Blast_Score=279, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6322021, Length=513, Percent_Identity=36.2573099415205, Blast_Score=279, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6319776, Length=576, Percent_Identity=32.6388888888889, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321731, Length=576, Percent_Identity=32.6388888888889, Blast_Score=277, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24583747, Length=494, Percent_Identity=39.0688259109312, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24583749, Length=494, Percent_Identity=39.0688259109312, Blast_Score=307, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24583745, Length=531, Percent_Identity=37.2881355932203, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24586599, Length=535, Percent_Identity=35.8878504672897, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24586587, Length=526, Percent_Identity=36.5019011406844, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI221330053, Length=510, Percent_Identity=37.4509803921569, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24586593, Length=494, Percent_Identity=37.246963562753, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24586597, Length=529, Percent_Identity=36.1058601134215, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24586591, Length=501, Percent_Identity=33.7325349301397, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24586589, Length=481, Percent_Identity=37.2141372141372, Blast_Score=268, Evalue=9e-72,
Organism=Drosophila melanogaster, GI45549022, Length=536, Percent_Identity=33.7686567164179, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI281360393, Length=429, Percent_Identity=35.1981351981352, Blast_Score=222, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 64581; Mature: 64450

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLALDCDRKWWHGGVIYQIYPLTFADGNGDGVGDLRGIIQRLDYLNDGDPDKTADLGVD
CCEEECCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCE
AIWLSPVNQSPMVDNGYDISDYRDICPIFGTLAEFKELLEQCHIRGIRVIMDMVLNHTSN
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QHPWFIESSASRDNPKSDWYLWQDPGYKDGLPNNWLSYFGGSGWTFNEDRQQYYFHVFNE
CCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECC
NQPDLNWRNPEVKAAIYDMLRYWLDMGVDGFRLDASSVYSKDQYYRDNPVKFGATDKNAY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCCCCEEECCCCCCCC
YNQDHLYDKDLPDNHGIIREIRALMDEYEDRVLIGETFIDSRLYDSNSFYGVNNDELHLP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHHCCEEECCCCEECCCCCCEEEE
FAFEFPFSPWYPGYLQREIEKKERITPAGAWPTYFLDNHDLPRHLSRWIECALCTNPTEI
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHEEHCCCCHHHH
AKAAATLLLTVRGTPVLYYGQEIGMVDNQDIPPELQRDQAVVASPTGELPPNRDGSRTPM
HHHHEEEEEEECCCEEEEECCEECCCCCCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCE
QWDASANAGFSFGKEVTPWLPVHANYQEVNVETTLKDDASILNFYRKLLYVRAQSEALRF
EECCCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHC
GSWRTLIHYPYEHMAYMRETASEQVLILINFAYEKPLELDKPITKGGWTVLASNKWESGK
CCEEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCC
TLALPENLQSFEIDVLRKA
EEECCCCCCCEEEEEEECC
>Mature Secondary Structure 
SLALDCDRKWWHGGVIYQIYPLTFADGNGDGVGDLRGIIQRLDYLNDGDPDKTADLGVD
CEEECCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCE
AIWLSPVNQSPMVDNGYDISDYRDICPIFGTLAEFKELLEQCHIRGIRVIMDMVLNHTSN
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QHPWFIESSASRDNPKSDWYLWQDPGYKDGLPNNWLSYFGGSGWTFNEDRQQYYFHVFNE
CCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECC
NQPDLNWRNPEVKAAIYDMLRYWLDMGVDGFRLDASSVYSKDQYYRDNPVKFGATDKNAY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCCCCEEECCCCCCCC
YNQDHLYDKDLPDNHGIIREIRALMDEYEDRVLIGETFIDSRLYDSNSFYGVNNDELHLP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHHCCEEECCCCEECCCCCCEEEE
FAFEFPFSPWYPGYLQREIEKKERITPAGAWPTYFLDNHDLPRHLSRWIECALCTNPTEI
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHEEHCCCCHHHH
AKAAATLLLTVRGTPVLYYGQEIGMVDNQDIPPELQRDQAVVASPTGELPPNRDGSRTPM
HHHHEEEEEEECCCEEEEECCEECCCCCCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCE
QWDASANAGFSFGKEVTPWLPVHANYQEVNVETTLKDDASILNFYRKLLYVRAQSEALRF
EECCCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHC
GSWRTLIHYPYEHMAYMRETASEQVLILINFAYEKPLELDKPITKGGWTVLASNKWESGK
CCEEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCC
TLALPENLQSFEIDVLRKA
EEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]