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The map label for this gene is phoR [H]

Identifier: 158318322

GI number: 158318322

Start: 8016280

End: 8017788

Strand: Reverse

Name: phoR [H]

Synonym: Franean1_6587

Alternate gene names: 158318322

Gene position: 8017788-8016280 (Counterclockwise)

Preceding gene: 158318323

Following gene: 158318321

Centisome position: 89.26

GC content: 73.09

Gene sequence:

>1509_bases
TTGCGGGCACGGTTGCTGTTGGCCCTGGTCGGCCTGCTGGCGCTCGGCCTGGTGCTCGGCGCGTTCGGCACCCAGAACGC
CGTCGAGTCGTACCTGCTCGGCCGGCTGGACCGGCAGGTGCGCGACGCCCACCCAGTGATGGAACAGACCTTGCTCGGCG
GCGACACGGACCACATGCCGTACCACCACGACGCCGACGACCGGGCGCCGCGGTTCGGCACCGCGTTCCTCGTCGGCACC
TACGGGGCGCTGTACGACAGCGCCGGCCGGCGAGTGGCCGAGACCAGCCCCGGCCCGAACGGCCCCGCGGCACCGACCCG
GCGCCCGGCCGTCACCCAGAGCATGCTCGCTGCCGCCCCGGTGCAGCCCGACCTGGCGACCGCCCCCCTGTGGACGGTCC
CCGCCGAAGGCGGCGGGGACAGGTTCAGGCTGCTCGCCGAGTGCTTCGGCAACGGAGACGTTCTGGTCGTCGCGGTGCCC
TTCGCCGAGATGGAGACCACTCTCGACAACGTCACCAGGATCGAGCTCATCGTGAGCGCGGCGATGCTGGTGGTGCTCGC
CGCGCTGGCCTACGTCATCATCCGCCTCGGGCTGCGCCCGCTGACCCGCATCGAACACACCGCGGGCATGATCGCGGACG
GCGACCTGACTCAACGGGTCACCGACACGGACCGCGGTACCGAGGTGGGGCGTCTCGGGCTGGCCTTCAACACGATGCTC
ACCGAGATCGAGGCGTCTTTCCGCGCCCGGGAGGCCTCCGAGCGGCGCCTGCGACGCTTCGTCGGGGACGCCAGCCACGA
ACTGCGCACCCCGCTGACGTCGATCCGCGGCTACGCCGAGATGTTCCGCAGGGGAGCGGCAAGCCGACCCGAGGACCTGG
CGATGGTCATGCGGCGCATCGAGGAGGAGTCGGCCCGGATGAGCGAGCTGGTCGACGACCTGCTGCTGCTCGCCCGCCTC
GACCACCAGCCCGACCTCGAGCGTGAACCCGTCGACCTGGCGGCCATGCTCCGTGACATCGCCGCCGACGCCCGCGCCGT
CAGCCCGGGACGGACGATCGAGGTCGACGCCCCGCCGATCCTCGAGGTGACGGGGGACGAGGGACGCCTGCGCCAGGCCG
TCGGGAACCTCGTCCGCAACGCGCTCGTCCACACCCCGCCCGAGGCGACGGTCTCCCTCACCGCCCGCGACGCCGACACG
GACGCGGATGGCGACGGCGACGCCGACGGCGATGCGGCGGCCGGTGCGGCGGATGACGACCGGGAGGTCGTCATCTCGGT
GATCGACCATGGACCCGGAGTCCCCGCTGACGCCGTCGACCACGTCTTCGAGCGGTTCTACCGCGCCGACTCCGGCCGCT
CCCGCGACGCCGGCGGGACGGGGCTGGGCCTGTCCATTGTCGAGGCCGTCGCCGCCGCGCACGGCGGACGGGCCGAGCAC
CGGCCGACACCGGGCGGCGGCGCCACGTTCCGGCTCGTCCTGCCCCGCCCCGATCCCTCTTCGTCATGA

Upstream 100 bases:

>100_bases
TGCCGCGGTGAGACGTCCGGCCCTGCCCCGGCGCGTCCTGCACCGCGTCCTGCACCGGCGCGTCCTGCGTCGGCATCTCG
TGTCCTCGCGGGTGGTCTCT

Downstream 100 bases:

>100_bases
GCTGGATCGGCTCCGTTCACCGCGACCCGCCAGGCTGATCTCGGCGCGGCCGGCCGGGATCCGTCCGGCGGGCGGGACTT
GCCGTGCTGGTGAGGTCTCT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRARLLLALVGLLALGLVLGAFGTQNAVESYLLGRLDRQVRDAHPVMEQTLLGGDTDHMPYHHDADDRAPRFGTAFLVGT
YGALYDSAGRRVAETSPGPNGPAAPTRRPAVTQSMLAAAPVQPDLATAPLWTVPAEGGGDRFRLLAECFGNGDVLVVAVP
FAEMETTLDNVTRIELIVSAAMLVVLAALAYVIIRLGLRPLTRIEHTAGMIADGDLTQRVTDTDRGTEVGRLGLAFNTML
TEIEASFRAREASERRLRRFVGDASHELRTPLTSIRGYAEMFRRGAASRPEDLAMVMRRIEEESARMSELVDDLLLLARL
DHQPDLEREPVDLAAMLRDIAADARAVSPGRTIEVDAPPILEVTGDEGRLRQAVGNLVRNALVHTPPEATVSLTARDADT
DADGDGDADGDAAAGAADDDREVVISVIDHGPGVPADAVDHVFERFYRADSGRSRDAGGTGLGLSIVEAVAAAHGGRAEH
RPTPGGGATFRLVLPRPDPSSS

Sequences:

>Translated_502_residues
MRARLLLALVGLLALGLVLGAFGTQNAVESYLLGRLDRQVRDAHPVMEQTLLGGDTDHMPYHHDADDRAPRFGTAFLVGT
YGALYDSAGRRVAETSPGPNGPAAPTRRPAVTQSMLAAAPVQPDLATAPLWTVPAEGGGDRFRLLAECFGNGDVLVVAVP
FAEMETTLDNVTRIELIVSAAMLVVLAALAYVIIRLGLRPLTRIEHTAGMIADGDLTQRVTDTDRGTEVGRLGLAFNTML
TEIEASFRAREASERRLRRFVGDASHELRTPLTSIRGYAEMFRRGAASRPEDLAMVMRRIEEESARMSELVDDLLLLARL
DHQPDLEREPVDLAAMLRDIAADARAVSPGRTIEVDAPPILEVTGDEGRLRQAVGNLVRNALVHTPPEATVSLTARDADT
DADGDGDADGDAAAGAADDDREVVISVIDHGPGVPADAVDHVFERFYRADSGRSRDAGGTGLGLSIVEAVAAAHGGRAEH
RPTPGGGATFRLVLPRPDPSSS
>Mature_502_residues
MRARLLLALVGLLALGLVLGAFGTQNAVESYLLGRLDRQVRDAHPVMEQTLLGGDTDHMPYHHDADDRAPRFGTAFLVGT
YGALYDSAGRRVAETSPGPNGPAAPTRRPAVTQSMLAAAPVQPDLATAPLWTVPAEGGGDRFRLLAECFGNGDVLVVAVP
FAEMETTLDNVTRIELIVSAAMLVVLAALAYVIIRLGLRPLTRIEHTAGMIADGDLTQRVTDTDRGTEVGRLGLAFNTML
TEIEASFRAREASERRLRRFVGDASHELRTPLTSIRGYAEMFRRGAASRPEDLAMVMRRIEEESARMSELVDDLLLLARL
DHQPDLEREPVDLAAMLRDIAADARAVSPGRTIEVDAPPILEVTGDEGRLRQAVGNLVRNALVHTPPEATVSLTARDADT
DADGDGDADGDAAAGAADDDREVVISVIDHGPGVPADAVDHVFERFYRADSGRSRDAGGTGLGLSIVEAVAAAHGGRAEH
RPTPGGGATFRLVLPRPDPSSS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=303, Percent_Identity=33.003300330033, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786600, Length=246, Percent_Identity=35.7723577235772, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1790346, Length=300, Percent_Identity=29.3333333333333, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787894, Length=332, Percent_Identity=29.5180722891566, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790861, Length=349, Percent_Identity=29.512893982808, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=307, Percent_Identity=28.0130293159609, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788279, Length=322, Percent_Identity=25.1552795031056, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=31.8725099601594, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789808, Length=326, Percent_Identity=28.2208588957055, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=308, Percent_Identity=28.8961038961039, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=24.8148148148148, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=26.7716535433071, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=23.0452674897119, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=269, Percent_Identity=23.7918215613383, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=318, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=356, Percent_Identity=27.247191011236, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53531; Mature: 53531

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARLLLALVGLLALGLVLGAFGTQNAVESYLLGRLDRQVRDAHPVMEQTLLGGDTDHMP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YHHDADDRAPRFGTAFLVGTYGALYDSAGRRVAETSPGPNGPAAPTRRPAVTQSMLAAAP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
VQPDLATAPLWTVPAEGGGDRFRLLAECFGNGDVLVVAVPFAEMETTLDNVTRIELIVSA
CCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
AMLVVLAALAYVIIRLGLRPLTRIEHTAGMIADGDLTQRVTDTDRGTEVGRLGLAFNTML
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCHHHHHCCCCCCCHHHHHHHHHHHHH
TEIEASFRAREASERRLRRFVGDASHELRTPLTSIRGYAEMFRRGAASRPEDLAMVMRRI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EEESARMSELVDDLLLLARLDHQPDLEREPVDLAAMLRDIAADARAVSPGRTIEVDAPPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
LEVTGDEGRLRQAVGNLVRNALVHTPPEATVSLTARDADTDADGDGDADGDAAAGAADDD
EEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
REVVISVIDHGPGVPADAVDHVFERFYRADSGRSRDAGGTGLGLSIVEAVAAAHGGRAEH
HHHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
RPTPGGGATFRLVLPRPDPSSS
CCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRARLLLALVGLLALGLVLGAFGTQNAVESYLLGRLDRQVRDAHPVMEQTLLGGDTDHMP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YHHDADDRAPRFGTAFLVGTYGALYDSAGRRVAETSPGPNGPAAPTRRPAVTQSMLAAAP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
VQPDLATAPLWTVPAEGGGDRFRLLAECFGNGDVLVVAVPFAEMETTLDNVTRIELIVSA
CCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
AMLVVLAALAYVIIRLGLRPLTRIEHTAGMIADGDLTQRVTDTDRGTEVGRLGLAFNTML
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCHHHHHCCCCCCCHHHHHHHHHHHHH
TEIEASFRAREASERRLRRFVGDASHELRTPLTSIRGYAEMFRRGAASRPEDLAMVMRRI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EEESARMSELVDDLLLLARLDHQPDLEREPVDLAAMLRDIAADARAVSPGRTIEVDAPPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
LEVTGDEGRLRQAVGNLVRNALVHTPPEATVSLTARDADTDADGDGDADGDAAAGAADDD
EEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
REVVISVIDHGPGVPADAVDHVFERFYRADSGRSRDAGGTGLGLSIVEAVAAAHGGRAEH
HHHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
RPTPGGGATFRLVLPRPDPSSS
CCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]