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The map label for this gene is ilvD

Identifier: 158319022

GI number: 158319022

Start: 8927975

End: 8929828

Strand: Reverse

Name: ilvD

Synonym: Franean1_7305

Alternate gene names: 158319022

Gene position: 8929828-8927975 (Counterclockwise)

Preceding gene: 158319023

Following gene: 158319021

Centisome position: 99.42

GC content: 71.47

Gene sequence:

>1854_bases
ATGCCCGCTTTGCGTTCCCGCACCACCACCCACGGTCGAAACATGGCCGGTGCCCGCGCCCTGTGGCGGGCGACCGGCAT
GACCGACGACGACTTCGGCAAGCCGATCGTCGCGATCGCGAACAGCTTCACGCAGTTCGTTCCCGGCCATGTCCACCTGC
GGGACCTCGGGAAGATCGTCGCGGACGCGGTGGCCGGGTCGGGCGGGGTGGCCAAGGAGTTCAACACGATCGCCGTCGAC
GACGGCATCGCGATGGGCCACGGCGGCATGCTGTACTCCCTGCCATCCCGGGAGATCATCGCGGACAGCGTCGAGTACAT
GGTCAACGCCCACTGCGCCGATGCGCTGGTCTGCATCTCGAACTGTGACAAGATCACCCCGGGGATGCTGATCGCCGCGC
TGCGGCTCAACATCCCGACCGTCTTCGTCTCCGGCGGCGCGATGGAATCCGGTCACGCCGTCGTCACCGGCGGGATCGTG
CGGTCGCGGCTCGACCTGATCGACGCGATGACCGCGGCCGTCAACCCCGACGTCAGCGACGCCGACCTGGACACCATCGA
GCGGTCCGCCTGCCCCACCTGCGGCTCCTGCTCCGGCATGTTCACGGCCAACTCGATGAACTGCCTGACCGAGGCGCTCG
GCCTGGCGCTGCCGGGCAACGGCTCGACGCTGGCCACCGCGGCGGCCCGGCGCGGCCTGTTCGTCGAGGCCGGTCGCCTG
GTCGTCGACCTGGCCCGCCGGTACTACGAGAAGGACGACGAGGCCGTCCTACCCCGCTCGATCGCGAGCGCGGCGGCGTT
CCGCAACGCGTTCGCGGTGGACGTCGCCATGGGCGGTTCGACGAACACCGTCCTGCACCTGCTCGCCGCCGCCGTCGAGG
CCGGGGTCGAGGTGACCCTCGACGACATCGACCAGGTCTCCCGCTCGGTGGCCTGCCTGTGCAAGGTGGCGCCCAGCTCG
ACCGACTACTACATGGAAGACGTCCACCGGGCCGGCGGGATCCCGGCGATCCTCGGTGAGCTCGACCGCGGCGGTCTGGT
GGACCCGAACGTGCACAGCGTGCACGCGGCGAGCCTGCGCGAGTTCCTCGACCGCTGGGACGTGCGCGGGGCGGACCCGT
CCCCGGACGCGATCGAGCTGTTCCACGCCGCGCCCGGCGGCGTGCGCACCGTCGAACCGTTCGGCTCGACGAACCGCTGG
GACACCCTCGACACCGACGCGAAGAACGGCTGCATCCGCTCGGTCGAGCACGCCTACTCGGCCGACGGCGGCCTGGCCGT
GCTGCGCGGCAACCTGGCCCCCGACGGCGCCGTGGTGAAGACGGCCGGCGTCGACGAGAGCCAGTGGACGTTCCGCGGGC
CCGCGCTGGTCGTCGAGAGCCAGGAGGCCGCGGTCGACGCGATCCTGAACAAGGTCGTCAAGGCGGGCGACGTGATCATC
GTCCGGTATGAGGGCCCCCGCGGTGGGCCCGGCATGCAGGAGATGCTCTACCCGACGGCGTTCCTCAAGGGCCGCGGCCT
CGGGCCGAAGTGCGCGCTGATCACCGATGGCCGCTTCTCCGGTGGCAGCTCGGGCCTGTCGATCGGCCACGTCTCCCCGG
AGGCGGCGCACGGTGGCCCGATCGCGCTCGTCCGGGACGGTGATCTCGTCGAGATCGACATCCCGCGGCGGCGGATCGAC
CTGCTGGTGCCGGACGCCGAGCTCGCCGCGCGGCGGGCCGAGATCGAGGCGAACGGCGGCTACCACCCGGCGAACAGGGA
GCGTGTCGTGTCGGCCGCGCTGCGCGCCTACGCGGCCATGGCGACGTCCGCCTCGACCGGTGCCGCCCGTGACGTCCGGC
TCATCACGGGATGA

Upstream 100 bases:

>100_bases
ACGTCCGCTTCGTCGTACCGACGGCTGTTCGCCCGCCCGCGTCCGGCACCCCGACGCACCGCCCGTCTTCAGCGCCCCAC
AGCCCAGCTCAGAGGTCGAG

Downstream 100 bases:

>100_bases
CATCTCTCTCGGTAGCTGAATCGATCGCGGTGTGTGTGCGAAGGTGGGGCCTGTTCGCTTGGCGCGACTTCAGGTAGTCG
CCTGATCACCTAGTGGTTGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MPALRSRTTTHGRNMAGARALWRATGMTDDDFGKPIVAIANSFTQFVPGHVHLRDLGKIVADAVAGSGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLIAALRLNIPTVFVSGGAMESGHAVVTGGIV
RSRLDLIDAMTAAVNPDVSDADLDTIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARRGLFVEAGRL
VVDLARRYYEKDDEAVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAGVEVTLDDIDQVSRSVACLCKVAPSS
TDYYMEDVHRAGGIPAILGELDRGGLVDPNVHSVHAASLREFLDRWDVRGADPSPDAIELFHAAPGGVRTVEPFGSTNRW
DTLDTDAKNGCIRSVEHAYSADGGLAVLRGNLAPDGAVVKTAGVDESQWTFRGPALVVESQEAAVDAILNKVVKAGDVII
VRYEGPRGGPGMQEMLYPTAFLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGPIALVRDGDLVEIDIPRRRID
LLVPDAELAARRAEIEANGGYHPANRERVVSAALRAYAAMATSASTGAARDVRLITG

Sequences:

>Translated_617_residues
MPALRSRTTTHGRNMAGARALWRATGMTDDDFGKPIVAIANSFTQFVPGHVHLRDLGKIVADAVAGSGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLIAALRLNIPTVFVSGGAMESGHAVVTGGIV
RSRLDLIDAMTAAVNPDVSDADLDTIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARRGLFVEAGRL
VVDLARRYYEKDDEAVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAGVEVTLDDIDQVSRSVACLCKVAPSS
TDYYMEDVHRAGGIPAILGELDRGGLVDPNVHSVHAASLREFLDRWDVRGADPSPDAIELFHAAPGGVRTVEPFGSTNRW
DTLDTDAKNGCIRSVEHAYSADGGLAVLRGNLAPDGAVVKTAGVDESQWTFRGPALVVESQEAAVDAILNKVVKAGDVII
VRYEGPRGGPGMQEMLYPTAFLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGPIALVRDGDLVEIDIPRRRID
LLVPDAELAARRAEIEANGGYHPANRERVVSAALRAYAAMATSASTGAARDVRLITG
>Mature_616_residues
PALRSRTTTHGRNMAGARALWRATGMTDDDFGKPIVAIANSFTQFVPGHVHLRDLGKIVADAVAGSGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLIAALRLNIPTVFVSGGAMESGHAVVTGGIVR
SRLDLIDAMTAAVNPDVSDADLDTIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARRGLFVEAGRLV
VDLARRYYEKDDEAVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAGVEVTLDDIDQVSRSVACLCKVAPSST
DYYMEDVHRAGGIPAILGELDRGGLVDPNVHSVHAASLREFLDRWDVRGADPSPDAIELFHAAPGGVRTVEPFGSTNRWD
TLDTDAKNGCIRSVEHAYSADGGLAVLRGNLAPDGAVVKTAGVDESQWTFRGPALVVESQEAAVDAILNKVVKAGDVIIV
RYEGPRGGPGMQEMLYPTAFLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGPIALVRDGDLVEIDIPRRRIDL
LVPDAELAARRAEIEANGGYHPANRERVVSAALRAYAAMATSASTGAARDVRLITG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=620, Percent_Identity=67.9032258064516, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=547, Percent_Identity=29.7989031078611, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI2367371, Length=500, Percent_Identity=31, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786464, Length=525, Percent_Identity=30.4761904761905, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=35.9477124183007, Blast_Score=349, Evalue=7e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_FRASN (A8L8S7)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001511530.1
- GeneID:   5675606
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_7305
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   FSP1855:FRANEAN1_7305-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 64401; Mature: 64269

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALRSRTTTHGRNMAGARALWRATGMTDDDFGKPIVAIANSFTQFVPGHVHLRDLGKIV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ADAVAGSGGVAKEFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHCCCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLIAALRLNIPTVFVSGGAMESGHAVVTGGIVRSRLDLIDAMTAAVNPDVSD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCC
ADLDTIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARRGLFVEAGRL
CCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCHHHHHHHHCCEEEEHHHH
VVDLARRYYEKDDEAVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAGVEVTL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEH
DDIDQVSRSVACLCKVAPSSTDYYMEDVHRAGGIPAILGELDRGGLVDPNVHSVHAASLR
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
EFLDRWDVRGADPSPDAIELFHAAPGGVRTVEPFGSTNRWDTLDTDAKNGCIRSVEHAYS
HHHHHHCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHC
ADGGLAVLRGNLAPDGAVVKTAGVDESQWTFRGPALVVESQEAAVDAILNKVVKAGDVII
CCCCEEEEECCCCCCCCEEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHCCCCEEE
VRYEGPRGGPGMQEMLYPTAFLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGP
EEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCC
IALVRDGDLVEIDIPRRRIDLLVPDAELAARRAEIEANGGYHPANRERVVSAALRAYAAM
EEEEECCCEEEEECCCCEEEEEECCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHH
ATSASTGAARDVRLITG
HCCCCCCCCCCEEEECC
>Mature Secondary Structure 
PALRSRTTTHGRNMAGARALWRATGMTDDDFGKPIVAIANSFTQFVPGHVHLRDLGKIV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ADAVAGSGGVAKEFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHCCCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLIAALRLNIPTVFVSGGAMESGHAVVTGGIVRSRLDLIDAMTAAVNPDVSD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCC
ADLDTIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARRGLFVEAGRL
CCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCHHHHHHHHCCEEEEHHHH
VVDLARRYYEKDDEAVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAGVEVTL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEH
DDIDQVSRSVACLCKVAPSSTDYYMEDVHRAGGIPAILGELDRGGLVDPNVHSVHAASLR
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
EFLDRWDVRGADPSPDAIELFHAAPGGVRTVEPFGSTNRWDTLDTDAKNGCIRSVEHAYS
HHHHHHCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHC
ADGGLAVLRGNLAPDGAVVKTAGVDESQWTFRGPALVVESQEAAVDAILNKVVKAGDVII
CCCCEEEEECCCCCCCCEEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHCCCCEEE
VRYEGPRGGPGMQEMLYPTAFLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGP
EEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCC
IALVRDGDLVEIDIPRRRIDLLVPDAELAARRAEIEANGGYHPANRERVVSAALRAYAAM
EEEEECCCEEEEECCCCEEEEEECCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHH
ATSASTGAARDVRLITG
HCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA