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The map label for this gene is adhA [H]

Identifier: 158318306

GI number: 158318306

Start: 7995180

End: 7996256

Strand: Reverse

Name: adhA [H]

Synonym: Franean1_6571

Alternate gene names: 158318306

Gene position: 7996256-7995180 (Counterclockwise)

Preceding gene: 158318307

Following gene: 158318304

Centisome position: 89.02

GC content: 76.04

Gene sequence:

>1077_bases
ATGTTGGCCTGGCAGGTCACTCGCCCCGCGCCGGTGGCCACGGCGCCACTGCGCGCGGTCGAGCTGCCCATCCCCGAGCC
CGGTCCCGGTCAGGTCCGTCTGAAGGTCGCCGCCTGCGGCGTCTGCCGGACGGACCTGCACCTGGCCGAGGGCGACCTCC
CGCCGCACCGGCCGCTCACCGTGCCCGGTCACGAGGTCGTCGGGTACGTCGACGCGCTCGGTCCCGGGGTCCACGGGGTT
TCCGGGCCAGCCGGGCCAGCCGGTGCGGCCGGCTCCCGGCGACCCGATCCGGCCCCGGCGGCCCCGATCCGGCTGGGTGA
CCGGCTCGGCATCGCCTGGCTCGCCGGAACGGATCAGACGTGCGCCTACTGCCGGCGCGGCGCCGAGAACCTCTGCCCCG
CGTCGCTCTACACAGGCTGGGACGCCGACGGCGGGTACGCCCAGTACGCCGTCGTCGACGCGGACTACGCCTACCGCCTG
CCCGCCGGCTACAGCGACGGCGAGCTGGCCCCGTTGCTGTGCGCCGGGATCGTCGGCTACCGGGCGCTGCTGCGCGCCGA
GCTTCCGCCCGGCGGCCGGCTGGGCGTCTACGGGTTCGGCGCGTCCGCGCATCTCGCCGCGCAGGTGGCGATCGCCCAGG
GCGCGACGGTGCACGTCATGACCAGGTCCGCCCGGGCCCGCCGCCTCGCCCTCGAGCTCGGCGCGGCGTCCGCGACCGGC
GCCTACGACTTCCCACCCGAGCCGCTCGACGGGGCGGTCCTGTTCGCACCGGTCGGCGATCTGGTCCCGGTCGCGCTCGC
CGCGCTGGACAGGGGCGGCACCCTCTCGATCGCCGGGATCCACCTCACCGACGTCCCGGTCCTGAACTACCGTCGGCACC
TGTTCCAGGAGCGCTCGGTGCGCAGCACGACCGCGAACACCCGCGCCGACGGCCGCGAGTTCCTGGAGATCGCCGGGCGC
CACCGGCTCGCGGTGACAACCACCCCGTACCCGCTGACGGCCGCCGACCAGGCGCTCGAGGACCTCGCACGCGACCGGGT
GGACGGCGCCGCCGTGCTGTTCCCGGACGGCGTCTGA

Upstream 100 bases:

>100_bases
CCTGCGGGTCGAGTTCCCGCGGGCTGAACATCCGCGGGCCGGTCAGCCGGCGCGCGGGTGTCCGCGCGGGCTGACCGGCC
GCTGACGGGGGGTGCGTCGC

Downstream 100 bases:

>100_bases
CGGCCGGCTTACGGGACGAGGCGGTAGAACCGGAAGAAGTCGTGCTCGATGGGCAGCGTCTCCGTCGAGGTGAAACCCGC
GAGTTCGGCGTAGCCGGCGA

Product: alcohol dehydrogenase zinc-binding type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLAWQVTRPAPVATAPLRAVELPIPEPGPGQVRLKVAACGVCRTDLHLAEGDLPPHRPLTVPGHEVVGYVDALGPGVHGV
SGPAGPAGAAGSRRPDPAPAAPIRLGDRLGIAWLAGTDQTCAYCRRGAENLCPASLYTGWDADGGYAQYAVVDADYAYRL
PAGYSDGELAPLLCAGIVGYRALLRAELPPGGRLGVYGFGASAHLAAQVAIAQGATVHVMTRSARARRLALELGAASATG
AYDFPPEPLDGAVLFAPVGDLVPVALAALDRGGTLSIAGIHLTDVPVLNYRRHLFQERSVRSTTANTRADGREFLEIAGR
HRLAVTTTPYPLTAADQALEDLARDRVDGAAVLFPDGV

Sequences:

>Translated_358_residues
MLAWQVTRPAPVATAPLRAVELPIPEPGPGQVRLKVAACGVCRTDLHLAEGDLPPHRPLTVPGHEVVGYVDALGPGVHGV
SGPAGPAGAAGSRRPDPAPAAPIRLGDRLGIAWLAGTDQTCAYCRRGAENLCPASLYTGWDADGGYAQYAVVDADYAYRL
PAGYSDGELAPLLCAGIVGYRALLRAELPPGGRLGVYGFGASAHLAAQVAIAQGATVHVMTRSARARRLALELGAASATG
AYDFPPEPLDGAVLFAPVGDLVPVALAALDRGGTLSIAGIHLTDVPVLNYRRHLFQERSVRSTTANTRADGREFLEIAGR
HRLAVTTTPYPLTAADQALEDLARDRVDGAAVLFPDGV
>Mature_358_residues
MLAWQVTRPAPVATAPLRAVELPIPEPGPGQVRLKVAACGVCRTDLHLAEGDLPPHRPLTVPGHEVVGYVDALGPGVHGV
SGPAGPAGAAGSRRPDPAPAAPIRLGDRLGIAWLAGTDQTCAYCRRGAENLCPASLYTGWDADGGYAQYAVVDADYAYRL
PAGYSDGELAPLLCAGIVGYRALLRAELPPGGRLGVYGFGASAHLAAQVAIAQGATVHVMTRSARARRLALELGAASATG
AYDFPPEPLDGAVLFAPVGDLVPVALAALDRGGTLSIAGIHLTDVPVLNYRRHLFQERSVRSTTANTRADGREFLEIAGR
HRLAVTTTPYPLTAADQALEDLARDRVDGAAVLFPDGV

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=214, Percent_Identity=31.7757009345794, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=26.7806267806268, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=26.8221574344023, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787863, Length=150, Percent_Identity=32, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082125, Length=214, Percent_Identity=26.6355140186916, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=25.5255255255255, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=320, Percent_Identity=24.375, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=318, Percent_Identity=23.2704402515723, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=30.5295950155763, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=319, Percent_Identity=31.0344827586207, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=357, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=354, Percent_Identity=29.3785310734463, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323980, Length=211, Percent_Identity=28.9099526066351, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=23.7082066869301, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=228, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37182; Mature: 37182

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAWQVTRPAPVATAPLRAVELPIPEPGPGQVRLKVAACGVCRTDLHLAEGDLPPHRPLT
CCEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCEECCCCEEECCCCCCCCCEE
VPGHEVVGYVDALGPGVHGVSGPAGPAGAAGSRRPDPAPAAPIRLGDRLGIAWLAGTDQT
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCHH
CAYCRRGAENLCPASLYTGWDADGGYAQYAVVDADYAYRLPAGYSDGELAPLLCAGIVGY
HHHHHCCHHHCCCCHHCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHH
RALLRAELPPGGRLGVYGFGASAHLAAQVAIAQGATVHVMTRSARARRLALELGAASATG
HHHHHHCCCCCCEEEEEEECCCHHHHEEEEECCCCEEEEEECCCHHHEEEEEECCCCCCC
AYDFPPEPLDGAVLFAPVGDLVPVALAALDRGGTLSIAGIHLTDVPVLNYRRHLFQERSV
CCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHH
RSTTANTRADGREFLEIAGRHRLAVTTTPYPLTAADQALEDLARDRVDGAAVLFPDGV
HHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MLAWQVTRPAPVATAPLRAVELPIPEPGPGQVRLKVAACGVCRTDLHLAEGDLPPHRPLT
CCEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCEECCCCEEECCCCCCCCCEE
VPGHEVVGYVDALGPGVHGVSGPAGPAGAAGSRRPDPAPAAPIRLGDRLGIAWLAGTDQT
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCHH
CAYCRRGAENLCPASLYTGWDADGGYAQYAVVDADYAYRLPAGYSDGELAPLLCAGIVGY
HHHHHCCHHHCCCCHHCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHH
RALLRAELPPGGRLGVYGFGASAHLAAQVAIAQGATVHVMTRSARARRLALELGAASATG
HHHHHHCCCCCCEEEEEEECCCHHHHEEEEECCCCEEEEEECCCHHHEEEEEECCCCCCC
AYDFPPEPLDGAVLFAPVGDLVPVALAALDRGGTLSIAGIHLTDVPVLNYRRHLFQERSV
CCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHH
RSTTANTRADGREFLEIAGRHRLAVTTTPYPLTAADQALEDLARDRVDGAAVLFPDGV
HHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]