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The map label for this gene is mscL [H]

Identifier: 158318955

GI number: 158318955

Start: 8838299

End: 8838688

Strand: Direct

Name: mscL [H]

Synonym: Franean1_7238

Alternate gene names: 158318955

Gene position: 8838299-8838688 (Clockwise)

Preceding gene: 158318953

Following gene: 158318956

Centisome position: 98.4

GC content: 64.36

Gene sequence:

>390_bases
ATGAAGGGCTTCAAAGAGTTCCTGCTGCGGGGGAACGTCGTCGACCTCGCGGTCGCCGTCGTGATCGGCACCGCCTTCAC
CGCGGTGGTCACGTCGCTGGTCGCGAACCTCTTCACCCCGCTCATCGCCGCGATCATCGGGAAGCCGGACTTCGCACAGC
TCACCTTCACGATCAACAACAGCGTCTTCTACTACGGTCGATTCCTGAACAGCCTCATCGCGTTCCTCTCGATCGCCGCG
GTGATCTACTTTGTCGTGGTCGCACCGGTCAGCAGGATCAATGAGCGGCGACGGCGCGGCCAGACGTCCCCGCTGGACGA
TCCGACGCTCACGGACGAGACCCGGTTGCTGACCGAGATCCGGGACCTGCTGGCGGCCGGGCGACGGTGA

Upstream 100 bases:

>100_bases
GGCCCGATGGTGTGGCGGGTGGGAACCACCACGAACCACCCGCTCGGGCGGTCACACGCTCGGCACGGCATCGCGGGGAA
GTCGACGTCCGGGGGGATGC

Downstream 100 bases:

>100_bases
ACGGCACCGGCACCGGCACGCCGGGGGACGCGGCAGGCGCCGCGGGTACGGAGGCCGGCCACGGTCAGCAGCCAGGCGGA
GTGCCCGGCGGAGCCGGCAC

Product: large conductance mechanosensitive channel protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MKGFKEFLLRGNVVDLAVAVVIGTAFTAVVTSLVANLFTPLIAAIIGKPDFAQLTFTINNSVFYYGRFLNSLIAFLSIAA
VIYFVVVAPVSRINERRRRGQTSPLDDPTLTDETRLLTEIRDLLAAGRR

Sequences:

>Translated_129_residues
MKGFKEFLLRGNVVDLAVAVVIGTAFTAVVTSLVANLFTPLIAAIIGKPDFAQLTFTINNSVFYYGRFLNSLIAFLSIAA
VIYFVVVAPVSRINERRRRGQTSPLDDPTLTDETRLLTEIRDLLAAGRR
>Mature_129_residues
MKGFKEFLLRGNVVDLAVAVVIGTAFTAVVTSLVANLFTPLIAAIIGKPDFAQLTFTINNSVFYYGRFLNSLIAFLSIAA
VIYFVVVAPVSRINERRRRGQTSPLDDPTLTDETRLLTEIRDLLAAGRR

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=131, Percent_Identity=41.2213740458015, Blast_Score=92, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 14206; Mature: 14206

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFKEFLLRGNVVDLAVAVVIGTAFTAVVTSLVANLFTPLIAAIIGKPDFAQLTFTINN
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECC
SVFYYGRFLNSLIAFLSIAAVIYFVVVAPVSRINERRRRGQTSPLDDPTLTDETRLLTEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RDLLAAGRR
HHHHHCCCC
>Mature Secondary Structure
MKGFKEFLLRGNVVDLAVAVVIGTAFTAVVTSLVANLFTPLIAAIIGKPDFAQLTFTINN
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECC
SVFYYGRFLNSLIAFLSIAAVIYFVVVAPVSRINERRRRGQTSPLDDPTLTDETRLLTEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RDLLAAGRR
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA