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The map label for this gene is devR [H]

Identifier: 158318665

GI number: 158318665

Start: 8446251

End: 8446985

Strand: Reverse

Name: devR [H]

Synonym: Franean1_6933

Alternate gene names: 158318665

Gene position: 8446985-8446251 (Counterclockwise)

Preceding gene: 158318667

Following gene: 158318664

Centisome position: 94.04

GC content: 68.84

Gene sequence:

>735_bases
ATGGCCGGCTGGACGCGAGGGCCGCCGCCGCGCCCGTTGGTCCTGGCGGGCGTAAGCCGATTGGCGAGGCGACTCCGAGG
CCGTATCGTCGCGCTCATGGAGAAGATCCGGGTGTTCGTTCTCGATGACCACGAGATCGTGCGTAATGGTCTGCGTCAGA
CGCTCGCCCGGCATGACGATATCGAGGTCGTCGGAGAGGCCGGGCTGGCCGCGGAGGCGTTGCGGCGGATTCCCGCGCTG
CATCCGCATGTGGCGGTGCTGGACGGGCGGCTGCCTGATGGCAGTGGCATCGACGTGTGCCGGGAGGTGCGGTCGGCGTT
GCCGGATGTGGCGTGCCTGATTCTGACCTCCTATGACGACGACGAGGCGCTGTTCTCGGCGATCATGGCGGGTGCGGCGG
GGTACGTGCTGAAGGAGATCCGGGGCAACGACCTGGTGGGGGCGATCCGGACGGTGGCGTCGGGGCAGTCGCTGCTGGCG
CCGTCGGTGACGCGGCGGGTGCTGGAGCGGCTGCGGGACGGGCCGAGCGAGGACCCGGCGATGGCGACGCTGAACCAGCG
GGAGCGCGAGATCCTGCAGCTGATCGCGGACGGGTTGACGAACCGGCAGATCGGCACGCGGCTGGGCCTGTCGGAGAAGA
CGGTGAAGAACTACGTGTCGAGCATTCTGGAGAAGCTCGGCCTGGCGAGCCGTACGCAGGCCGCCGTCTACCTGATGAAG
CAGACCGGGGAGTAG

Upstream 100 bases:

>100_bases
CCGGACGCGCGGATCCACCACTACGGTGAGCCGGTGGGCAGCTCCCGCTGACGGGCGGTCCAGGCGGGCGGCGGCCACCC
GACCAGCGGTTGCGGTGTGA

Downstream 100 bases:

>100_bases
CCCGGGCGTGTGCGGGGGGTGGCCGCCGGCTGCCCCCCCGCACACGCGTCCGCCCGGGATCCCACCGAGGTGTCTGACAG
GTGCCGTCTGACGGGTGAAC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAGWTRGPPPRPLVLAGVSRLARRLRGRIVALMEKIRVFVLDDHEIVRNGLRQTLARHDDIEVVGEAGLAAEALRRIPAL
HPHVAVLDGRLPDGSGIDVCREVRSALPDVACLILTSYDDDEALFSAIMAGAAGYVLKEIRGNDLVGAIRTVASGQSLLA
PSVTRRVLERLRDGPSEDPAMATLNQREREILQLIADGLTNRQIGTRLGLSEKTVKNYVSSILEKLGLASRTQAAVYLMK
QTGE

Sequences:

>Translated_244_residues
MAGWTRGPPPRPLVLAGVSRLARRLRGRIVALMEKIRVFVLDDHEIVRNGLRQTLARHDDIEVVGEAGLAAEALRRIPAL
HPHVAVLDGRLPDGSGIDVCREVRSALPDVACLILTSYDDDEALFSAIMAGAAGYVLKEIRGNDLVGAIRTVASGQSLLA
PSVTRRVLERLRDGPSEDPAMATLNQREREILQLIADGLTNRQIGTRLGLSEKTVKNYVSSILEKLGLASRTQAAVYLMK
QTGE
>Mature_243_residues
AGWTRGPPPRPLVLAGVSRLARRLRGRIVALMEKIRVFVLDDHEIVRNGLRQTLARHDDIEVVGEAGLAAEALRRIPALH
PHVAVLDGRLPDGSGIDVCREVRSALPDVACLILTSYDDDEALFSAIMAGAAGYVLKEIRGNDLVGAIRTVASGQSLLAP
SVTRRVLERLRDGPSEDPAMATLNQREREILQLIADGLTNRQIGTRLGLSEKTVKNYVSSILEKLGLASRTQAAVYLMKQ
TGE

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=36.0576923076923, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=35.8208955223881, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788222, Length=194, Percent_Identity=32.4742268041237, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788546, Length=214, Percent_Identity=29.4392523364486, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786747, Length=203, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788712, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26509; Mature: 26378

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGWTRGPPPRPLVLAGVSRLARRLRGRIVALMEKIRVFVLDDHEIVRNGLRQTLARHDD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCC
IEVVGEAGLAAEALRRIPALHPHVAVLDGRLPDGSGIDVCREVRSALPDVACLILTSYDD
HHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCHHEEHEEECCCC
DEALFSAIMAGAAGYVLKEIRGNDLVGAIRTVASGQSLLAPSVTRRVLERLRDGPSEDPA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
MATLNQREREILQLIADGLTNRQIGTRLGLSEKTVKNYVSSILEKLGLASRTQAAVYLMK
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QTGE
HCCC
>Mature Secondary Structure 
AGWTRGPPPRPLVLAGVSRLARRLRGRIVALMEKIRVFVLDDHEIVRNGLRQTLARHDD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCC
IEVVGEAGLAAEALRRIPALHPHVAVLDGRLPDGSGIDVCREVRSALPDVACLILTSYDD
HHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCHHEEHEEECCCC
DEALFSAIMAGAAGYVLKEIRGNDLVGAIRTVASGQSLLAPSVTRRVLERLRDGPSEDPA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
MATLNQREREILQLIADGLTNRQIGTRLGLSEKTVKNYVSSILEKLGLASRTQAAVYLMK
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QTGE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]