Click here to switch to the map view.

The map label for this gene is yhcA [H]

Identifier: 158318555

GI number: 158318555

Start: 8313517

End: 8315193

Strand: Reverse

Name: yhcA [H]

Synonym: Franean1_6823

Alternate gene names: 158318555

Gene position: 8315193-8313517 (Counterclockwise)

Preceding gene: 158318556

Following gene: 158318552

Centisome position: 92.58

GC content: 73.82

Gene sequence:

>1677_bases
ATGGACGTCCCCCTCAACCGCCGCCCGAGCCAACGCGCCGTCGTCGCCACGCTGTTCGTCGCGACGATGTTCATCACGAT
CATGGACACCACGATCGTCAACGTGGCGCTCCCCTCCATCGCGGCCGACCTGGGCGTGAGCTCCGGGTCGATCGACGAGG
TCGTGATCGCCTACCTGGTCAGCCTGGCCGTCTCCATCCCGGCGTCGGGCTGGCTCGCGGACAGGTTCGGCAGCCGGCCG
GTGTTTCTCGCCGCGCTGGGCGTGTTCACGGCGGCCTCCGCCCTGTGCGGGCTCGCCGGCAGCCTCACCGCGCTGGTGGT
CTTCCGGGTGCTGCAGGGCGTCGGCGGTGGCCTGCTCACCCCGGTTGGCATGGCGATGCTCTACCGGGTCTACCCACCGG
CGGAGCGGGCCCGGGCGGCCCGGATTCTCATCGTGCCCACCGTCGTCGCGCCGGCCGTCGGCCCGATCCTCGGCGGGGTG
CTGACCGACCAGGCGTCCTGGCACTGGGTGTTCCTGGTCAACGTGCCGATCGGGATCGCCGCGTTCGGCTTCGGCCTGGC
GTTCCTGGCCGGCTCCCGGGTGCCGGGTGCCGGCCGCTTCGACGCGCTGGGCTTCGTGCTCTCGGCGAGTGGCTTCGCCC
TCGTCCTCTACGCGCTGTCCGTCGGGCCGAACCACGGCTGGCTGTCGGCCGGGACCCTCACGGCCGCCGGGGTCGGGCTC
CTGGCGACCGGGGCCACCGTGTGGTGGGAGCTGCGCCGCACCCAGCCGCTGCTGGCCCTGCGGCTACTCGGCAACGACCT
GTTCCGCACCGTCAGCCTGACCCTGTCGATCGCGTTCATGGCGTTCATGGGCGTGCTGTTCCTCGTCCCGCTGTTCATGC
AGACGGTGCGGGGCGTCAGCGCGACGACGTCCGGGCTCGTCGTCTTCCCTGAGGCCCTGGGTGTGCTGACCGCCACCCAG
ATCGCCGGGCGCCTCTACCCGAGGATCGGGCCGCGCCGGCTGATGGCCGGCGGCCTGGTCTTCGCGGCCGCCTCGATGCT
CGCCCTCGGCTTTCTCGACTCGGCCGGATCCCTCTGGCCGCTGCGCGCGCTGCTGTTCGGGGTCGGCTTCGGTATCGGCT
TCGTGATGATGCCGGCCCAGACCGCGGCCTTCGCCACCATCTCCACGCAGCAGACGGCCCAGGCCTCCGCGCTGTTCAAC
GCGCAGCGCCAGCTCGCCTCCGCGATCGGGGTCGCGCTGGTCTCCACCGCGCTCAGCCTGGCGCGACCCGCCGCCACGGG
GCCCGCCGCCACGGGGCCCGGCGGCGGGTCGGTCGTCGGCGACACCGGCTCCTTCCGGTGGGCGTTCGCCGTCGCCGCGG
CACTGGCCGCCCTCGGGCTCCTCGCCGCGCTGCGCGTTCGGGACGCCGACGCCGCCCCCACCATGCGCCCACCCGCGGCG
GTGCCGGCCACCGCCGCGGAGACCGTCCTACTCGGGCACGGTAGGGATGACCAGGGTGGAGGTTCCAGGGCCGGTGCTGA
CGGTCACGTCGACCGGGCTCGCGTTGGGAGTGAGGACGTCGGCGGCGCCGCCGGAGACCCGGACACCGATGCGGTGGCCG
GCGGCGAAGCGGTGGTGGACCGGCCGGATGCCGATCTCGAAGGCGGTGGGCTCCCCGGCGGTCACCGGCGTCGGTGA

Upstream 100 bases:

>100_bases
TGAGGTTGCCTCACTATGAGGGTCGGACGATGCCGGCCCGTGAACGTCCGACGCCGGAGCCCTGTCCCACCTCGGCCGCG
GCGGGACGGAAGGAGTCGGC

Downstream 100 bases:

>100_bases
CGTGTGCGACTCGCGGTGGCTGGCCCGCAGGAAACCATCGTTCACCACCGTGGACGCGCCGTCCGGGGCTACGTCGAGCA
GCTCCACGTAGAAGTTGGCG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MDVPLNRRPSQRAVVATLFVATMFITIMDTTIVNVALPSIAADLGVSSGSIDEVVIAYLVSLAVSIPASGWLADRFGSRP
VFLAALGVFTAASALCGLAGSLTALVVFRVLQGVGGGLLTPVGMAMLYRVYPPAERARAARILIVPTVVAPAVGPILGGV
LTDQASWHWVFLVNVPIGIAAFGFGLAFLAGSRVPGAGRFDALGFVLSASGFALVLYALSVGPNHGWLSAGTLTAAGVGL
LATGATVWWELRRTQPLLALRLLGNDLFRTVSLTLSIAFMAFMGVLFLVPLFMQTVRGVSATTSGLVVFPEALGVLTATQ
IAGRLYPRIGPRRLMAGGLVFAAASMLALGFLDSAGSLWPLRALLFGVGFGIGFVMMPAQTAAFATISTQQTAQASALFN
AQRQLASAIGVALVSTALSLARPAATGPAATGPGGGSVVGDTGSFRWAFAVAAALAALGLLAALRVRDADAAPTMRPPAA
VPATAAETVLLGHGRDDQGGGSRAGADGHVDRARVGSEDVGGAAGDPDTDAVAGGEAVVDRPDADLEGGGLPGGHRRR

Sequences:

>Translated_558_residues
MDVPLNRRPSQRAVVATLFVATMFITIMDTTIVNVALPSIAADLGVSSGSIDEVVIAYLVSLAVSIPASGWLADRFGSRP
VFLAALGVFTAASALCGLAGSLTALVVFRVLQGVGGGLLTPVGMAMLYRVYPPAERARAARILIVPTVVAPAVGPILGGV
LTDQASWHWVFLVNVPIGIAAFGFGLAFLAGSRVPGAGRFDALGFVLSASGFALVLYALSVGPNHGWLSAGTLTAAGVGL
LATGATVWWELRRTQPLLALRLLGNDLFRTVSLTLSIAFMAFMGVLFLVPLFMQTVRGVSATTSGLVVFPEALGVLTATQ
IAGRLYPRIGPRRLMAGGLVFAAASMLALGFLDSAGSLWPLRALLFGVGFGIGFVMMPAQTAAFATISTQQTAQASALFN
AQRQLASAIGVALVSTALSLARPAATGPAATGPGGGSVVGDTGSFRWAFAVAAALAALGLLAALRVRDADAAPTMRPPAA
VPATAAETVLLGHGRDDQGGGSRAGADGHVDRARVGSEDVGGAAGDPDTDAVAGGEAVVDRPDADLEGGGLPGGHRRR
>Mature_558_residues
MDVPLNRRPSQRAVVATLFVATMFITIMDTTIVNVALPSIAADLGVSSGSIDEVVIAYLVSLAVSIPASGWLADRFGSRP
VFLAALGVFTAASALCGLAGSLTALVVFRVLQGVGGGLLTPVGMAMLYRVYPPAERARAARILIVPTVVAPAVGPILGGV
LTDQASWHWVFLVNVPIGIAAFGFGLAFLAGSRVPGAGRFDALGFVLSASGFALVLYALSVGPNHGWLSAGTLTAAGVGL
LATGATVWWELRRTQPLLALRLLGNDLFRTVSLTLSIAFMAFMGVLFLVPLFMQTVRGVSATTSGLVVFPEALGVLTATQ
IAGRLYPRIGPRRLMAGGLVFAAASMLALGFLDSAGSLWPLRALLFGVGFGIGFVMMPAQTAAFATISTQQTAQASALFN
AQRQLASAIGVALVSTALSLARPAATGPAATGPGGGSVVGDTGSFRWAFAVAAALAALGLLAALRVRDADAAPTMRPPAA
VPATAAETVLLGHGRDDQGGGSRAGADGHVDRARVGSEDVGGAAGDPDTDAVAGGEAVVDRPDADLEGGGLPGGHRRR

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=400, Percent_Identity=33.25, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1790195, Length=405, Percent_Identity=34.5679012345679, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788710, Length=400, Percent_Identity=29.75, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1788392, Length=396, Percent_Identity=32.8282828282828, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI87081983, Length=405, Percent_Identity=32.3456790123457, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1790146, Length=159, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788509, Length=163, Percent_Identity=31.9018404907975, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082320, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=484, Percent_Identity=23.7603305785124, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325455, Length=329, Percent_Identity=25.2279635258359, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56609; Mature: 56609

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVPLNRRPSQRAVVATLFVATMFITIMDTTIVNVALPSIAADLGVSSGSIDEVVIAYLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SLAVSIPASGWLADRFGSRPVFLAALGVFTAASALCGLAGSLTALVVFRVLQGVGGGLLT
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
PVGMAMLYRVYPPAERARAARILIVPTVVAPAVGPILGGVLTDQASWHWVFLVNVPIGIA
HHHHHHHHHCCCCHHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHH
AFGFGLAFLAGSRVPGAGRFDALGFVLSASGFALVLYALSVGPNHGWLSAGTLTAAGVGL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCHHHHCHHH
LATGATVWWELRRTQPLLALRLLGNDLFRTVSLTLSIAFMAFMGVLFLVPLFMQTVRGVS
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATTSGLVVFPEALGVLTATQIAGRLYPRIGPRRLMAGGLVFAAASMLALGFLDSAGSLWP
CCCCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LRALLFGVGFGIGFVMMPAQTAAFATISTQQTAQASALFNAQRQLASAIGVALVSTALSL
HHHHHHHHHHHHHHHEECCCHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARPAATGPAATGPGGGSVVGDTGSFRWAFAVAAALAALGLLAALRVRDADAAPTMRPPAA
HCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPATAAETVLLGHGRDDQGGGSRAGADGHVDRARVGSEDVGGAAGDPDTDAVAGGEAVVD
CCCCHHCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEC
RPDADLEGGGLPGGHRRR
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDVPLNRRPSQRAVVATLFVATMFITIMDTTIVNVALPSIAADLGVSSGSIDEVVIAYLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SLAVSIPASGWLADRFGSRPVFLAALGVFTAASALCGLAGSLTALVVFRVLQGVGGGLLT
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
PVGMAMLYRVYPPAERARAARILIVPTVVAPAVGPILGGVLTDQASWHWVFLVNVPIGIA
HHHHHHHHHCCCCHHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHH
AFGFGLAFLAGSRVPGAGRFDALGFVLSASGFALVLYALSVGPNHGWLSAGTLTAAGVGL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCHHHHCHHH
LATGATVWWELRRTQPLLALRLLGNDLFRTVSLTLSIAFMAFMGVLFLVPLFMQTVRGVS
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATTSGLVVFPEALGVLTATQIAGRLYPRIGPRRLMAGGLVFAAASMLALGFLDSAGSLWP
CCCCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LRALLFGVGFGIGFVMMPAQTAAFATISTQQTAQASALFNAQRQLASAIGVALVSTALSL
HHHHHHHHHHHHHHHEECCCHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARPAATGPAATGPGGGSVVGDTGSFRWAFAVAAALAALGLLAALRVRDADAAPTMRPPAA
HCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPATAAETVLLGHGRDDQGGGSRAGADGHVDRARVGSEDVGGAAGDPDTDAVAGGEAVVD
CCCCHHCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEC
RPDADLEGGGLPGGHRRR
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]