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The map label for this gene is ampH [C]

Identifier: 158318741

GI number: 158318741

Start: 8549757

End: 8551160

Strand: Reverse

Name: ampH [C]

Synonym: Franean1_7012

Alternate gene names: 158318741

Gene position: 8551160-8549757 (Counterclockwise)

Preceding gene: 158318744

Following gene: 158318738

Centisome position: 95.2

GC content: 73.65

Gene sequence:

>1404_bases
ATGACTTTGCCGTCCGAGGGGTTGCTGCCGGGTACCCGCCGCGCCTTGCTGCACCGGCTGGCGGTCGGGCAGGCGGAGGG
GCGCACGCCCTCGCTGGTCGGCGCGGTCGTGCGCGGCGGCCGGCTGGTCTGGGCCGACGGTCGGAGCATGATCGACGGGC
ACAGCCCGGACGCCGACGTCCAGTACCGGATCGGCTCGATCACGAAGACCTTTGTCGCGGTGCAGGTCATGCGCCTGCGT
GACGAGGGCGTACTGGACCTGGCCGATTCGCTGGACCGTCACCTGCCCGGCACCGCGGCGGGGCCAGGGGCCGGGGCCGG
GGCAGGGGCCCTGACGATCGCCCAACTGCTCGGCCACACCTCGGGCCTCGCGTCCGAGCCGCCCGGTCCCTGGTGGGAAC
GCACGCCTGGAACGCTGCGGCCACTGCTCGACGACGTGCTCCACGAGCCGGCGGTACGCCATCCGGCGGGCCGCCGCTTC
CACTACTCGAACCCCGGGTTCGCGCTGCTCGGAGCGCTGGTCAGCCGGCTGCGCGGACAACCGTGGGGCGATGCGCTGCA
CGAGGAGGTGCTGGCGCCGCTCGGTTTGACCCGGACCACGCTCTCCCCGCAGGCACCGCACGCCGGCGGCTTCGGGGTGC
ATCCCTGGGCGGATGTGATGGTGCCCGAGCCGTTGGAGGACACCGGTGTGATGGCGCCGGCGGGTCAGCTCTGGTCGACC
GCCGCCGACCTGTCCCGCTGGGCCGCGTTCCTGGCGCAGGGCGACAAGGCCGTTCTGAGCGCCGACACCCTCGCCGAGAT
GCGCCAGCCGGCGTCTGGCCCCGACGAGGCGGACGACTGGGCCACCGCCTACGGGCTCGGCCTGCATCTACGACGACAGA
ACGGCCGACTGCTGTACGGCCACAACGGCTCGATGCCGGGATTCCTGGCCACCCTCCTGGTGAGTCAGCGCGACGACGTC
GCCGCCGTCGTCCTGGCGAACGCGACCGCTGGGCCGGCGGTGGCGCTGATCGCCGCCGACCTGATCCGGATCGTCGCCGA
GCACGAACCGTGCATCCCGGACCCGTGGCGCCCGCTGCCGGCCGTCGATCCGGAGCTTCTGGCGCTCACCGGCCTGTGGC
ACTGGGGCCCGTCGCCACACCTGCTGCACCTGCGCGCCGACCGTGGGCTGGAGCTCATCCCGCAGGGCCAGTCGGGCCGC
GGCGCCCGTTTCCGTGCTGAGGCGGACGGCACCTGGACCGGGCTGGACGGGTACTACGCGGGTGAGACGCTGCGCGTCGT
CCGCGCCCCGGGCGGCGCCGCCAGCCACCTGGACATCGGCACATTCGTGTTCACCCGCACGCCCTACGACCCGGACGCGG
AGATCCCCGGCGGCCTCGACCCGGGCGGCTGGCAGACATACTGA

Upstream 100 bases:

>100_bases
CCGCTCGGATGGCCCTGGGTCGACCGCGGGATCATGACGGTGTGCCAGGTCGACGCGCGGTGAAGAATCTTTCGGGGTGC
AACGCGAGGAGGAACGAGCG

Downstream 100 bases:

>100_bases
CATGCGTTCCAGGACCACGGTCCGAGCGTCGGTGCCAGACCGCGGCCGCCAGGCGCACGCGCGGCTCCCACGGTTCTAGG
AATGCGGATCAGCGGGCAAC

Product: beta-lactamase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTLPSEGLLPGTRRALLHRLAVGQAEGRTPSLVGAVVRGGRLVWADGRSMIDGHSPDADVQYRIGSITKTFVAVQVMRLR
DEGVLDLADSLDRHLPGTAAGPGAGAGAGALTIAQLLGHTSGLASEPPGPWWERTPGTLRPLLDDVLHEPAVRHPAGRRF
HYSNPGFALLGALVSRLRGQPWGDALHEEVLAPLGLTRTTLSPQAPHAGGFGVHPWADVMVPEPLEDTGVMAPAGQLWST
AADLSRWAAFLAQGDKAVLSADTLAEMRQPASGPDEADDWATAYGLGLHLRRQNGRLLYGHNGSMPGFLATLLVSQRDDV
AAVVLANATAGPAVALIAADLIRIVAEHEPCIPDPWRPLPAVDPELLALTGLWHWGPSPHLLHLRADRGLELIPQGQSGR
GARFRAEADGTWTGLDGYYAGETLRVVRAPGGAASHLDIGTFVFTRTPYDPDAEIPGGLDPGGWQTY

Sequences:

>Translated_467_residues
MTLPSEGLLPGTRRALLHRLAVGQAEGRTPSLVGAVVRGGRLVWADGRSMIDGHSPDADVQYRIGSITKTFVAVQVMRLR
DEGVLDLADSLDRHLPGTAAGPGAGAGAGALTIAQLLGHTSGLASEPPGPWWERTPGTLRPLLDDVLHEPAVRHPAGRRF
HYSNPGFALLGALVSRLRGQPWGDALHEEVLAPLGLTRTTLSPQAPHAGGFGVHPWADVMVPEPLEDTGVMAPAGQLWST
AADLSRWAAFLAQGDKAVLSADTLAEMRQPASGPDEADDWATAYGLGLHLRRQNGRLLYGHNGSMPGFLATLLVSQRDDV
AAVVLANATAGPAVALIAADLIRIVAEHEPCIPDPWRPLPAVDPELLALTGLWHWGPSPHLLHLRADRGLELIPQGQSGR
GARFRAEADGTWTGLDGYYAGETLRVVRAPGGAASHLDIGTFVFTRTPYDPDAEIPGGLDPGGWQTY
>Mature_466_residues
TLPSEGLLPGTRRALLHRLAVGQAEGRTPSLVGAVVRGGRLVWADGRSMIDGHSPDADVQYRIGSITKTFVAVQVMRLRD
EGVLDLADSLDRHLPGTAAGPGAGAGAGALTIAQLLGHTSGLASEPPGPWWERTPGTLRPLLDDVLHEPAVRHPAGRRFH
YSNPGFALLGALVSRLRGQPWGDALHEEVLAPLGLTRTTLSPQAPHAGGFGVHPWADVMVPEPLEDTGVMAPAGQLWSTA
ADLSRWAAFLAQGDKAVLSADTLAEMRQPASGPDEADDWATAYGLGLHLRRQNGRLLYGHNGSMPGFLATLLVSQRDDVA
AVVLANATAGPAVALIAADLIRIVAEHEPCIPDPWRPLPAVDPELLALTGLWHWGPSPHLLHLRADRGLELIPQGQSGRG
ARFRAEADGTWTGLDGYYAGETLRVVRAPGGAASHLDIGTFVFTRTPYDPDAEIPGGLDPGGWQTY

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=318, Percent_Identity=28.6163522012579, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI239752721, Length=318, Percent_Identity=28.6163522012579, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI239741085, Length=318, Percent_Identity=28.6163522012579, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786574, Length=199, Percent_Identity=28.1407035175879, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=329, Percent_Identity=25.8358662613982, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 49439; Mature: 49308

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSEGLLPGTRRALLHRLAVGQAEGRTPSLVGAVVRGGRLVWADGRSMIDGHSPDADV
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCE
QYRIGSITKTFVAVQVMRLRDEGVLDLADSLDRHLPGTAAGPGAGAGAGALTIAQLLGHT
EEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
SGLASEPPGPWWERTPGTLRPLLDDVLHEPAVRHPAGRRFHYSNPGFALLGALVSRLRGQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
PWGDALHEEVLAPLGLTRTTLSPQAPHAGGFGVHPWADVMVPEPLEDTGVMAPAGQLWST
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHH
AADLSRWAAFLAQGDKAVLSADTLAEMRQPASGPDEADDWATAYGLGLHLRRQNGRLLYG
HHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHCEEEEEECCCCEEEC
HNGSMPGFLATLLVSQRDDVAAVVLANATAGPAVALIAADLIRIVAEHEPCIPDPWRPLP
CCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AVDPELLALTGLWHWGPSPHLLHLRADRGLELIPQGQSGRGARFRAEADGTWTGLDGYYA
CCCHHHHEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEECCCCCEECCCCEEC
GETLRVVRAPGGAASHLDIGTFVFTRTPYDPDAEIPGGLDPGGWQTY
CCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLPSEGLLPGTRRALLHRLAVGQAEGRTPSLVGAVVRGGRLVWADGRSMIDGHSPDADV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCE
QYRIGSITKTFVAVQVMRLRDEGVLDLADSLDRHLPGTAAGPGAGAGAGALTIAQLLGHT
EEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
SGLASEPPGPWWERTPGTLRPLLDDVLHEPAVRHPAGRRFHYSNPGFALLGALVSRLRGQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
PWGDALHEEVLAPLGLTRTTLSPQAPHAGGFGVHPWADVMVPEPLEDTGVMAPAGQLWST
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHH
AADLSRWAAFLAQGDKAVLSADTLAEMRQPASGPDEADDWATAYGLGLHLRRQNGRLLYG
HHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHCEEEEEECCCCEEEC
HNGSMPGFLATLLVSQRDDVAAVVLANATAGPAVALIAADLIRIVAEHEPCIPDPWRPLP
CCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AVDPELLALTGLWHWGPSPHLLHLRADRGLELIPQGQSGRGARFRAEADGTWTGLDGYYA
CCCHHHHEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEECCCCCEECCCCEEC
GETLRVVRAPGGAASHLDIGTFVFTRTPYDPDAEIPGGLDPGGWQTY
CCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]